Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent

Anticancer Research

Volumn 31, Issue 11, 2011, Pages 3799-3807

  Sreevalsan, Sandeep ^a   Joseph, Sonia ^b   Jutooru, Indira ^a   Chadalapaka, Gayathri ^a   Safe, Stephen H ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Apoptosis; Cannabinoids; Dual specificity phosphatases; Prostate cancer cell lines; Protein tyrosine phosphatases

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABIDIOL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATASE; VANADATE SODIUM;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN LNCAP; CELL STRAIN SW480; COLON CANCER; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN CLEAVAGE;

APOPTOSIS; BENZOXAZINES; BLOTTING, WESTERN; CALCIUM CHANNEL BLOCKERS; CANNABIDIOL; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; HUMANS; MALE; MORPHOLINES; NAPHTHALENES; PHOSPHORIC MONOESTER HYDROLASES; POLY(ADP-RIBOSE) POLYMERASES; PROSTATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 83055161839     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Aggarwal BB, Vijayalekshmi RV and Sung B: Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res 15: 425-30, 2009.
2. Pathak AK, Bhutani M, Nair AS, Ahn KS, Chakraborty A, Kadara H, Guha S, Sethi G and Aggarwal BB: Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 5: 943-55, 2007. (Pubitemid 47416671)
3. Ahn KS, Sethi G, Sung B, Goel A, Ralhan R and Aggarwal BB: Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. Cancer Res 68: 4406-15, 2008.
4. Lee J, Hahm ER and Singh SV: Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis 31: 1991-1998, 2010.
5. Pandey MK, Sung B and Aggarwal BB: Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. Int J Cancer 127: 282-92, 2010.
6. Yu LJ, Wu ML, Li H, Chen XY, Wang Q, Sun Y, Kong QY and Liu J: Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. Neoplasia 10: 736-744, 2008. (Pubitemid 351883890)
7. Glienke W, Maute L, Wicht J and Bergmann L: Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and down-regulation of survivin/BIRC5 gene expression. Cancer Invest 28: 166-171, 2010.
8. Nonn L, Duong D and Peehl DM: Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis 28: 1188-1196, 2007. (Pubitemid 47062677)
9. Krishnan AV, Moreno J, Nonn L, Malloy P, Swami S, Peng L, Peehl DM and Feldman D: Novel pathways that contribute to the antiproliferative and chemopreventive activities of calcitriol in prostate cancer. J Steroid Biochem Mol Biol 103: 694-702, 2007. (Pubitemid 46401340)
10. Guzman M: Cannabinoids: potential anticancer agents. Nat Rev Cancer 3: 745-55, 2003.
11. Sarfaraz S, Adhami VM, Syed DN, Afaq F and Mukhtar H: Cannabinoids for cancer treatment: progress and promise. Cancer Res 68: 339-342, 2008. (Pubitemid 351380057)
12. Bernadette H: Cannabinoid therapeutics: high hopes for the future. Drug Discov Today 10: 459-462, 2005.
13. Hall W, Christie M and Currow D: Cannabinoids and cancer: causation, remediation, and palliation. Lancet Oncol 6: 35-42, 2005. (Pubitemid 40100410)
14. Carracedo A, Lorente M, Egia A, Blazquez C, Garcia S, Giroux V, Malicet C, Villuendas R, Gironella M, Gonzalez-Feria L, Piris MA, Iovanna JL, Guzman M and Velasco G: The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 9: 301-912, 2006.
15. Blazquez C, Salazar M, Carracedo A, Lorente M, Egia A, Gonzalez-Feria L, Haro A, Velasco G and Guzman M: Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res 68: 1945-1952, 2008. (Pubitemid 351416581)
16. Sarfaraz S, Afaq F, Adhami VM and Mukhtar H: Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 65: 1635-1641, 2005. (Pubitemid 40478586)
17. Sarfaraz S, Afaq F, Adhami VM, Malik A and Mukhtar H: Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest. J Biol Chem 281: 39480-39491, 2006. (Pubitemid 46041908)
18. Caffarel MM, Sarrio D, Palacios J, Guzman M and Sanchez C: Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through CDC2 regulation. Cancer Res 66: 6615-6621, 2006. (Pubitemid 44085617)
19. Greenhough A, Patsos HA, Williams AC and Paraskeva C: The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. Int J Cancer 121: 2172-2180, 2007. (Pubitemid 47585595)
20. Wang D, Wang H, Ning W, Backlund MG, Dey SK and DuBois RN: Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res 68: 6468-76, 2008.
21. Vaccani A, Massi P, Colombo A, Rubino T and Parolaro D: Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 144: 1032-1036, 2005. (Pubitemid 40593001)
22. Massi P, Vaccani A, Ceruti S, Colombo A, Abbracchio MP and Parolaro D: Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. J Pharmacol Exp Ther 308: 838-845, 2004. (Pubitemid 38263956)
23. Ramer R, Merkord J, Rohde H and Hinz B: Cannabidiol inhibits cancer cell invasion via up-regulation of tissue inhibitor of matrix metalloproteinases-1. Biochem Pharmacol 79: 955-966, 2010.
24. McKallip RJ, Jia W, Schlomer J, Warren JW, Nagarkatti PS and Nagarkatti M: Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22PHOX and NOX4 expression. Mol Pharmacol 70: 897-908, 2006. (Pubitemid 44268447)
25. Xian XS, Park H, Cho YK, Lee IS, Kim SW, Choi MG, Chung IS, Han KH and Park JM: Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells. J Cell Biochem 110: 321-332, 2010.
26. Sreevalsan S, Jutooru I, Chadalapaka G, Walker M and Safe S: 1,1-Bis(3′-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells. Int J Oncol 35: 1191-1199, 2009.
27. King EM, Holden NS, Gong W, Rider CF and Newton R: Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK. J Biol Chem 284: 26803-26815, 2009.
28. Lawan A, Al-Harthi S, Cadalbert L, McCluskey AG, Shweash M, Grassia G, Grant A, Boyd M, Currie S and Plevin R: Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival. J Biol Chem 286: 12933-12943, 2011.
29. Qin J, Chen HG, Yan Q, Deng M, Liu J, Doerge S, Ma W, Dong Z and Li DW: Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway. Cancer Res 68: 4150-4162, 2008.
30. Ramirez CJ, Haberbusch JM, Soprano DR and Soprano KJ: Retinoic acid-induced repression of AP-1 activity is mediated by protein phosphatase 2A in ovarian carcinoma cells. J Cell Biochem 96: 170-182, 2005. (Pubitemid 41420112)
31. Chuang TD, Chen SJ, Lin FF, Veeramani S, Kumar S, Batra SK, Tu Y and Lin MF: Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ERBB-2 and regulates prostate cancer cell growth. J Biol Chem 285: 23598-23606, 2010.
32. Balavenkatraman KK, Jandt E, Friedrich K, Kautenburger T, Pool-Zobel BL, Ostman A and Bohmer FD: DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients. Oncogene 25: 6319-6324, 2006. (Pubitemid 44564747)
33. Choi JY, Na M, Hyun Hwang I, Ho Lee S, Young Bae E, Yeon Kim B and Seog Ahn J: Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C. B. Clarke. Molecules 14: 266-72, 2009.
34. Eljaschewitsch E, Witting A, Mawrin C, Lee T, Schmidt PM, Wolf S, Hoertnagl H, Raine CS, Schneider-Stock R, Nitsch R and Ullrich O: The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron 49: 67-79, 2006. (Pubitemid 43017186)
35. Romero-Sandoval EA, Horvath R, Landry RP and DeLeo JA: Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol Pain 5: 25-39, 2009.