메뉴 건너뛰기




Volumn 10, Issue 14, 2011, Pages 2287-2294

Surviving without oxygen: Hypoxia regulation of mammary morphogenesis and anoikis

Author keywords

3D culture; Anoikis; Bim; Cycling hypoxia; HIF 1; Hypoxia; Hypoxia reoxygenation; Lumen formation; MCF 10A; Morphogenesis

Indexed keywords

BIM PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; OXYGEN;

EID: 79960456668     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.14.16532     Document Type: Review
Times cited : (13)

References (64)
  • 2
    • 0026920895 scopus 로고
    • Physiological properties of malignant tumors
    • Vaupel P. Physiological properties of malignant tumors. NMR Biomed 1992; 5:220-5.
    • (1992) NMR Biomed , vol.5 , pp. 220-225
    • Vaupel, P.1
  • 4
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL. Hypoxia - a key regulatory factor in tumor growth. Nat Rev Cancer 2002; 2:38-47. (Pubitemid 37328806)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 8
    • 0037484174 scopus 로고    scopus 로고
    • Modelling tissue-specific signaling and organ function in three dimensions
    • DOI 10.1242/jcs.00503
    • Schmeichel KL, Bissell MJ. Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci 2003; 116:2377-88. (Pubitemid 36790120)
    • (2003) Journal of Cell Science , vol.116 , Issue.12 , pp. 2377-2388
    • Schmeichel, K.L.1    Bissell, M.J.2
  • 9
    • 0037020196 scopus 로고    scopus 로고
    • The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini
    • Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 2002; 111:29-40.
    • (2002) Cell , vol.111 , pp. 29-40
    • Debnath, J.1    Mills, K.R.2    Collins, N.L.3    Reginato, M.J.4    Muthuswamy, S.K.5    Brugge, J.S.6
  • 13
    • 41149095517 scopus 로고    scopus 로고
    • Entosis, a cell death process related to cell cannibalism between tumor cells
    • Paris
    • Mailleux AA, Overholtzer M, Brugge JS. [Entosis, a cell death process related to cell cannibalism between tumor cells]. Med Sci (Paris) 2008; 24:246-8.
    • (2008) Med Sci , vol.24 , pp. 246-248
    • Mailleux, A.A.1    Overholtzer, M.2    Brugge, J.S.3
  • 14
    • 0038482050 scopus 로고    scopus 로고
    • Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
    • DOI 10.1074/jbc.M301010200
    • Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem 2003; 278:18811-6. (Pubitemid 36799262)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.21 , pp. 18811-18816
    • Ley, R.1    Balmanno, K.2    Hadfield, K.3    Weston, C.4    Cook, S.J.5
  • 15
    • 1542275411 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover
    • Ley R, Ewings KE, Hadfield K, Howes E, Balmanno K, Cook SJ. Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover. J Biol Chem 2004; 279:8837-47.
    • (2004) J Biol Chem , vol.279 , pp. 8837-8847
    • Ley, R.1    Ewings, K.E.2    Hadfield, K.3    Howes, E.4    Balmanno, K.5    Cook, S.J.6
  • 16
    • 77951169413 scopus 로고    scopus 로고
    • ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells
    • Haenssen KK, Caldwell SA, Shahriari KS, Jackson SR, Whelan KA, Klein-Szanto AJ, et al. ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells. J Cell Sci 2010; 123:1373-82.
    • (2010) J Cell Sci , vol.123 , pp. 1373-1382
    • Haenssen, K.K.1    Caldwell, S.A.2    Shahriari, K.S.3    Jackson, S.R.4    Whelan, K.A.5    Klein-Szanto, A.J.6
  • 19
    • 0034854417 scopus 로고    scopus 로고
    • ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
    • DOI 10.1038/ncb0901-785
    • Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol 2001; 3:785-92. (Pubitemid 32842683)
    • (2001) Nature Cell Biology , vol.3 , Issue.9 , pp. 785-792
    • Muthuswamy, S.K.1    Li, D.2    Lelievre, S.3    Bissell, M.J.4    Brugge, J.S.5
  • 20
    • 59449085594 scopus 로고    scopus 로고
    • Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma
    • Castro NP, Osorio CA, Torres C, Bastos EP, Mourao-Neto M, Soares FA, et al. Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma. Breast Cancer Res 2008; 10:87.
    • (2008) Breast Cancer Res , vol.10 , pp. 87
    • Castro, N.P.1    Osorio, C.A.2    Torres, C.3    Bastos, E.P.4    Mourao-Neto, M.5    Soares, F.A.6
  • 21
    • 77956312911 scopus 로고    scopus 로고
    • Malignant precursor cells pre-exist in human breast DCIS and require autophagy for survival
    • Espina V, Mariani BD, Gallagher RI, Tran K, Banks S, Wiedemann J, et al. Malignant precursor cells pre-exist in human breast DCIS and require autophagy for survival. PLoS One 5:10240.
    • PLoS One , vol.5 , pp. 10240
    • Espina, V.1    Mariani, B.D.2    Gallagher, R.I.3    Tran, K.4    Banks, S.5    Wiedemann, J.6
  • 22
    • 78650599928 scopus 로고    scopus 로고
    • What is the malignant nature of human ductal carcinoma in situ?
    • Espina V, Liotta LA. What is the malignant nature of human ductal carcinoma in situ? Nat Rev Cancer 11:68-75.
    • Nat Rev Cancer , vol.11 , pp. 68-75
    • Espina, V.1    Liotta, L.A.2
  • 23
    • 0032132806 scopus 로고    scopus 로고
    • A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
    • Coquelle A, Toledo F, Stern S, Bieth A, Debatisse M. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol Cell 1998; 2:259-65. (Pubitemid 128373652)
    • (1998) Molecular Cell , vol.2 , Issue.2 , pp. 259-265
    • Coquelle, A.1    Toledo, F.2    Stern, S.3    Bieth, A.4    Debatisse, M.5
  • 26
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • Reynolds TY, Rockwell S, Glazer PM. Genetic instability induced by the tumor microenvironment. Cancer Res 1996; 56:5754-7. (Pubitemid 26422184)
    • (1996) Cancer Research , vol.56 , Issue.24 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 27
    • 23244464226 scopus 로고    scopus 로고
    • Microenvironmental influences on mutagenesis in mammary epithelial cells
    • DOI 10.1002/ijc.21088
    • Papp-Szabo E, Josephy PD, Coomber BL. Microenvironmental inf luences on mutagenesis in mammary epithelial cells. Int J Cancer 2005; 116:679-85. (Pubitemid 41099698)
    • (2005) International Journal of Cancer , vol.116 , Issue.5 , pp. 679-685
    • Papp-Szabo, E.1    Josephy, P.D.2    Coomber, B.L.3
  • 30
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • DOI 10.1016/S0092-8674(00)80108-7
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86:353-64. (Pubitemid 26272076)
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 33
    • 0022397272 scopus 로고
    • The vascular pattern of basal cell tumors: Light microscopy and scanning electron microscopic study on vascular corrosion casts
    • DOI 10.1016/0026-2862(85)90026-3
    • Grunt TW, Lametschwandtner A, Staindl O. The vascular pattern of basal cell tumors: light microscopy and scanning electron microscopic study on vascular corrosion casts. Microvasc Res 1985; 29:371-86. (Pubitemid 16158231)
    • (1985) Microvascular Research , vol.29 , Issue.3 , pp. 371-386
    • Grunt, T.W.1    Lametschwandtner, A.2    Staindl, O.3
  • 34
    • 0023956748 scopus 로고
    • Methods in laboratory investigation. Characterizatization of solid tumor microvasculature: A three-dimensional analysis using the polymer casting technique
    • Shah-Yukich AA, Nelson AC. Characterization of solid tumor microvasculature: a three-dimensional analysis using the polymer casting technique. Lab Invest 1988; 58:236-44. (Pubitemid 18075285)
    • (1988) Laboratory Investigation , vol.58 , Issue.2 , pp. 236-244
    • Shah-Yukich, A.A.1    Nelson, A.C.2
  • 35
    • 77953319433 scopus 로고    scopus 로고
    • Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: Role of Krebs cycle metabolites
    • Serra-Perez A, Planas AM, Nunez-O'Mara A, Berra E, Garcia-Villoria J, Ribes A, et al. Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites. J Biol Chem 285:18217-24.
    • J Biol Chem , vol.285 , pp. 18217-18224
    • Serra-Perez, A.1    Planas, A.M.2    Nunez-O'Mara, A.3    Berra, E.4    Garcia-Villoria, J.5    Ribes, A.6
  • 36
    • 70349306550 scopus 로고    scopus 로고
    • Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis
    • Feigin ME, Muthuswamy SK. Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol 2009; 21:694-700.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 694-700
    • Feigin, M.E.1    Muthuswamy, S.K.2
  • 37
    • 0021984681 scopus 로고
    • Oxygen-derived free radicals in postischemic tissue injury
    • McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312:159-63. (Pubitemid 15192863)
    • (1985) New England Journal of Medicine , vol.312 , Issue.3 , pp. 159-163
    • McCord, J.M.1
  • 38
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • DOI 10.1074/jbc.M212360200
    • Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003; 278:12207-13. (Pubitemid 36800201)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.14 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 41
    • 35648965243 scopus 로고    scopus 로고
    • Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
    • Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, et al. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med 2007; 4:294.
    • (2007) PLoS Med , vol.4 , pp. 294
    • Gong, Y.1    Somwar, R.2    Politi, K.3    Balak, M.4    Chmielecki, J.5    Jiang, X.6
  • 42
    • 0036918282 scopus 로고    scopus 로고
    • Impact of tumor hypoxia and anemia on radiation therapy outcomes
    • DOI 10.1634/theoncologist.7-6-492
    • Harrison LB, Chadha M, Hill RJ, Hu K, Shasha D. Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist 2002; 7:492-508. (Pubitemid 36008998)
    • (2002) Oncologist , vol.7 , Issue.6 , pp. 492-508
    • Harrison, L.B.1    Chadha, M.2    Hill, R.J.3    Hu, K.4    Shasha, D.5
  • 43
    • 33749670528 scopus 로고    scopus 로고
    • Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells
    • DOI 10.1016/j.ejcb.2006.06.001, PII S0171933506001166
    • Kwon DS, Kwon CH, Kim JH, Woo JS, Jung JS, Kim YK. Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells. Eur J Cell Biol 2006; 85:1189-99. (Pubitemid 44548871)
    • (2006) European Journal of Cell Biology , vol.85 , Issue.11 , pp. 1189-1199
    • Kwon, D.S.1    Kwon, C.H.2    Kim, J.H.3    Woo, J.S.4    Jung, J.S.5    Kim, Y.K.6
  • 45
    • 61849168107 scopus 로고    scopus 로고
    • The critical role of ERK in death resistance and invasiveness of hypoxia-selected glioblastoma cells
    • Kim JY, Kim YJ, Lee S, Park JH. The critical role of ERK in death resistance and invasiveness of hypoxia-selected glioblastoma cells. BMC Cancer 2009; 9:27.
    • (2009) BMC Cancer , vol.9 , pp. 27
    • Kim, J.Y.1    Kim, Y.J.2    Lee, S.3    Park, J.H.4
  • 46
    • 69949101473 scopus 로고    scopus 로고
    • Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
    • Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009; 461:109-13.
    • (2009) Nature , vol.461 , pp. 109-113
    • Schafer, Z.T.1    Grassian, A.R.2    Song, L.3    Jiang, Z.4    Gerhart-Hines, Z.5    Irie, H.Y.6
  • 48
    • 1642373712 scopus 로고    scopus 로고
    • lck-induced Cell Motility, and Urokinase-type Plasminogen Activator Secretion Involve Activation of Epidermal Growth Factor Receptor/Extracellular Signal Regulated Kinase Pathways
    • DOI 10.1074/jbc.M311400200
    • Mahabeleshwar GH, Das R, Kundu GC. Tyrosine kinase, p56lck-induced cell motility and urokinase-type plasminogen activator secretion involve activation of epidermal growth factor receptor/extracellular signal regulated kinase pathways. J Biol Chem 2004; 279:9733-42. (Pubitemid 38372571)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.11 , pp. 9733-9742
    • Mahabeleshwar, G.H.1    Das, R.2    Kundu, G.C.3
  • 50
    • 0034699326 scopus 로고    scopus 로고
    • Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis
    • Baek JH, Jang JE, Kang CM, Chung HY, Kim ND, Kim KW. Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis. Oncogene 2000; 19:4621-31.
    • (2000) Oncogene , vol.19 , pp. 4621-4631
    • Baek, J.H.1    Jang, J.E.2    Kang, C.M.3    Chung, H.Y.4    Kim, N.D.5    Kim, K.W.6
  • 51
    • 71549136449 scopus 로고    scopus 로고
    • Adrenomedullin protects against hypoxia/reoxygenation-induced cell death by suppression of reactive oxygen species via thiol redox systems
    • Kim SM, Kim JY, Lee S, Park JH. Adrenomedullin protects against hypoxia/reoxygenation-induced cell death by suppression of reactive oxygen species via thiol redox systems. FEBS Lett 584:213-8.
    • FEBS Lett , vol.584 , pp. 213-218
    • Kim, S.M.1    Kim, J.Y.2    Lee, S.3    Park, J.H.4
  • 52
  • 53
    • 34547610957 scopus 로고    scopus 로고
    • UPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells
    • DOI 10.1083/jcb.200701092
    • Lester RD, Jo M, Montel V, Takimoto S, Gonias SL. uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol 2007; 178:425-36. (Pubitemid 47196151)
    • (2007) Journal of Cell Biology , vol.178 , Issue.3 , pp. 425-436
    • Lester, R.D.1    Jo, M.2    Montel, V.3    Takimoto, S.4    Gonias, S.L.5
  • 55
    • 33644747418 scopus 로고    scopus 로고
    • HIF-2alpha regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development and tumor growth
    • Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, et al. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development and tumor growth. Genes Dev 2006; 20:557-70.
    • (2006) Genes Dev , vol.20 , pp. 557-570
    • Covello, K.L.1    Kehler, J.2    Yu, H.3    Gordan, J.D.4    Arsham, A.M.5    Hu, C.J.6
  • 56
    • 78149243774 scopus 로고    scopus 로고
    • Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation
    • Louie E, Nik S, Chen JS, Schmidt M, Song B, Pacson C, et al. Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation. Breast Cancer Res 12:94.
    • Breast Cancer Res , vol.12 , pp. 94
    • Louie, E.1    Nik, S.2    Chen, J.S.3    Schmidt, M.4    Song, B.5    Pacson, C.6
  • 58
    • 77954177298 scopus 로고    scopus 로고
    • Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: Contribution of the pentose phosphate pathway to this stabilization
    • Osada-Oka M, Hashiba Y, Akiba S, Imaoka S, Sato T. Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization. FEBS Lett 584:3073-9.
    • FEBS Lett , vol.584 , pp. 3073-3079
    • Osada-Oka, M.1    Hashiba, Y.2    Akiba, S.3    Imaoka, S.4    Sato, T.5
  • 59
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    • Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 2001; 276:9519-25.
    • (2001) J Biol Chem , vol.276 , pp. 9519-9525
    • Chen, C.1    Pore, N.2    Behrooz, A.3    Ismail-Beigi, F.4    Maity, A.5
  • 60
    • 0033975258 scopus 로고    scopus 로고
    • Effects of gestational hypoxia on mRNA levels of Glut3 and Glut4 transporters, hypoxia inducible factor-1 and thyroid hormone receptors in developing rat brain
    • Royer C, Lachuer J, Crouzoulon G, Roux J, Peyronnet J, Mamet J, et al. Effects of gestational hypoxia on mRNA levels of Glut3 and Glut4 transporters, hypoxia inducible factor-1 and thyroid hormone receptors in developing rat brain. Brain Res 2000; 856:119-28.
    • (2000) Brain Res , vol.856 , pp. 119-128
    • Royer, C.1    Lachuer, J.2    Crouzoulon, G.3    Roux, J.4    Peyronnet, J.5    Mamet, J.6
  • 61
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1 and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, et al. Hypoxia response elements in the aldolase A, enolase 1 and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996; 271:32529-37.
    • (1996) J Biol Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6
  • 62
    • 34249863298 scopus 로고    scopus 로고
    • Autophagy suppresses tumor progression by limiting chromosomal instability
    • Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007; 21:1367-81.
    • (2007) Genes Dev , vol.21 , pp. 1367-1381
    • Mathew, R.1    Kongara, S.2    Beaudoin, B.3    Karp, C.M.4    Bray, K.5    Degenhardt, K.6
  • 63
    • 41449109334 scopus 로고    scopus 로고
    • Induction of autophagy during extracellular matrix detachment promotes cell survival
    • Fung C, Lock R, Gao S, Salas E, Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell 2008; 19:797-806.
    • (2008) Mol Biol Cell , vol.19 , pp. 797-806
    • Fung, C.1    Lock, R.2    Gao, S.3    Salas, E.4    Debnath, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.