Specific disintegration of complex II succinate:Ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction

Cell Death and Differentiation

Volumn 18, Issue 2, 2011, Pages 338-349

  Lemarie, A ^a,b   Huc, L ^a   Pazarentzos, E ^a   Mahul Mellier, A L ^a   Grimm, S ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b INSERM   (France)

Author keywords

apoptosis; complex II; mitochondria; respiratory chain; ROS

Indexed keywords

CISPLATIN; DOXORUBICIN; ETOPOSIDE; FAS LIGAND; MENADIONE; PROTEIN SUBUNIT; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE A; SUCCINATE DEHYDROGENASE B; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PH; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION;

APOPTOSIS; ELECTRON TRANSPORT COMPLEX II; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SUCCINATE DEHYDROGENASE; THENOYLTRIFLUOROACETONE;

EID: 78651282654     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.93     Document Type: Article

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