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Volumn 11, Issue 24, 2012, Pages 4530-4535

The "Sharp" blade against HIF-mediated metastasis

Author keywords

Angiogenesis; Breast cancer; Cancer metabolism; HIF; Hypoxia; Metastasis; p63; Sharp1; VHL

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROGESTERONE RECEPTOR; PROTEIN; SHARP 1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84871496171     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.22820     Document Type: Review
Times cited : (14)

References (141)
  • 1
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • PMID:19308069
    • Klein CA. Parallel progression of primary tumours and metastases. Nat Rev Cancer 2009; 9:302-12; PMID:19308069; http://dx.doi.org/10.1038/nrc2627.
    • (2009) Nat Rev Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 2
    • 41849150003 scopus 로고    scopus 로고
    • Metastasis: A therapeutic target for cancer
    • PMID:18253104
    • Steeg PS, Theodorescu D. Metastasis: a therapeutic target for cancer. Nat Clin Pract Oncol 2008; 5:206-19; PMID:18253104; http://dx.doi.org/10.1038/ ncponc1066.
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 206-219
    • Steeg, P.S.1    Theodorescu, D.2
  • 3
    • 80051724097 scopus 로고    scopus 로고
    • Epithelial cell polarity: A major gatekeeper against cancer?
    • PMID:21617693
    • Royer C, Lu X. Epithelial cell polarity: a major gatekeeper against cancer? Cell Death Differ 2011; 18:1470-7; PMID:21617693; http://dx.doi.org/10. 1038/cdd.2011.60.
    • (2011) Cell Death Differ , vol.18 , pp. 1470-1477
    • Royer, C.1    Lu, X.2
  • 4
    • 84862833208 scopus 로고    scopus 로고
    • Targeting invadopodia to block breast cancer metastasis
    • PMID:21725138
    • Eckert MA, Yang J. Targeting invadopodia to block breast cancer metastasis. Oncotarget 2011; 2:562-8; PMID:21725138.
    • (2011) Oncotarget , vol.2 , pp. 562-568
    • Eckert, M.A.1    Yang, J.2
  • 5
    • 79951675007 scopus 로고    scopus 로고
    • Therapeutic targets in cancer cell metabolism and death
    • PMID:21212794
    • Iaccarino I, Martins LM. Therapeutic targets in cancer cell metabolism and death. Cell Death Differ 2011; 18:565-70; PMID:21212794; http://dx.doi.org/10.1038/cdd.2010.174.
    • (2011) Cell Death Differ , vol.18 , pp. 565-570
    • Iaccarino, I.1    Martins, L.M.2
  • 6
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • PMID:9697772
    • Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394:485-90; PMID:9697772; http://dx.doi.org/ 10.1038/28867.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3    Fukumura, D.4    Brusselmans, K.5    Dewerchin, M.6
  • 7
    • 60549092506 scopus 로고    scopus 로고
    • Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    • PMID:19168635
    • Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci USA 2009; 106:2353-8; PMID:19168635; http://dx.doi.org/10.1073/pnas.0812801106.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2353-2358
    • Lee, K.1    Qian, D.Z.2    Rey, S.3    Wei, H.4    Liu, J.O.5    Semenza, G.L.6
  • 8
    • 70449580319 scopus 로고    scopus 로고
    • Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
    • PMID:19805192
    • Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci USA 2009; 106:17910-5; PMID:19805192; http://dx.doi.org/10.1073/pnas.0909353106.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 17910-17915
    • Lee, K.1    Zhang, H.2    Qian, D.Z.3    Rey, S.4    Liu, J.O.5    Semenza, G.L.6
  • 9
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • PMID:19249681
    • Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009; 15:232-9; PMID:19249681; http://dx.doi.org/10.1016/j.ccr.2009.01.021.
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 10
    • 60649116477 scopus 로고    scopus 로고
    • Silencing or fueling metastasis with VEGF inhibitors: Antiangiogenesis revisited
    • PMID:19249675
    • Loges S, Mazzone M, Hohensinner P, Carmeliet P. Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited. Cancer Cell 2009; 15:167-70;PMID:19249675; http://dx.doi.org/10.1016/j.ccr.2009.02.007.
    • (2009) Cancer Cell , vol.15 , pp. 167-170
    • Loges, S.1    Mazzone, M.2    Hohensinner, P.3    Carmeliet, P.4
  • 11
    • 76749124316 scopus 로고    scopus 로고
    • VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2
    • PMID:19834490
    • Zhang Z, Neiva KG, Lingen MW, Ellis LM, Nör JE. VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2. Cell Death Differ 2010; 17:499-512; PMID:19834490; http://dx.doi.org/10.1038/ cdd.2009.152.
    • (2010) Cell Death Differ , vol.17 , pp. 499-512
    • Zhang, Z.1    Neiva, K.G.2    Lingen, M.W.3    Ellis, L.M.4    Nör, J.E.5
  • 12
    • 79955805684 scopus 로고    scopus 로고
    • Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells
    • PMID:21233846
    • Trisciuoglio D, Gabellini C, Desideri M, Ragazzoni Y, De Luca T, Ziparo E, et al. Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells. Cell Death Differ 2011; 18:1024-35; PMID:21233846; http://dx.doi.org/10.1038/cdd.2010.175.
    • (2011) Cell Death Differ , vol.18 , pp. 1024-1035
    • Trisciuoglio, D.1    Gabellini, C.2    Desideri, M.3    Ragazzoni, Y.4    De Luca, T.5    Ziparo, E.6
  • 13
    • 79959969644 scopus 로고    scopus 로고
    • Isthmin exerts pro-survival and deathpromoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state
    • PMID:21544092
    • Zhang Y, Chen M, Venugopal S, Zhou Y, Xiang W, Li YH, et al. Isthmin exerts pro-survival and deathpromoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state. Cell Death Dis 2011; 2:e153; PMID:21544092; http://dx.doi.org/10.1038/cddis.2011.37.
    • (2011) Cell Death Dis , vol.2
    • Zhang, Y.1    Chen, M.2    Venugopal, S.3    Zhou, Y.4    Xiang, W.5    Li, Y.H.6
  • 14
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    • PMID:17482131
    • Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007; 11:407-20; PMID:17482131; http://dx.doi.org/10.1016/j.ccr.2007.04.001.
    • (2007) Cancer Cell , vol.11 , pp. 407-420
    • Zhang, H.1    Gao, P.2    Fukuda, R.3    Kumar, G.4    Krishnamachary, B.5    Zeller, K.I.6
  • 15
    • 34548257176 scopus 로고    scopus 로고
    • HIF-dependent antitumorigenic effect of antioxidants in vivo
    • PMID:17785204
    • Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, et al. HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell 2007; 12:230-8; PMID:17785204; http://dx.doi.org/10.1016/j.ccr.2007.08.004.
    • (2007) Cancer Cell , vol.12 , pp. 230-238
    • Gao, P.1    Zhang, H.2    Dinavahi, R.3    Li, F.4    Xiang, Y.5    Raman, V.6
  • 16
    • 79957567239 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    • PMID:21620138
    • Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011; 145:732-44; PMID:21620138; http://dx.doi.org/10.1016/j.cell.2011.03.054.
    • (2011) Cell , vol.145 , pp. 732-744
    • Luo, W.1    Hu, H.2    Chang, R.3    Zhong, J.4    Knabel, M.5    O'Meally, R.6
  • 17
    • 77955284188 scopus 로고    scopus 로고
    • The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
    • PMID:20399150
    • Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, et al. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab 2010; 11:364-78; PMID:20399150; http://dx.doi.org/10. 1016/j.cmet.2010.03.001.
    • (2010) Cell Metab , vol.11 , pp. 364-378
    • Zhang, N.1    Fu, Z.2    Linke, S.3    Chicher, J.4    Gorman, J.J.5    Visk, D.6
  • 18
    • 79951678403 scopus 로고    scopus 로고
    • miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity
    • PMID:20885442
    • Puisségur MP, Mazure NM, Bertero T, Pradelli L, Grosso S, Robbe-Sermesant K, et al. miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ 2011; 18:465-78; PMID:20885442; http://dx.doi.org/ 10.1038/cdd.2010.119.
    • (2011) Cell Death Differ , vol.18 , pp. 465-478
    • Puisségur, M.P.1    Mazure, N.M.2    Bertero, T.3    Pradelli, L.4    Grosso, S.5    Robbe-Sermesant, K.6
  • 19
    • 80052711240 scopus 로고    scopus 로고
    • Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress
    • PMID:21372848
    • Liu X, Hajnóczky G. Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress. Cell Death Differ 2011; 18:1561-72; PMID:21372848; http://dx.doi.org/10.1038/cdd. 2011.13.
    • (2011) Cell Death Differ , vol.18 , pp. 1561-1572
    • Liu, X.1    Hajnóczky, G.2
  • 20
    • 79958757918 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion
    • PMID:21364657
    • Ben Mosbah I, Alfany-Fernández I, Martel C, Zaouali MA, Bintanel-Morcillo M, Rimola A, et al. Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. Cell Death Dis 2010; 1:e52; PMID:21364657; http://dx.doi.org/10.1038/cddis.2010.29.
    • (2010) Cell Death Dis , vol.1
    • Ben Mosbah, I.1    Alfany-Fernández, I.2    Martel, C.3    Zaouali, M.A.4    Bintanel-Morcillo, M.5    Rimola, A.6
  • 21
    • 0037096732 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
    • PMID:12067980
    • Comerford KM, Wallace TJ, Karhausen J, Louis NA, Montalto MC, Colgan SP. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 2002; 62:3387-94; PMID:12067980.
    • (2002) Cancer Res , vol.62 , pp. 3387-3394
    • Comerford, K.M.1    Wallace, T.J.2    Karhausen, J.3    Louis, N.A.4    Montalto, M.C.5    Colgan, S.P.6
  • 22
    • 12144287046 scopus 로고    scopus 로고
    • Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
    • PMID:15024076
    • Erler JT, Cawthorne CJ, Williams KJ, Koritzinsky M, Wouters BG, Wilson C, et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol 2004; 24:2875-89; PMID:15024076; http: //dx.doi .org/10.1128/MCB.24.7.2875-2889.2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 2875-2889
    • Erler, J.T.1    Cawthorne, C.J.2    Williams, K.J.3    Koritzinsky, M.4    Wouters, B.G.5    Wilson, C.6
  • 23
    • 76749170208 scopus 로고    scopus 로고
    • Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation
    • PMID:19798106
    • Verbrugge I, Maas C, Heijkoop M, Verheij M, Borst J. Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation. Cell Death Differ 2010; 17:551-61; PMID:19798106; http://dx.doi.org/10.1038/cdd.2009.141.
    • (2010) Cell Death Differ , vol.17 , pp. 551-561
    • Verbrugge, I.1    Maas, C.2    Heijkoop, M.3    Verheij, M.4    Borst, J.5
  • 24
    • 79952630372 scopus 로고    scopus 로고
    • Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level
    • PMID:21072058
    • Morizot A, Mérino D, Lalaoui N, Jacquemin G, Granci V, Iessi E, et al. Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level. Cell Death Differ 2011; 18:700-11; PMID:21072058; http://dx.doi.org/10. 1038/cdd.2010.144.
    • (2011) Cell Death Differ , vol.18 , pp. 700-711
    • Morizot, A.1    Mérino, D.2    Lalaoui, N.3    Jacquemin, G.4    Granci, V.5    Iessi, E.6
  • 25
    • 33645748171 scopus 로고    scopus 로고
    • Regulation of E-cadherin expression by VHL and hypoxia-inducible factor
    • PMID:16585181
    • Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, Chandra A, et al. Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res 2006; 66:3567-75; PMID:16585181; http://dx.doi.org/10.1158/0008-5472.CAN- 05-2670.
    • (2006) Cancer Res , vol.66 , pp. 3567-3575
    • Esteban, M.A.1    Tran, M.G.2    Harten, S.K.3    Hill, P.4    Castellanos, M.C.5    Chandra, A.6
  • 26
    • 77950476293 scopus 로고    scopus 로고
    • ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: Implications for Gleason grading
    • PMID:20385358
    • Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti CA, et al. ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell 2010; 17:319-32; PMID:20385358; http://dx.doi.org/10.1016/j.ccr. 2010.02.030.
    • (2010) Cancer Cell , vol.17 , pp. 319-332
    • Mak, P.1    Leav, I.2    Pursell, B.3    Bae, D.4    Yang, X.5    Taglienti, C.A.6
  • 27
    • 80052221592 scopus 로고    scopus 로고
    • Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition
    • PMID:21884981
    • Wu MZ, Tsai YP, Yang MH, Huang CH, Chang SY, Chang CC, et al. Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition. Mol Cell 2011; 43:811-22; PMID:21884981; http://dx.doi.org/10.1016/ j.molcel.2011.07.012.
    • (2011) Mol Cell , vol.43 , pp. 811-822
    • Wu, M.Z.1    Tsai, Y.P.2    Yang, M.H.3    Huang, C.H.4    Chang, S.Y.5    Chang, C.C.6
  • 28
    • 80051495448 scopus 로고    scopus 로고
    • Transcription factors that mediate epithelialmesenchymal transition lead to multidrug resistance by upregulating ABC transporters
    • PMID:21734725
    • Saxena M, Stephens MA, Pathak H, Rangarajan A. Transcription factors that mediate epithelialmesenchymal transition lead to multidrug resistance by upregulating ABC transporters. Cell Death Dis 2011; 2:e179; PMID:21734725; http://dx.doi.org/10.1038/cddis.2011.61.
    • (2011) Cell Death Dis , vol.2
    • Saxena, M.1    Stephens, M.A.2    Pathak, H.3    Rangarajan, A.4
  • 29
    • 79954534290 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and senescence: Two cancer-related processes are crossing paths
    • Albany NY PMID:20975209
    • Smit MA, Peeper DS. Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths. Aging (Albany NY) 2010; 2:735-41; PMID:20975209.
    • (2010) Aging , vol.2 , pp. 735-741
    • Smit, M.A.1    Peeper, D.S.2
  • 30
    • 33646365644 scopus 로고    scopus 로고
    • Lysyl oxidase is essential for hypoxia-induced metastasis
    • PMID:16642001
    • Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 2006; 440:1222-6; PMID:16642001; http://dx.doi.org/10.1038/nature04695.
    • (2006) Nature , vol.440 , pp. 1222-1226
    • Erler, J.T.1    Bennewith, K.L.2    Nicolau, M.3    Dornhöfer, N.4    Kong, C.5    Le, Q.T.6
  • 31
    • 80053645045 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
    • PMID:21911388
    • Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci USA 2011; 108:16369-74; PMID:21911388; http://dx.doi.org/10.1073/pnas.1113483108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16369-16374
    • Wong, C.C.1    Gilkes, D.M.2    Zhang, H.3    Chen, J.4    Wei, H.5    Chaturvedi, P.6
  • 32
    • 84860389759 scopus 로고    scopus 로고
    • HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
    • PMID:21860410
    • Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, et al. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 2012; 31:1757-70; PMID:21860410; http://dx.doi.org/10.1038/onc.2011.365.
    • (2012) Oncogene , vol.31 , pp. 1757-1770
    • Zhang, H.1    Wong, C.C.2    Wei, H.3    Gilkes, D.M.4    Korangath, P.5    Chaturvedi, P.6
  • 33
    • 78651338243 scopus 로고    scopus 로고
    • Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression
    • PMID:21220510
    • Carbonaro M, O'Brate A, Giannakakou P. Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression. J Cell Biol 2011; 192:83-99; PMID:21220510; http://dx.doi.org/10.1083/jcb.201004145.
    • (2011) J Cell Biol , vol.192 , pp. 83-99
    • Carbonaro, M.1    O'Brate, A.2    Giannakakou, P.3
  • 34
    • 84863982875 scopus 로고    scopus 로고
    • SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
    • PMID:22801492
    • Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, et al. SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature 2012; 487:380-4; PMID:22801492; http://dx.doi.org/10.1038/nature11207.
    • (2012) Nature , vol.487 , pp. 380-384
    • Montagner, M.1    Enzo, E.2    Forcato, M.3    Zanconato, F.4    Parenti, A.5    Rampazzo, E.6
  • 35
    • 84655161946 scopus 로고    scopus 로고
    • HIF1α and HIF2α: Sibling rivalry in hypoxic tumour growth and progression
    • PMID:22169972
    • Keith B, Johnson RS, Simon MC. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2012; 12:9-22; PMID:22169972.
    • (2012) Nat Rev Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 36
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • PMID:7539918
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92:5510-4; PMID:7539918; http://dx.doi.org/10.1073/pnas. 92.12.5510.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 37
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • PMID:9000051
    • Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997; 11:72-82; PMID:9000051; http://dx.doi.org/10.1101/gad.11.1.72.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 38
    • 0343683375 scopus 로고    scopus 로고
    • HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels
    • PMID:9178256
    • Flamme I, Fröhlich T, von Reutern M, Kappel A, Damert A, Risau W. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. Mech Dev 1997; 63:51-60; PMID:9178256; http://dx.doi.org/10.1016/S0925-4773(97)00674-6.
    • (1997) Mech Dev , vol.63 , pp. 51-60
    • Flamme, I.1    Fröhlich, T.2    Von Reutern, M.3    Kappel, A.4    Damert, A.5    Risau, W.6
  • 39
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • PMID:9113979
    • Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997; 94:4273-8; PMID:9113979; http://dx.doi.org/10.1073/pnas.94.9.4273.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 40
    • 0030887045 scopus 로고    scopus 로고
    • Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
    • PMID:9079689
    • Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, et al. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 1997; 272:8581-93; PMID:9079689; http://dx.doi.org/10.1074/jbc.272.13.8581.
    • (1997) J Biol Chem , vol.272 , pp. 8581-8593
    • Hogenesch, J.B.1    Chan, W.K.2    Jackiw, V.H.3    Brown, R.C.4    Gu, Y.Z.5    Pray-Grant, M.6
  • 41
    • 23644435597 scopus 로고    scopus 로고
    • Genetic evidence for a tumor suppressor role of HIF-2alpha
    • PMID:16098466
    • Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, et al. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell 2005; 8:131-41; PMID:16098466; http://dx.doi.org/10.1016/j.ccr.2005.07.003.
    • (2005) Cancer Cell , vol.8 , pp. 131-141
    • Acker, T.1    Diez-Juan, A.2    Aragones, J.3    Tjwa, M.4    Brusselmans, K.5    Moons, L.6
  • 42
    • 77956867103 scopus 로고    scopus 로고
    • Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease
    • PMID:20676049
    • Ousset M, Bouquet F, Fallone F, Biard D, Dray C, Valet P, et al. Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease. Cell Cycle 2010; 9:2814-22; PMID:20676049; http://dx.doi.org/10.4161/cc.9.14.12253.
    • (2010) Cell Cycle , vol.9 , pp. 2814-2822
    • Ousset, M.1    Bouquet, F.2    Fallone, F.3    Biard, D.4    Dray, C.5    Valet, P.6
  • 43
    • 77953490088 scopus 로고    scopus 로고
    • HIF-2alpha: Many cancers, one engine?
    • PMID:20348840
    • Franovic A, Lee S. HIF-2alpha: many cancers, one engine? Cell Cycle 2010; 9:859-60; PMID:20348840; http://dx.doi.org/10.4161/cc.9.5.11183.
    • (2010) Cell Cycle , vol.9 , pp. 859-860
    • Franovic, A.1    Lee, S.2
  • 44
    • 80051647245 scopus 로고    scopus 로고
    • Regulation of life span by mitochondrial respiration: The HIF-1 and ROS connection
    • Albany NY PMID:21389351
    • Hwang AB, Lee SJ. Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection. Aging (Albany NY) 2011; 3:304-10; PMID:21389351.
    • (2011) Aging , vol.3 , pp. 304-310
    • Hwang, A.B.1    Lee, S.J.2
  • 45
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • PMID:18498744
    • Kaelin WG Jr., Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008; 30:393-402; PMID:18498744; http://dx.doi.org/10.1016/j.molcel.2008.04.009.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 46
    • 33749006252 scopus 로고    scopus 로고
    • Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha
    • PMID:16951198
    • Qian DZ, Kachhap SK, Collis SJ, Verheul HM, Carducci MA, Atadja P, et al. Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. Cancer Res 2006; 66:8814-21; PMID:16951198; http://dx.doi.org/10.1158/0008-5472.CAN-05-4598.
    • (2006) Cancer Res , vol.66 , pp. 8814-8821
    • Qian, D.Z.1    Kachhap, S.K.2    Collis, S.J.3    Verheul, H.M.4    Carducci, M.A.5    Atadja, P.6
  • 47
    • 54549113030 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    • PMID:18923434
    • Kaelin WG Jr. The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer 2008; 8:865-73; PMID:18923434; http://dx.doi.org/10. 1038/nrc2502.
    • (2008) Nat Rev Cancer , vol.8 , pp. 865-873
    • Kaelin Jr., W.G.1
  • 48
    • 0036527785 scopus 로고    scopus 로고
    • The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
    • PMID:12086861
    • Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 2002; 1:247-55; PMID:12086861; http://dx.doi.org/10.1016/S1535-6108(02)00044-2.
    • (2002) Cancer Cell , vol.1 , pp. 247-255
    • Maranchie, J.K.1    Vasselli, J.R.2    Riss, J.3    Bonifacino, J.S.4    Linehan, W.M.5    Klausner, R.D.6
  • 49
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • PMID:12086860
    • Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002; 1:237-46; PMID:12086860; http://dx.doi.org/10.1016/S1535-6108(02) 00043-0.
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr., W.G.5
  • 50
    • 79959979647 scopus 로고    scopus 로고
    • Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
    • PMID:21525936
    • Badiola N, Penas C, Miñano-Molina A, Barneda-Zahonero B, Fadó R, Sánchez-Opazo G, et al. Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12. Cell Death Dis 2011; 2:e149; PMID:21525936; http://dx.doi.org/10.1038/cddis.2011.31.
    • (2011) Cell Death Dis , vol.2
    • Badiola, N.1    Penas, C.2    Miñano-Molina, A.3    Barneda-Zahonero, B.4    Fadó, R.5    Sánchez-Opazo, G.6
  • 51
    • 81855212680 scopus 로고    scopus 로고
    • Phosphorylation of von Hippel-Lindau protein by checkpoint kinase 2 regulates p53 transactivation
    • PMID:22071692
    • Roe JS, Kim HR, Hwang IY, Ha NC, Kim ST, Cho EJ, et al. Phosphorylation of von Hippel-Lindau protein by checkpoint kinase 2 regulates p53 transactivation. Cell Cycle 2011; 10:3920-8; PMID:22071692; http://dx.doi.org/ 10.4161/cc.10.22.18096.
    • (2011) Cell Cycle , vol.10 , pp. 3920-3928
    • Roe, J.S.1    Kim, H.R.2    Hwang, I.Y.3    Ha, N.C.4    Kim, S.T.5    Cho, E.J.6
  • 52
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxiainducible factors and the response to hypoxic stress
    • PMID:20965423
    • Majmundar AJ, Wong WJ, Simon MC. Hypoxiainducible factors and the response to hypoxic stress. Mol Cell 2010; 40:294-309; PMID:20965423; http://dx.doi.org/10.1016/j.molcel.2010.09.022.
    • (2010) Mol Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 53
    • 78650168971 scopus 로고    scopus 로고
    • Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression
    • PMID:20671746
    • Guitart AV, Debeissat C, Hermitte F, Villacreces A, Ivanovic Z, Boeuf H, et al. Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression. Cell Death Differ 2011; 18:174-82; PMID:20671746; http://dx.doi.org/10.1038/cdd.2010.85.
    • (2011) Cell Death Differ , vol.18 , pp. 174-182
    • Guitart, A.V.1    Debeissat, C.2    Hermitte, F.3    Villacreces, A.4    Ivanovic, Z.5    Boeuf, H.6
  • 54
    • 84856103312 scopus 로고    scopus 로고
    • Oxygen matters: Tissue culture oxygen levels affect mitochondrial function and structure as well as responses to HIV viroproteins
    • PMID:22190005
    • Tiede LM, Cook EA, Morsey B, Fox HS. Oxygen matters: tissue culture oxygen levels affect mitochondrial function and structure as well as responses to HIV viroproteins. Cell Death Dis 2011; 2:e246; PMID:22190005; http://dx.doi.org/10.1038/cddis.2011.128.
    • (2011) Cell Death Dis , vol.2
    • Tiede, L.M.1    Cook, E.A.2    Morsey, B.3    Fox, H.S.4
  • 55
    • 84863008531 scopus 로고    scopus 로고
    • Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation
    • PMID:22202117
    • Sheffer M, Simon AJ, Jacob-Hirsch J, Rechavi G, Domany E, Givol D, et al. Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation. Oncotarget 2011; 2:1191-202; PMID:22202117.
    • (2011) Oncotarget , vol.2 , pp. 1191-1202
    • Sheffer, M.1    Simon, A.J.2    Jacob-Hirsch, J.3    Rechavi, G.4    Domany, E.5    Givol, D.6
  • 56
    • 79958289721 scopus 로고    scopus 로고
    • HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
    • Albany NY PMID:21248371
    • Nardinocchi L, Puca R, D'Orazi G. HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation. Aging (Albany NY) 2011; 3:33-43; PMID:21248371.
    • (2011) Aging , vol.3 , pp. 33-43
    • Nardinocchi, L.1    Puca, R.2    D'Orazi, G.3
  • 57
    • 76749120374 scopus 로고    scopus 로고
    • Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2
    • PMID:19834492
    • Chen ZX, Pervaiz S. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. Cell Death Differ 2010; 17:408-20; PMID:19834492; http://dx.doi.org/10.1038/cdd.2009.132.
    • (2010) Cell Death Differ , vol.17 , pp. 408-420
    • Chen, Z.X.1    Pervaiz, S.2
  • 58
    • 79960029137 scopus 로고    scopus 로고
    • Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo
    • PMID:21490676
    • Russo R, Berliocchi L, Adornetto A, Varano GP, Cavaliere F, Nucci C, et al. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell Death Dis 2011; 2:e144; PMID:21490676; http://dx.doi.org/10.1038/cddis.2011.29.
    • (2011) Cell Death Dis , vol.2
    • Russo, R.1    Berliocchi, L.2    Adornetto, A.3    Varano, G.P.4    Cavaliere, F.5    Nucci, C.6
  • 59
    • 79952255381 scopus 로고    scopus 로고
    • STAT3, HIF-1, glucose addiction and Warburg effect
    • Albany NY PMID:21149895
    • Darnell JE Jr. STAT3, HIF-1, glucose addiction and Warburg effect. Aging (Albany NY) 2010; 2:890-1; PMID:21149895.
    • (2010) Aging , vol.2 , pp. 890-891
    • Darnell Jr., J.E.1
  • 60
    • 79952666779 scopus 로고    scopus 로고
    • A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
    • Albany NY PMID:21084727
    • Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, et al. A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging (Albany NY) 2010; 2:823-42; PMID:21084727.
    • (2010) Aging , vol.2 , pp. 823-842
    • Demaria, M.1    Giorgi, C.2    Lebiedzinska, M.3    Esposito, G.4    D'Angeli, L.5    Bartoli, A.6
  • 61
    • 77954155633 scopus 로고    scopus 로고
    • Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"
    • Albany NY PMID:20442453
    • Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, et al. Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling". Aging (Albany NY) 2010; 2:185-99; PMID:20442453.
    • (2010) Aging , vol.2 , pp. 185-199
    • Pavlides, S.1    Tsirigos, A.2    Vera, I.3    Flomenberg, N.4    Frank, P.G.5    Casimiro, M.C.6
  • 62
    • 78649231611 scopus 로고    scopus 로고
    • mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α
    • PMID:21095582
    • Cam H, Easton JB, High A, Houghton PJ. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol Cell 2010; 40:509-20; PMID:21095582; http://dx.doi.org/10.1016/j.molcel.2010.10. 030.
    • (2010) Mol Cell , vol.40 , pp. 509-520
    • Cam, H.1    Easton, J.B.2    High, A.3    Houghton, P.J.4
  • 63
    • 77956176703 scopus 로고    scopus 로고
    • IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter
    • PMID:21480565
    • Mitchell GC, Fillinger JL, Sittadjody S, Avila JL, Burd R, Limesand KH. IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter. Cell Death Dis 2010; 1:e50; PMID:21480565; http://dx.doi.org/10.1038/cddis.2010.28.
    • (2010) Cell Death Dis , vol.1
    • Mitchell, G.C.1    Fillinger, J.L.2    Sittadjody, S.3    Avila, J.L.4    Burd, R.5    Limesand, K.H.6
  • 64
    • 79959327789 scopus 로고    scopus 로고
    • VEGF-independent angiogenic pathways induced by PDGF-C
    • PMID:20871734
    • Li X, Kumar A, Zhang F, Lee C, Li Y, Tang Z, et al. VEGF-independent angiogenic pathways induced by PDGF-C. Oncotarget 2010; 1:309-14; PMID:20871734.
    • (2010) Oncotarget , vol.1 , pp. 309-314
    • Li, X.1    Kumar, A.2    Zhang, F.3    Lee, C.4    Li, Y.5    Tang, Z.6
  • 65
    • 79959908506 scopus 로고    scopus 로고
    • HIF induces human embryonic stem cell markers in cancer cells
    • PMID:21712410
    • Mathieu J, Zhang Z, Zhou W, Wang AJ, Heddleston JM, Pinna CM, et al. HIF induces human embryonic stem cell markers in cancer cells. Cancer Res 2011; 71:4640-52; PMID:21712410; http://dx.doi.org/10.1158/0008-5472.CAN-10-3320.
    • (2011) Cancer Res , vol.71 , pp. 4640-4652
    • Mathieu, J.1    Zhang, Z.2    Zhou, W.3    Wang, A.J.4    Heddleston, J.M.5    Pinna, C.M.6
  • 67
    • 80053992515 scopus 로고    scopus 로고
    • Integration of CNS survival and differentiation by HIF2β
    • PMID:21546908
    • Ko CY, Tsai MY, Tseng WF, Cheng CH, Huang CR, Wu JS, et al. Integration of CNS survival and differentiation by HIF2β. Cell Death Differ 2011; 18:1757-70; PMID:21546908; http://dx.doi.org/10.1038/cdd.2011.44.
    • (2011) Cell Death Differ , vol.18 , pp. 1757-1770
    • Ko, C.Y.1    Tsai, M.Y.2    Tseng, W.F.3    Cheng, C.H.4    Huang, C.R.5    Wu, J.S.6
  • 68
    • 80053958281 scopus 로고    scopus 로고
    • Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins
    • PMID:21546903
    • Torii S, Goto Y, Ishizawa T, Hoshi H, Goryo K, Yasumoto K, et al. Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death Differ 2011; 18:1711-25; PMID:21546903; http://dx.doi.org/10.1038/cdd. 2011.47.
    • (2011) Cell Death Differ , vol.18 , pp. 1711-1725
    • Torii, S.1    Goto, Y.2    Ishizawa, T.3    Hoshi, H.4    Goryo, K.5    Yasumoto, K.6
  • 69
    • 77952238024 scopus 로고    scopus 로고
    • Nitric oxide repression of Nanog promotes mouse embryonic stem cell differentiation
    • PMID:20075941
    • Mora-Castilla S, Tejedo JR, Hmadcha A, Cahuana GM, Martín F, Soria B, et al. Nitric oxide repression of Nanog promotes mouse embryonic stem cell differentiation. Cell Death Differ 2010; 17:1025-33; PMID:20075941; http://dx.doi.org/10.1038/cdd.2009.204.
    • (2010) Cell Death Differ , vol.17 , pp. 1025-1033
    • Mora-Castilla, S.1    Tejedo, J.R.2    Hmadcha, A.3    Cahuana, G.M.4    Martín, F.5    Soria, B.6
  • 70
    • 79955814688 scopus 로고    scopus 로고
    • Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation
    • PMID:21274009
    • Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, et al. Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation. Cell Death Differ 2011; 18:1016-23; PMID:21274009; http://dx.doi.org/10.1038/cdd.2010.171.
    • (2011) Cell Death Differ , vol.18 , pp. 1016-1023
    • Stacpoole, S.R.1    Bilican, B.2    Webber, D.J.3    Luzhynskaya, A.4    He, X.L.5    Compston, A.6
  • 71
    • 79951676433 scopus 로고    scopus 로고
    • Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP
    • PMID:20798687
    • Casati A, Frascoli M, Traggiai E, Proietti M, Schenk U, Grassi F. Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP. Cell Death Differ 2011; 18:396-404; PMID:20798687; http://dx.doi.org/10.1038/ cdd.2010.107.
    • (2011) Cell Death Differ , vol.18 , pp. 396-404
    • Casati, A.1    Frascoli, M.2    Traggiai, E.3    Proietti, M.4    Schenk, U.5    Grassi, F.6
  • 72
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • PMID:18829540
    • Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 2008; 68:7846-54; PMID:18829540; http://dx.doi.org/10.1158/0008-5472.CAN-08-1942.
    • (2008) Cancer Res , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6
  • 73
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop - A motor of cellular plasticity in development and cancer?
    • PMID:20706219
    • Brabletz S, Brabletz T. The ZEB/miR-200 feedback loop - a motor of cellular plasticity in development and cancer? EMBO Rep 2010; 11:670-7; PMID:20706219; http://dx.doi.org/10.1038/embor.2010.117.
    • (2010) EMBO Rep , vol.11 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 74
    • 77957008603 scopus 로고    scopus 로고
    • Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α
    • PMID:20890122
    • Manisterski M, Golan M, Amir S, Weisman Y, Mabjeesh NJ. Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α. Cell Cycle 2010; 9:3723-9; PMID:20890122; http://dx.doi.org/10.4161/cc.9.18.12931.
    • (2010) Cell Cycle , vol.9 , pp. 3723-3729
    • Manisterski, M.1    Golan, M.2    Amir, S.3    Weisman, Y.4    Mabjeesh, N.J.5
  • 75
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • PMID:18987634
    • Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 2008; 8:967-75; PMID:18987634; http://dx.doi.org/10.1038/ nrc2540.
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 76
    • 79958730602 scopus 로고    scopus 로고
    • Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia
    • PMID:21364661
    • Li Q, Li H, Roughton K, Wang X, Kroemer G, Blomgren K, et al. Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia. Cell Death Dis 2010; 1:e56; PMID:21364661; http://dx.doi.org/10.1038/cddis.2010.33.
    • (2010) Cell Death Dis , vol.1
    • Li, Q.1    Li, H.2    Roughton, K.3    Wang, X.4    Kroemer, G.5    Blomgren, K.6
  • 77
    • 78651282654 scopus 로고    scopus 로고
    • Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction
    • PMID:20706275
    • Lemarie A, Huc L, Pazarentzos E, Mahul-Mellier AL, Grimm S. Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction. Cell Death Differ 2011; 18:338-49; PMID:20706275; http://dx.doi.org/10.1038/cdd.2010.93.
    • (2011) Cell Death Differ , vol.18 , pp. 338-349
    • Lemarie, A.1    Huc, L.2    Pazarentzos, E.3    Mahul-Mellier, A.L.4    Grimm, S.5
  • 79
    • 79960456668 scopus 로고    scopus 로고
    • Surviving without oxygen: Hypoxia regulation of mammary morphogenesis and anoikis
    • PMID:21670595
    • Whelan KA, Reginato MJ. Surviving without oxygen: hypoxia regulation of mammary morphogenesis and anoikis. Cell Cycle 2011; 10:2287-94; PMID:21670595; http://dx.doi.org/10.4161/cc.10.14.16532.
    • (2011) Cell Cycle , vol.10 , pp. 2287-2294
    • Whelan, K.A.1    Reginato, M.J.2
  • 80
    • 11144222884 scopus 로고    scopus 로고
    • Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: Correlation with tumor angiogenesis and cyclooxygenase-2 expression
    • PMID:15623639
    • Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, et al. Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res 2004; 10:8554-60; PMID:15623639; http://dx.doi.org/10.1158/1078-0432.CCR-0946-03.
    • (2004) Clin Cancer Res , vol.10 , pp. 8554-8560
    • Yoshimura, H.1    Dhar, D.K.2    Kohno, H.3    Kubota, H.4    Fujii, T.5    Ueda, S.6
  • 81
    • 73149112785 scopus 로고    scopus 로고
    • HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: High HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization
    • PMID:19903792
    • Noguera R, Fredlund E, Piqueras M, Pietras A, Beckman S, Navarro S, et al. HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. Clin Cancer Res 2009; 15:7130-6; PMID:19903792; http: //dx.doi.org/10.1158/1078-0432.CCR-09-0223.
    • (2009) Clin Cancer Res , vol.15 , pp. 7130-7136
    • Noguera, R.1    Fredlund, E.2    Piqueras, M.3    Pietras, A.4    Beckman, S.5    Navarro, S.6
  • 82
    • 12944266844 scopus 로고    scopus 로고
    • The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma
    • PMID:15709180
    • Lidgren A, Hedberg Y, Grankvist K, Rasmuson T, Vasko J, Ljungberg B. The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma. Clin Cancer Res 2005; 11:1129-35; PMID:15709180.
    • (2005) Clin Cancer Res , vol.11 , pp. 1129-1135
    • Lidgren, A.1    Hedberg, Y.2    Grankvist, K.3    Rasmuson, T.4    Vasko, J.5    Ljungberg, B.6
  • 83
    • 37549043546 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma
    • PMID:18094421
    • Klatte T, Seligson DB, Riggs SB, Leppert JT, Berkman MK, Kleid MD, et al. Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. Clin Cancer Res 2007; 13:7388-93; PMID:18094421; http://dx.doi.org/10.1158/1078-0432. CCR-07-0411.
    • (2007) Clin Cancer Res , vol.13 , pp. 7388-7393
    • Klatte, T.1    Seligson, D.B.2    Riggs, S.B.3    Leppert, J.T.4    Berkman, M.K.5    Kleid, M.D.6
  • 84
    • 79955805703 scopus 로고    scopus 로고
    • miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells
    • PMID:21164520
    • Tomé M, López-Romero P, Albo C, Sepúlveda JC, Fernández-Gutiérrez B, Dopazo A, et al. miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells. Cell Death Differ 2011; 18:985-95; PMID:21164520; http://dx.doi.org/10.1038/cdd. 2010.167.
    • (2011) Cell Death Differ , vol.18 , pp. 985-995
    • Tomé, M.1    López-Romero, P.2    Albo, C.3    Sepúlveda, J.C.4    Fernández-Gutiérrez, B.5    Dopazo, A.6
  • 85
    • 84858964529 scopus 로고    scopus 로고
    • Novel insights into FH-associated disease are KEAPing the lid on oncogenic HIF signalling
    • PMID:22064867
    • Adam J, Ratcliffe PJ, Pollard PJ. Novel insights into FH-associated disease are KEAPing the lid on oncogenic HIF signalling. Oncotarget 2011; 2:820-1; PMID:22064867.
    • (2011) Oncotarget , vol.2 , pp. 820-821
    • Adam, J.1    Ratcliffe, P.J.2    Pollard, P.J.3
  • 86
    • 60549083336 scopus 로고    scopus 로고
    • Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-inducedstabilization of hypoxia-inducible factor-1alpha
    • PMID:19176399
    • Kim WY, Oh SH, Woo JK, Hong WK, Lee HY. Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation- inducedstabilization of hypoxia-inducible factor-1alpha. Cancer Res 2009; 69:1624-32; PMID:19176399; http://dx.doi.org/10.1158/0008-5472.CAN-08-0505.
    • (2009) Cancer Res , vol.69 , pp. 1624-1632
    • Kim, W.Y.1    Oh, S.H.2    Woo, J.K.3    Hong, W.K.4    Lee, H.Y.5
  • 87
    • 81155139688 scopus 로고    scopus 로고
    • Biological functions of p53 isoforms through evolution: Lessons from animal and cellular models
    • PMID:21941372
    • Marcel V, Dichtel-Danjoy ML, Sagne C, Hafsi H, Ma D, Ortiz-Cuaran S, et al. Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ 2011; 18:1815-24; PMID:21941372; http://dx.doi.org/10.1038/cdd.2011.120.
    • (2011) Cell Death Differ , vol.18 , pp. 1815-1824
    • Marcel, V.1    Dichtel-Danjoy, M.L.2    Sagne, C.3    Hafsi, H.4    Ma, D.5    Ortiz-Cuaran, S.6
  • 88
    • 77953619656 scopus 로고    scopus 로고
    • Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stemlike characteristics in a hypoxic environment
    • PMID:20139893
    • Takeuchi M, Kimura S, Kuroda J, Ashihara E, Kawatani M, Osada H, et al. Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stemlike characteristics in a hypoxic environment. Cell Death Differ 2010; 17:1211-20; PMID:20139893; http://dx.doi.org/10.1038/cdd.2010.6.
    • (2010) Cell Death Differ , vol.17 , pp. 1211-1220
    • Takeuchi, M.1    Kimura, S.2    Kuroda, J.3    Ashihara, E.4    Kawatani, M.5    Osada, H.6
  • 89
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • PMID:13130303
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3:721-32; PMID:13130303; http://dx.doi.org/10.1038/nrc1187.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 90
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in tumorigenesis
    • PMID:18259193
    • Rankin EB, Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 2008; 15:678-85; PMID:18259193; http://dx.doi.org/10.1038/cdd.2008.21.
    • (2008) Cell Death Differ , vol.15 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 92
    • 77956400210 scopus 로고    scopus 로고
    • Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment
    • PMID:20855962
    • Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle 2010; 9:3515-33; PMID:20855962; http://dx.doi.org/10.4161/cc.9.17.12928.
    • (2010) Cell Cycle , vol.9 , pp. 3515-3533
    • Martinez-Outschoorn, U.E.1    Trimmer, C.2    Lin, Z.3    Whitaker-Menezes, D.4    Chiavarina, B.5    Zhou, J.6
  • 94
    • 80053438087 scopus 로고    scopus 로고
    • The HIF-1α-c-Myc pathway and tumorigenesis: Evading the apoptotic gate-keeper
    • PMID:21971179
    • Fer N, Melillo G. The HIF-1α-c-Myc pathway and tumorigenesis: evading the apoptotic gate-keeper. Cell Cycle 2011; 10:3228; PMID:21971179; http://dx.doi.org/10.4161/cc.10.19.17049.
    • (2011) Cell Cycle , vol.10 , pp. 3228
    • Fer, N.1    Melillo, G.2
  • 95
    • 33846652552 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression
    • PMID:17234764
    • Liao D, Corle C, Seagroves TN, Johnson RS. Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 2007; 67:563-72; PMID:17234764; http://dx.doi.org/10.1158/0008-5472.CAN-06-2701.
    • (2007) Cancer Res , vol.67 , pp. 563-572
    • Liao, D.1    Corle, C.2    Seagroves, T.N.3    Johnson, R.S.4
  • 96
    • 77649177217 scopus 로고    scopus 로고
    • Differential activation and antagonistic function of HIF-alpha isoforms in macrophages are essential for NO homeostasis
    • PMID:20194441
    • Takeda N, O'Dea EL, Doedens A, Kim JW, Weidemann A, Stockmann C, et al. Differential activation and antagonistic function of HIF-alpha isoforms in macrophages are essential for NO homeostasis. Genes Dev 2010; 24:491-501; PMID:20194441; http://dx.doi.org/10.1101/gad.1881410.
    • (2010) Genes Dev , vol.24 , pp. 491-501
    • Takeda, N.1    O'Dea, E.L.2    Doedens, A.3    Kim, J.W.4    Weidemann, A.5    Stockmann, C.6
  • 97
    • 77954350645 scopus 로고    scopus 로고
    • Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina
    • PMID:20544853
    • Weidemann A, Krohne TU, Aguilar E, Kurihara T, Takeda N, Dorrell MI, et al. Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia 2010; 58:1177-85; PMID:20544853.
    • (2010) Glia , vol.58 , pp. 1177-1185
    • Weidemann, A.1    Krohne, T.U.2    Aguilar, E.3    Kurihara, T.4    Takeda, N.5    Dorrell, M.I.6
  • 98
    • 77749254869 scopus 로고    scopus 로고
    • Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis
    • PMID:20142499
    • Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemann A, Takeda N, Doedens A, et al. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci USA 2010; 107:4329-34; PMID:20142499; http://dx.doi.org/10.1073/pnas.0912766107.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4329-4334
    • Stockmann, C.1    Kerdiles, Y.2    Nomaksteinsky, M.3    Weidemann, A.4    Takeda, N.5    Doedens, A.6
  • 99
    • 80052700964 scopus 로고    scopus 로고
    • miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition
    • PMID:21527937
    • Magenta A, Cencioni C, Fasanaro P, Zaccagnini G, Greco S, Sarra-Ferraris G, et al. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition. Cell Death Differ 2011; 18:1628-39; PMID:21527937; http://dx.doi.org/10.1038/cdd.2011.42.
    • (2011) Cell Death Differ , vol.18 , pp. 1628-1639
    • Magenta, A.1    Cencioni, C.2    Fasanaro, P.3    Zaccagnini, G.4    Greco, S.5    Sarra-Ferraris, G.6
  • 100
    • 79956027131 scopus 로고    scopus 로고
    • The Siah2-HIF-FoxA2 axis in prostate cancer - New markers and therapeutic opportunities
    • PMID:21037926
    • Qi J, Pellecchia M, Ronai ZA. The Siah2-HIF-FoxA2 axis in prostate cancer - new markers and therapeutic opportunities. Oncotarget 2010; 1:379-85; PMID:21037926.
    • (2010) Oncotarget , vol.1 , pp. 379-385
    • Qi, J.1    Pellecchia, M.2    Ronai, Z.A.3
  • 101
    • 79954775922 scopus 로고    scopus 로고
    • Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
    • PMID:21152246
    • Kuo MT, Savaraj N, Feun LG. Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. Oncotarget 2010; 1:246-51; PMID:21152246.
    • (2010) Oncotarget , vol.1 , pp. 246-251
    • Kuo, M.T.1    Savaraj, N.2    Feun, L.G.3
  • 102
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • PMID:15542432
    • Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004; 6:485-95; PMID:15542432; http://dx.doi.org/10.1016/j.ccr.2004.09.026.
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.4    Huang, Y.5    Gerber, H.P.6
  • 103
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • PMID:16724055
    • Pouysségur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006; 441:437-43; PMID:16724055; http://dx.doi.org/10.1038/nature04871.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouysségur, J.1    Dayan, F.2    Mazure, N.M.3
  • 104
    • 68549133541 scopus 로고    scopus 로고
    • Medical oncology: Endocrine-therapyrelated symptoms and breast cancer. Nature reviews
    • Buzdar AU. Medical oncology: Endocrine-therapyrelated symptoms and breast cancer. Nature reviews. Clin Oncol 2009; 6:309-10.
    • (2009) Clin Oncol , vol.6 , pp. 309-310
    • Buzdar, A.U.1
  • 105
    • 77956699083 scopus 로고    scopus 로고
    • Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates
    • PMID:20379195
    • Yalcin-Ozuysal O, Fiche M, Guitierrez M, Wagner KU, Raffoul W, Brisken C. Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ 2010; 17:1600-12; PMID:20379195; http://dx.doi.org/10. 1038/cdd.2010.37.
    • (2010) Cell Death Differ , vol.17 , pp. 1600-1612
    • Yalcin-Ozuysal, O.1    Fiche, M.2    Guitierrez, M.3    Wagner, K.U.4    Raffoul, W.5    Brisken, C.6
  • 106
    • 74249123376 scopus 로고    scopus 로고
    • miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells
    • PMID:19730444
    • Spizzo R, Nicoloso MS, Lupini L, Lu Y, Fogarty J, Rossi S, et al. miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ 2010; 17:246-54; PMID:19730444; http://dx.doi.org/10.1038/cdd.2009.117.
    • (2010) Cell Death Differ , vol.17 , pp. 246-254
    • Spizzo, R.1    Nicoloso, M.S.2    Lupini, L.3    Lu, Y.4    Fogarty, J.5    Rossi, S.6
  • 107
    • 80053116010 scopus 로고    scopus 로고
    • Mutations in the BRCT binding site of BRCA1 result in hyperrecombination
    • Albany NY PMID:21666281
    • Dever SM, Golding SE, Rosenberg E, Adams BR, Idowu MO, Quillin JM, et al. Mutations in the BRCT binding site of BRCA1 result in hyperrecombination. Aging (Albany NY) 2011; 3:515-32; PMID:21666281.
    • (2011) Aging , vol.3 , pp. 515-532
    • Dever, S.M.1    Golding, S.E.2    Rosenberg, E.3    Adams, B.R.4    Idowu, M.O.5    Quillin, J.M.6
  • 108
    • 80053108088 scopus 로고    scopus 로고
    • BRCA1 A-complex fine tunes repair functions of BRCA1
    • Albany NY PMID:21805697
    • Harris JL, Khanna KK. BRCA1 A-complex fine tunes repair functions of BRCA1. Aging (Albany NY) 2011; 3:461-3; PMID:21805697.
    • (2011) Aging , vol.3 , pp. 461-463
    • Harris, J.L.1    Khanna, K.K.2
  • 109
    • 34748856245 scopus 로고    scopus 로고
    • Use of molecular biomarkers for predicting the response to radiotherapy with or without chemotherapy
    • PMID:17827456
    • Riesterer O, Milas L, Ang KK. Use of molecular biomarkers for predicting the response to radiotherapy with or without chemotherapy. J Clin Oncol 2007; 25:4075-83; PMID:17827456; http://dx.doi.org/10.1200/JCO.2007.11.8497.
    • (2007) J Clin Oncol , vol.25 , pp. 4075-4083
    • Riesterer, O.1    Milas, L.2    Ang, K.K.3
  • 110
    • 77956710766 scopus 로고    scopus 로고
    • Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates pacli-taxel- Induced apoptosis in breast cancer cells
    • PMID:20431602
    • Kutuk O, Letai A. Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates pacli-taxel- induced apoptosis in breast cancer cells. Cell Death Differ 2010; 17:1624-35; PMID:20431602; http://dx.doi.org/10. 1038/cdd.2010.41.
    • (2010) Cell Death Differ , vol.17 , pp. 1624-1635
    • Kutuk, O.1    Letai, A.2
  • 111
    • 78650179541 scopus 로고    scopus 로고
    • Involvement of NF-κB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells
    • PMID:20798686
    • Li QQ, Chen ZQ, Cao XX, Xu JD, Xu JW, Chen YY, et al. Involvement of NF-κB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells. Cell Death Differ 2011; 18:16-25; PMID:20798686; http://dx.doi.org/10.1038/cdd.2010.103.
    • (2011) Cell Death Differ , vol.18 , pp. 16-25
    • Li, Q.Q.1    Chen, Z.Q.2    Cao, X.X.3    Xu, J.D.4    Xu, J.W.5    Chen, Y.Y.6
  • 112
    • 80051483357 scopus 로고    scopus 로고
    • Celecoxib and acetylbritannilactone interact synergistically to suppress breast cancer cell growth via COX-2-dependent and -independent mechanisms
    • PMID:21796157
    • Liu B, Wen JK, Li BH, Fang XM, Wang JJ, Zhang YP, et al. Celecoxib and acetylbritannilactone interact synergistically to suppress breast cancer cell growth via COX-2-dependent and -independent mechanisms. Cell Death Dis 2011; 2:e185; PMID:21796157; http://dx.doi.org/10.1038/cddis.2011.64.
    • (2011) Cell Death Dis , vol.2
    • Liu, B.1    Wen, J.K.2    Li, B.H.3    Fang, X.M.4    Wang, J.J.5    Zhang, Y.P.6
  • 113
    • 50649102521 scopus 로고    scopus 로고
    • Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice
    • PMID:18648504
    • Rossner MJ, Oster H, Wichert SP, Reinecke L, Wehr MC, Reinecke J, et al. Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice. PLoS One 2008; 3:e2762; PMID:18648504; http://dx.doi.org/10.1371/journal. pone.0002762.
    • (2008) PLoS One , vol.3
    • Rossner, M.J.1    Oster, H.2    Wichert, S.P.3    Reinecke, L.4    Wehr, M.C.5    Reinecke, J.6
  • 114
    • 78951475020 scopus 로고    scopus 로고
    • p53 and its mutants in tumor cell migration and invasion
    • PMID:21263025
    • Muller PA, Vousden KH, Norman JC. p53 and its mutants in tumor cell migration and invasion. J Cell Biol 2011; 192:209-18; PMID:21263025; http://dx.doi.org/10.1083/jcb.201009059.
    • (2011) J Cell Biol , vol.192 , pp. 209-218
    • Muller, P.A.1    Vousden, K.H.2    Norman, J.C.3
  • 115
    • 78651289008 scopus 로고    scopus 로고
    • Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells
    • PMID:20689556
    • Kogan-Sakin I, Tabach Y, Buganim Y, Molchadsky A, Solomon H, Madar S, et al. Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells. Cell Death Differ 2011; 18:271-81; PMID:20689556; http://dx.doi.org/10.1038/cdd.2010.94.
    • (2011) Cell Death Differ , vol.18 , pp. 271-281
    • Kogan-Sakin, I.1    Tabach, Y.2    Buganim, Y.3    Molchadsky, A.4    Solomon, H.5    Madar, S.6
  • 116
    • 79960024581 scopus 로고    scopus 로고
    • Reciprocal influence of the p53 and the hypoxic pathways
    • PMID:21614094
    • Sermeus A, Michiels C. Reciprocal influence of the p53 and the hypoxic pathways. Cell Death Dis 2011; 2:e164; PMID:21614094; http://dx.doi.org/10.1038/ cddis.2011.48.
    • (2011) Cell Death Dis , vol.2
    • Sermeus, A.1    Michiels, C.2
  • 117
    • 84856098041 scopus 로고    scopus 로고
    • Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells
    • PMID:22170099
    • Michaelis M, Rothweiler F, Barth S, Cinatl J, van Rikxoort M, Löschmann N, et al. Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells. Cell Death Dis 2011; 2:e243; PMID:22170099; http://dx.doi.org/10.1038/cddis.2011.129.
    • (2011) Cell Death Dis , vol.2
    • Michaelis, M.1    Rothweiler, F.2    Barth, S.3    Cinatl, J.4    Van Rikxoort, M.5    Löschmann, N.6
  • 118
    • 79960024585 scopus 로고    scopus 로고
    • NF-Y joins E2Fs, p53 and other stress transcription factors at the apoptosis table
    • PMID:21614092
    • Gatta R, Dolfini D, Mantovani R. NF-Y joins E2Fs, p53 and other stress transcription factors at the apoptosis table. Cell Death Dis 2011; 2:e162; PMID:21614092; http://dx.doi.org/10.1038/cddis.2011.45.
    • (2011) Cell Death Dis , vol.2
    • Gatta, R.1    Dolfini, D.2    Mantovani, R.3
  • 119
    • 79955868549 scopus 로고    scopus 로고
    • SUMO-specific protease 2 in Mdm2-mediated regulation of p53
    • PMID:21183956
    • Jiang M, Chiu SY, Hsu W. SUMO-specific protease 2 in Mdm2-mediated regulation of p53. Cell Death Differ 2011; 18:1005-15; PMID:21183956; http://dx.doi.org/10.1038/cdd.2010.168.
    • (2011) Cell Death Differ , vol.18 , pp. 1005-1015
    • Jiang, M.1    Chiu, S.Y.2    Hsu, W.3
  • 120
    • 84865273469 scopus 로고    scopus 로고
    • Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors
    • PMID:22190384
    • Antico Arciuch VG, Russo MA, Dima M, Kang KS, Dasrath F, Liao XH, et al. Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors. Oncotarget 2011; 2:1109-26; PMID:22190384.
    • (2011) Oncotarget , vol.2 , pp. 1109-1126
    • Antico Arciuch, V.G.1    Russo, M.A.2    Dima, M.3    Kang, K.S.4    Dasrath, F.5    Liao, X.H.6
  • 121
    • 84858589052 scopus 로고    scopus 로고
    • DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death
    • PMID:22190353
    • Hill R, Madureira PA, Waisman DM, Lee PW. DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death. Oncotarget 2011; 2:1094-108; PMID:22190353.
    • (2011) Oncotarget , vol.2 , pp. 1094-1108
    • Hill, R.1    Madureira, P.A.2    Waisman, D.M.3    Lee, P.W.4
  • 122
    • 84055203847 scopus 로고    scopus 로고
    • Wiring the oncogenic circuitry: Pin1 unleashes mutant p53
    • PMID:21926448
    • Napoli M, Girardini JE, Piazza S, Del Sal G. Wiring the oncogenic circuitry: Pin1 unleashes mutant p53. Oncotarget 2011; 2:654-6; PMID:21926448.
    • (2011) Oncotarget , vol.2 , pp. 654-656
    • Napoli, M.1    Girardini, J.E.2    Piazza, S.3    Del Sal, G.4
  • 123
    • 79952269372 scopus 로고    scopus 로고
    • DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    • Albany NY PMID:21212465
    • Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany NY) 2010; 2:924-35; PMID:21212465.
    • (2010) Aging , vol.2 , pp. 924-935
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 124
    • 77958558613 scopus 로고    scopus 로고
    • TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
    • PMID:20962848
    • Su X, Chakravarti D, Cho MS, Liu L, Gi YJ, Lin YL, et al. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature 2010; 467:986-90; PMID:20962848; http://dx.doi.org/10.1038/nature09459.
    • (2010) Nature , vol.467 , pp. 986-990
    • Su, X.1    Chakravarti, D.2    Cho, M.S.3    Liu, L.4    Gi, Y.J.5    Lin, Y.L.6
  • 125
    • 78449242874 scopus 로고    scopus 로고
    • Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis
    • PMID:20975948
    • Beaudry VG, Jiang D, Dusek RL, Park EJ, Knezevich S, Ridd K, et al. Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet 2010; 6:e1001168; PMID:20975948; http://dx.doi.org/10.1371/journal.pgen. 1001168.
    • (2010) PLoS Genet , vol.6
    • Beaudry, V.G.1    Jiang, D.2    Dusek, R.L.3    Park, E.J.4    Knezevich, S.5    Ridd, K.6
  • 126
    • 78651277059 scopus 로고    scopus 로고
    • p53 directly transactivates Δ133p53 α, regulating cell fate outcome in response to DNA damage
    • PMID:20689555
    • Aoubala M, Murray-Zmijewski F, Khoury MP, Fernandes K, Perrier S, Bernard H, et al. p53 directly transactivates Δ133p53 α, regulating cell fate outcome in response to DNA damage. Cell Death Differ 2011; 18:248-58; PMID:20689555; http://dx.doi.org/10.1038/cdd.2010.91.
    • (2011) Cell Death Differ , vol.18 , pp. 248-258
    • Aoubala, M.1    Murray-Zmijewski, F.2    Khoury, M.P.3    Fernandes, K.4    Perrier, S.5    Bernard, H.6
  • 127
    • 79958279335 scopus 로고    scopus 로고
    • Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation
    • PMID:21151771
    • Barton CE, Johnson KN, Mays DM, Boehnke K, Shyr Y, Boukamp P, et al. Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation. Cell Death Dis 2010; 1:e74; PMID:21151771; http://dx.doi.org/ 10.1038/cddis.2010.49.
    • (2010) Cell Death Dis , vol.1
    • Barton, C.E.1    Johnson, K.N.2    Mays, D.M.3    Boehnke, K.4    Shyr, Y.5    Boukamp, P.6
  • 128
    • 78349313142 scopus 로고    scopus 로고
    • The p63 target HBP1 is required for skin differentiation and stratification
    • PMID:20523354
    • Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober OM, et al. The p63 target HBP1 is required for skin differentiation and stratification. Cell Death Differ 2010; 17:1896-907; PMID:20523354; http://dx.doi.org/10.1038/cdd.2010.59.
    • (2010) Cell Death Differ , vol.17 , pp. 1896-1907
    • Borrelli, S.1    Candi, E.2    Hu, B.3    Dolfini, D.4    Ravo, M.5    Grober, O.M.6
  • 129
    • 77958479635 scopus 로고    scopus 로고
    • Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression
    • PMID:20888799
    • Lena AM, Cipollone R, Amelio I, Catani MV, Ramadan S, Browne G, et al. Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression. Biochem Biophys Res Commun 2010; 401:568-73; PMID:20888799; http://dx.doi.org/10.1016/j.bbrc.2010.09.102.
    • (2010) Biochem Biophys Res Commun , vol.401 , pp. 568-573
    • Lena, A.M.1    Cipollone, R.2    Amelio, I.3    Catani, M.V.4    Ramadan, S.5    Browne, G.6
  • 130
    • 84862864843 scopus 로고    scopus 로고
    • Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome
    • PMID:22203497
    • Neilsen PM, Noll JE, Suetani RJ, Schulz RB, Al-Ejeh F, Evdokiou A, et al. Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome. Oncotarget 2011; 2:1203-17; PMID:22203497.
    • (2011) Oncotarget , vol.2 , pp. 1203-1217
    • Neilsen, P.M.1    Noll, J.E.2    Suetani, R.J.3    Schulz, R.B.4    Al-Ejeh, F.5    Evdokiou, A.6
  • 131
    • 79952691843 scopus 로고    scopus 로고
    • The p53 inducing drug dosage may determine quiescence or senescence
    • Albany NY PMID:21068468
    • Lane DP, Verma C, Fang CC. The p53 inducing drug dosage may determine quiescence or senescence. Aging (Albany NY) 2010; 2:748; PMID:21068468.
    • (2010) Aging , vol.2 , pp. 748
    • Lane, D.P.1    Verma, C.2    Fang, C.C.3
  • 132
    • 79955054710 scopus 로고    scopus 로고
    • Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
    • PMID:21445056
    • Xu J, Reumers J, Couceiro JR, De Smet F, Gallardo R, Rudyak S, et al. Gain of function of mutant p53 by coaggregation with multiple tumor suppressors. Nat Chem Biol 2011; 7:285-95; PMID:21445056; http://dx.doi.org/10.1038/ nchembio.546.
    • (2011) Nat Chem Biol , vol.7 , pp. 285-295
    • Xu, J.1    Reumers, J.2    Couceiro, J.R.3    De Smet, F.4    Gallardo, R.5    Rudyak, S.6
  • 133
    • 80051789515 scopus 로고    scopus 로고
    • p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
    • PMID:21760596
    • Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ 2011; 18:1487-99; PMID:21760596; http://dx.doi.org/10.1038/cdd.2011.81.
    • (2011) Cell Death Differ , vol.18 , pp. 1487-1499
    • Melino, G.1
  • 134
    • 77952238224 scopus 로고    scopus 로고
    • p53-family proteins and their regulators: Hubs and spokes in tumor suppression
    • PMID:20379196
    • Collavin L, Lunardi A, Del Sal G. p53-family proteins and their regulators: hubs and spokes in tumor suppression. Cell Death Differ 2010; 17:901-11; PMID:20379196; http://dx.doi.org/10.1038/cdd.2010.35.
    • (2010) Cell Death Differ , vol.17 , pp. 901-911
    • Collavin, L.1    Lunardi, A.2    Del Sal, G.3
  • 136
    • 79956265753 scopus 로고    scopus 로고
    • Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediategrade primary breast cancer
    • PMID:21364658
    • Sayeed A, Meng Z, Luciani G, Chen LC, Bennington JL, Dairkee SH. Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediategrade primary breast cancer. Cell Death Dis 2010; 1:e53; PMID:21364658; http://dx.doi.org/10.1038/cddis.2010.30.
    • (2010) Cell Death Dis , vol.1
    • Sayeed, A.1    Meng, Z.2    Luciani, G.3    Chen, L.C.4    Bennington, J.L.5    Dairkee, S.H.6
  • 137
    • 63049136592 scopus 로고    scopus 로고
    • A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
    • PMID:19345189
    • Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, et al. A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell 2009; 137:87-98; PMID:19345189; http://dx.doi.org/10.1016/j.cell.2009.01.039.
    • (2009) Cell , vol.137 , pp. 87-98
    • Adorno, M.1    Cordenonsi, M.2    Montagner, M.3    Dupont, S.4    Wong, C.5    Hann, B.6
  • 138
    • 38849110894 scopus 로고    scopus 로고
    • Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression
    • PMID:18233956
    • Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Imaizumi T, Imanaka T, et al. Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression. Genes Cells 2008; 13:131-44; PMID:18233956; http://dx.doi.org/10.1111/j.1365-2443.2007.01153.x.
    • (2008) Genes Cells , vol.13 , pp. 131-144
    • Sato, F.1    Bhawal, U.K.2    Kawamoto, T.3    Fujimoto, K.4    Imaizumi, T.5    Imanaka, T.6
  • 139
    • 77953597349 scopus 로고    scopus 로고
    • A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways
    • PMID:20404562
    • Podar K, Anderson KC. A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways. Cell Cycle 2010; 9:1722-8; PMID:20404562; http://dx.doi.org/10.4161/cc.9.9.11358.
    • (2010) Cell Cycle , vol.9 , pp. 1722-1728
    • Podar, K.1    Anderson, K.C.2
  • 140
    • 80054884802 scopus 로고    scopus 로고
    • Cell death pathology: Perspective for human diseases
    • PMID:21964290
    • Agostini M, Tucci P, Melino G. Cell death pathology: perspective for human diseases. Biochem Biophys Res Commun 2011; 414:451-5; PMID:21964290; http://dx.doi.org/10.1016/j.bbrc.2011.09.081.
    • (2011) Biochem Biophys Res Commun , vol.414 , pp. 451-455
    • Agostini, M.1    Tucci, P.2    Melino, G.3
  • 141
    • 80054839348 scopus 로고    scopus 로고
    • Cell death pathology: Cross-talk with autophagy and its clinical implications
    • PMID:21963447
    • Amelio I, Melino G, Knight RA. Cell death pathology: cross-talk with autophagy and its clinical implications. Biochem Biophys Res Commun 2011; 414:277-81; PMID:21963447; http://dx.doi.org/10.1016/j.bbrc.2011.09.080.
    • (2011) Biochem Biophys Res Commun , vol.414 , pp. 277-281
    • Amelio, I.1    Melino, G.2    Knight, R.A.3


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