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Volumn 162, Issue 3, 2011, Pages 584-596

Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action

Author keywords

adenosine; brainstem; cannabinoids; endocannabinoids; pain; receptors; serotonin; transporters; TRP channels

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; CANNABICHROMENE; CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; RESINIFERATOXIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; VANILLOID RECEPTOR 1;

EID: 78651436142     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01063.x     Document Type: Article
Times cited : (135)

References (73)
  • 1
    • 34547844249 scopus 로고    scopus 로고
    • Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization
    • Akopian AN, Ruparel NB, Jeske NA, Hargreaves KM, (2007). Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol 583: 175-193.
    • (2007) J Physiol , vol.583 , pp. 175-193
    • Akopian, A.N.1    Ruparel, N.B.2    Jeske, N.A.3    Hargreaves, K.M.4
  • 2
    • 38749149923 scopus 로고    scopus 로고
    • Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation
    • Akopian AN, Ruparel NB, Patwardhan A, Hargreaves KM, (2008). Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. J Neurosci 28: 1064-1075.
    • (2008) J Neurosci , vol.28 , pp. 1064-1075
    • Akopian, A.N.1    Ruparel, N.B.2    Patwardhan, A.3    Hargreaves, K.M.4
  • 3
    • 72149097863 scopus 로고    scopus 로고
    • Guide to Receptors and Channels (GRAC), 4th edn
    • Alexander SPH, Mathie A, Peters JA, (2009). Guide to Receptors and Channels (GRAC), 4th edn. Br J Pharmacol 158 (Suppl. 1): S1-S254.
    • (2009) Br J Pharmacol , vol.158 , Issue.SUPPL. 1
    • Alexander, S.P.H.1    Mathie, A.2    Peters, J.A.3
  • 4
    • 0021288912 scopus 로고
    • Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry
    • Basbaum AI, Fields HL, (1984). Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7: 309-338.
    • (1984) Annu Rev Neurosci , vol.7 , pp. 309-338
    • Basbaum, A.I.1    Fields, H.L.2
  • 5
    • 0025054545 scopus 로고
    • Hyperalgesia during naloxone-precipitated withdrawal from morphine is correlated with increased on cell activity in the rostral ventromedial medulla
    • Bederson JB, Fields HL, Barbaro NM, (1990). Hyperalgesia during naloxone-precipitated withdrawal from morphine is correlated with increased ON cell activity in the rostral ventromedial medulla. Somatosens Mot Res 7: 185-203.
    • (1990) Somatosens Mot Res , vol.7 , pp. 185-203
    • Bederson, J.B.1    Fields, H.L.2    Barbaro, N.M.3
  • 6
    • 34250893737 scopus 로고    scopus 로고
    • Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states
    • Bee LA, Dickenson AH, (2007). Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states. Neuroscience 147: 786-793.
    • (2007) Neuroscience , vol.147 , pp. 786-793
    • Bee, L.A.1    Dickenson, A.H.2
  • 7
    • 0028981582 scopus 로고
    • Functional characteristics of the midbrain periaqueductal gray
    • Behbehani MM, (1995). Functional characteristics of the midbrain periaqueductal gray. Prog Neurobiol 46: 575-605.
    • (1995) Prog Neurobiol , vol.46 , pp. 575-605
    • Behbehani, M.M.1
  • 8
    • 0018420264 scopus 로고
    • Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia
    • Behbehani MM, Fields HL, (1979). Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia. Brain Res 170: 85-93.
    • (1979) Brain Res , vol.170 , pp. 85-93
    • Behbehani, M.M.1    Fields, H.L.2
  • 9
    • 0027336034 scopus 로고
    • Activation of serotonin1A receptors inhibits midbrain periaqueductal gray neurons of the rat
    • Behbehani MM, Liu H, Jiang M, Pun RY, Shipley MT, (1993). Activation of serotonin1A receptors inhibits midbrain periaqueductal gray neurons of the rat. Brain Res 612: 56-60.
    • (1993) Brain Res , vol.612 , pp. 56-60
    • Behbehani, M.M.1    Liu, H.2    Jiang, M.3    Pun, R.Y.4    Shipley, M.T.5
  • 10
    • 0031031557 scopus 로고    scopus 로고
    • Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes
    • Bisogno T, Maurelli S, Melck D, De Petrocellis L, Di Marzo V, (1997). Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes. J Biol Chem 272: 3315-3323.
    • (1997) J Biol Chem , vol.272 , pp. 3315-3323
    • Bisogno, T.1    Maurelli, S.2    Melck, D.3    De Petrocellis, L.4    Di Marzo, V.5
  • 11
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, et al. (2001). Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 134: 845-852.
    • (2001) Br J Pharmacol , vol.134 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3    Tchilibon, S.4    Ponde, D.E.5    Brandi, I.6
  • 12
    • 0036011159 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications
    • Bisogno T, De Petrocellis L, Di Marzo V, (2002). Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications. Curr Pharm Des 8: 533-547.
    • (2002) Curr Pharm des , vol.8 , pp. 533-547
    • Bisogno, T.1    De Petrocellis, L.2    Di Marzo, V.3
  • 13
    • 55849152371 scopus 로고    scopus 로고
    • A new tr(i)p to sense pain: TRPA1 channel as a target for novel analgesics
    • Cai X, (2008). A new tr(i)p to sense pain: TRPA1 channel as a target for novel analgesics. Expert Rev Neurother 8: 1675-1681.
    • (2008) Expert Rev Neurother , vol.8 , pp. 1675-1681
    • Cai, X.1
  • 14
    • 46649094780 scopus 로고    scopus 로고
    • Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
    • Campos AC, Guimarães FS, (2008). Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology (Berl) 199: 223-230.
    • (2008) Psychopharmacology (Berl) , vol.199 , pp. 223-230
    • Campos, A.C.1    Guimarães, F.S.2
  • 15
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression
    • Carrier EJ, Auchampach JA, Hillard CJ, (2006). Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci U S A 103: 7895-7900.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 16
    • 72749107868 scopus 로고    scopus 로고
    • The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors
    • Castillo A, Tolón MR, Fernández-Ruiz J, Romero J, Martinez-Orgado J, (2010). The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. Neurobiol Dis 37: 434-440.
    • (2010) Neurobiol Dis , vol.37 , pp. 434-440
    • Castillo, A.1    Tolón, M.R.2    Fernández-Ruiz, J.3    Romero, J.4    Martinez-Orgado, J.5
  • 17
    • 44249117614 scopus 로고    scopus 로고
    • Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8
    • De Petrocellis L, Vellani V, Schiano-Moriello A, Marini P, Magherini PC, Orlando P, et al. (2008). Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. J Pharmacol Exp Ther 325: 1007-1015.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 1007-1015
    • De Petrocellis, L.1    Vellani, V.2    Schiano-Moriello, A.3    Marini, P.4    Magherini, P.C.5    Orlando, P.6
  • 18
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, et al. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258: 1946-1949.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3    Pertwee, R.G.4    Stevenson, L.A.5    Griffin, G.6
  • 19
    • 0034002260 scopus 로고    scopus 로고
    • Pain modulation: Expectation, opioid analgesia and virtual pain
    • Fields HL, (2000). Pain modulation: expectation, opioid analgesia and virtual pain. Prog Brain Res 122: 245-253.
    • (2000) Prog Brain Res , vol.122 , pp. 245-253
    • Fields, H.L.1
  • 20
    • 3042789578 scopus 로고    scopus 로고
    • State-dependent opioid control of pain
    • Fields HL, (2004). State-dependent opioid control of pain. Nat Rev Neurosci 5: 565-575.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 565-575
    • Fields, H.L.1
  • 21
    • 0021049145 scopus 로고
    • Evidence that disinhibition of brain stem neurones contributes to morphine analgesia
    • Fields HL, Vanegas H, Hentall ID, Zorman G, (1983). Evidence that disinhibition of brain stem neurones contributes to morphine analgesia. Nature 306: 684-686.
    • (1983) Nature , vol.306 , pp. 684-686
    • Fields, H.L.1    Vanegas, H.2    Hentall, I.D.3    Zorman, G.4
  • 22
    • 0025959669 scopus 로고
    • Neurotransmitters in nociceptive modulatory circuits
    • Fields HL, Heinricher MM, Mason P, (1991). Neurotransmitters in nociceptive modulatory circuits. Annu Rev Neurosci 14: 219-245.
    • (1991) Annu Rev Neurosci , vol.14 , pp. 219-245
    • Fields, H.L.1    Heinricher, M.M.2    Mason, P.3
  • 23
    • 0028843805 scopus 로고
    • Dorsal horn projection targets of on and off cells in the rostral ventromedial medulla
    • Fields HL, Malick A, Burstein R, (1995). Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J Neurophysiol 74: 1742-1759.
    • (1995) J Neurophysiol , vol.74 , pp. 1742-1759
    • Fields, H.L.1    Malick, A.2    Burstein, R.3
  • 24
    • 28044469299 scopus 로고    scopus 로고
    • Sensory suppression during feeding
    • Foo H, Mason P, (2005). Sensory suppression during feeding. Proc Natl Acad Sci U S A 102: 16865-16869.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16865-16869
    • Foo, H.1    Mason, P.2
  • 25
    • 0023256877 scopus 로고
    • Local circuit neurons in the rat ventrobasal thalamus-A GABA immunocytochemical study
    • Harris RM, Hendrickson AE, (1987). Local circuit neurons in the rat ventrobasal thalamus-a GABA immunocytochemical study. Neuroscience 21: 229-236.
    • (1987) Neuroscience , vol.21 , pp. 229-236
    • Harris, R.M.1    Hendrickson, A.E.2
  • 26
    • 84882489794 scopus 로고    scopus 로고
    • The brainstem and nociceptive modulation. In: Bushnell M.C., Basbaum A.I. (eds). Academic Press: San Diego, CA, pp.
    • Heinricher MM, Ingram SL, (2008). The brainstem and nociceptive modulation. In:, Bushnell MC, Basbaum AI, (eds). The Senses, A Comprehensive Reference. Pain, Vol. 5. Academic Press: San Diego, CA, pp. 593-626.
    • (2008) The Senses, A Comprehensive Reference. Pain, Vol. 5. , pp. 593-626
    • Heinricher, M.M.1    Ingram, S.L.2
  • 27
    • 0031924039 scopus 로고    scopus 로고
    • Analysis of excitatory amino acid transmission within the rostral ventromedial medulla: Implications for circuitry
    • Heinricher MM, McGaraughty S, (1998). Analysis of excitatory amino acid transmission within the rostral ventromedial medulla: implications for circuitry. Pain 75: 247-255.
    • (1998) Pain , vol.75 , pp. 247-255
    • Heinricher, M.M.1    McGaraughty, S.2
  • 28
    • 4444328321 scopus 로고    scopus 로고
    • Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla
    • Heinricher MM, Neubert MJ, (2004). Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla. J Neurophysiol 92: 1982-1989.
    • (2004) J Neurophysiol , vol.92 , pp. 1982-1989
    • Heinricher, M.M.1    Neubert, M.J.2
  • 29
    • 0027943806 scopus 로고
    • Interference with GABA transmission in the rostral ventromedial medulla: Disinhibition of off-cells as a central mechanism in nociceptive modulation
    • Heinricher MM, Tortorici V, (1994). Interference with GABA transmission in the rostral ventromedial medulla: disinhibition of off-cells as a central mechanism in nociceptive modulation. Neuroscience 63: 533-546.
    • (1994) Neuroscience , vol.63 , pp. 533-546
    • Heinricher, M.M.1    Tortorici, V.2
  • 30
    • 0024405321 scopus 로고
    • Putative nociceptive modulating neurons in the rostral ventromedial medulla of the rat: Firing of on and off cells is related to nociceptive responsiveness
    • Heinricher MM, Barbaro NM, Fields HL, (1989). Putative nociceptive modulating neurons in the rostral ventromedial medulla of the rat: firing of ON and OFF cells is related to nociceptive responsiveness. Somatosens Mot Res 6: 427-439.
    • (1989) Somatosens Mot Res , vol.6 , pp. 427-439
    • Heinricher, M.M.1    Barbaro, N.M.2    Fields, H.L.3
  • 31
    • 63449092750 scopus 로고    scopus 로고
    • Descending control of nociception: Specificity, recruitment and plasticity
    • Heinricher MM, Tavares I, Leith JL, Lumb BM, (2009). Descending control of nociception: specificity, recruitment and plasticity. Brain Res Rev 60: 214-225.
    • (2009) Brain Res Rev , vol.60 , pp. 214-225
    • Heinricher, M.M.1    Tavares, I.2    Leith, J.L.3    Lumb, B.M.4
  • 32
    • 74949135431 scopus 로고    scopus 로고
    • Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors
    • Hoffman AF, Laaris N, Kawamura M, Masino SA, Lupica CR, (2010). Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors. J Neurosci 30: 545-555.
    • (2010) J Neurosci , vol.30 , pp. 545-555
    • Hoffman, A.F.1    Laaris, N.2    Kawamura, M.3    Masino, S.A.4    Lupica, C.R.5
  • 33
    • 53049098141 scopus 로고    scopus 로고
    • GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT 1A receptor activation-induced antinociception in the rat
    • Huo FQ, Qu CL, Li YQ, Tang JS, Jia H, (2008). GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT 1A receptor activation-induced antinociception in the rat. Pain 139: 398-405.
    • (2008) Pain , vol.139 , pp. 398-405
    • Huo, F.Q.1    Qu, C.L.2    Li, Y.Q.3    Tang, J.S.4    Jia, H.5
  • 35
    • 2142817905 scopus 로고    scopus 로고
    • Isoflurane differentially modulates medullary on and off neurons while suppressing hind-limb motor withdrawals
    • Jinks SL, Carstens E, Antognini JF, (2004). Isoflurane differentially modulates medullary on and off neurons while suppressing hind-limb motor withdrawals. Anesthesiology 100: 1224-1234.
    • (2004) Anesthesiology , vol.100 , pp. 1224-1234
    • Jinks, S.L.1    Carstens, E.2    Antognini, J.F.3
  • 37
    • 65549086503 scopus 로고    scopus 로고
    • Cannabinoids against pain. Efficacy and strategies to reduce psychoactivity: A clinical perspective
    • Karst M, Wippermann S, (2009). Cannabinoids against pain. Efficacy and strategies to reduce psychoactivity: a clinical perspective. Expert Opin Investig Drugs 18: 125-133.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 125-133
    • Karst, M.1    Wippermann, S.2
  • 39
    • 33644803655 scopus 로고    scopus 로고
    • Role for medullary pain facilitating neurons in secondary thermal hyperalgesia
    • Kincaid W, Neubert MJ, Xu M, Kim CJ, Heinricher MM, (2006). Role for medullary pain facilitating neurons in secondary thermal hyperalgesia. J Neurophysiol 95: 33-41.
    • (2006) J Neurophysiol , vol.95 , pp. 33-41
    • Kincaid, W.1    Neubert, M.J.2    Xu, M.3    Kim, C.J.4    Heinricher, M.M.5
  • 40
    • 0034816216 scopus 로고    scopus 로고
    • Synergistic mu-opioid and 5-HT1A presynaptic inhibition of GABA release in rat periaqueductal gray neurons
    • Kishimoto K, Koyama S, Akaike N, (2001). Synergistic mu-opioid and 5-HT1A presynaptic inhibition of GABA release in rat periaqueductal gray neurons. Neuropharmacology 41: 529-538.
    • (2001) Neuropharmacology , vol.41 , pp. 529-538
    • Kishimoto, K.1    Koyama, S.2    Akaike, N.3
  • 42
    • 58149269741 scopus 로고    scopus 로고
    • Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor
    • Liou GI, Auchampach JA, Hillard CJ, Zhu G, Yousufzai B, Mian S, et al. (2008). Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor. Invest Ophthalmol Vis Sci 49: 5526-5531.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 5526-5531
    • Liou, G.I.1    Auchampach, J.A.2    Hillard, C.J.3    Zhu, G.4    Yousufzai, B.5    Mian, S.6
  • 43
    • 68049129534 scopus 로고    scopus 로고
    • Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation
    • Magen I, Avraham Y, Ackerman Z, Vorobiev L, Mechoulam R, Berry EM, (2009). Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. J Hepatol 51: 528-534.
    • (2009) J Hepatol , vol.51 , pp. 528-534
    • Magen, I.1    Avraham, Y.2    Ackerman, Z.3    Vorobiev, L.4    Mechoulam, R.5    Berry, E.M.6
  • 44
    • 77249134168 scopus 로고    scopus 로고
    • Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
    • Magen I, Avraham Y, Ackerman Z, Vorobiev L, Mechoulam R, Berry EM, (2010). Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation. Br J Pharmacol 159: 950-957.
    • (2010) Br J Pharmacol , vol.159 , pp. 950-957
    • Magen, I.1    Avraham, Y.2    Ackerman, Z.3    Vorobiev, L.4    Mechoulam, R.5    Berry, E.M.6
  • 45
    • 33644766044 scopus 로고    scopus 로고
    • Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors
    • Maione S, Bisogno T, de Novellis V, Palazzo E, Cristino L, Valenti M, et al. (2006). Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. J Pharmacol Exp Ther 316: 969-982.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 969-982
    • Maione, S.1    Bisogno, T.2    De Novellis, V.3    Palazzo, E.4    Cristino, L.5    Valenti, M.6
  • 46
    • 34548514615 scopus 로고    scopus 로고
    • The antinociceptive effect of 2-chloro-2′-C-methyl-N6- cyclopentyladenosine (2′-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat
    • Maione S, de Novellis V, Cappellacci L, Palazzo E, Vita D, Luongo L, et al. (2007). The antinociceptive effect of 2-chloro-2′-C-methyl-N6- cyclopentyladenosine (2′-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat. Pain 131: 281-292.
    • (2007) Pain , vol.131 , pp. 281-292
    • Maione, S.1    De Novellis, V.2    Cappellacci, L.3    Palazzo, E.4    Vita, D.5    Luongo, L.6
  • 47
    • 54949140705 scopus 로고    scopus 로고
    • Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: Cannabinoid and non-cannabinoid receptor-mediated mechanisms
    • Maione S, Morera E, Marabese I, Ligresti A, Luongo L, Ortar G, et al. (2008). Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. Br J Pharmacol 155: 775-782.
    • (2008) Br J Pharmacol , vol.155 , pp. 775-782
    • Maione, S.1    Morera, E.2    Marabese, I.3    Ligresti, A.4    Luongo, L.5    Ortar, G.6
  • 48
    • 65649106202 scopus 로고    scopus 로고
    • Functional interaction between TRPV1 and micro-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia
    • Maione S, Starowicz K, Cristino L, Guida F, Palazzo E, Luongo L, et al. (2009). Functional interaction between TRPV1 and micro-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia. J Neurophysiol 101: 2411-2422.
    • (2009) J Neurophysiol , vol.101 , pp. 2411-2422
    • Maione, S.1    Starowicz, K.2    Cristino, L.3    Guida, F.4    Palazzo, E.5    Luongo, L.6
  • 49
    • 0036682222 scopus 로고    scopus 로고
    • The endogenous cannabinoid system controls extinction of aversive memories
    • Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, et al. (2002). The endogenous cannabinoid system controls extinction of aversive memories. Nature 418: 530-534.
    • (2002) Nature , vol.418 , pp. 530-534
    • Marsicano, G.1    Wotjak, C.T.2    Azad, S.C.3    Bisogno, T.4    Rammes, G.5    Cascio, M.G.6
  • 51
  • 52
    • 0023091057 scopus 로고
    • Activation of periaqueductal grey pools of β-endorphin by analgetic electrical stimulation in freely moving rats
    • DOI 10.1016/0006-8993(87)91239-X
    • Millan MJ, Członkowski A, Millan MH, Herz A, (1987). Activation of periaqueductal grey pools of beta-endorphin by analgetic electrical stimulation in freely moving rats. Brain Res 407: 199-203. (Pubitemid 17049849)
    • (1987) Brain Research , vol.407 , Issue.1 , pp. 199-203
    • Millan, M.J.1    Czlonkowski, A.2    Millan, M.H.3    Herz, A.4
  • 53
    • 0023035577 scopus 로고
    • Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission
    • Moreau JL, Fields HL, (1986). Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission. Brain Res 397: 37-46.
    • (1986) Brain Res , vol.397 , pp. 37-46
    • Moreau, J.L.1    Fields, H.L.2
  • 54
    • 3242680716 scopus 로고    scopus 로고
    • Nociceptive facilitating neurons in the rostral ventromedial medulla
    • Neubert MJ, Kincaid W, Heinricher MM, (2004). Nociceptive facilitating neurons in the rostral ventromedial medulla. Pain 110: 158-165.
    • (2004) Pain , vol.110 , pp. 158-165
    • Neubert, M.J.1    Kincaid, W.2    Heinricher, M.M.3
  • 55
    • 21744455551 scopus 로고    scopus 로고
    • Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat
    • de Novellis V, Mariani L, Palazzo E, Vita D, Marabese I, Scafuro M, et al. (2005). Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat. Neuroscience 134: 269-281.
    • (2005) Neuroscience , vol.134 , pp. 269-281
    • De Novellis, V.1    Mariani, L.2    Palazzo, E.3    Vita, D.4    Marabese, I.5    Scafuro, M.6
  • 56
    • 54049133600 scopus 로고    scopus 로고
    • The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats
    • de Novellis V, Palazzo E, Rossi F, De Petrocellis L, Petrosino S, Guida F, et al. (2008). The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. Neuropharmacology 55: 1105-1113.
    • (2008) Neuropharmacology , vol.55 , pp. 1105-1113
    • De Novellis, V.1    Palazzo, E.2    Rossi, F.3    De Petrocellis, L.4    Petrosino, S.5    Guida, F.6
  • 57
    • 0037542450 scopus 로고    scopus 로고
    • Novel selective and metabolically stable inhibitors of anandamide cellular uptake
    • Ortar G, Ligresti A, De Petrocellis L, Morera E, Di Marzo V, (2003). Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem Pharmacol 65: 1473-1481.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1473-1481
    • Ortar, G.1    Ligresti, A.2    De Petrocellis, L.3    Morera, E.4    Di Marzo, V.5
  • 58
    • 0037192598 scopus 로고    scopus 로고
    • Interaction between vanilloid and glutamate receptors in the central modulation of nociception
    • Palazzo E, de Novellis V, Marabese I, Cuomo D, Rossi F, Berrino L, et al. (2002). Interaction between vanilloid and glutamate receptors in the central modulation of nociception. Eur J Pharmacol 439: 69-75.
    • (2002) Eur J Pharmacol , vol.439 , pp. 69-75
    • Palazzo, E.1    De Novellis, V.2    Marabese, I.3    Cuomo, D.4    Rossi, F.5    Berrino, L.6
  • 60
    • 74549185125 scopus 로고    scopus 로고
    • FAAH and MAGL inhibitors: Therapeutic opportunities from regulating endocannabinoid levels
    • Petrosino S, Di Marzo V, (2010). FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels. Curr Opin Investig Drugs 11: 51-62.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 51-62
    • Petrosino, S.1    Di Marzo, V.2
  • 61
    • 70349333074 scopus 로고    scopus 로고
    • Cannabinoids as pharmacotherapies for neuropathic pain: From the bench to the bedside
    • Rahn EJ, Hohmann AG, (2009). Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside. Neurotherapeutics 6: 713-737.
    • (2009) Neurotherapeutics , vol.6 , pp. 713-737
    • Rahn, E.J.1    Hohmann, A.G.2
  • 62
    • 35648993556 scopus 로고    scopus 로고
    • Supraspinal modulation of pain by cannabinoids: The role of GABA and glutamate
    • Rea K, Roche M, Finn DP, (2007). Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate. Br J Pharmacol 152: 633-648.
    • (2007) Br J Pharmacol , vol.152 , pp. 633-648
    • Rea, K.1    Roche, M.2    Finn, D.P.3
  • 63
    • 65549106424 scopus 로고    scopus 로고
    • 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats
    • Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, Guimarães FS, (2009). 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. Br J Pharmacol 156: 181-188.
    • (2009) Br J Pharmacol , vol.156 , pp. 181-188
    • Resstel, L.B.1    Tavares, R.F.2    Lisboa, S.F.3    Joca, S.R.4    Corrêa, F.M.5    Guimarães, F.S.6
  • 64
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1a receptors
    • Russo EB, Burnett A, Hall B, Parker KK, (2005). Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res 30: 1037-1043.
    • (2005) Neurochem Res , vol.30 , pp. 1037-1043
    • Russo, E.B.1    Burnett, A.2    Hall, B.3    Parker, K.K.4
  • 65
    • 64849093208 scopus 로고    scopus 로고
    • TRPA1-mediated responses in trigeminal sensory neurons: Interaction between TRPA1 and TRPV1
    • Salas MM, Hargreaves KM, Akopian AN, (2009). TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci 29: 1568-1578.
    • (2009) Eur J Neurosci , vol.29 , pp. 1568-1578
    • Salas, M.M.1    Hargreaves, K.M.2    Akopian, A.N.3
  • 66
    • 0021140631 scopus 로고
    • Relative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat
    • Sandkühler J, Gebhart GF, (1984). Relative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat. Brain Res 305: 77-87.
    • (1984) Brain Res , vol.305 , pp. 77-87
    • Sandkühler, J.1    Gebhart, G.F.2
  • 67
    • 37249040918 scopus 로고    scopus 로고
    • Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways
    • Starowicz K, Maione S, Cristino L, Palazzo E, Marabese I, Rossi F, et al. (2007). Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways. J Neurosci 27: 13739-13749.
    • (2007) J Neurosci , vol.27 , pp. 13739-13749
    • Starowicz, K.1    Maione, S.2    Cristino, L.3    Palazzo, E.4    Marabese, I.5    Rossi, F.6
  • 68
    • 67749120393 scopus 로고    scopus 로고
    • Transient receptor potential A1 increase glutamate release on brain stem neurons
    • Sun B, Bang SI, Jin YH, (2009). Transient receptor potential A1 increase glutamate release on brain stem neurons. Neuroreport 20: 1002-1006.
    • (2009) Neuroreport , vol.20 , pp. 1002-1006
    • Sun, B.1    Bang, S.I.2    Jin, Y.H.3
  • 69
    • 33748746852 scopus 로고    scopus 로고
    • Adenosine sensory transduction pathways contribute to activation of the sensory irritation response to inspired irritant vapors
    • Vaughan RP, Szewczyk MT Jr, Lanosa MJ, Desesa CR, Gianutsos G, Morris JB, (2006). Adenosine sensory transduction pathways contribute to activation of the sensory irritation response to inspired irritant vapors. Toxicol Sci 93: 411-421.
    • (2006) Toxicol Sci , vol.93 , pp. 411-421
    • Vaughan, R.P.1    Szewczyk Jr., M.T.2    Lanosa, M.J.3    Desesa, C.R.4    Gianutsos, G.5    Morris, J.B.6
  • 70
    • 0029745360 scopus 로고    scopus 로고
    • Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids
    • Watanabe K, Kayano Y, Matsunaga T, Yamamoto I, Yoshimura H, (1996). Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids. Biol Pharm Bull 19: 1109-1111.
    • (1996) Biol Pharm Bull , vol.19 , pp. 1109-1111
    • Watanabe, K.1    Kayano, Y.2    Matsunaga, T.3    Yamamoto, I.4    Yoshimura, H.5
  • 71
    • 0031049046 scopus 로고    scopus 로고
    • Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias
    • Wiertelak EP, Roemer B, Maier SF, Watkins LR, (1997). Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias. Brain Res 748: 143-150.
    • (1997) Brain Res , vol.748 , pp. 143-150
    • Wiertelak, E.P.1    Roemer, B.2    Maier, S.F.3    Watkins, L.R.4
  • 72
    • 33846069212 scopus 로고    scopus 로고
    • NMDA receptor-mediated activation of medullary pro-nociceptive neurons is required for secondary thermal hyperalgesia
    • Xu M, Kim CJ, Neubert MJ, Heinricher MM, (2007). NMDA receptor-mediated activation of medullary pro-nociceptive neurons is required for secondary thermal hyperalgesia. Pain 127: 253-262.
    • (2007) Pain , vol.127 , pp. 253-262
    • Xu, M.1    Kim, C.J.2    Neubert, M.J.3    Heinricher, M.M.4
  • 73
    • 74549165354 scopus 로고    scopus 로고
    • Antidepressant-like effects of cannabidiol in mice: Possible involvement of 5-HT1A receptors
    • Zanelati TV, Biojone C, Moreira FA, Guimarães FS, Joca SR, (2010). Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol 159: 122-128.
    • (2010) Br J Pharmacol , vol.159 , pp. 122-128
    • Zanelati, T.V.1    Biojone, C.2    Moreira, F.A.3    Guimarães, F.S.4    Joca, S.R.5


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