Cannabidiol, a nonpsychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT 1A somatodendritic autoreceptors in the dorsal raphe nucleus

British Journal of Pharmacology

Volumn 165, Issue 8, 2012, Pages 2620-2634

  Rock, E M ^a   Bolognini, D ^b   Limebeer, C L ^a   Cascio, M G ^b   Anavi Goffer, S ^b   Fletcher, P J ^c   Mechoulam, R ^d   Pertwee, R G ^b   Parker, Linda A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c UNIVERSITY OF TORONTO   (Canada)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

5 HT 1A; Cannabidiol; Conditioned disgust; Emesis; Endocannabinoid; Gaping; Nausea; Rat; Shrew; Taste reactivity; Vomiting

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; CANNABIDIOL; CISPLATIN; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; LITHIUM CHLORIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; NICOTINE; SEROTONIN 1A RECEPTOR; ANTIEMETIC AGENT; CANNABIS; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 1 AGONIST; SEROTONIN 1 ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIEMETIC ACTIVITY; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE; NAUSEA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SHREW; VOMITING; ANIMAL; ANIMAL BEHAVIOR; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RAPHE NUCLEUS; RAT; SPRAGUE DAWLEY RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ANTIEMETICS; BEHAVIOR, ANIMAL; CANNABIDIOL; CANNABIS; FEMALE; MALE; NAUSEA; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS; SHREWS; VOMITING;

EID: 83255165010     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01621.x     Document Type: Article

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