메뉴 건너뛰기




Volumn 122, Issue 9, 2001, Pages 895-908

Sphingomyelin and ceramide as regulators of development and lifespan

Author keywords

Aging; Antioxidant; Cancer; Cardiovascular disease; Evolution; Oxidative stress; Sphingolipids; Tumor necrosis factor

Indexed keywords

CERAMIDE; GROWTH FACTOR; HORMONE; INTERLEUKIN 1BETA; NEUROTRANSMITTER; PHOSPHATASE; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 0035880016     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00246-9     Document Type: Review
Times cited : (133)

References (79)
  • 2
    • 0031779350 scopus 로고    scopus 로고
    • Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor
    • Adam-Klages, S., Schwandner, R., Adam, D., Kreder, D., Bernardo, K., Kronke, M., 1998. Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor. J. Leukoc. Biol. 63, 678-682.
    • (1998) J. Leukoc. Biol. , vol.63 , pp. 678-682
    • Adam-Klages, S.1    Schwandner, R.2    Adam, D.3    Kreder, D.4    Bernardo, K.5    Kronke, M.6
  • 4
    • 0028867688 scopus 로고
    • Neuroendocrine ageing
    • Bjorntorp, P., 1995. Neuroendocrine ageing. J. Intern. Med. 238, 401-404.
    • (1995) J. Intern. Med. , vol.238 , pp. 401-404
    • Bjorntorp, P.1
  • 5
    • 0034199463 scopus 로고    scopus 로고
    • Prostate cancer prevention trials in the USA
    • Brawley, O.W., Pames, H., 2000. Prostate cancer prevention trials in the USA. Fur. J. Cancer 36, 1312-1315.
    • (2000) Fur. J. Cancer , vol.36 , pp. 1312-1315
    • Brawley, O.W.1    Pames, H.2
  • 6
    • 0032421354 scopus 로고    scopus 로고
    • Functions of lipid rafts in biological membranes
    • Brown, D.A., London, F., 1998. Functions of lipid rafts in biological membranes. Annu. Rev. Cell Dev. Biol. 14, 111-136.
    • (1998) Annu. Rev. Cell Dev. Biol. , vol.14 , pp. 111-136
    • Brown, D.A.1    London, F.2
  • 7
    • 0032925851 scopus 로고    scopus 로고
    • Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults
    • Bruce-Keller, A.J., Umberger, G., McFall, R., Mattson, M.P., 1999. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann. Neurol. 45, 8-15.
    • (1999) Ann. Neurol. , vol.45 , pp. 8-15
    • Bruce-Keller, A.J.1    Umberger, G.2    McFall, R.3    Mattson, M.P.4
  • 9
    • 0033870405 scopus 로고    scopus 로고
    • Energy restriction dilutes the changes related to dietary fat type in membrane phospholipid fatty acid composition in rats
    • Cha, M.C., Jones, P.J., 2000. Energy restriction dilutes the changes related to dietary fat type in membrane phospholipid fatty acid composition in rats. Metabolism 49, 977-983.
    • (2000) Metabolism , vol.49 , pp. 977-983
    • Cha, M.C.1    Jones, P.J.2
  • 10
    • 0031694479 scopus 로고    scopus 로고
    • Sphingolipids in atherosclerosis and vascular biology
    • Chatterjee, S., 1998. Sphingolipids in atherosclerosis and vascular biology. Arterioscler. Thromb. Vase. Biol. 18, 1523-1533.
    • (1998) Arterioscler. Thromb. Vase. Biol. , vol.18 , pp. 1523-1533
    • Chatterjee, S.1
  • 11
    • 0030815108 scopus 로고    scopus 로고
    • Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation
    • Chmura, S.J., Mauceri, HJ., Advani, S., Heimann, R., Beckett, M.A., Nodzenski, E., Quintans, J., Kufe, D.W., Weichselbaum, R.R., 1997. Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res. 57, 4340-4347.
    • (1997) Cancer Res. , vol.57 , pp. 4340-4347
    • Chmura, S.J.1    Mauceri, H.J.2    Advani, S.3    Heimann, R.4    Beckett, M.A.5    Nodzenski, E.6    Quintans, J.7    Kufe, D.W.8    Weichselbaum, R.R.9
  • 12
    • 0031041448 scopus 로고    scopus 로고
    • Cytokine response modifier a (CrmA) inhibits ceramide formation in response to tumor necrosis factor: CrmA and Bcl-2 target distinct components in the apoptotic pathway
    • Dbaibo, G.S., Perry, D.K., Gamard, C.J., Platt, R., Poirier, G.G., Obeid, L.M., Hannun, Y.A., 1997. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J. Exp. Med. 185, 481-490.
    • (1997) J. Exp. Med. , vol.185 , pp. 481-490
    • Dbaibo, G.S.1    Perry, D.K.2    Gamard, C.J.3    Platt, R.4    Poirier, G.G.5    Obeid, L.M.6    Hannun, Y.A.7
  • 15
    • 0033566286 scopus 로고    scopus 로고
    • Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease
    • Duan, W., Mattson, M.P., 1999. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J. Neurosci. Res. 57, 195-206.
    • (1999) J. Neurosci. Res. , vol.57 , pp. 195-206
    • Duan, W.1    Mattson, M.P.2
  • 16
    • 0030036916 scopus 로고    scopus 로고
    • Fumonisins, mycotoxins of increasing importance: Their nature and their effects. Pharmacol
    • Dutton, M.F., 1996. Fumonisins, mycotoxins of increasing importance: their nature and their effects. Pharmacol. Ther. 70, 137-161.
    • (1996) Ther. , vol.70 , pp. 137-161
    • Dutton, M.F.1
  • 18
    • 0031710551 scopus 로고    scopus 로고
    • UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes
    • Farrell, A.M., et al., 1998. UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes. J. Lipid Res. 39, 2031-2038.
    • (1998) J. Lipid Res. , vol.39 , pp. 2031-2038
    • Farrell, A.M.1
  • 19
    • 0030885945 scopus 로고    scopus 로고
    • Mitochondrial free radical signal in ceramide-dependent apoptosis: A putative mechanism for neuronal death in Parkinson's disease
    • France-Lanord, V., Brugg, B., Michel, P.P., Agid, Y., Ruberg, M., 1997. Mitochondrial free radical signal in ceramide-dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease. J. Neurochem. 69, 1612-1621.
    • (1997) J. Neurochem. , vol.69 , pp. 1612-1621
    • France-Lanord, V.1    Brugg, B.2    Michel, P.P.3    Agid, Y.4    Ruberg, M.5
  • 20
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
    • Garcia-Ruiz, C., Colell, A., Mari, M., Morales, A., Fernandez-Checa, J.C., 1997. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 272, 11369-11377.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11369-11377
    • Garcia-Ruiz, C.1    Colell, A.2    Mari, M.3    Morales, A.4    Fernandez-Checa, J.C.5
  • 21
    • 0031013786 scopus 로고    scopus 로고
    • Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA
    • Geley, S., Hartmann, B.L., Kofler, R., 1997. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEES Lett. 400, 15-18.
    • (1997) FEES Lett. , vol.400 , pp. 15-18
    • Geley, S.1    Hartmann, B.L.2    Kofler, R.3
  • 22
    • 0026452763 scopus 로고
    • Effects of aging on the conent, composition and synthesis of sphingomyelin in the central nervous system
    • Giusto, N.M., et al., 1992. Effects of aging on the conent, composition and synthesis of sphingomyelin in the central nervous system. Lipids 27, 835-839.
    • (1992) Lipids , vol.27 , pp. 835-839
    • Giusto, N.M.1
  • 23
    • 0030026613 scopus 로고    scopus 로고
    • Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity
    • Goodman, Y., Mattson, M.P., 1996. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity. J. Neurochem. 6, 869-872.
    • (1996) J. Neurochem. , vol.6 , pp. 869-872
    • Goodman, Y.1    Mattson, M.P.2
  • 24
    • 0028806780 scopus 로고
    • Finasteride: A clinical review
    • Gormley, G.J., 1995. Finasteride: a clinical review. Biomed. Pharmacother. 49, 319-324.
    • (1995) Biomed. Pharmacother. , vol.49 , pp. 319-324
    • Gormley, G.J.1
  • 25
    • 0030856714 scopus 로고    scopus 로고
    • Direct inhibition of mitochondrial respiratory chain complex II by cell-permiable ceramide
    • Gudz, T.I., et al., 1997. Direct inhibition of mitochondrial respiratory chain complex II by cell-permiable ceramide. J. Biol. Chem. 272, 24154-24158.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24154-24158
    • Gudz, T.I.1
  • 26
    • 0034088054 scopus 로고    scopus 로고
    • Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: Preservation of glucose transport and mitochondrial function after exposure to amyloid -peptide and oxidative and metabolic insults
    • Guo, Z., Ersoz, A., Butterfield, D.A., Mattson, M.P., 2000. Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose transport and mitochondrial function after exposure to amyloid -peptide and oxidative and metabolic insults. J. Neurochem. 75, 314-320.
    • (2000) J. Neurochem. , vol.75 , pp. 314-320
    • Guo, Z.1    Ersoz, A.2    Butterfield, D.A.3    Mattson, M.P.4
  • 27
    • 0030725895 scopus 로고    scopus 로고
    • Ceramide and the eukaryotic stress response
    • Hannun, Y.A., Obeid, L.M., 1997. Ceramide and the eukaryotic stress response. Biochem. Soc. Trans. 25, 1171-1175.
    • (1997) Biochem. Soc. Trans. , vol.25 , pp. 1171-1175
    • Hannun, Y.A.1    Obeid, L.M.2
  • 28
    • 0031016544 scopus 로고    scopus 로고
    • Ceramide induces apoptosis in PC 12 cells
    • Hartfield, P.J., Mayne, G.C., Murray, A.W., 1997. Ceramide induces apoptosis in PC 12 cells. FEBS Lett. 401, 148-152.
    • (1997) FEBS Lett. , vol.401 , pp. 148-152
    • Hartfield, P.J.1    Mayne, G.C.2    Murray, A.W.3
  • 30
    • 0032534016 scopus 로고    scopus 로고
    • Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations
    • Irie, F., Hirabayashi, Y., 1998. Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations. J. Neurosci. Res. 54, 475-485.
    • (1998) J. Neurosci. Res. , vol.54 , pp. 475-485
    • Irie, F.1    Hirabayashi, Y.2
  • 32
    • 0028070326 scopus 로고
    • Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor
    • Jayadev, S., Linardic, C.M., Hannun, T.A., 1994. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor. J. Biol. Chem. 269, 5757-5763.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5757-5763
    • Jayadev, S.1    Linardic, C.M.2    Hannun, T.A.3
  • 34
    • 0028953260 scopus 로고
    • Evidence that ceramide selectively inhibits protein kinase C-a translocation and modulates bradykinin activation of phospholipase D
    • Jones, M.J., Murray, A.W., 1995. Evidence that ceramide selectively inhibits protein kinase C-a translocation and modulates bradykinin activation of phospholipase D. J. Bio. Chem. 270, 5007-5013.
    • (1995) J. Bio. Chem. , vol.270 , pp. 5007-5013
    • Jones, M.J.1    Murray, A.W.2
  • 35
    • 0031898446 scopus 로고    scopus 로고
    • A potential role for ceramide in the regulation of mouse epidermal keratinocyte proliferation and differentiation
    • Jung, E.M., Griner, R.D., Mann-Blakeney, R., Bollag, W.B., 1998. A potential role for ceramide in the regulation of mouse epidermal keratinocyte proliferation and differentiation. J. Invest. Dermatol. 110, 318-323.
    • (1998) J. Invest. Dermatol. , vol.110 , pp. 318-323
    • Jung, E.M.1    Griner, R.D.2    Mann-Blakeney, R.3    Bollag, W.B.4
  • 38
    • 0034489693 scopus 로고    scopus 로고
    • Dietary restriction increases survival of newly-generated neural cells and induces BDNF expression in the dentate gyrus of rats
    • Lee, J., Duan, W., Long, J.M., Ingram, D.K., Mattson, M.P., 2000. Dietary restriction increases survival of newly-generated neural cells and induces BDNF expression in the dentate gyrus of rats. J. Mol. Neurosci. 15, 99-108.
    • (2000) J. Mol. Neurosci. , vol.15 , pp. 99-108
    • Lee, J.1    Duan, W.2    Long, J.M.3    Ingram, D.K.4    Mattson, M.P.5
  • 39
    • 0022406161 scopus 로고
    • Two types of hydrocarbon chain interdigitation in sphinomyelin bilayers
    • Levine, J.W., Thompson, T.E., Barenholz, Y., Huang, C., 1985. Two types of hydrocarbon chain interdigitation in sphinomyelin bilayers. Biochemistry 24, 6282-6286.
    • (1985) Biochemistry , vol.24 , pp. 6282-6286
    • Levine, J.W.1    Thompson, T.E.2    Barenholz, Y.3    Huang, C.4
  • 40
    • 0034578528 scopus 로고    scopus 로고
    • Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging
    • Lightle, S.A., et al., 2000. Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging. Mech. Ageing Dev. 120, 111-125.
    • (2000) Mech. Ageing Dev. , vol.120 , pp. 111-125
    • Lightle, S.A.1
  • 41
    • 0030960327 scopus 로고    scopus 로고
    • Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione
    • Liu, B., Hannun, Y.A., 1997. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J. Biol. Chem. 272, 16281-16287.
    • (1997) J. Biol. Chem. , vol.272 , pp. 16281-16287
    • Liu, B.1    Hannun, Y.A.2
  • 42
    • 0027968517 scopus 로고
    • Renaturation and tumor necrosis factor - A stimulation of a 97-kDa ceramide-activated protein kinase
    • Liu, J., Mathias, S., Yang, Z., Kolesnick, R.N. 1994, Renaturation and tumor necrosis factor - a stimulation of a 97-kDa ceramide-activated protein kinase, J. Biol. Chem. 269, 3047-3052.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3047-3052
    • Liu, J.1    Mathias, S.2    Yang, Z.3    Kolesnick, R.N.4
  • 43
    • 0031134930 scopus 로고    scopus 로고
    • Sphingomyelin metabolism is developmentally regulated in rat lung
    • Longo, C.A., et al., 1997. Sphingomyelin metabolism is developmentally regulated in rat lung. Am. J. Respir. Cell Mol. Biol. 16, 605-612.
    • (1997) Am. J. Respir. Cell Mol. Biol. , vol.16 , pp. 605-612
    • Longo, C.A.1
  • 44
    • 0033911968 scopus 로고    scopus 로고
    • Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levels
    • Lopez-Marure, R., Ventura, J.L., Sanchez, L., Montano, L.F., Zentella, A., 2000. Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levels. Eur. J. Biochem. 267, 4325-4333.
    • (2000) Eur. J. Biochem. , vol.267 , pp. 4325-4333
    • Lopez-Marure, R.1    Ventura, J.L.2    Sanchez, L.3    Montano, L.F.4    Zentella, A.5
  • 45
    • 0032704158 scopus 로고    scopus 로고
    • Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin
    • Mansat-de Mas, V., Bezombes, C., Quillet-Mary, A., Bettaleb, A., D'orgeix, A.D., Laurent, G., Jaffrezou, J.P., 1999. Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin. Mol. Pharmacol. 56, 867-874.
    • (1999) Mol. Pharmacol. , vol.56 , pp. 867-874
    • Mansat-de Mas, V.1    Bezombes, C.2    Quillet-Mary, A.3    Bettaleb, A.4    D'Orgeix, A.D.5    Laurent, G.6    Jaffrezou, J.P.7
  • 46
    • 0032211769 scopus 로고    scopus 로고
    • Signal transduction of stress via ceramide
    • Mathias, S., Pena, L.A., Kolesnick, R.N., 1998. Signal transduction of stress via ceramide. Biochem. J. 335, 465-480.
    • (1998) Biochem. J. , vol.335 , pp. 465-480
    • Mathias, S.1    Pena, L.A.2    Kolesnick, R.N.3
  • 47
    • 0030611750 scopus 로고    scopus 로고
    • Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese Superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
    • Mattson, M.P., Goodman, Y., Luo, H., Fu, W., Furukawa, K., 1997. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese Superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J. Neurosci. Res. 49, 681-697.
    • (1997) J. Neurosci. Res. , vol.49 , pp. 681-697
    • Mattson, M.P.1    Goodman, Y.2    Luo, H.3    Fu, W.4    Furukawa, K.5
  • 48
    • 0034329742 scopus 로고    scopus 로고
    • Apoptosis in neurodegenerative disorders
    • Mattson, M.P., 2000a. Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol. 1, 120-129.
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 120-129
    • Mattson, M.P.1
  • 49
    • 0034672398 scopus 로고    scopus 로고
    • Neuroprotective signaling and the aging brain: Take away my food and let me run
    • Mattson, M.P., 2000b. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res. 886, 47-53.
    • (2000) Brain Res. , vol.886 , pp. 47-53
    • Mattson, M.P.1
  • 50
    • 0034746288 scopus 로고    scopus 로고
    • NF-kappaB in neuronal plasticity and neurodegenerative disorders
    • Mattson, M.P., Camandola, S., 2001. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J. Clin. Invest. 107, 247-254.
    • (2001) J. Clin. Invest. , vol.107 , pp. 247-254
    • Mattson, M.P.1    Camandola, S.2
  • 51
    • 0035149823 scopus 로고    scopus 로고
    • Emerging roles for telomerase in neuronal development and apoptosis
    • Mattson, M.P., Klapper, W., 2001. Emerging roles for telomerase in neuronal development and apoptosis. J. Neurosci. Res. 63, 1-9.
    • (2001) J. Neurosci. Res. , vol.63 , pp. 1-9
    • Mattson, M.P.1    Klapper, W.2
  • 52
    • 0029013314 scopus 로고
    • Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases
    • Merrill, A.H., Schmelz, E.M., Wang, E., Schroeder, J.J., Dillehay, D.L., Riley, R.T., 1995. Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases. J. Nutr. 125, S1677-S1682.
    • (1995) J. Nutr. , vol.125
    • Merrill, A.H.1    Schmelz, E.M.2    Wang, E.3    Schroeder, J.J.4    Dillehay, D.L.5    Riley, R.T.6
  • 53
    • 15644367786 scopus 로고    scopus 로고
    • Importance of sphingolipids and inhibitors of sphingolipid metabolism as components of animal diets
    • Merrill, A.H., Schmelz, E.M., Wang, E., Dillehay, D.L., Rice, L.G., Meredith, F., Riley, R.T., 1997. Importance of sphingolipids and inhibitors of sphingolipid metabolism as components of animal diets. J. Nutr. 127, S830-S833.
    • (1997) J. Nutr. , vol.127
    • Merrill, A.H.1    Schmelz, E.M.2    Wang, E.3    Dillehay, D.L.4    Rice, L.G.5    Meredith, F.6    Riley, R.T.7
  • 54
    • 0032520898 scopus 로고    scopus 로고
    • Bipotential roles of ceramide in the growth of hippocampal neurons: Promotion of cell survival and dendritic outgrowth in dose- and developmental stage-dependent manners
    • Mitoma, J., et al., 1998. Bipotential roles of ceramide in the growth of hippocampal neurons: promotion of cell survival and dendritic outgrowth in dose- and developmental stage-dependent manners. J. Neurosci. Res. 51, 712-722.
    • (1998) J. Neurosci. Res. , vol.51 , pp. 712-722
    • Mitoma, J.1
  • 55
    • 0032939630 scopus 로고    scopus 로고
    • Ceramide potentiates, but sphingomyelin inhibits, vitamin D-induced keratinocyte differentiation: Comparison between keratinocytes and HL-60 cells
    • Pillai, S., Mahajan, M., Carlomusto, M., 1999. Ceramide potentiates, but sphingomyelin inhibits, vitamin D-induced keratinocyte differentiation: comparison between keratinocytes and HL-60 cells. Arch. Dermatol. Res. 291, 284-289.
    • (1999) Arch. Dermatol. Res. , vol.291 , pp. 284-289
    • Pillai, S.1    Mahajan, M.2    Carlomusto, M.3
  • 56
    • 0032920732 scopus 로고    scopus 로고
    • Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells
    • Pruschy, M., Resch, H., Shi, Y.Q., Aalame, N., Glanzmann, C., Bodis, S., 1999. Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells. Br. J. Cancer 80, 693-698.
    • (1999) Br. J. Cancer , vol.80 , pp. 693-698
    • Pruschy, M.1    Resch, H.2    Shi, Y.Q.3    Aalame, N.4    Glanzmann, C.5    Bodis, S.6
  • 57
    • 0033779101 scopus 로고    scopus 로고
    • Structure, function, and control of phosphoinositide-specific phospholipase C
    • Rebecchi, M.J., Pentyala, S.N., 2000. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 80, 1291-1335.
    • (2000) Physiol. Rev. , vol.80 , pp. 1291-1335
    • Rebecchi, M.J.1    Pentyala, S.N.2
  • 58
    • 0032524973 scopus 로고    scopus 로고
    • Altered cytokine production in the elderly
    • Rink, L., Cakman, L, Kirchner, H., 1998. Altered cytokine production in the elderly. Mech. Ageing Dev. 102, 199-209.
    • (1998) Mech. Ageing Dev. , vol.102 , pp. 199-209
    • Rink, L.1    Cakman, L.2    Kirchner, H.3
  • 59
    • 0032749349 scopus 로고    scopus 로고
    • Under-nutrition decreases serine palmitoyltransferase activity in developing rat hypothalamus
    • Rotta, L.N., et al. 1999, Under-nutrition decreases serine palmitoyltransferase activity in developing rat hypothalamus, Ann. Nutr. Metab. 43, 152-158.
    • (1999) Ann. Nutr. Metab. , vol.43 , pp. 152-158
    • Rotta, L.N.1
  • 60
    • 0031597895 scopus 로고    scopus 로고
    • Role of hormones in mammary cancer initiation and progression
    • Russo, I.H., Russo, J., 1998. Role of hormones in mammary cancer initiation and progression. J. Mammary Gland Biol. Neoplasia. 3, 49-61.
    • (1998) J. Mammary Gland Biol. Neoplasia. , vol.3 , pp. 49-61
    • Russo, I.H.1    Russo, J.2
  • 61
    • 0033575320 scopus 로고    scopus 로고
    • Ceramide induces Bcl-2 dephosphorylation via a mechanism involving mitochondrial PP2A
    • Ruvolo, P.P., et al., 1999. Ceramide induces Bcl-2 dephosphorylation via a mechanism involving mitochondrial PP2A. J. Biol. Chem. 274, 20296-20300.
    • (1999) J. Biol. Chem. , vol.274 , pp. 20296-20300
    • Ruvolo, P.P.1
  • 64
    • 0026458406 scopus 로고
    • TNF activates NF-KB by phosphatidylcholine-specific phospholipase C-induced acidic sphingomyelin breakdown
    • Schütze, S., Potthoff, K., Machleidt, T., Berkovic, D., Wiegmann, K., Kronke, M., 1992. TNF activates NF-KB by phosphatidylcholine-specific phospholipase C-induced acidic sphingomyelin breakdown. Cell 71, 765-776.
    • (1992) Cell , vol.71 , pp. 765-776
    • Schütze, S.1    Potthoff, K.2    Machleidt, T.3    Berkovic, D.4    Wiegmann, K.5    Kronke, M.6
  • 65
    • 0033538073 scopus 로고    scopus 로고
    • Inhibition of receptor internalization by monodansyl cadaverine selectively blocks p55 TNF receptor death domain signaling
    • Schutze, S., Machleidt, T., Adam, D., Schwandner, R., Wiegmann, K., Kruse, M.L., Heinrich, M., Wickel, M., Kronke, M., 1999. Inhibition of receptor internalization by monodansyl cadaverine selectively blocks p55 TNF receptor death domain signaling. J. Biol Chem. 274, 10203-10212.
    • (1999) J. Biol Chem. , vol.274 , pp. 10203-10212
    • Schutze, S.1    Machleidt, T.2    Adam, D.3    Schwandner, R.4    Wiegmann, K.5    Kruse, M.L.6    Heinrich, M.7    Wickel, M.8    Kronke, M.9
  • 66
    • 0032489554 scopus 로고    scopus 로고
    • TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase
    • Schwandner, R., Wiegmann, K., Bernardo, K., Kreder, D., Kronke, M., 1998. TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase. J. Biol. Chem. 273, 5916-5922.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5916-5922
    • Schwandner, R.1    Wiegmann, K.2    Bernardo, K.3    Kreder, D.4    Kronke, M.5
  • 67
    • 0033961443 scopus 로고    scopus 로고
    • Role of p53 family members in apoptosis
    • Sheikh, M.S., Fornace, A.J. Jr., 2000. Role of p53 family members in apoptosis. J. Cell Physiol. 182, 171-181.
    • (2000) J. Cell Physiol. , vol.182 , pp. 171-181
    • Sheikh, M.S.1    Fornace Jr., A.J.2
  • 68
    • 0029949938 scopus 로고    scopus 로고
    • PrICE: A downstream target for ceramide induced apoptosis and for the inhibitory action of Bcl-2
    • Smyth, M.J., Perry, D.K., Zhang, J., Poirier, G.G., Hannun, Y.A., Obeid, L.M., 1996. prICE: a downstream target for ceramide induced apoptosis and for the inhibitory action of Bcl-2. Biochem. J. 316, 25-28.
    • (1996) Biochem. J. , vol.316 , pp. 25-28
    • Smyth, M.J.1    Perry, D.K.2    Zhang, J.3    Poirier, G.G.4    Hannun, Y.A.5    Obeid, L.M.6
  • 70
    • 0034308223 scopus 로고    scopus 로고
    • Ceramide as a second messenger: Sticky solutions to sticky problems
    • Venkataraman, K., Futerman, A.H., 2000. Ceramide as a second messenger: sticky solutions to sticky problems. Trends Cell Biol. 10, 408-412.
    • (2000) Trends Cell Biol. , vol.10 , pp. 408-412
    • Venkataraman, K.1    Futerman, A.H.2
  • 71
    • 0030965162 scopus 로고    scopus 로고
    • Cell death induction by TNF: A matter of self control
    • Wallach, D., 1997. Cell death induction by TNF: a matter of self control. TIBS 22, 107-109.
    • (1997) TIBS , vol.22 , pp. 107-109
    • Wallach, D.1
  • 72
    • 0033081893 scopus 로고    scopus 로고
    • A typical PKC zeta is activated by ceramide, resulting in coactivation of NF-KB/JNK kinase and cell survival
    • Wang, Y.M., Seibenhener, M.L., Vandenplas, M.L., Woolen, M.W., 1999a. A typical PKC zeta is activated by ceramide, resulting in coactivation of NF-KB/JNK kinase and cell survival. J. Neurosci. Res. 55, 293-302.
    • (1999) J. Neurosci. Res. , vol.55 , pp. 293-302
    • Wang, Y.M.1    Seibenhener, M.L.2    Vandenplas, M.L.3    Woolen, M.W.4
  • 73
    • 0033571159 scopus 로고    scopus 로고
    • Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy
    • Wang, X.Z., Beebe, J.R., Pwiti, L., Bielawska, A., Smyth, M.J., 1999b. Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy. Cancer Res. 59, 5842-5848.
    • (1999) Cancer Res. , vol.59 , pp. 5842-5848
    • Wang, X.Z.1    Beebe, J.R.2    Pwiti, L.3    Bielawska, A.4    Smyth, M.J.5
  • 74
    • 0031549576 scopus 로고    scopus 로고
    • Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging
    • Weindruch, R., Sohal, R.S., 1997. Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. New Eng. J. Med. 337, 986-994.
    • (1997) New Eng. J. Med. , vol.337 , pp. 986-994
    • Weindruch, R.1    Sohal, R.S.2
  • 76
    • 0001611514 scopus 로고    scopus 로고
    • Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism
    • Yu, Z.F., Mattson, M.P., 1999. Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J. Neurosci. Res. 57, 830-839.
    • (1999) J. Neurosci. Res. , vol.57 , pp. 830-839
    • Yu, Z.F.1    Mattson, M.P.2
  • 77
    • 0034488193 scopus 로고    scopus 로고
    • Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis
    • Yu, Z., Nikolova-Karakashian, M., Zhou, D., Cheng, G., Schuchman, E.H., Mattson, M.P., 2000. Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis. J. Mol. Neurosci. 15, 85-98.
    • (2000) J. Mol. Neurosci. , vol.15 , pp. 85-98
    • Yu, Z.1    Nikolova-Karakashian, M.2    Zhou, D.3    Cheng, G.4    Schuchman, E.H.5    Mattson, M.P.6
  • 79
    • 0033581321 scopus 로고    scopus 로고
    • Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation
    • Zhu, H., Guo, Q., Mattson, M.P., 1999. Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation. Brain Res. 842, 224-229.
    • (1999) Brain Res. , vol.842 , pp. 224-229
    • Zhu, H.1    Guo, Q.2    Mattson, M.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.