-
1
-
-
0026793292
-
Development and characterisation of a rat brain capillary endothelial culture: Towards an in vitro blood-brain barrier
-
Abbott NJ, Hughes CC, Revest PA, and Greenwood J (1992) Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier. J Cell Sci 103:23-37.
-
(1992)
J Cell Sci
, vol.103
, pp. 23-37
-
-
Abbott, N.J.1
Hughes, C.C.2
Revest, P.A.3
Greenwood, J.4
-
2
-
-
0034901124
-
A phase I trial of doxorubicin, paclitaxel and valspodar (PSC 833), a modulator of multidrug resistance
-
Advani R, Fisher GA, Lum BL, Hausdorff J, Halsey J, Litchman M, and Sikic BI (2001) A phase I trial of doxorubicin, paclitaxel and valspodar (PSC 833), a modulator of multidrug resistance. Clin Cancer Res 7:1221-1229.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1221-1229
-
-
Advani, R.1
Fisher, G.A.2
Lum, B.L.3
Hausdorff, J.4
Halsey, J.5
Litchman, M.6
Sikic, B.I.7
-
3
-
-
0035875858
-
Phase I/II trial of the multidrug-resistance modulator valspodar combined with cisplatin and doxorubicin in refractory ovarian cancer
-
Baekelandt M, Lehne G, Trope CG, Szanto I, Pfeiffer P, Gustavssson B, and Kristensen GB (2001) Phase I/II trial of the multidrug-resistance modulator valspodar combined with cisplatin and doxorubicin in refractory ovarian cancer. J Clin Oncol 19:2983-2993.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2983-2993
-
-
Baekelandt, M.1
Lehne, G.2
Trope, C.G.3
Szanto, I.4
Pfeiffer, P.5
Gustavssson, B.6
Kristensen, G.B.7
-
4
-
-
0033750523
-
Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein
-
Bardelmeijer HA, Beijnen JH, Brouwer KR, Rosing H, Nooijen WJ, Schellens JH, and van Tellingen O (2000) Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein. Clin Cancer Res 6:4416-4421.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4416-4421
-
-
Bardelmeijer, H.A.1
Beijnen, J.H.2
Brouwer, K.R.3
Rosing, H.4
Nooijen, W.J.5
Schellens, J.H.6
Van Tellingen, O.7
-
5
-
-
0036605677
-
Functional expression and localization of P-glycoprotein at the blood brain barrier
-
Bendayan R, Lee G, and Bendayan M (2002) Functional expression and localization of P-glycoprotein at the blood brain barrier. Microsc Res Tech 57:365-380.
-
(2002)
Microsc Res Tech
, vol.57
, pp. 365-380
-
-
Bendayan, R.1
Lee, G.2
Bendayan, M.3
-
6
-
-
0037205138
-
In vitro P-glycoprotein affinity for atypical and conventional antipsychotics
-
Boulton DW, DeVane CL, Liston HL, and Markowitz JS (2002) In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci 71:163-169.
-
(2002)
Life Sci
, vol.71
, pp. 163-169
-
-
Boulton, D.W.1
DeVane, C.L.2
Liston, H.L.3
Markowitz, J.S.4
-
7
-
-
2342518813
-
Prevalence of marijuana use disorders in the United States: 1991-1992 and 2001-2002
-
Compton WM, Grant BF, Colliver JD, Glantz MD, and Stinson FS (2004) Prevalence of marijuana use disorders in the United States: 1991-1992 and 2001-2002. J Am Med Assoc 291:2114-2121.
-
(2004)
J Am Med Assoc
, vol.291
, pp. 2114-2121
-
-
Compton, W.M.1
Grant, B.F.2
Colliver, J.D.3
Glantz, M.D.4
Stinson, F.S.5
-
8
-
-
0025837207
-
Controlled clinical trial of cannabidiol in Huntington's disease
-
Consroe P, Laguna J, Allender J, Snider S, Stern L, Sandyk R, Kennedy K, and Schram K (1991) Controlled clinical trial of cannabidiol in Huntington's disease. Pharmacol Biochem Behav 40:701-708.
-
(1991)
Pharmacol Biochem Behav
, vol.40
, pp. 701-708
-
-
Consroe, P.1
Laguna, J.2
Allender, J.3
Snider, S.4
Stern, L.5
Sandyk, R.6
Kennedy, K.7
Schram, K.8
-
9
-
-
0000712439
-
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
-
Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, and Bertino JR (1989) Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 86:695-698.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 695-698
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Casals, D.3
Rittman-Grauer, L.4
Biedler, J.L.5
Melamed, M.R.6
Bertino, J.R.7
-
10
-
-
0030924052
-
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein
-
Dey S, Ramachandra M, Pastan I, Gottesman MM, and Ambudkar SV (1997) Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci USA 94:10594-10599.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10594-10599
-
-
Dey, S.1
Ramachandra, M.2
Pastan, I.3
Gottesman, M.M.4
Ambudkar, S.V.5
-
11
-
-
0029995238
-
Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells
-
Evers R, Zaman GJ, van Deemter L, Jansen H, Calafat J, Oomen LC, Oude Elferink RP, Borst P, and Schinkel AH (1996) Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. J Clin Investig 97:1211-1218.
-
(1996)
J Clin Investig
, vol.97
, pp. 1211-1218
-
-
Evers, R.1
Zaman, G.J.2
Van Deemter, L.3
Jansen, H.4
Calafat, J.5
Oomen, L.C.6
Oude Elferink, R.P.7
Borst, P.8
Schinkel, A.H.9
-
12
-
-
0027300475
-
P-glycoprotein expression in human, mouse, hamster and rat hepatocytes in primary culture
-
Fardel O, Morel F, and Guillouzo A (1993) P-glycoprotein expression in human, mouse, hamster and rat hepatocytes in primary culture. Carcinogenesis 14:781-783.
-
(1993)
Carcinogenesis
, vol.14
, pp. 781-783
-
-
Fardel, O.1
Morel, F.2
Guillouzo, A.3
-
13
-
-
0037131893
-
The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans
-
Fromm MF (2002) The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans. Adv Drug Deliv Rev 54:1295-1310.
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 1295-1310
-
-
Fromm, M.F.1
-
14
-
-
0027345980
-
Structure and function of P-glycoprotein in normal liver and small intestine
-
Gatmaitan ZC and Arias IM (1993) Structure and function of P-glycoprotein in normal liver and small intestine. Adv Pharmacol 24:77-97.
-
(1993)
Adv Pharmacol
, vol.24
, pp. 77-97
-
-
Gatmaitan, Z.C.1
Arias, I.M.2
-
15
-
-
0037255987
-
Pharmacokinetics and pharmacodynamics of cannabinoids
-
Grotenhermen F (2003) Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet 42:327-360.
-
(2003)
Clin Pharmacokinet
, vol.42
, pp. 327-360
-
-
Grotenhermen, F.1
-
16
-
-
0012352186
-
Neuroprotective antioxidants from marijuana
-
Hampson AJ, Grimaldi M, Lolic M, Wink D, Rosenthal R, and Axelrod J (2000) Neuroprotective antioxidants from marijuana. Ann NY Acad Sci 899:274-282.
-
(2000)
Ann NY Acad Sci
, vol.899
, pp. 274-282
-
-
Hampson, A.J.1
Grimaldi, M.2
Lolic, M.3
Wink, D.4
Rosenthal, R.5
Axelrod, J.6
-
17
-
-
0020605073
-
Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein
-
Kartner N, Shales M, Riordan JR, and Ling V (1983) Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein. Cancer Res 43:4413-4419.
-
(1983)
Cancer Res
, vol.43
, pp. 4413-4419
-
-
Kartner, N.1
Shales, M.2
Riordan, J.R.3
Ling, V.4
-
19
-
-
0024401963
-
Identification of P-glycoprotein in renal brush border membranes
-
Lieberman DM, Reithmeier RA, Ling V, Charuk JH, Goldberg H, and Skorecki KL (1989) Identification of P-glycoprotein in renal brush border membranes. Biochem Biophys Res Commun 162:244-252.
-
(1989)
Biochem Biophys Res Commun
, vol.162
, pp. 244-252
-
-
Lieberman, D.M.1
Reithmeier, R.A.2
Ling, V.3
Charuk, J.H.4
Goldberg, H.5
Skorecki, K.L.6
-
20
-
-
0031044101
-
Rhodamine 123 accumulates extensively in the isolated perfused rat kidney and is secreted by the organic cation system
-
Masereeuw R, Moons MM, and Russel FG (1997) Rhodamine 123 accumulates extensively in the isolated perfused rat kidney and is secreted by the organic cation system. Eur J Pharmacol 321:315-323.
-
(1997)
Eur J Pharmacol
, vol.321
, pp. 315-323
-
-
Masereeuw, R.1
Moons, M.M.2
Russel, F.G.3
-
21
-
-
1342280974
-
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines
-
Massi P, Vaccani A, Ceruti S, Colombo A, Abbracchio MP, and Parolaro D (2004) Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. J Pharmacol Exp Ther 308:838-845.
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 838-845
-
-
Massi, P.1
Vaccani, A.2
Ceruti, S.3
Colombo, A.4
Abbracchio, M.P.5
Parolaro, D.6
-
22
-
-
0030781139
-
Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833
-
Mayer U, Wagenaar E, Dorobek B, Beijnen JH, Borst P, and Schinkel AH (1997) Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833. J Clin Investig 100:2430-2436.
-
(1997)
J Clin Investig
, vol.100
, pp. 2430-2436
-
-
Mayer, U.1
Wagenaar, E.2
Dorobek, B.3
Beijnen, J.H.4
Borst, P.5
Schinkel, A.H.6
-
24
-
-
33645851325
-
Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Δ9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract
-
Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, and Stadelmann AM (2005) Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Δ9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract. Ther Drug Monit 27:799-810.
-
(2005)
Ther Drug Monit
, vol.27
, pp. 799-810
-
-
Nadulski, T.1
Pragst, F.2
Weinberg, G.3
Roser, P.4
Schnelle, M.5
Fronk, E.M.6
Stadelmann, A.M.7
-
25
-
-
21844473814
-
Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: In vivo evidence of involvement of P-glycoprotein in risperidone disposition
-
Nakagami T, Yasui-Furukori N, Saito M, Tateishi T, and Kaneo S (2005) Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition. Clin Pharmacol Ther 78:43-51.
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 43-51
-
-
Nakagami, T.1
Yasui-Furukori, N.2
Saito, M.3
Tateishi, T.4
Kaneo, S.5
-
27
-
-
0035371589
-
Cannabinoid-induced alterations in brain disposition of drugs of abuse
-
Reid MJ and Bornheim LM (2001) Cannabinoid-induced alterations in brain disposition of drugs of abuse. Biochem Pharmacol 61:1357-1367.
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 1357-1367
-
-
Reid, M.J.1
Bornheim, L.M.2
-
28
-
-
0035135376
-
Therapeutic aspects of cannabis and cannabinoids
-
Robson P (2001) Therapeutic aspects of cannabis and cannabinoids. Br J Psychiatry 178:107-115.
-
(2001)
Br J Psychiatry
, vol.178
, pp. 107-115
-
-
Robson, P.1
-
29
-
-
0029098340
-
Multidrug resistance and the role of P-glycoprotein knockout mice
-
Schinkel AH, Mol CA, Wagenaar E, van Deemter L, Smit JJ, and Borst P (1995a) Multidrug resistance and the role of P-glycoprotein knockout mice. Eur J Cancer 31A:1295-1298.
-
(1995)
Eur J Cancer
, vol.31 A
, pp. 1295-1298
-
-
Schinkel, A.H.1
Mol, C.A.2
Wagenaar, E.3
Van Deemter, L.4
Smit, J.J.5
Borst, P.6
-
30
-
-
0028825399
-
Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin and cyclosporin A
-
Schinkel AH, Wagenaar E, van Deemter L, Mol CA, and Borst P (1995b) Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin and cyclosporin A. J Clin Investig 96:1698-1705.
-
(1995)
J Clin Investig
, vol.96
, pp. 1698-1705
-
-
Schinkel, A.H.1
Wagenaar, E.2
Van Deemter, L.3
Mol, C.A.4
Borst, P.5
-
31
-
-
0027937143
-
ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells
-
Shapiro AB and Ling V (1994) ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells. J Biol Chem 269:3745-3754.
-
(1994)
J Biol Chem
, vol.269
, pp. 3745-3754
-
-
Shapiro, A.B.1
Ling, V.2
-
32
-
-
0031869860
-
Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs
-
Smit JW, Weert B, Schinkel AH, and Meijer DK (1998) Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs. J Pharmacol Exp Ther 286:321-327.
-
(1998)
J Pharmacol Exp Ther
, vol.286
, pp. 321-327
-
-
Smit, J.W.1
Weert, B.2
Schinkel, A.H.3
Meijer, D.K.4
-
33
-
-
0035822323
-
Cannabinoids for control of chemotherapy induced nausea and vomiting: Quantitative systematic review
-
Tramer MR, Carroll D, Campbell FA, Reynolds DJ, Moore RA, and McQuay HJ (2001) Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. BMJ 323:16-21.
-
(2001)
BMJ
, vol.323
, pp. 16-21
-
-
Tramer, M.R.1
Carroll, D.2
Campbell, F.A.3
Reynolds, D.J.4
Moore, R.A.5
McQuay, H.J.6
-
34
-
-
17844388088
-
Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
-
Vaccani A, Massi P, Colombo A, Rubino T, and Parolaro D (2005) Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 144:1032-1036.
-
(2005)
Br J Pharmacol
, vol.144
, pp. 1032-1036
-
-
Vaccani, A.1
Massi, P.2
Colombo, A.3
Rubino, T.4
Parolaro, D.5
-
35
-
-
0024267858
-
Characterization of an "in vitro" blood-brain barrier: Effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs
-
van Bree JB, de Boer AG, Danhof M, Ginsel LA, and Breimer DD (1988) Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs. J Pharmacol Exp Ther 247:1233-1239.
-
(1988)
J Pharmacol Exp Ther
, vol.247
, pp. 1233-1239
-
-
Van Bree, J.B.1
De Boer, A.G.2
Danhof, M.3
Ginsel, L.A.4
Breimer, D.D.5
-
36
-
-
0033862088
-
Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines
-
van der Sandt IC, Blom-Roosemalen MC, de Boer AG, and Breimer DD (2000) Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. Eur J Pharm Sci 11:207-214.
-
(2000)
Eur J Pharm Sci
, vol.11
, pp. 207-214
-
-
Van Der Sandt, I.C.1
Blom-Roosemalen, M.C.2
De Boer, A.G.3
Breimer, D.D.4
-
37
-
-
0007544439
-
MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
-
van Helvoort A, Smith AJ, Sprong H, Fritzsche I, Schinkel AH, Borst P, and van Meer G (1996) MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87:507-517.
-
(1996)
Cell
, vol.87
, pp. 507-517
-
-
Van Helvoort, A.1
Smith, A.J.2
Sprong, H.3
Fritzsche, I.4
Schinkel, A.H.5
Borst, P.6
Van Meer, G.7
-
38
-
-
33645877951
-
Cannabinoids stimulate ATPase activity of P-glycoprotein
-
Wang JS, DeVane CL, Donovan JL, Gibson BB, Gefroh HA, and Markowitz JS (2004a) Cannabinoids stimulate ATPase activity of P-glycoprotein. Neuropsychopharmacology 29 (Suppl 1):S73.
-
(2004)
Neuropsychopharmacology
, vol.29
, Issue.1 SUPPL.
-
-
Wang, J.S.1
DeVane, C.L.2
Donovan, J.L.3
Gibson, B.B.4
Gefroh, H.A.5
Markowitz, J.S.6
-
39
-
-
1642306919
-
Olanzapine penetration into brain is greater in transgenic Abcb1a P-glycoprotein-deficient mice than FVB1 (wild-type) animals
-
Wang JS, Taylor R, Ruan Y, Donovan JL, Markowitz JS, and Lindsay De Vane C (2004b) Olanzapine penetration into brain is greater in transgenic Abcb1a P-glycoprotein-deficient mice than FVB1 (wild-type) animals. Neuropsychopharmacology 29:551-557.
-
(2004)
Neuropsychopharmacology
, vol.29
, pp. 551-557
-
-
Wang, J.S.1
Taylor, R.2
Ruan, Y.3
Donovan, J.L.4
Markowitz, J.S.5
De Lindsay Vane, C.6
-
40
-
-
0242557605
-
Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells
-
Zhu HJ and Liu GQ (2003) Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells. Acta Pharmacol Sin 24:1143-1149.
-
(2003)
Acta Pharmacol Sin
, vol.24
, pp. 1143-1149
-
-
Zhu, H.J.1
Liu, G.Q.2
|