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Volumn 213, Issue 2, 2010, Pages 225-229

Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors

Author keywords

5 HT1A; Anxiety; Cannabidiol; DPAG; Electrical stimulation; Elevated T maze; Panic

Indexed keywords

CANNABIDIOL; SEROTONIN 1A RECEPTOR; N-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-N-(2-PYRIDINYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 1 AGONIST; SEROTONIN 1 ANTAGONIST;

EID: 77953917373     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.05.004     Document Type: Article
Times cited : (90)

References (54)
  • 1
    • 0028101302 scopus 로고
    • Columnar organization in the midbrain periaqueductal gray: modules for emotional expression?
    • [Review]
    • Bandler R., Shipley M.T. Columnar organization in the midbrain periaqueductal gray: modules for emotional expression?. Trends Neurosci 1994, 17(9):379-389. [Review].
    • (1994) Trends Neurosci , vol.17 , Issue.9 , pp. 379-389
    • Bandler, R.1    Shipley, M.T.2
  • 2
    • 0031004215 scopus 로고    scopus 로고
    • The effect of central and systemic injection of the 5-HT1A receptor agonist 8-OHDPAT and the 5-HT1A receptor antagonist WAY100635 on periaqueductal grey-induced defence behaviour
    • Beckett S., Marsden C.A. The effect of central and systemic injection of the 5-HT1A receptor agonist 8-OHDPAT and the 5-HT1A receptor antagonist WAY100635 on periaqueductal grey-induced defence behaviour. J Psychopharmacol 1997, 11(1):35-40.
    • (1997) J Psychopharmacol , vol.11 , Issue.1 , pp. 35-40
    • Beckett, S.1    Marsden, C.A.2
  • 3
    • 0026648596 scopus 로고
    • Attenuation of chemically induced defence response by 5-HT1 receptor agonists administered into the periaqueductal gray
    • Beckett S.R., Lawrence A.J., Marsden C.A., Marshall P.W. Attenuation of chemically induced defence response by 5-HT1 receptor agonists administered into the periaqueductal gray. Psychopharmacology 1992, 108(1-2):110-114.
    • (1992) Psychopharmacology , vol.108 , Issue.1-2 , pp. 110-114
    • Beckett, S.R.1    Lawrence, A.J.2    Marsden, C.A.3    Marshall, P.W.4
  • 4
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno T., Hanus L., De Petrocellis L., Tchilibon S., Ponde D.E., Brandi I., et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 2001, 134(4):845-852.
    • (2001) Br J Pharmacol , vol.134 , Issue.4 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3    Tchilibon, S.4    Ponde, D.E.5    Brandi, I.6
  • 5
    • 46649094780 scopus 로고    scopus 로고
    • Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
    • Campos A.C., Guimarães F.S. Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology 2008, 199(2):223-230.
    • (2008) Psychopharmacology , vol.199 , Issue.2 , pp. 223-230
    • Campos, A.C.1    Guimarães, F.S.2
  • 6
    • 71549171421 scopus 로고    scopus 로고
    • Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids
    • Campos A.C., Guimarães F.S. Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33(8):1517-1521.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , Issue.8 , pp. 1517-1521
    • Campos, A.C.1    Guimarães, F.S.2
  • 7
    • 0015656165 scopus 로고
    • Letter: cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents
    • Carlini E.A., Leite J.R., Tannhauser M., Berardi A.C. Letter: cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents. J Pharm Pharmacol 1973, 25(8):664-665.
    • (1973) J Pharm Pharmacol , vol.25 , Issue.8 , pp. 664-665
    • Carlini, E.A.1    Leite, J.R.2    Tannhauser, M.3    Berardi, A.C.4
  • 8
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression
    • Carrier E.J., Auchampach J.A., Hillard C.J. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci USA 2006, 103(20):7895-7900.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.20 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 9
    • 28344440863 scopus 로고    scopus 로고
    • Effects of fluoxetine and buspirone on the panicolytic-like response induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray
    • de Bortoli V.C., Nogueira R.L., Zangrossi H. Effects of fluoxetine and buspirone on the panicolytic-like response induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray. Psychopharmacology (Berl) 2006, 183(4):422-428.
    • (2006) Psychopharmacology (Berl) , vol.183 , Issue.4 , pp. 422-428
    • de Bortoli, V.C.1    Nogueira, R.L.2    Zangrossi, H.3
  • 10
    • 44249099434 scopus 로고    scopus 로고
    • Alprazolam potentiates the antiaversive effect induced by the activation of 5-HT(1A) and 5-HT (2A) receptors in the rat dorsal periaqueductal gray
    • de Bortoli V.C., Nogueira R.L., Zangrossi H. Alprazolam potentiates the antiaversive effect induced by the activation of 5-HT(1A) and 5-HT (2A) receptors in the rat dorsal periaqueductal gray. Psychopharmacology (Berl) 2008, 198(3):341-349.
    • (2008) Psychopharmacology (Berl) , vol.198 , Issue.3 , pp. 341-349
    • de Bortoli, V.C.1    Nogueira, R.L.2    Zangrossi, H.3
  • 11
    • 4444365487 scopus 로고    scopus 로고
    • Involvement of 5-HT1A and 5-HT2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze
    • de Paula Soares V., Zangrossi H. Involvement of 5-HT1A and 5-HT2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze. Brain Res Bull 2004, 64(2):181-188.
    • (2004) Brain Res Bull , vol.64 , Issue.2 , pp. 181-188
    • de Paula Soares, V.1    Zangrossi, H.2
  • 12
    • 57649222030 scopus 로고    scopus 로고
    • Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats
    • de Paula Soares V., Zangrossi Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats. Behav Brain Res 2009, 197(1):178-185.
    • (2009) Behav Brain Res , vol.197 , Issue.1 , pp. 178-185
    • de Paula Soares, V.1    Zangrossi2
  • 13
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992, 258(5090):1946-1949.
    • (1992) Science , vol.258 , Issue.5090 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3    Pertwee, R.G.4    Stevenson, L.A.5    Griffin, G.6
  • 14
    • 58149520644 scopus 로고    scopus 로고
    • Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing
    • Fusar-Poli P., Crippa J.A., Bhattacharyya S., Borgwardt S.J., Allen P., Martin-Santos R., et al. Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Arch Gen Psychiatry 2009, 66(1):95-105.
    • (2009) Arch Gen Psychiatry , vol.66 , Issue.1 , pp. 95-105
    • Fusar-Poli, P.1    Crippa, J.A.2    Bhattacharyya, S.3    Borgwardt, S.J.4    Allen, P.5    Martin-Santos, R.6
  • 15
    • 0000720482 scopus 로고
    • Brain defense systems and anxiety
    • Elsevier Science Publishers, Amsterdam
    • Graeff F.G. Brain defense systems and anxiety. Handbook of anxiety: the neurobiology of anxiety 1990, vol. 3:307-354. Elsevier Science Publishers, Amsterdam.
    • (1990) Handbook of anxiety: the neurobiology of anxiety , vol.3 , pp. 307-354
    • Graeff, F.G.1
  • 16
    • 3042549948 scopus 로고    scopus 로고
    • Serotonin, the periaqueductal gray and panic
    • [Review]
    • Graeff F.G. Serotonin, the periaqueductal gray and panic. Neurosci Biobehav Rev 2004, 28(3):239-259. [Review].
    • (2004) Neurosci Biobehav Rev , vol.28 , Issue.3 , pp. 239-259
    • Graeff, F.G.1
  • 18
    • 0345490863 scopus 로고    scopus 로고
    • The elevated T-maze as an experimental model of anxiety
    • [Review]
    • Graeff F.G., Netto C.F., Zangrossi H. The elevated T-maze as an experimental model of anxiety. Neurosci Biobehav Rev 1998, 23(2):237-246. [Review].
    • (1998) Neurosci Biobehav Rev , vol.23 , Issue.2 , pp. 237-246
    • Graeff, F.G.1    Netto, C.F.2    Zangrossi, H.3
  • 19
    • 0035709447 scopus 로고    scopus 로고
    • Comparison between two models of experimental anxiety in healthy volunteers and panic disorder patients
    • Graeff F.G., Silva M., Del Ben C.M., Zuardi A.W., Hetem L.A., Guimarães F.S. Comparison between two models of experimental anxiety in healthy volunteers and panic disorder patients. Neurosci Biobehav Rev 2001, 25(7-8):53-59.
    • (2001) Neurosci Biobehav Rev , vol.25 , Issue.7-8 , pp. 53-59
    • Graeff, F.G.1    Silva, M.2    Del Ben, C.M.3    Zuardi, A.W.4    Hetem, L.A.5    Guimarães, F.S.6
  • 21
    • 70349189518 scopus 로고    scopus 로고
    • Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
    • Izzo A.A., Borrelli F., Capasso R., Di Marzo V., Mechoulam R. Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 2009, 30(10):515-527.
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.10 , pp. 515-527
    • Izzo, A.A.1    Borrelli, F.2    Capasso, R.3    Di Marzo, V.4    Mechoulam, R.5
  • 22
    • 0029134515 scopus 로고
    • Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: elements of face and predictive validity
    • Jenck F., Moreau J.L., Martin J.R. Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: elements of face and predictive validity. Psychiatry Res 1995, 57(2):181-191.
    • (1995) Psychiatry Res , vol.57 , Issue.2 , pp. 181-191
    • Jenck, F.1    Moreau, J.L.2    Martin, J.R.3
  • 23
    • 0016210392 scopus 로고
    • Cannabidiol interferes with the effects of delta 9-tetrahydrocannabinol in man
    • Karniol I.G., Shirakawa I., Kasinski N., Pfeferman A., Carlini E.A. Cannabidiol interferes with the effects of delta 9-tetrahydrocannabinol in man. Eur J Pharmacol 1974, 28(1):172-177.
    • (1974) Eur J Pharmacol , vol.28 , Issue.1 , pp. 172-177
    • Karniol, I.G.1    Shirakawa, I.2    Kasinski, N.3    Pfeferman, A.4    Carlini, E.A.5
  • 24
    • 17444370570 scopus 로고    scopus 로고
    • Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease
    • Lastres-Becker I., Molina-Holgado F., Ramos J.A., Mechoulam R., Fernandez-Ruiz J. Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease. Neurobiol Dis 2005, 19(1-2):96-107.
    • (2005) Neurobiol Dis , vol.19 , Issue.1-2 , pp. 96-107
    • Lastres-Becker, I.1    Molina-Holgado, F.2    Ramos, J.A.3    Mechoulam, R.4    Fernandez-Ruiz, J.5
  • 25
    • 70849116349 scopus 로고    scopus 로고
    • Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats
    • Lemos J.I., Resstel L.B., Guimarães F.S. Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats. Behav Brain Res 2010, 207(1):105-111.
    • (2010) Behav Brain Res , vol.207 , Issue.1 , pp. 105-111
    • Lemos, J.I.1    Resstel, L.B.2    Guimarães, F.S.3
  • 26
    • 0034012283 scopus 로고    scopus 로고
    • Panic disorder-a malfunction of multiple transmitter control systems within the midbrain periaqueductal gray matter
    • Lovick T.A. Panic disorder-a malfunction of multiple transmitter control systems within the midbrain periaqueductal gray matter. Neuroscientist 2000, 6:48-59.
    • (2000) Neuroscientist , vol.6 , pp. 48-59
    • Lovick, T.A.1
  • 27
    • 77249134168 scopus 로고    scopus 로고
    • Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
    • Magen I., Avraham Y., Ackerman Z., Vorobiev L., Mechoulam R., Berry E.M. Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation. Br J Pharmacol 2010, 159(4):950-957.
    • (2010) Br J Pharmacol , vol.159 , Issue.4 , pp. 950-957
    • Magen, I.1    Avraham, Y.2    Ackerman, Z.3    Vorobiev, L.4    Mechoulam, R.5    Berry, E.M.6
  • 28
    • 0017743744 scopus 로고
    • A solid state sine-wave stimulator
    • Marseillan R.F. A solid state sine-wave stimulator. Physiol Behav 1977, 19(2):339-340.
    • (1977) Physiol Behav , vol.19 , Issue.2 , pp. 339-340
    • Marseillan, R.F.1
  • 30
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R., Ben-Shabat S., Hanus L., Ligumsky M., Kaminski N.E., Schatz A.R., et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 1995, 50(1):83-90.
    • (1995) Biochem Pharmacol , vol.50 , Issue.1 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3    Ligumsky, M.4    Kaminski, N.E.5    Schatz, A.R.6
  • 31
    • 0037207079 scopus 로고    scopus 로고
    • Cannabidiol: an overview of some pharmacological aspects
    • Mechoulam R., Parker L.A., Gallily R. Cannabidiol: an overview of some pharmacological aspects. Chem Phys Lipids 2002, 121(1-2):35-43.
    • (2002) Chem Phys Lipids , vol.121 , Issue.1-2 , pp. 35-43
    • Mechoulam, R.1    Parker, L.A.2    Gallily, R.3
  • 32
    • 18244396915 scopus 로고    scopus 로고
    • Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
    • Mishima K., Hayakawa K., Abe K., Ikeda T., Egashira N., Iwasaki K., et al. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke 2005, 36(5):1077-1082.
    • (2005) Stroke , vol.36 , Issue.5 , pp. 1077-1082
    • Mishima, K.1    Hayakawa, K.2    Abe, K.3    Ikeda, T.4    Egashira, N.5    Iwasaki, K.6
  • 33
    • 0017652749 scopus 로고
    • Hypnotic-like effects of cannabidiol in the rat
    • Monti J.M. Hypnotic-like effects of cannabidiol in the rat. Psychopharmacology 1977, 55(3):263-265.
    • (1977) Psychopharmacology , vol.55 , Issue.3 , pp. 263-265
    • Monti, J.M.1
  • 34
    • 17444393586 scopus 로고    scopus 로고
    • Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice
    • Moreira F.A., Guimarães F.S. Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice. Eur J Pharmacol 2005, 512(2-3):199-205.
    • (2005) Eur J Pharmacol , vol.512 , Issue.2-3 , pp. 199-205
    • Moreira, F.A.1    Guimarães, F.S.2
  • 36
    • 0014440086 scopus 로고
    • Sensations evoked by stimulation in the midbrain of man
    • Nashold, Wilson W.P., Slaughter D.G. Sensations evoked by stimulation in the midbrain of man. J Neurosurg 1969, 30(1):14-24.
    • (1969) J Neurosurg , vol.30 , Issue.1 , pp. 14-24
    • Nashold1    Wilson, W.P.2    Slaughter, D.G.3
  • 37
    • 0029164519 scopus 로고
    • Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion
    • Nogueira R.L., Graeff F.G. Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion. Pharmacol Biochem Behav 1995, 52(1):1-6.
    • (1995) Pharmacol Biochem Behav , vol.52 , Issue.1 , pp. 1-6
    • Nogueira, R.L.1    Graeff, F.G.2
  • 39
    • 0000183704 scopus 로고
    • Approach-escape interactions in rat brain
    • Olds M.E., Olds J. Approach-escape interactions in rat brain. Am J Physiol 1962, 203:803-810.
    • (1962) Am J Physiol , vol.203 , pp. 803-810
    • Olds, M.E.1    Olds, J.2
  • 41
    • 0345376845 scopus 로고    scopus 로고
    • Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze
    • Poltronieri S.C., Zangrossi H., de Barros Viana M. Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze. Behav Brain Res 2003, 147(1-2):185-192.
    • (2003) Behav Brain Res , vol.147 , Issue.1-2 , pp. 185-192
    • Poltronieri, S.C.1    Zangrossi, H.2    de Barros Viana, M.3
  • 42
    • 33746647403 scopus 로고    scopus 로고
    • Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats
    • Resstel L.B., Joca S.R., Moreira F.A., Corrêa F.M., Guimarães F.S. Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats. Behav Brain Res 2006, 172(2):294-298.
    • (2006) Behav Brain Res , vol.172 , Issue.2 , pp. 294-298
    • Resstel, L.B.1    Joca, S.R.2    Moreira, F.A.3    Corrêa, F.M.4    Guimarães, F.S.5
  • 43
    • 65549106424 scopus 로고    scopus 로고
    • 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats
    • Resstel L.B., Tavares R.F., Lisboa S.F., Joca S.R., Corrêa F.M., Guimarães F.S. 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. Br J Pharmacol 2009, 156(1):181-188.
    • (2009) Br J Pharmacol , vol.156 , Issue.1 , pp. 181-188
    • Resstel, L.B.1    Tavares, R.F.2    Lisboa, S.F.3    Joca, S.R.4    Corrêa, F.M.5    Guimarães, F.S.6
  • 44
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1a receptors
    • Russo E.B., Burnett A., Hall B., Parker K.K. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res 2005, 30(8):1037-1043.
    • (2005) Neurochem Res , vol.30 , Issue.8 , pp. 1037-1043
    • Russo, E.B.1    Burnett, A.2    Hall, B.3    Parker, K.K.4
  • 46
    • 0034078058 scopus 로고    scopus 로고
    • Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety
    • Teixeira R.C., Zangrossi H., Graeff F.G. Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacol Biochem Behav 2000, 65(4):571-576.
    • (2000) Pharmacol Biochem Behav , vol.65 , Issue.4 , pp. 571-576
    • Teixeira, R.C.1    Zangrossi, H.2    Graeff, F.G.3
  • 47
    • 33847653702 scopus 로고    scopus 로고
    • Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    • Thomas A., Baillie G.L., Phillips A.M., Razdan R.K., Ross R.A., Pertwee R.G. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol 2007, 150(5):613-623.
    • (2007) Br J Pharmacol , vol.150 , Issue.5 , pp. 613-623
    • Thomas, A.1    Baillie, G.L.2    Phillips, A.M.3    Razdan, R.K.4    Ross, R.A.5    Pertwee, R.G.6
  • 49
    • 0028097568 scopus 로고
    • The elevated T-maze: a new animal model of anxiety and memory
    • Viana M.B., Tomaz C., Graeff F.G. The elevated T-maze: a new animal model of anxiety and memory. Pharmacol Biochem Behav 1994, 49(3):549-554.
    • (1994) Pharmacol Biochem Behav , vol.49 , Issue.3 , pp. 549-554
    • Viana, M.B.1    Tomaz, C.2    Graeff, F.G.3
  • 50
    • 0030800475 scopus 로고    scopus 로고
    • Behavioral validation of the elevated T-maze, a new animal model of anxiety
    • Zangrossi, Graeff F.G. Behavioral validation of the elevated T-maze, a new animal model of anxiety. Brain Res Bull 1997, 44(1):1-5.
    • (1997) Brain Res Bull , vol.44 , Issue.1 , pp. 1-5
    • Zangrossi1    Graeff, F.G.2
  • 51
    • 0041743267 scopus 로고    scopus 로고
    • Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze
    • Zanoveli J.M., Nogueira R.L., Zangrossi Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze. Eur J Pharmacol 2003, 473(2-3):153-161.
    • (2003) Eur J Pharmacol , vol.473 , Issue.2-3 , pp. 153-161
    • Zanoveli, J.M.1    Nogueira, R.L.2    Zangrossi3
  • 52
    • 0020079139 scopus 로고
    • Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects
    • Zuardi A.W., Shirakawa I., Finkelfarb E., Karniol I.G. Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology 1982, 76(3):245-250.
    • (1982) Psychopharmacology , vol.76 , Issue.3 , pp. 245-250
    • Zuardi, A.W.1    Shirakawa, I.2    Finkelfarb, E.3    Karniol, I.G.4
  • 53
    • 0025876938 scopus 로고
    • Effects of cannabidiol in animal models predictive of antipsychotic activity
    • Zuardi A.W., Antunes Rodrigues J., Cunha J.M. Effects of cannabidiol in animal models predictive of antipsychotic activity. Psychopharmacology 1991, 104:260-264.
    • (1991) Psychopharmacology , vol.104 , pp. 260-264
    • Zuardi, A.W.1    Antunes Rodrigues, J.2    Cunha, J.M.3
  • 54
    • 0027483116 scopus 로고
    • Effects of ipsapirone and cannabidiol on human experimental anxiety
    • Zuardi A.W., Cosme R.A., Graeff F.G., Guimarães F.S. Effects of ipsapirone and cannabidiol on human experimental anxiety. J Psychopharmacol 1993, 7(1):82-88.
    • (1993) J Psychopharmacol , vol.7 , Issue.1 , pp. 82-88
    • Zuardi, A.W.1    Cosme, R.A.2    Graeff, F.G.3    Guimarães, F.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.