메뉴 건너뛰기




Volumn 2, Issue 12, 2011, Pages 1191-1202

Genome-wide analysis discloses reversal of the hypoxiainduced changes of gene expression in colon cancer cells by zinc supplementation

Author keywords

CDNA microarray; Cobalt; Colon cancer; Hypoxia; Pathway analysis; Principal component analysis (PCA)

Indexed keywords

ANTINEOPLASTIC AGENT; COBALT; DOXORUBICIN; HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; ZINC;

EID: 84863008531     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.395     Document Type: Article
Times cited : (29)

References (51)
  • 1
    • 0029051439 scopus 로고
    • Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995; 92:5510-5514.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 4
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin WG, Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008; 30:393-402.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 6
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003; 3:721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 7
    • 77950922592 scopus 로고    scopus 로고
    • Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy
    • McCarty MF, Barroso-Aranda J, Contreras F. Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy. Med Hypotheses. 2010; 74:789-797.
    • (2010) Med Hypotheses , vol.74 , pp. 789-797
    • McCarty, M.F.1    Barroso-Aranda, J.2    Contreras, F.3
  • 8
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene. 2010; 29:625-634.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 12
    • 49849084552 scopus 로고    scopus 로고
    • Requirement of hypoxia-inducible factor-1alpha downregulation in mediating the antitumor activity of the antiepidermal growth factor receptor monoclonal antibody cetuximab
    • Li X, Lu Y, Liang K, Pan T, Mendelsohn J, Fan Z. Requirement of hypoxia-inducible factor-1alpha downregulation in mediating the antitumor activity of the antiepidermal growth factor receptor monoclonal antibody cetuximab. Mol Cancer Ther. 2008; 7:1207-1217.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1207-1217
    • Li, X.1    Lu, Y.2    Liang, K.3    Pan, T.4    Mendelsohn, J.5    Fan, Z.6
  • 13
    • 0035696301 scopus 로고    scopus 로고
    • Functions of zinc in signaling, proliferation and differentiation of mammalian cells
    • Beyersmann D, Haase H. Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals. 2001; 14:331-341.
    • (2001) Biometals , vol.14 , pp. 331-341
    • Beyersmann, D.1    Haase, H.2
  • 16
    • 7944222171 scopus 로고    scopus 로고
    • Zinc deficiency DNA damage and cancer risk
    • Ho E. Zinc deficiency, DNA damage and cancer risk. J Nutr Biochem. 2004; 15:572-578.
    • (2004) J Nutr Biochem , vol.15 , pp. 572-578
    • Ho, E.1
  • 17
    • 69949108875 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha
    • Nardinocchi L, Puca R, Sacchi A, Rechavi G, Givol D, D'Orazi G. Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha. PLoS ONE. 2009; 4:6819.
    • (2009) PLoS ONE , vol.4 , pp. 6819
    • Nardinocchi, L.1    Puca, R.2    Sacchi, A.3    Rechavi, G.4    Givol, D.5    D'Orazi, G.6
  • 21
    • 33744954065 scopus 로고    scopus 로고
    • Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways
    • Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussis J, Gleadle JM. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J Biol Chem. 2006; 281:15215-15226.
    • (2006) J Biol Chem , vol.281 , pp. 15215-15226
    • Elvidge, G.P.1    Glenny, L.2    Appelhoff, R.J.3    Ratcliffe, P.J.4    Ragoussis, J.5    Gleadle, J.M.6
  • 22
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia--a key regulatory factor in tumour growth
    • Harris AL. Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer. 2002; 2:38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 24
    • 0141890293 scopus 로고    scopus 로고
    • The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia
    • Leonard MO, Cottell DC, Godson C, Brady HR, Taylor CT. The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia. J Biol Chem. 2003; 278:40296-40304.
    • (2003) J Biol Chem , vol.278 , pp. 40296-40304
    • Leonard, M.O.1    Cottell, D.C.2    Godson, C.3    Brady, H.R.4    Taylor, C.T.5
  • 26
    • 33646765735 scopus 로고    scopus 로고
    • Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes
    • Mense SM, Sengupta A, Zhou M, Lan C, Bentsman G, Volsky DJ, Zhang L. Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiol Genomics. 2006; 25:435-449
    • (2006) Physiol Genomics , vol.25 , pp. 435-449
    • Mense, S.M.1    Sengupta, A.2    Zhou, M.3    Lan, C.4    Bentsman, G.5    Volsky, D.J.6    Zhang, L.7
  • 28
    • 26944465042 scopus 로고    scopus 로고
    • Array-based comparative gene expression analysis of tumor cells with increased apoptosis resistance after hypoxic selection
    • Weinmann M, Belka C, Güner D, Goecke B, Müller I, Bamberg M, Jendrossek V. Array-based comparative gene expression analysis of tumor cells with increased apoptosis resistance after hypoxic selection. Oncogene. 2005; 24:5914-5922.
    • (2005) Oncogene , vol.24 , pp. 5914-5922
    • Weinmann, M.1    Belka, C.2    Güner, D.3    Goecke, B.4    Müller, I.5    Bamberg, M.6    Jendrossek, V.7
  • 30
    • 25144472027 scopus 로고    scopus 로고
    • Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells
    • Vengellur A, Phillips JM, Hogenesch JB, LaPres JJ. Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells. Physiol Genomics. 2005; 22:308-318.
    • (2005) Physiol Genomics , vol.22 , pp. 308-318
    • Vengellur, A.1    Phillips, J.M.2    Hogenesch, J.B.3    LaPres, J.J.4
  • 31
    • 0345170089 scopus 로고    scopus 로고
    • Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts
    • Vengellur A, Woods BG, Ryan HE, Johnson RS, LaPres JJ. Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. Gene Expr. 2003; 11:181-197.
    • (2003) Gene Expr , vol.11 , pp. 181-197
    • Vengellur, A.1    Woods, B.G.2    Ryan, H.E.3    Johnson, R.S.4    LaPres, J.J.5
  • 32
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
    • Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouysségur J, Mazure NM. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol. 2009; 29:2570-2581.
    • (2009) Mol Cell Biol , vol.29 , pp. 2570-2581
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5    Pouysségur, J.6    Mazure, N.M.7
  • 33
    • 62749124795 scopus 로고    scopus 로고
    • Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9 A one transcription factor (HIF-1) show?
    • Kaluz S, Kaluzova M, Liao SY, Lerman M, Stanbridge EJ. Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show? Biochim Biophys Acta. 2009; 1795:162-172.
    • (2009) Biochim Biophys Acta , vol.1795 , pp. 162-172
    • Kaluz, S.1    Kaluzova, M.2    Liao, S.Y.3    Lerman, M.4    Stanbridge, E.J.5
  • 34
    • 0029820166 scopus 로고    scopus 로고
    • Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database
    • Allikmets R, Gerrard B, Hutchinson A, Dean M. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum Mol Genet. 1996; 5:1649-1655.
    • (1996) Hum Mol Genet , vol.5 , pp. 1649-1655
    • Allikmets, R.1    Gerrard, B.2    Hutchinson, A.3    Dean, M.4
  • 35
    • 69049111041 scopus 로고    scopus 로고
    • An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia
    • Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res. 2009; 37:4587-4602.
    • (2009) Nucleic Acids Res , vol.37 , pp. 4587-4602
    • Benita, Y.1    Kikuchi, H.2    Smith, A.D.3    Zhang, M.Q.4    Chung, D.C.5    Xavier, R.J.6
  • 36
    • 41949130508 scopus 로고    scopus 로고
    • Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1
    • Choi DW, Seo YM, Kim EA, Sung KS, Ahn JW, Park SJ, Lee SR, Choi CY. Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. J Biol Chem. 2008; 283:4682-4689.
    • (2008) J Biol Chem , vol.283 , pp. 4682-4689
    • Choi, D.W.1    Seo, Y.M.2    Kim, E.A.3    Sung, K.S.4    Ahn, J.W.5    Park, S.J.6    Lee, S.R.7    Choi, C.Y.8
  • 38
    • 58149354210 scopus 로고    scopus 로고
    • An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response
    • Calzado MA, de la Vega L, Moller A, Bowtell DD, Schmitz ML. An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nature Cell Biol. 2009; 11:85-91.
    • (2009) Nature Cell Biol , vol.11 , pp. 85-91
    • Calzado, M.A.1    de la Vega, L.2    Moller, A.3    Bowtell, D.D.4    Schmitz, M.L.5
  • 40
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer. 2008; 8:851-864.
    • (2008) Nat Rev Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 41
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 2004; 11:891-899.
    • (2004) Nat Rev Cancer , vol.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 42
    • 33749478922 scopus 로고    scopus 로고
    • Cancer's molecular sweet tooth and the Warburg effect
    • Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 2006; 66:8927-8930.
    • (2006) Cancer Res , vol.66 , pp. 8927-8930
    • Kim, J.W.1    Dang, C.V.2
  • 43
    • 34147172349 scopus 로고    scopus 로고
    • HIF-1-regulated glucose metabolism A key to apoptosis resistance?
    • Fulds S, Debatin K-M. HIF-1-regulated glucose metabolism. A key to apoptosis resistance? Cell Cycle. 2007; 6:790-792.
    • (2007) Cell Cycle , vol.6 , pp. 790-792
    • Fulds, S.1    Debatin, K.-M.2
  • 44
    • 77953184918 scopus 로고    scopus 로고
    • HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
    • Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengsrtner MO. HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature. 2010; 465:577-583.
    • (2010) Nature , vol.465 , pp. 577-583
    • Sendoel, A.1    Kohler, I.2    Fellmann, C.3    Lowe, S.W.4    Hengsrtner, M.O.5
  • 45
    • 79958289721 scopus 로고    scopus 로고
    • HIF-1a antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
    • Nardinocchi L, Puca R, D'Orazi G. HIF-1a antagonizes p53-mediated apoptosis by triggering HIPK2 degradation. Aging (Albany NY). 2011; 3:33-43.
    • (2011) Aging (Albany NY) , vol.3 , pp. 33-43
    • Nardinocchi, L.1    Puca, R.2    D'Orazi, G.3
  • 47
    • 77957148038 scopus 로고    scopus 로고
    • Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/ p53 apoptotic signaling in cancer cells
    • Nardinocchi L, Puca R, Givol D, D'Orazi G. Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/ p53 apoptotic signaling in cancer cells. FEBS Lett. 2010; 584:4253-4258.
    • (2010) FEBS Lett , vol.584 , pp. 4253-4258
    • Nardinocchi, L.1    Puca, R.2    Givol, D.3    D'Orazi, G.4
  • 48
    • 85039674862 scopus 로고    scopus 로고
    • Affymetrix. Guide to probe logarithmic intensity error (PLIER) estimation. available at
    • Affymetrix. Guide to probe logarithmic intensity error (PLIER) estimation. available at http://www.affymetrix.com/support/technical/technotes/plier_technote.pdf. 2005.
    • (2005)
  • 49
  • 50
    • 77954871394 scopus 로고    scopus 로고
    • Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes
    • Zeisel A, Amir A, Kostler WJ, Domany E. Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes. BMC Bioinformatics. 2010; 11:400-407.
    • (2010) BMC Bioinformatics , vol.11 , pp. 400-407
    • Zeisel, A.1    Amir, A.2    Kostler, W.J.3    Domany, E.4
  • 51
    • 19544387813 scopus 로고    scopus 로고
    • Sorting points into neighborhoods (SPIN): data analysis and visualization by ordering distance matrices
    • Tsafrir D, Tsafrir I, Ein-Dor L, Zuk O, Notterman DA, Domany E. Sorting points into neighborhoods (SPIN): data analysis and visualization by ordering distance matrices. Bioinformatics. 2005; 21:2301-2308.
    • (2005) Bioinformatics , vol.21 , pp. 2301-2308
    • Tsafrir, D.1    Tsafrir, I.2    Ein-Dor, L.3    Zuk, O.4    Notterman, D.A.5    Domany, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.