The p63 target HBP1 is required for skin differentiation and stratification

Cell Death and Differentiation

Volumn 17, Issue 12, 2010, Pages 1896-1907

  Borrelli, S ^a   Candi, E ^b   Hu, B ^c   Dolfini, D ^a   Ravo, M ^d   Grober, O M V ^d   Weisz, A ^d,e   Dotto, G P ^c   Melino, G ^b,f   Vigano M A ^a   Mantovani, R ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

^e CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^f UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

HBP1; keratinocytes; p63

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; MESSENGER RNA; PROTEIN P63; PROTEINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE REPRESSION; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SKIN CELL;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION PROFILING; HIGH MOBILITY GROUP PROTEINS; HUMANS; KERATINOCYTES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PHOSPHOPROTEINS; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SKIN; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

MUS;

EID: 78349313142     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.59     Document Type: Article

References (49)

1. Aylon Y, Oren M. Living with p53, dying of p53. Cell 2007; 130: 597-600.
2. McKeon F. p63 and the epithelial stem cell: more than status quo? Genes Dev 2004; 18: 465-469.
3. Rinne T, Hamel B, van Bokhoven H, Brunner HG. Pattern of p63 mutations and their phenotypes-update. Am J Med Genet A 2006; 140: 1396-1406.
4. 1 regulation and tumor suppression. Gene 2004; 336: 1-13.
5. Yao CJ, Works K, Romagnoli PA, Austin GE. Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells. Leukemia 2005; 19: 1958-1968.
6. Zhang X, Kim J, Ruthazer R, McDevitt MA, Wazer DE, Paulson KE et al. The HBP1 transcriptional repressor participates in RAS-induced premature senescence. Mol Cell Biol 2006; 26: 8252-8266.
7. Paulson KE, Rieger-Christ K, McDevitt MA, Kuperwasser C, Kim J, Unanue VE et al. Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer. Cancer Res 2007; 67: 6136-6145.
8. Chikh A, Sayan E, Thibaut S, Lena AM, DiGiorgi S, Bernard BA et al. Expression of GATA-3 in epidermis and hair follicle: relationship to p63. Biochem Biophys Res Commun 2007; 361: 1-6.
9. Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A et al. Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ 2006; 13: 1037-1047.
10. Viganò MA, Mantovani R. Hitting the numbers: the emerging network of p63 targets. Cell Cycle 2007; 6: 233-239.
11. Richardson RJ, Dixon J, Malhotra S, Hardman MJ, Knowles L, Boot-Handford RP et al. Irf6 is a key determinant of the keratinocyte proliferation differentiation switch. Nat Genet 2006; 38: 1329-1334.
12. Barbaro V, Testa A, Di Iorio E, Mavilio F, Pellegrini G, De Luca M. C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells. J Cell Biol 2007; 177: 1037-1049.
13. Borrelli S, Testoni B, Callari M, Alotto D, Castagnoli C, Romano R-A et al. Reciprocal regulation of p63 by C/EBPdelta in human keratinocytes. BMC Mol Biol 2007; 8: 85.
14. Koizumi H, Kartasova T, Tanaka H, Ohkawara A, Kuroki T. Differentiation-associated localization of small proline-rich protein in normal and diseased human skin. Br J Dermatol 1996; 134: 686-692.
15. Mägert HJ, Kreutzmann P, Drögemüller K, Ständker L, Adermann K, Walden M et al. The 15-domain serine proteinase inhibitor LEKTI: biochemical properties, genomic organization, and pathophysiological role. Eur J Med Res 2002; 7: 49-56.
16. Yang T, Liang D, Koch PJ, Hohl D, Kheradmand F, Overbeek PA. Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. Genes Dev 2004; 18: 2354-2358.
17. Leong J, Hughes-Fulford M, Rakhlin N, Habib A, Maclouf J, Goldyne ME. Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation. Exp Cell Res 1996; 224: 79-87.
18. Qin H, Wang J, Liang Y, Taniguchi Y, Tanigaki K, Han H. RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2. Nucleic Acids Res 2004; 32: 1492-1501.
19. Grossi M, Hiou-Feige A, Tommasi Di Vignano A, Calautti E, Ostano P et al. Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression. Proc Natl Acad Sci USA 2005; 102: 11313-11318.
20. Nguyen BC, Lefort K, Mandinova A, Antonini D, Devgan V, Della Gatta G et al. Crossregulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev 2006; 20: 1028-1042.
21. Pearton DJ, Nirunsuksiri W, Rehemtulla A, Lewis SP, Presland RB, Dale BA. Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates. Exp Dermatol 2001; 10: 193-203.
22. Emami N, Diamandis EP. Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin. J Biol Chem 2008; 283: 3031-3041.
23. Cassidy AJ, van Steensel MA, Steijlen PM, van Geel M, van der Velden J, Morley SM et al. A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am J Hum Genet 2005; 77: 909-917.
24. Hohenester E. Structural insight into Slit-Robo signalling. Biochem Soc Trans 2008; 36: 251-256.
25. Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT et al. Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development 2008; 135: 2161-2172.
26. Yang L, Yamasaki K, Shirakata Y, Dai X, Tokumaru S, Yahata Y et al. Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes. J Dermatol Sci 2006; 42: 111-119.
27. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell 2004; 7: 525-534.
28. Neufang G, Furstenberger G, Heidt M, Marks F, Muller-Decker K. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Proc Natl Acad Sci USA 2001; 98: 7629-7634.
29. Grose R, Harris BS, Cooper L, Topilko P, Martin P. Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse. Dev Dyn 2002; 223: 371-378.
30. Longworth MS, Wilson R, Laimins LA. HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs. EMBO J 2005; 24: 1821-1830.
31. Rotzer D, Krampert M, Sulyok S, Braun S, Stark HJ, Boukamp P et al. Id proteins: novel targets of activin action, which regulate epidermal homeostasis. Oncogene 2006; 25: 2070-2081.
32. Stelnicki EJ, Kömüves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S et al. HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development. J Invest Dermatol 1998; 110: 110-115.
33. Ford R, Wang G, Jannati P, Adler D, Racanelli P, Higgins PJ et al. Modulation of SPARC expression during butyrate-induced terminal differentiation of cultured human keratinocytes: regulation via a TGF-beta-dependent pathway. Exp Cell Res 1993; 206: 261-275.
34. Szepietowski JC, Reich A, McKenzie RC. The multifunctional role of leukaemia inhibitory factor in cutaneous biology. Acta Dermatovenerol Alp Panonica Adriat 2004; 13: 125-129.
35. Choi SY, Shin HC, Kim SY, Park YW. Role of TMPRSS4 during cancer progression. Drug News Perspect 2008; 21: 417-423.
36. Zhang H, Zhang Y, Duan HO, Kirley SD, Lin SX, McDougal WS et al. TIP30 is associated with progression and metastasis of prostate cancer. Int J Cancer 2008; 123: 810-816.
37. Jenkins TD, Opitz OG, Okano J, Rustgi AK. Transactivation of the human keratin 4 and Epstein-Barr virus ED-L2 promoters by gut-enriched Krüppel-like factor. J Biol Chem 1998; 273: 10747-10754.
38. Tanioka M, Miyagawa-Hayashino A, Manabe T, Toichi E, Miyachi Y, Takahashi K. Circumscribed palmo-plantar hypokeratosis: a disease with two subtypes. J Invest Dermatol 2009; 129: 1045-1047.
39. Martinsson H, Yhr M, Enerbäck C. Expression patterns of S100A7 (psoriasin) and S100A9 (calgranulin-B) in keratinocyte differentiation. Exp Dermatol 2005; 14: 161-168.
40. Eckert RL, Sturniolo MT, Jans R, Kraft CA, Jiang H, Rorke EA. TIG3: a regulator of type I transglutaminase activity in epidermis. Amino Acids 2009; 36: 739-746.
41. Yu AS, Enck AH, Lencer WI, Schneeberger EE. Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. J Biol Chem 2003; 278: 17350-17359.
42. Bommer GT, Jäger C, Dürr EM, Baehs S, Eichhorst ST, Brabletz T et al. DRO1, a gene downregulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. J Biol Chem 2005; 280: 7962-7975.
43. Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008; 134: 451-460.
44. Chau BN, Diaz RL, Saunders MA, Cheng C, Chang AN, Warrener P et al. Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses. Cancer Res 2009; 69: 1368-1374.
45. Vogler R, Sauer B, Kim DS, Schäfer-Korting M, Kleuser B. Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. J Invest Dermatol 2003; 120: 693-700.
46. Gartel AL, Goufman E, Tevosian SG, Shih H, Yee AS, Tyner AL. Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins. Oncogene 1998; 17: 3463-3469.
47. Maurelli R, Zambruno G, Guerra L, Abbruzzese C, Dimri G, Gellini M et al. Inactivation of p16INK4a (inhibitor of cyclin-dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment. FASEB J 2006; 20: 1516-1518.
48. Su X, Cho MS, Gi YJ, Ayanga BA, Sherr CJ, Flores ER. Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBOJ 2009; 28: 1904-1915.
49. Ogata A, Shimizu T, Abe R, Shimizu H, Sakai M. Expression of c-maf and mafB genes in the skin during rat embryonic development. Acta Histochem 2004; 106: 65-67.