메뉴 건너뛰기




Volumn 10, Issue 22, 2011, Pages 3920-3928

Phosphorylation of von Hippel-Lindau protein by checkpoint kinase 2 regulates p53 transactivation

Author keywords

Chk2; DNA damage; p53; pVHL; Renal cell carcinoma

Indexed keywords

CHECKPOINT KINASE 2; PROTEIN P53; SERINE; VON HIPPEL LINDAU PROTEIN;

EID: 81855212680     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.22.18096     Document Type: Article
Times cited : (26)

References (49)
  • 1
    • 65949112237 scopus 로고    scopus 로고
    • Treatment of kidney cancer: Insights provided by the VHL tumor-suppressor protein
    • PMID:19402056; DOI:10.1002/cncr.24232
    • Kaelin WG Jr. Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein. Cancer 2009; 115:2262-72; PMID:19402056; DOI:10.1002/cncr.24232.
    • (2009) Cancer , vol.115 , pp. 2262-2272
    • Kaelin Jr., W.G.1
  • 2
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • PMID:19946328; DOI:10.1038/onc.2009.441
    • Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010; 29:625-34; PMID:19946328; DOI:10.1038/onc.2009.441.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 3
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • PMID:12209156; DOI:10.1038/nrc885
    • Kaelin WG Jr. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2002; 2:673-82; PMID:12209156; DOI:10.1038/nrc885.
    • (2002) Nat Rev Cancer , vol.2 , pp. 673-682
    • Kaelin Jr., W.G.1
  • 4
    • 0032578357 scopus 로고    scopus 로고
    • pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation
    • PMID:9751722; DOI:10.1073/pnas.95.20.11661
    • Iliopoulos O, Ohh M, Kaelin WG Jr. pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc Natl Acad Sci USA 1998; 95:11661-6; PMID:9751722; DOI:10.1073/pnas.95.20.11661.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11661-11666
    • Iliopoulos, O.1    Ohh, M.2    Kaelin Jr., W.G.3
  • 5
    • 0029028652 scopus 로고
    • Characterization of the VHL tumor suppressor gene product: Localization, complex formation, and the effect of natural inactivating mutations
    • PMID:7604013; DOI:10.1073/pnas.92.14.6459
    • Duan DR, Humphrey JS, Chen DY, Weng Y, Sukegawa J, Lee S, et al. Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. Proc Natl Acad Sci USA 1995; 92:6459-63; PMID:7604013; DOI:10.1073/pnas.92.14.6459.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6459-6463
    • Duan, D.R.1    Humphrey, J.S.2    Chen, D.Y.3    Weng, Y.4    Sukegawa, J.5    Lee, S.6
  • 6
    • 0033587146 scopus 로고    scopus 로고
    • The tumor suppressor protein VHL targets HIF for oxygen-dependant proteolysis
    • PMID:10353251; DOI:10.1038/20459
    • Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al. The tumor suppressor protein VHL targets HIF for oxygen-dependant proteolysis. Nature 1999; 399:271-5; PMID:10353251; DOI:10.1038/20459.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3    Clifford, S.C.4    Vaux, E.C.5    Cockman, M.E.6
  • 7
    • 28844484134 scopus 로고    scopus 로고
    • Renal cell carcinoma
    • PMID:16339096; DOI:10.1056/NEJMra043172
    • Cohen HT, McGovern FJ. Renal cell carcinoma. N Engl J Med 2005; 353:2477-90; PMID:16339096; DOI:10.1056/NEJMra043172.
    • (2005) N Engl J Med , vol.353 , pp. 2477-2490
    • Cohen, H.T.1    McGovern, F.J.2
  • 8
    • 0028981766 scopus 로고
    • Germline mutations in the von-Hippel Lindau disease tumor suppressor gene: Correlation with phenotype
    • PMID:7728151; DOI:10.1002/humu.1380050109
    • Chen F, Kishida T, Yao M, Hustad T, Glavac D, Dean M, et al. Germline mutations in the von-Hippel Lindau disease tumor suppressor gene: correlation with phenotype. Hum Mutat 1995; 5:66-75; PMID:7728151; DOI:10.1002/humu. 1380050109.
    • (1995) Hum Mutat , vol.5 , pp. 66-75
    • Chen, F.1    Kishida, T.2    Yao, M.3    Hustad, T.4    Glavac, D.5    Dean, M.6
  • 9
    • 0031834186 scopus 로고    scopus 로고
    • Genotype-phenotype correlation in von Hippel lindau disease
    • PMID:9681856; DOI:10.1046/j.1365-2796.1998.00336.x
    • Neumann HP, Bender B. Genotype-phenotype correlation in von Hippel lindau disease. J Intern Med 1998; 243:541-5; PMID:9681856; DOI:10.1046/j.1365-2796. 1998.00336.x.
    • (1998) J Intern Med , vol.243 , pp. 541-545
    • Neumann, H.P.1    Bender, B.2
  • 10
    • 1642603441 scopus 로고    scopus 로고
    • von Hippel-Lindau tumor suppressor: Not only HIF's executioner
    • PMID:15162797; DOI:10.1016/j.molmed.2004.02.004
    • Czyzyk-Krzeska MF, Meller J. von Hippel-Lindau tumor suppressor: not only HIF's executioner. Trends Mol Med 2004; 10:146-9; PMID:15162797; DOI:10.1016/j.molmed.2004.02.004.
    • (2004) Trends Mol Med , vol.10 , pp. 146-149
    • Czyzyk-Krzeska, M.F.1    Meller, J.2
  • 11
    • 78049302116 scopus 로고    scopus 로고
    • p53 post-translational modification: Deregulated in tumorigenesis
    • PMID:20932800; DOI:10.1016/j.molmed.2010.09.002
    • Dai C, Gu W. p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med 2010; 16:528-36; PMID:20932800; DOI:10.1016/j.molmed.2010.09.002.
    • (2010) Trends Mol Med , vol.16 , pp. 528-536
    • Dai, C.1    Gu, W.2
  • 12
    • 20044376659 scopus 로고    scopus 로고
    • Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance
    • PMID:15572731; DOI:10.1200/JCO.2005.02.191
    • Mizutani Y, Nakanishi H, Yamamoto K, Li YN, Matsubara H, Mikami K, et al. Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance. J Clin Oncol 2005; 23:448-54; PMID:15572731; DOI:10.1200/JCO.2005.02.191.
    • (2005) J Clin Oncol , vol.23 , pp. 448-454
    • Mizutani, Y.1    Nakanishi, H.2    Yamamoto, K.3    Li, Y.N.4    Matsubara, H.5    Mikami, K.6
  • 13
    • 0034213623 scopus 로고    scopus 로고
    • Enhancement of Fas-mediated apoptosis in renal cell carcinoma cells by adriamycin
    • PMID:10850437
    • Wu XX, Mizutani Y, Kakehi Y, Yoshida O, Ogawa O. Enhancement of Fas-mediated apoptosis in renal cell carcinoma cells by adriamycin. Cancer Res 2000; 60:2912-8; PMID:10850437.
    • (2000) Cancer Res , vol.60 , pp. 2912-2918
    • Wu, X.X.1    Mizutani, Y.2    Kakehi, Y.3    Yoshida, O.4    Ogawa, O.5
  • 14
    • 35548967197 scopus 로고    scopus 로고
    • Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: Evidence for contribution to apoptosis resistance
    • PMID:17486061; DOI:10.1038/sj.onc.1210510
    • Zantl N, Weirich G, Zall H, Seiffert BM, Fischer SF, Kirschnek S, et al. Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance. Oncogene 2007; 26:7038-48; PMID:17486061; DOI:10.1038/sj.onc.1210510.
    • (2007) Oncogene , vol.26 , pp. 7038-7048
    • Zantl, N.1    Weirich, G.2    Zall, H.3    Seiffert, B.M.4    Fischer, S.F.5    Kirschnek, S.6
  • 15
    • 33646140913 scopus 로고    scopus 로고
    • p53 stabilization and transactivation by a von Hippel-Lindau protein
    • PMID:16678111; DOI:10.1016/j.molcel.2006.04.006
    • Roe JS, Kim HS, Lee SM, Kim ST, Cho EJ, Youn HD. p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol Cell 2006; 22:395-405; PMID:16678111; DOI:10.1016/j.molcel.2006.04.006.
    • (2006) Mol Cell , vol.22 , pp. 395-405
    • Roe, J.S.1    Kim, H.S.2    Lee, S.M.3    Kim, S.T.4    Cho, E.J.5    Youn, H.D.6
  • 16
    • 33749663052 scopus 로고    scopus 로고
    • The positive regulation of p53 by the tumor suppressor VHL
    • PMID:16969113; DOI:10.4161/cc.5.18.3247
    • Roe JS, Youn HD. The positive regulation of p53 by the tumor suppressor VHL. Cell Cycle 2006; 5:2054-6; PMID:16969113; DOI:10.4161/cc.5.18.3247.
    • (2006) Cell Cycle , vol.5 , pp. 2054-2056
    • Roe, J.S.1    Youn, H.D.2
  • 17
    • 33745049797 scopus 로고    scopus 로고
    • VHL and p53: Tumor suppressors team up to prevent cancer
    • PMID:16713574; DOI:10.1016/j.molcel.2006.05.001
    • Semenza GL. VHL and p53: tumor suppressors team up to prevent cancer. Mol Cell 2006; 22:437-9; PMID:16713574; DOI:10.1016/j.molcel.2006.05.001.
    • (2006) Mol Cell , vol.22 , pp. 437-439
    • Semenza, G.L.1
  • 18
    • 67349265185 scopus 로고    scopus 로고
    • The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM (EL)
    • PMID:19305426; DOI:10.1038/onc.2009.35
    • Guo Y, Schoell MC, Freeman RS. The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM (EL). Oncogene 2009; 28:1864-74; PMID:19305426; DOI:10.1038/onc.2009.35.
    • (2009) Oncogene , vol.28 , pp. 1864-1874
    • Guo, Y.1    Schoell, M.C.2    Freeman, R.S.3
  • 19
    • 79960360757 scopus 로고    scopus 로고
    • von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage
    • PMID:21358672; DOI:10.1038/onc.2011.40
    • Roe JS, Kim HR, Hwang IY, Cho EJ, Youn HD. von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage. Oncogene 2011; 30:3127-38; PMID:21358672; DOI:10.1038/onc.2011.40.
    • (2011) Oncogene , vol.30 , pp. 3127-3138
    • Roe, J.S.1    Kim, H.R.2    Hwang, I.Y.3    Cho, E.J.4    Youn, H.D.5
  • 20
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • PMID:12781359; DOI:10.1016/S1535-6108(03)00110-7
    • Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003; 3:421-9; PMID:12781359; DOI:10.1016/S1535-6108(03) 00110-7.
    • (2003) Cancer Cell , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 21
    • 0037013243 scopus 로고    scopus 로고
    • Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach
    • PMID:11821419; DOI:10.1074/jbc.M111705200
    • O'Neill T, Giarratani L, Chen P, Iyer L, Lee CH, Bobiak M, et al. Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J Biol Chem 2002; 277:16102-15; PMID:11821419; DOI:10.1074/jbc.M111705200.
    • (2002) J Biol Chem , vol.277 , pp. 16102-16115
    • O'Neill, T.1    Giarratani, L.2    Chen, P.3    Iyer, L.4    Lee, C.H.5    Bobiak, M.6
  • 22
    • 7844234770 scopus 로고    scopus 로고
    • Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene
    • PMID:9829911; DOI:10.1002/(SICI)1098-1004(1998)12:6<417::AID- HUMU8>3.0.CO;2-K
    • Stolle C, Glenn G, Zbar B, Humphrey JS, Choyke P, Walther M, et al. Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene. Hum Mutat 1998; 12:417-23; PMID:9829911; DOI:10.1002/(SICI) 1098-1004(1998)12:6<417::AID-HUMU8>3.0.CO;2-K.
    • (1998) Hum Mutat , vol.12 , pp. 417-423
    • Stolle, C.1    Glenn, G.2    Zbar, B.3    Humphrey, J.S.4    Choyke, P.5    Walther, M.6
  • 23
    • 18444368709 scopus 로고    scopus 로고
    • Structural basis for the recognition of hydroxyproline in HIF-1alpha by pVHL
    • PMID:12050673; DOI:10.1038/nature00767
    • Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, et al. Structural basis for the recognition of hydroxyproline in HIF-1alpha by pVHL. Nature 2002; 417:975-8; PMID:12050673; DOI:10.1038/nature00767.
    • (2002) Nature , vol.417 , pp. 975-978
    • Hon, W.C.1    Wilson, M.I.2    Harlos, K.3    Claridge, T.D.4    Schofield, C.J.5    Pugh, C.W.6
  • 24
    • 0037035851 scopus 로고    scopus 로고
    • Structure of an HIF-1alpha-pVHL complex: Hydroxyproline recognition in signaling
    • PMID:12004076; DOI:10.1126/science.1073440
    • Min JH, Yang H, Ivan M, Gertler F, Kaelin WG Jr, Pavletich NP. Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. Science 2002; 296:1886-9; PMID:12004076; DOI:10.1126/science.1073440.
    • (2002) Science , vol.296 , pp. 1886-1889
    • Min, J.H.1    Yang, H.2    Ivan, M.3    Gertler, F.4    Kaelin Jr., W.G.5    Pavletich, N.P.6
  • 25
    • 0031587821 scopus 로고    scopus 로고
    • Recruitment of p300/CBP in p53-dependent signal pathways
    • PMID:9215639; DOI:10.1016/S0092-8674(00)80304-9
    • Avantaggiati ML, Ogryzko V, Gardner K, Giordano A, Levine AS, Kelly K. Recruitment of p300/CBP in p53-dependent signal pathways. Cell 1997; 89:1175-84; PMID:9215639; DOI:10.1016/S0092-8674(00)80304-9.
    • (1997) Cell , vol.89 , pp. 1175-1184
    • Avantaggiati, M.L.1    Ogryzko, V.2    Gardner, K.3    Giordano, A.4    Levine, A.S.5    Kelly, K.6
  • 26
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • PMID:9288740; DOI:10.1016/S0092-8674(00)80521-8
    • Gu W, Roeder RG. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 1997; 90:595-606; PMID:9288740; DOI:10.1016/S0092-8674(00)80521-8.
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 27
    • 33845656738 scopus 로고    scopus 로고
    • Acetylation of the p53 DNA-binding domain regulates apoptosis induction
    • PMID:17189187; DOI:10.1016/j.molcel.2006.11.026
    • Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, et al. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 2006; 24:841-51; PMID:17189187; DOI:10.1016/j.molcel.2006.11.026.
    • (2006) Mol Cell , vol.24 , pp. 841-851
    • Sykes, S.M.1    Mellert, H.S.2    Holbert, M.A.3    Li, K.4    Marmorstein, R.5    Lane, W.S.6
  • 28
    • 33845668241 scopus 로고    scopus 로고
    • Tip60-dependent acetylation of p53 modulates the decision between cell cycle arrest and apoptosis
    • PMID:17189186; DOI:10.1016/j.molcel.2006.11.021
    • Tang Y, Luo J, Zhang W, Gu W. Tip60-dependent acetylation of p53 modulates the decision between cell cycle arrest and apoptosis. Mol Cell 2006; 24:827-39; PMID:17189186; DOI:10.1016/j.molcel.2006.11.021.
    • (2006) Mol Cell , vol.24 , pp. 827-839
    • Tang, Y.1    Luo, J.2    Zhang, W.3    Gu, W.4
  • 29
    • 59649103088 scopus 로고    scopus 로고
    • Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation
    • PMID:19166313; DOI:10.1021/bi801716 h
    • Jenkins LM, Yamaguchi H, Hayashi R, Cherry S, Tropea JE, Miller M, et al. Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation. Biochemistry 2009; 48:1244-55; PMID:19166313; DOI:10.1021/bi801716 h.
    • (2009) Biochemistry , vol.48 , pp. 1244-1255
    • Jenkins, L.M.1    Yamaguchi, H.2    Hayashi, R.3    Cherry, S.4    Tropea, J.E.5    Miller, M.6
  • 30
    • 38049144664 scopus 로고    scopus 로고
    • Differential recognition of phosphorylated transactivation domains of p53 by different p300 domains
    • PMID:18155245; DOI:10.1016/j.jmb.2007.11.082
    • Polley S, Guha S, Roy NS, Kar S, Sakaguchi K, Chuman Y, et al. Differential recognition of phosphorylated transactivation domains of p53 by different p300 domains. J Mol Biol 2008; 376:8-12; PMID:18155245; DOI:10.1016/j.jmb.2007.11.082.
    • (2008) J Mol Biol , vol.376 , pp. 8-12
    • Polley, S.1    Guha, S.2    Roy, N.S.3    Kar, S.4    Sakaguchi, K.5    Chuman, Y.6
  • 31
    • 57649233025 scopus 로고    scopus 로고
    • Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex
    • PMID:18684714; DOI:10.1074/jbc.M801407200
    • Foy RL, Song IY, Chitalia VC, Cohen HT, Saksouk N, Cayrou C, et al. Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. J Biol Chem 2008; 283:28817-26; PMID:18684714; DOI:10.1074/jbc.M801407200.
    • (2008) J Biol Chem , vol.283 , pp. 28817-28826
    • Foy, R.L.1    Song, I.Y.2    Chitalia, V.C.3    Cohen, H.T.4    Saksouk, N.5    Cayrou, C.6
  • 32
    • 1242316175 scopus 로고    scopus 로고
    • Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent
    • PMID:14973063; DOI:10.1158/0008-5472.CAN-03-0884
    • Zhou MI, Wang H, Foy RL, Ross JJ, Cohen HT. Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent. Cancer Res 2004; 64:1278-86; PMID:14973063; DOI:10.1158/0008-5472.CAN-03-0884.
    • (2004) Cancer Res , vol.64 , pp. 1278-1286
    • Zhou, M.I.1    Wang, H.2    Foy, R.L.3    Ross, J.J.4    Cohen, H.T.5
  • 33
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • PMID:17486112; DOI:10.1038/ncb1599
    • Berkovich E, Monnat RJ Jr, Kastan MB. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 2007; 9:683-90; PMID:17486112; DOI:10.1038/ncb1599.
    • (2007) Nat Cell Biol , vol.9 , pp. 683-690
    • Berkovich, E.1    Monnat Jr., R.J.2    Kastan, M.B.3
  • 34
    • 43149118801 scopus 로고    scopus 로고
    • Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites
    • PMID:18451799; DOI:10.1038/nprot.2008.54
    • Berkovich E, Monnat RJ Jr, Kastan MB. Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites. Nat Protoc 2008; 3:915-22; PMID:18451799; DOI:10.1038/nprot.2008.54.
    • (2008) Nat Protoc , vol.3 , pp. 915-922
    • Berkovich, E.1    Monnat Jr., R.J.2    Kastan, M.B.3
  • 35
    • 66049150672 scopus 로고    scopus 로고
    • SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
    • (Albany NY) PMID:20157594
    • McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, et al. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) 2009; 1:109-21; PMID:20157594.
    • (2009) Aging , vol.1 , pp. 109-121
    • McCord, R.A.1    Michishita, E.2    Hong, T.3    Berber, E.4    Boxer, L.D.5    Kusumoto, R.6
  • 36
    • 33745918951 scopus 로고    scopus 로고
    • TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    • PMID:16839880; DOI:10.1016/j.cell.2006.05.036
    • Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006; 126:107-20; PMID:16839880; DOI:10.1016/j.cell.2006.05.036.
    • (2006) Cell , vol.126 , pp. 107-120
    • Bensaad, K.1    Tsuruta, A.2    Selak, M.A.3    Vidal, M.N.4    Nakano, K.5    Bartrons, R.6
  • 37
    • 33745149291 scopus 로고    scopus 로고
    • p53 regulates mitochondrial respiration
    • PMID:16728594; DOI:10.1126/science.1126863
    • Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, et al. p53 regulates mitochondrial respiration. Science 2006; 312:1650-3; PMID:16728594; DOI:10.1126/science.1126863.
    • (2006) Science , vol.312 , pp. 1650-1653
    • Matoba, S.1    Kang, J.G.2    Patino, W.D.3    Wragg, A.4    Boehm, M.5    Gavrilova, O.6
  • 38
    • 30344444484 scopus 로고    scopus 로고
    • Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
    • PMID:16341205; DOI:10.1038/ncb1343
    • Murr R, Loizou JI, Yang YG, Cuenin C, Li H, Wang ZQ, et al. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat Cell Biol 2006; 8:91-9; PMID:16341205; DOI:10.1038/ncb1343.
    • (2006) Nat Cell Biol , vol.8 , pp. 91-99
    • Murr, R.1    Loizou, J.I.2    Yang, Y.G.3    Cuenin, C.4    Li, H.5    Wang, Z.Q.6
  • 39
    • 0033615647 scopus 로고    scopus 로고
    • Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
    • PMID:10531348; DOI:10.1074/jbc.274.44.31463
    • Tominaga K, Morisaki H, Kaneko Y, Fujimoto A, Tanaka T, Ohtsubo M, et al. Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53. J Biol Chem 1999; 274:31463-7; PMID:10531348; DOI:10.1074/jbc.274.44. 31463.
    • (1999) J Biol Chem , vol.274 , pp. 31463-31467
    • Tominaga, K.1    Morisaki, H.2    Kaneko, Y.3    Fujimoto, A.4    Tanaka, T.5    Ohtsubo, M.6
  • 40
    • 0034142325 scopus 로고    scopus 로고
    • Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
    • PMID:10673500
    • Chehab NH, Malikzay A, Appel M, Halazonetis TD. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev 2000; 14:278-88; PMID:10673500.
    • (2000) Genes Dev , vol.14 , pp. 278-288
    • Chehab, N.H.1    Malikzay, A.2    Appel, M.3    Halazonetis, T.D.4
  • 41
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • PMID:10673501
    • Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000; 14:289-300; PMID:10673501.
    • (2000) Genes Dev , vol.14 , pp. 289-300
    • Shieh, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 42
    • 33845187365 scopus 로고    scopus 로고
    • Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint
    • PMID:17157788; DOI:10.1016/j.ccr.2006.10.012
    • Bruno T, De-Nicola F, Iezzi S, Lecis D, D'Angelo C, Di-Padova M, et al. Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell 2006; 10:473-86; PMID:17157788; DOI:10.1016/j.ccr.2006.10.012.
    • (2006) Cancer Cell , vol.10 , pp. 473-486
    • Bruno, T.1    De-Nicola, F.2    Iezzi, S.3    Lecis, D.4    D'Angelo, C.5    Di-Padova, M.6
  • 43
    • 0042861598 scopus 로고    scopus 로고
    • Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect
    • PMID:12923786; DOI:10.1002/pmic.200300464
    • Unwin RD, Craven RA, Harnden P, Hanrahan S, Totty N, Knowles M, et al. Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect. Proteomics 2003; 3:1620-32; PMID:12923786; DOI:10.1002/pmic.200300464.
    • (2003) Proteomics , vol.3 , pp. 1620-1632
    • Unwin, R.D.1    Craven, R.A.2    Harnden, P.3    Hanrahan, S.4    Totty, N.5    Knowles, M.6
  • 44
    • 33746015048 scopus 로고    scopus 로고
    • Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma
    • PMID:16739133; DOI:10.1002/pmic.200500811
    • Craven RA, Hanrahan S, Totty N, Harnden P, Stanley AJ, Maher ER, et al. Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma. Proteomics 2006; 6:3880-93; PMID:16739133; DOI:10.1002/pmic. 200500811.
    • (2006) Proteomics , vol.6 , pp. 3880-3893
    • Craven, R.A.1    Hanrahan, S.2    Totty, N.3    Harnden, P.4    Stanley, A.J.5    Maher, E.R.6
  • 45
    • 16244418734 scopus 로고    scopus 로고
    • A new role for the von Hippel-Lindau tumor suppressor protein: Stimulation of mitochondrial oxidative phosphorylation complex biogenesis
    • PMID:15604095; DOI:10.1093/carcin/bgi001
    • Hervouet E, Demont J, Pecina P, Vojtísková A, Houstek J, Simonnet H, et al. A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis. Carcinogenesis 2005; 26:531-9; PMID:15604095; DOI:10.1093/carcin/ bgi001.
    • (2005) Carcinogenesis , vol.26 , pp. 531-539
    • Hervouet, E.1    Demont, J.2    Pecina, P.3    Vojtísková, A.4    Houstek, J.5    Simonnet, H.6
  • 46
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    • PMID:17482131; DOI:10.1016/j.ccr.2007.04.001
    • Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007; 11:407-20; PMID:17482131; DOI:10.1016/j.ccr.2007.04.001.
    • (2007) Cancer Cell , vol.11 , pp. 407-420
    • Zhang, H.1    Gao, P.2    Fukuda, R.3    Kumar, G.4    Krishnamachary, B.5    Zeller, K.I.6
  • 47
    • 70349472696 scopus 로고    scopus 로고
    • The Warburg effect is genetically determined in inherited pheochromocytomas
    • PMID:19763184; DOI:10.1371/journal.pone.0007094
    • Favier J, Brière JJ, Burnichon N, Rivière J, Vescovo L, Benit P, et al. The Warburg effect is genetically determined in inherited pheochromocytomas. PLoS ONE 2009; 4:7094; PMID:19763184; DOI:10.1371/journal. pone.0007094.
    • (2009) PLoS ONE , vol.4 , pp. 7094
    • Favier, J.1    Brière, J.J.2    Burnichon, N.3    Rivière, J.4    Vescovo, L.5    Benit, P.6
  • 48
    • 19944433653 scopus 로고    scopus 로고
    • Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
    • PMID:15652751; DOI:10.1016/j.ccr.2004.11.022
    • Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell 2005; 7:77-85; PMID:15652751; DOI:10.1016/j.ccr.2004.11.022.
    • (2005) Cancer Cell , vol.7 , pp. 77-85
    • Selak, M.A.1    Armour, S.M.2    MacKenzie, E.D.3    Boulahbel, H.4    Watson, D.G.5    Mansfield, K.D.6
  • 49
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • PMID:9836640; DOI:10.1126/science.282.5395.1893
    • Matsuoka S, Huang M, Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998; 282:1893-7; PMID:9836640; DOI:10.1126/science.282.5395.1893.
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.