The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 17, 2000, Pages 9561-9566

  Malfait, A M ^a   Gallily, R ^b   Sumariwalla, P F ^a   Malik, A S ^a   Andreakos, E ^a   Mechoulam, R ^b   Feldmann, M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRHEUMATIC AGENT; CANNABIDIOL; CANNABIS DERIVATIVE; GAMMA INTERFERON; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; GRANULOCYTE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY BURST; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ANIMALIA; BOVINAE; CANNABIS; MURINAE;

EID: 0034662868     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.160105897     Document Type: Article

References (44)

1. Mechoulam, R. & Shvo, Y. (1963) Tetrahedron 19, 2073-2078.
2. Mechoulam, R. (1970) Science 168, 1159-1166.
3. Turner, C. F., Elsohly, M. A. & Boeren, E. C. (1980) J. Nat. Prod. 43, 169-234.
4. Razdan, R. K. (1986) Pharmacol. Rev. 38, 75-149.
5. Mechoulam, R., Devane, W. A. & Glaser, R. (1992) Marijuana/Cannabinoids: Neurobiology and Neurophysiology, eds. Murphy, L. & Bartke, A. (CRC, Boca Raton, FL), pp. 1-33.
6. Klein, T. W., Newton, C. & Friedman, H. (1998) Immunol. Today 19, 373-380.
7. Specter, S., Lancz, G. & Hazelden, J. (1990) Int. J. Immunopharmacol. 12, 261-267.
8. Klein, T. W., Kawakami, Y., Newton, C. & Friedman, H. (1991) J. Toxicol. Environ. Health 32, 465-477.
9. Cabral, G. A., Pettit, D. A. & Fisher-Stenger, K. (1993) in Drugs of Abuse, Immunity, and Immunodeficiency, ed. Friedman, H. (Plenum, New York), pp. 93-105.
10. McCoy, K. L., Gainey, D. & Cabral, G. A. (1995) J. Pharmacol. Exp. Ther. 273, 1216-1223.
11. Coffey, R. G., Yamamoto, Y., Snella, E. & Pross, S. (1996) Biochem. Pharmacol. 52, 743-751.
12. Formukong, E. A., Evans, A. T. & Evans, F. J. (1988) Inflammation 12, 361-371.
13. Watzl, B., Scuderi, P. & Watson, R. R. (1991) Int. J. Immunopharmacol. 13, 1091-1097.
14. Srivastava, M. D., Srivastava, B. I. S. & Brouhard, B. (1998) Immunopharmacology 40, 179-185.
15. Rosenkrantz, H., Fleischman, R. W. & Grant, R. J. (1981) Toxicol. Appl. Pharmacol. 58, 118-131.
16. Courtenay, J. S., Dallman, M. J., Dayan, A. D., Martin, A. & Mosedale, B. (1980) Nature (London) 283, 666-668.
17. Ranges, G. E., Sriram, S. & Cooper, S. M. (1985) J. Exp. Med. 162, 1105-1110.
18. Seki, N., Sudo, Y., Yoshioka, T., Sugihar, S., Fujitsu, T., Sakuma, S., Ogawa, T., Hamaoka, T., Senoh, H. & Fujiwara, H. (1988) J. Immunol. 140, 1477-1484.
19. Mauri, C., Williams, R. O., Walmsley, M. & Feldmann, M. (1996) Eur. J. Immunol. 26, 1511-1514.
20. Thorbecke, G. J., Shah, R., Leu, C. H., Kuruvilla, A. P., Hardison, A. M. & Palladino, M. A. (1992) Proc. Natl. Acad. Sci. USA 89, 7375-7379.
21. Williams, R. O., Feldmann, M. & Maini, R. N. (1992) Proc. Natl. Acad. Sci. USA 89, 9784-9788.
22. Feldmann, M., Elliot, M. J., Woody, J. N. & Maini, R. N. (1997) Adv. Immunol. 64, 243-350.
23. Gaoni, Y. & Mechoulam, R. (1971) J. Am. Chem. Soc. 93, 217-224.
24. Sher, T., Rottern, S. & Gallily, R. (1990) Cancer Immunol. Immunother. 31, 86-92.
25. Gerlier, D. & Thomasset, N. (1986) J. Immunol. Methods 94, 57-61.
26. Malfait, A. M., Butler, D. M., Presky, D. H., Maini, R. N., Brennan, F. M. & Feldmann, M. (1998) Clin. Exp. Immunol. 111, 377-383.
27. Butler, D. M., Malfait, A. M., Mason, L. J., Warden, P. J., Kollias, G., Maini, R. N., Feldmann, M. & Brennan, F. M. (1997) J. Immunol. 159, 2867-2876.
28. Espevik, T. & Nissen-Meyer, J. (1986) J. Immunol. Methods 95, 99-105.
29. Baker, D., Butler, D., Scallon, B. J., O'Neill, J. K., Turk, J. L. & Feldmann, M. (1994) Eur. J. Immunol. 24, 2040-2048.
30. Holmdahl, R., Jansson, R., Larsson, E., Rubin, K. & Klareskog, L. (1986) Arthritis Rheum. 29, 106-113.
31. Boissier, M. C., Feng, X. Z., Carlioz, A., Roudier, R. & Fournier, C. (1987) Ann. Rheum. Dis. 46, 691-700.
32. Sulcova, E., Mechoulam, R. & Fride, E. (1998) Pharmacol. Biochem. Behav. 59, 347-353.
33. Butler, D. M., Malfait, A. M., Maini, R. N., Brennan, F. M. & Feldmann, M. (1999) Eur. J. Immunol. 29, 2205-2212.
34. Hampson, A. J., Grimaldi, M., Axelrod, J. & Wink, D. (1998) Proc. Natl. Acad. Sci. USA 95, 8268-8273.
35. Mechoulam, R., Hanus, L. & Fride, E. (1998) Progr. Med. Chem. 35, 199-243.
36. Zurier, R. B., Rossetti, R. G., Lane, J. H., Goldberg, J. M., Hunter, S. A. & Burstein, S. H. (1998) Arthritis Rheum. 41, 163-170.
37. Adams, I. B. & Martin, B. R. (1996) Addiction 91, 1585-1614.
38. Patrini, G., Sacerdote, P., Fuzio, D., Manfred, B. & Parolaro, D. (1997) J. Neuroimmunol. 80, 143-148.
39. Cunha, J. M., Carlini, E. A., Pereira, A. E., Ramos, O. L., Pimentel, C., Gagliardi, R., Sanvito, W. L., Lander, N. & Mechoulam, R. (1980) Pharmacology 21, 175-185.
40. Consroe, P., Laguna, J., Allender, J., Snider, S., Stern, L., Sandyk, R., Kennedy, K. & Schram, K. (1991) Pharmacol. Biochem. Behav. 40, 701-708.
41. Zuardi, A. W., Guimaraes, F. S. & Moreira, A. C. (1993) Brazil. J. Med. Biol. Res. 26, 213-217.
42. Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S. & Howlett, A. C. (1988) Mol. Pharmacol. 34, 605-613.
43. Munro, S., Thomas, K. L. & Abu-Shaar, M. (1993) Nature (London) 365, 61-65.
44. Thomas, B. F., Gilliam, A. F., Burch, D. F., Roche, M. J. & Seltzman, H. H. (1998) J. Pharmacol. Exp. Ther. 285, 285-292.