메뉴 건너뛰기




Volumn 2, Issue JAN, 2012, Pages

Current knowledge on pancreatic cancer

Author keywords

Cancer; Chemoprevention; Neoadjuvants; Oncogenes; Pancreas; Signaling; Suppressor genes; Surgery

Indexed keywords

AXITINIB; BEVACIZUMAB; CAPECITABINE; CHEMOKINE RECEPTOR CXCR4; CHOLECYSTOKININ RECEPTOR; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; ERLOTINIB; FOCAL ADHESION KINASE; GEMCITABINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE B; PROTEIN P53; SMAD2 PROTEIN; SMAD3 PROTEIN; SOMATOMEDIN C; SONIC HEDGEHOG PROTEIN; SORAFENIB; TELOMERASE; TERTOMOTIDE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; WNT PROTEIN;

EID: 84871209416     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2012.00006     Document Type: Review
Times cited : (64)

References (222)
  • 1
    • 33645294370 scopus 로고    scopus 로고
    • 3,3'-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5
    • Abdelrahim, M., Newman, K., Vanderlaag, K., Samudio, I., and Safe, S. (2006). 3,3'-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis 27, 717-728.
    • (2006) Carcinogenesis , vol.27 , pp. 717-728
    • Abdelrahim, M.1    Newman, K.2    Vanderlaag, K.3    Samudio, I.4    Safe, S.5
  • 3
    • 0035152551 scopus 로고    scopus 로고
    • Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: frequent alterations in the APC/β-catenin pathway and chromosome 11p
    • Abraham, S. C., Wu, T. T., Klimstra, D. S., Finn, L. S., Lee, J. H., Yeo, C. J., Cameron, J. L., and Hruban, R. H. (2001). Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: frequent alterations in the APC/β-catenin pathway and chromosome 11p. Am. J. Pathol. 159, 1619-1627.
    • (2001) Am. J. Pathol. , vol.159 , pp. 1619-1627
    • Abraham, S.C.1    Wu, T.T.2    Klimstra, D.S.3    Finn, L.S.4    Lee, J.H.5    Yeo, C.J.6    Cameron, J.L.7    Hruban, R.H.8
  • 4
    • 0000216411 scopus 로고
    • A relationship between cancer of stomach and the ABO blood groups
    • Aird, I., Bentall, H. H., and Roberts, J. A. (1953). A relationship between cancer of stomach and the ABO blood groups. Br. Med. J. 1, 799-801.
    • (1953) Br. Med. J. , vol.1 , pp. 799-801
    • Aird, I.1    Bentall, H.H.2    Roberts, J.A.3
  • 5
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera, C., Shibata, D., Forrester, K., Martin, J., Arnheim, N., and Perucho, M. (1988). Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53, 549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3    Martin, J.4    Arnheim, N.5    Perucho, M.6
  • 7
    • 0142072036 scopus 로고    scopus 로고
    • Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma
    • Andea, A., Sarkar, F., and Adsay, V. N. (2003). Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod. Pathol. 16, 996-1006.
    • (2003) Mod. Pathol. , vol.16 , pp. 996-1006
    • Andea, A.1    Sarkar, F.2    Adsay, V.N.3
  • 9
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells
    • Asano, T., Yao, Y., Zhu, J., Li, D., Abbruzzese, J. L., and Reddy, S. A. (2004). The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells. Oncogene 23, 8571-8580.
    • (2004) Oncogene , vol.23 , pp. 8571-8580
    • Asano, T.1    Yao, Y.2    Zhu, J.3    Li, D.4    Abbruzzese, J.L.5    Reddy, S.A.6
  • 10
    • 35648979450 scopus 로고    scopus 로고
    • Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice
    • Baker, C. H., Trevino, J. G., Summy, J. M., Zhang, F., Caron, A., Nesbit, M., Gallick, G. E., and Fidler, I. J. (2006). Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice. Int. J. Oncol. 29, 125-138.
    • (2006) Int. J. Oncol. , vol.29 , pp. 125-138
    • Baker, C.H.1    Trevino, J.G.2    Summy, J.M.3    Zhang, F.4    Caron, A.5    Nesbit, M.6    Gallick, G.E.7    Fidler, I.J.8
  • 11
    • 25444493107 scopus 로고    scopus 로고
    • Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer
    • Banerjee, S., Zhang, Y., Ali, S., Bhuiyan, M., Wang, Z., Chiao, P. J., Philip, P. A., Abbruzzese, J., and Sarkar, F. H. (2005). Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res. 65, 9064-9072.
    • (2005) Cancer Res. , vol.65 , pp. 9064-9072
    • Banerjee, S.1    Zhang, Y.2    Ali, S.3    Bhuiyan, M.4    Wang, Z.5    Chiao, P.J.6    Philip, P.A.7    Abbruzzese, J.8    Sarkar, F.H.9
  • 12
    • 33750083369 scopus 로고    scopus 로고
    • Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene
    • Banville, N., Geraghty, R., Fox, E., Leahy, D. T., Green, A., Keegan, D., Geoghegan, J., O'Donoghue, D., Hyland, J., and Sheahan, K. (2006). Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene. Hum. Pathol. 37, 1498-1502.
    • (2006) Hum. Pathol. , vol.37 , pp. 1498-1502
    • Banville, N.1    Geraghty, R.2    Fox, E.3    Leahy, D.T.4    Green, A.5    Keegan, D.6    Geoghegan, J.7    O'Donoghue, D.8    Hyland, J.9    Sheahan, K.10
  • 13
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • Bardeesy, N., and DePinho, R. A. (2002). Pancreatic cancer biology and genetics. Nat. Rev. Cancer 2, 897-909.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    DePinho, R.A.2
  • 15
    • 0036532026 scopus 로고    scopus 로고
    • Histone modifications in transcriptional regulation
    • Berger, S. L. (2002). Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev. 12, 142-148.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 142-148
    • Berger, S.L.1
  • 16
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • Berlin, J. D., Catalano, P., Thomas, J. P., Kugler, J. W., Haller, D. G., and Benson, A. B. III. (2002). Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J. Clin. Oncol. 20, 3270-3275.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson III, A.B.6
  • 18
    • 33845247353 scopus 로고    scopus 로고
    • Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study
    • Bernhardt, S. L., Gjertsen, M. K., Trachsel, S., Moller, M., Eriksen, J. A., Meo, M., Buanes, T., and Gaudernack, G. (2006). Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study. Br. J. Cancer 95, 1474-1482.
    • (2006) Br. J. Cancer , vol.95 , pp. 1474-1482
    • Bernhardt, S.L.1    Gjertsen, M.K.2    Trachsel, S.3    Moller, M.4    Eriksen, J.A.5    Meo, M.6    Buanes, T.7    Gaudernack, G.8
  • 20
    • 23844490779 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line
    • Biliran, H. Jr., Wang, Y., Banerjee, S., Xu, H., Heng, H., Thakur, A., Bollig, A., Sarkar, F. H., and Liao, J. D. (2005). Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line. Clin. Cancer Res. 11, 6075-6086.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 6075-6086
    • Biliran Jr., H.1    Wang, Y.2    Banerjee, S.3    Xu, H.4    Heng, H.5    Thakur, A.6    Bollig, A.7    Sarkar, F.H.8    Liao, J.D.9
  • 21
    • 71449100603 scopus 로고    scopus 로고
    • Strategies for TGF-β modulation: a review of recent patents
    • Bonafoux, D., and Lee, W. C. (2009). Strategies for TGF-β modulation: a review of recent patents. Expert Opin. Ther. Pat. 19, 1759-1769.
    • (2009) Expert Opin. Ther. Pat. , vol.19 , pp. 1759-1769
    • Bonafoux, D.1    Lee, W.C.2
  • 22
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial
    • Bramhall, S. R., Rosemurgy, A., Brown, P. D., Bowry, C., and Buckels, J. A. (2001). Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J. Clin. Oncol. 19, 3447-3455.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3    Bowry, C.4    Buckels, J.A.5
  • 23
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall, S. R., Schulz, J., Nemunaitis, J., Brown, P. D., Baillet, M., and Buckels, J. A. (2002). A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br. J. Cancer 87, 161-167.
    • (2002) Br. J. Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 24
    • 0031891450 scopus 로고    scopus 로고
    • Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas
    • Brat, D. J., Lillemoe, K. D., Yeo, C. J., Warfield, P. B., and Hruban, R. H. (1998). Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas. Am. J. Surg. Pathol. 22, 163-169.
    • (1998) Am. J. Surg. Pathol. , vol.22 , pp. 163-169
    • Brat, D.J.1    Lillemoe, K.D.2    Yeo, C.J.3    Warfield, P.B.4    Hruban, R.H.5
  • 25
    • 0032176282 scopus 로고    scopus 로고
    • Progression of atypical ductal hyperplasia/carcinoma in situ of the pancreas to invasive adenocarcinoma
    • Brockie, E., Anand, A., and Albores-Saavedra, J. (1998). Progression of atypical ductal hyperplasia/carcinoma in situ of the pancreas to invasive adenocarcinoma. Ann. Diagn. Pathol. 2, 286-292.
    • (1998) Ann. Diagn. Pathol. , vol.2 , pp. 286-292
    • Brockie, E.1    Anand, A.2    Albores-Saavedra, J.3
  • 26
    • 37249071337 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cell
    • Bruserud, O., Stapnes, C., Ersvaer, E., Gjertsen, B. T., and Ryningen, A. (2007). Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cell. Curr. Pharm. Biotechnol. 8, 388-400.
    • (2007) Curr. Pharm. Biotechnol. , vol.8 , pp. 388-400
    • Bruserud, O.1    Stapnes, C.2    Ersvaer, E.3    Gjertsen, B.T.4    Ryningen, A.5
  • 33
    • 50849115450 scopus 로고    scopus 로고
    • Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study
    • Chauffert, B., Mornex, F., Bonnetain, F., Rougier, P., Mariette, C., Bouche, O., Bosset, J. F., Aparicio, T., Mineur, L., Azzedine, A., Hammel, P., Butel, J., Stremsdoerfer, N., Maingon, P., and Bedenne, L. (2008). Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study. Ann. Oncol. 19, 1592-1599.
    • (2008) Ann. Oncol. , vol.19 , pp. 1592-1599
    • Chauffert, B.1    Mornex, F.2    Bonnetain, F.3    Rougier, P.4    Mariette, C.5    Bouche, O.6    Bosset, J.F.7    Aparicio, T.8    Mineur, L.9    Azzedine, A.10    Hammel, P.11    Butel, J.12    Stremsdoerfer, N.13    Maingon, P.14    Bedenne, L.15
  • 34
    • 0037083621 scopus 로고    scopus 로고
    • Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale
    • Colucci, G., Giuliani, F., Gebbia, V., Biglietto, M., Rabitti, P., Uomo, G., Cigolari, S., Testa, A., Maiello, E., and Lopez, M. (2002). Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale. Cancer 94, 902-910.
    • (2002) Cancer , vol.94 , pp. 902-910
    • Colucci, G.1    Giuliani, F.2    Gebbia, V.3    Biglietto, M.4    Rabitti, P.5    Uomo, G.6    Cigolari, S.7    Testa, A.8    Maiello, E.9    Lopez, M.10
  • 35
    • 77950498286 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study
    • Gruppo Oncologico Italia Meridionale (GOIM), Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente (GISCAD), and Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC)
    • Colucci, G., Labianca, R., Di Costanzo, F., Gebbia, V., Carteni, G., Massidda, B., Dapretto, E., Manzione, L., Piazza, E., Sannicolo, M., Ciaparrone, M., Cavanna, L., Giuliani, F., Maiello, E., Testa, A., Pederzoli, P., Falconi, M., Gallo, C., Di Maio, M., Perrone, F., Gruppo Oncologico Italia Meridionale (GOIM), Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente (GISCAD), and Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC). (2010). Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study. J. Clin. Oncol. 28, 1645-1651.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1645-1651
    • Colucci, G.1    Labianca, R.2    Di Costanzo, F.3    Gebbia, V.4    Carteni, G.5    Massidda, B.6    Dapretto, E.7    Manzione, L.8    Piazza, E.9    Sannicolo, M.10    Ciaparrone, M.11    Cavanna, L.12    Giuliani, F.13    Maiello, E.14    Testa, A.15    Pederzoli, P.16    Falconi, M.17    Gallo, C.18    Di Maio, M.19    Perrone, F.20    more..
  • 36
    • 0037246247 scopus 로고    scopus 로고
    • On the role of Hsp27 in regulating apoptosis
    • Concannon, C. G., Gorman, A. M., and Samali, A. (2003). On the role of Hsp27 in regulating apoptosis. Apoptosis 8, 61-70.
    • (2003) Apoptosis , vol.8 , pp. 61-70
    • Concannon, C.G.1    Gorman, A.M.2    Samali, A.3
  • 39
    • 0034536747 scopus 로고    scopus 로고
    • Predictors of pancreatic cancer mortality among a large cohort of United States adults
    • Coughlin, S. S., Calle, E. E., Patel, A. V., and Thun, M. J. (2000). Predictors of pancreatic cancer mortality among a large cohort of United States adults. Cancer Causes Control 11, 915-923.
    • (2000) Cancer Causes Control , vol.11 , pp. 915-923
    • Coughlin, S.S.1    Calle, E.E.2    Patel, A.V.3    Thun, M.J.4
  • 40
    • 0141724605 scopus 로고    scopus 로고
    • The genetics of pancreatic cancer
    • Cowgill, S. M., and Muscarella, P. (2003). The genetics of pancreatic cancer. Am. J. Surg. 186, 279-286.
    • (2003) Am. J. Surg. , vol.186 , pp. 279-286
    • Cowgill, S.M.1    Muscarella, P.2
  • 41
    • 0034045040 scopus 로고    scopus 로고
    • Histone deacetylases, transcriptional control, and cancer
    • Cress, W. D., and Seto, E. (2000). Histone deacetylases, transcriptional control, and cancer. J. Cell. Physiol. 184, 1-16.
    • (2000) J. Cell. Physiol. , vol.184 , pp. 1-16
    • Cress, W.D.1    Seto, E.2
  • 42
    • 0017156835 scopus 로고
    • Morphological lesions associated with human primary invasive nonendocrine pancreas cancer
    • Cubilla, A. L., and Fitzgerald, P. J. (1976). Morphological lesions associated with human primary invasive nonendocrine pancreas cancer. Cancer Res. 36, 2690-2698.
    • (1976) Cancer Res. , vol.36 , pp. 2690-2698
    • Cubilla, A.L.1    Fitzgerald, P.J.2
  • 45
    • 77952317079 scopus 로고    scopus 로고
    • Pooling-based genome-wide association study implicates γ-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis
    • Diergaarde, B., Brand, R., Lamb, J., Cheong, S. Y., Stello, K., Barmada, M. M., Feingold, E., and Whitcomb, D. C. (2010). Pooling-based genome-wide association study implicates γ-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis. Pancreatology 10, 194-200.
    • (2010) Pancreatology , vol.10 , pp. 194-200
    • Diergaarde, B.1    Brand, R.2    Lamb, J.3    Cheong, S.Y.4    Stello, K.5    Barmada, M.M.6    Feingold, E.7    Whitcomb, D.C.8
  • 46
    • 0036832620 scopus 로고    scopus 로고
    • Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells
    • Ding, X. Z., and Adrian, T. E. (2002). Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Pancreas 25, e71-e76.
    • (2002) Pancreas , vol.25
    • Ding, X.Z.1    Adrian, T.E.2
  • 48
    • 68549104124 scopus 로고    scopus 로고
    • Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases
    • Dong, J. T., and Chen, C. (2009). Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell. Mol. Life Sci. 66, 2691-2706.
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 2691-2706
    • Dong, J.T.1    Chen, C.2
  • 49
    • 33750497231 scopus 로고    scopus 로고
    • Evaluation of the 4q32-34 locus in European familial pancreatic cancer
    • German National Case Collection for Familial Pancreatic Cancer. European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer
    • Earl, J., Yan, L., Vitone, L. J., Risk, J., Kemp, S. J., McFaul, C., Neoptolemos, J. P., Greenhalf, W., European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer Kress, R., Sina-Frey, M., Hahn, S. A., Rieder, H., Bartsch, D. K., and German National Case Collection for Familial Pancreatic Cancer. (2006). Evaluation of the 4q32-34 locus in European familial pancreatic cancer. Cancer Epidemiol. Biomarkers Prev. 15, 1948-1955.
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 1948-1955
    • Earl, J.1    Yan, L.2    Vitone, L.J.3    Risk, J.4    Kemp, S.J.5    McFaul, C.6    Neoptolemos, J.P.7    Greenhalf, W.8    Kress, R.9    Sina-Frey, M.10    Hahn, S.A.11    Rieder, H.12    Bartsch, D.K.13
  • 50
    • 9444296055 scopus 로고    scopus 로고
    • Cyclooxygenase-2-dependent and-independent effects of celecoxib in pancreatic cancer cell lines
    • El-Rayes, B. F., Ali, S., Sarkar, F. H., and Philip, P. A. (2004). Cyclooxygenase-2-dependent and-independent effects of celecoxib in pancreatic cancer cell lines. Mol. Cancer Ther. 3, 1421-1426.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1421-1426
    • El-Rayes, B.F.1    Ali, S.2    Sarkar, F.H.3    Philip, P.A.4
  • 51
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller, M. (2008). Epigenetics in cancer. N. Engl. J. Med. 358, 1148-1159.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 52
    • 1842609941 scopus 로고    scopus 로고
    • Inhibition of AKT abrogates chemotherapy-induced NF-κB survival mechanisms: implications for therapy in pancreatic cancer
    • Fahy, B. N., Schlieman, M. G., Virudachalam, S., and Bold, R. J. (2004). Inhibition of AKT abrogates chemotherapy-induced NF-κB survival mechanisms: implications for therapy in pancreatic cancer. J. Am. Coll. Surg. 198, 591-599.
    • (2004) J. Am. Coll. Surg. , vol.198 , pp. 591-599
    • Fahy, B.N.1    Schlieman, M.G.2    Virudachalam, S.3    Bold, R.J.4
  • 53
    • 0042817910 scopus 로고    scopus 로고
    • Liver receptor homolog 1 controls the expression of carboxyl ester lipase
    • Fayard, E., Schoonjans, K., Annicotte, J. S., and Auwerx, J. (2003). Liver receptor homolog 1 controls the expression of carboxyl ester lipase. J. Biol. Chem. 278, 35725-35731.
    • (2003) J. Biol. Chem. , vol.278 , pp. 35725-35731
    • Fayard, E.1    Schoonjans, K.2    Annicotte, J.S.3    Auwerx, J.4
  • 54
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E. R., and Vogelstein, B. (1990). A genetic model for colorectal tumorigenesis. Cell 61, 759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 60
    • 34249915517 scopus 로고    scopus 로고
    • Molecular genetics of intraductal papillary-mucinous neoplasms of the pancreas
    • Furukawa, T. (2007). Molecular genetics of intraductal papillary-mucinous neoplasms of the pancreas. J. Hepatobiliary Pancreat. Surg. 14, 233-237.
    • (2007) J. Hepatobiliary Pancreat. Surg. , vol.14 , pp. 233-237
    • Furukawa, T.1
  • 61
    • 0028801180 scopus 로고
    • Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis
    • Furukawa, T., Duguid, W. P., Kobari, M., Matsuno, S., and Tsao, M. S. (1995). Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis. Am. J. Pathol. 147, 889-895.
    • (1995) Am. J. Pathol. , vol.147 , pp. 889-895
    • Furukawa, T.1    Duguid, W.P.2    Kobari, M.3    Matsuno, S.4    Tsao, M.S.5
  • 63
    • 0036636579 scopus 로고    scopus 로고
    • Nucleoside analogues and nucleobases in cancer treatment
    • Galmarini, C. M., Mackey, J. R., and Dumontet, C. (2002). Nucleoside analogues and nucleobases in cancer treatment. Lancet Oncol. 3, 415-424.
    • (2002) Lancet Oncol. , vol.3 , pp. 415-424
    • Galmarini, C.M.1    Mackey, J.R.2    Dumontet, C.3
  • 64
    • 26244452319 scopus 로고    scopus 로고
    • Molecular prognostic markers in pancreatic cancer: a systematic review
    • Garcea, G., Neal, C. P., Pattenden, C. J., Steward, W. P., and Berry, D. P. (2005). Molecular prognostic markers in pancreatic cancer: a systematic review. Eur. J. Cancer 41, 2213-2236.
    • (2005) Eur. J. Cancer , vol.41 , pp. 2213-2236
    • Garcea, G.1    Neal, C.P.2    Pattenden, C.J.3    Steward, W.P.4    Berry, D.P.5
  • 65
    • 4444229311 scopus 로고    scopus 로고
    • Conclusions from the European Study Group for Pancreatic Cancer adjuvant trial of chemoradiotherapy and chemotherapy for pancreatic cancer
    • Ghaneh, P., and Neoptolemos, J. P. (2004). Conclusions from the European Study Group for Pancreatic Cancer adjuvant trial of chemoradiotherapy and chemotherapy for pancreatic cancer. Surg. Oncol. Clin. N. Am. 13, 567-587.
    • (2004) Surg. Oncol. Clin. N. Am. , vol.13 , pp. 567-587
    • Ghaneh, P.1    Neoptolemos, J.P.2
  • 67
    • 77951709577 scopus 로고    scopus 로고
    • Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages
    • doi: 10.1371/journal.pmed.1000267
    • Gillen, S., Schuster, T., Meyer Zum Buschenfelde, C., Friess, H., and Kleeff, J. (2010). Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med. 7, e1000267. doi: 10.1371/journal.pmed.1000267
    • (2010) PLoS Med. , vol.7
    • Gillen, S.1    Schuster, T.2    Meyer Zum Buschenfelde, C.3    Friess, H.4    Kleeff, J.5
  • 69
    • 0042905956 scopus 로고    scopus 로고
    • Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines
    • Glaser, K. B., Staver, M. J., Waring, J. F., Stender, J., Ulrich, R. G., and Davidsen, S. K. (2003). Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. Mol. Cancer Ther. 2, 151-163.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 151-163
    • Glaser, K.B.1    Staver, M.J.2    Waring, J.F.3    Stender, J.4    Ulrich, R.G.5    Davidsen, S.K.6
  • 70
    • 17644430199 scopus 로고    scopus 로고
    • Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+
    • Goggins, M., Offerhaus, G. J., Hilgers, W., Griffin, C. A., Shekher, M., Tang, D., Sohn, T. A., Yeo, C. J., Kern, S. E., and Hruban, R. H. (1998a). Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am. J. Pathol. 152, 1501-1507.
    • (1998) Am. J. Pathol. , vol.152 , pp. 1501-1507
    • Goggins, M.1    Offerhaus, G.J.2    Hilgers, W.3    Griffin, C.A.4    Shekher, M.5    Tang, D.6    Sohn, T.A.7    Yeo, C.J.8    Kern, S.E.9    Hruban, R.H.10
  • 71
    • 0032404111 scopus 로고    scopus 로고
    • Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas
    • Goggins, M., Shekher, M., Turnacioglu, K., Yeo, C. J., Hruban, R. H., and Kern, S. E. (1998b). Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res. 58, 5329-5332.
    • (1998) Cancer Res. , vol.58 , pp. 5329-5332
    • Goggins, M.1    Shekher, M.2    Turnacioglu, K.3    Yeo, C.J.4    Hruban, R.H.5    Kern, S.E.6
  • 74
    • 37549022694 scopus 로고    scopus 로고
    • DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
    • Griffiths, E. A., and Gore, S. D. (2008). DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin. Hematol. 45, 23-30.
    • (2008) Semin. Hematol. , vol.45 , pp. 23-30
    • Griffiths, E.A.1    Gore, S.D.2
  • 78
    • 0242403449 scopus 로고    scopus 로고
    • Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma
    • Hakam, A., Fang, Q., Karl, R., and Coppola, D. (2003). Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. Dig. Dis. Sci. 48, 1972-1978.
    • (2003) Dig. Dis. Sci. , vol.48 , pp. 1972-1978
    • Hakam, A.1    Fang, Q.2    Karl, R.3    Coppola, D.4
  • 79
    • 42349093032 scopus 로고    scopus 로고
    • Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer
    • doi:10.1186/1471-2407-8-82
    • Heinemann, V., Boeck, S., Hinke, A., Labianca, R., and Louvet, C. (2008). Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer 8, 82. doi:10.1186/1471-2407-8-82
    • (2008) BMC Cancer , vol.8 , pp. 82
    • Heinemann, V.1    Boeck, S.2    Hinke, A.3    Labianca, R.4    Louvet, C.5
  • 81
    • 45149091560 scopus 로고    scopus 로고
    • Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head
    • Heinrich, S., Pestalozzi, B. C., Schafer, M., Weber, A., Bauerfeind, P., Knuth, A., and Clavien, P. A. (2008). Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head. J. Clin. Oncol. 26, 2526-2531.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2526-2531
    • Heinrich, S.1    Pestalozzi, B.C.2    Schafer, M.3    Weber, A.4    Bauerfeind, P.5    Knuth, A.6    Clavien, P.A.7
  • 82
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann, P. C., Huber, S. L., Herrler, T., Aicher, A., Ellwart, J. W., Guba, M., Bruns, C. J., and Heeschen, C. (2007). Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1, 313-323.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6    Bruns, C.J.7    Heeschen, C.8
  • 84
    • 34248656480 scopus 로고    scopus 로고
    • Histone deacetylases-an important class of cellular regulators with a variety of functions
    • Hildmann, C., Riester, D., and Schwienhorst, A. (2007). Histone deacetylases-an important class of cellular regulators with a variety of functions. Appl. Microbiol. Biotechnol. 75, 487-497.
    • (2007) Appl. Microbiol. Biotechnol. , vol.75 , pp. 487-497
    • Hildmann, C.1    Riester, D.2    Schwienhorst, A.3
  • 89
    • 34547597687 scopus 로고    scopus 로고
    • Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells
    • Hu, W. G., Liu, T., Xiong, J. X., and Wang, C. Y. (2007). Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells. Acta Pharmacol. Sin. 28, 1224-1230.
    • (2007) Acta Pharmacol. Sin. , vol.28 , pp. 1224-1230
    • Hu, W.G.1    Liu, T.2    Xiong, J.X.3    Wang, C.Y.4
  • 95
    • 27244433702 scopus 로고    scopus 로고
    • Real-time expression profiling of microRNA precursors in human cancer cell lines
    • Jiang, J., Lee, E. J., Gusev, Y., and Schmittgen, T. D. (2005). Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Res. 33, 5394-5403.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 5394-5403
    • Jiang, J.1    Lee, E.J.2    Gusev, Y.3    Schmittgen, T.D.4
  • 96
  • 99
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • Karin, M. (2006). Nuclear factor-κB in cancer development and progression. Nature 441, 431-436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 100
    • 39749085793 scopus 로고    scopus 로고
    • Effect of Z-360, a novel orally active CCK-2/gastrin receptor antagonist on tumor growth in human pancreatic adenocarcinoma cell lines in vivo and mode of action determinations in vitro
    • Kawasaki, D., Emori, Y., Eta, R., Iino, Y., Hamano, H., Yoshinaga, K., Tanaka, T., Takei, M., and Watson, S. A. (2008). Effect of Z-360, a novel orally active CCK-2/gastrin receptor antagonist on tumor growth in human pancreatic adenocarcinoma cell lines in vivo and mode of action determinations in vitro. Cancer Chemother. Pharmacol. 61, 883-892.
    • (2008) Cancer Chemother. Pharmacol. , vol.61 , pp. 883-892
    • Kawasaki, D.1    Emori, Y.2    Eta, R.3    Iino, Y.4    Hamano, H.5    Yoshinaga, K.6    Tanaka, T.7    Takei, M.8    Watson, S.A.9
  • 101
    • 33645094927 scopus 로고    scopus 로고
    • Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate
    • Khan, N., Afaq, F., Saleem, M., Ahmad, N., and Mukhtar, H. (2006). Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res. 66, 2500-2505.
    • (2006) Cancer Res. , vol.66 , pp. 2500-2505
    • Khan, N.1    Afaq, F.2    Saleem, M.3    Ahmad, N.4    Mukhtar, H.5
  • 103
    • 0032518616 scopus 로고    scopus 로고
    • Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum
    • Kornmann, M., Arber, N., and Korc, M. (1998). Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum. J. Clin. Invest. 101, 344-352.
    • (1998) J. Clin. Invest. , vol.101 , pp. 344-352
    • Kornmann, M.1    Arber, N.2    Korc, M.3
  • 104
    • 33846148370 scopus 로고    scopus 로고
    • pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4α tumor suppressor gene
    • Kotake, Y., Cao, R., Viatour, P., Sage, J., Zhang, Y., and Xiong, Y. (2007). pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4α tumor suppressor gene. Genes Dev. 21, 49-54.
    • (2007) Genes Dev. , vol.21 , pp. 49-54
    • Kotake, Y.1    Cao, R.2    Viatour, P.3    Sage, J.4    Zhang, Y.5    Xiong, Y.6
  • 105
  • 107
    • 24344483878 scopus 로고    scopus 로고
    • Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses
    • Levy, L., and Hill, C. S. (2005). Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol. Cell. Biol. 25, 8108-8125.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 8108-8125
    • Levy, L.1    Hill, C.S.2
  • 108
    • 7644223910 scopus 로고    scopus 로고
    • Nuclear factor-κB and IκB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis
    • Li, L., Aggarwal, B. B., Shishodia, S., Abbruzzese, J., and Kurzrock, R. (2004a). Nuclear factor-κB and IκB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 101, 2351-2362.
    • (2004) Cancer , vol.101 , pp. 2351-2362
    • Li, L.1    Aggarwal, B.B.2    Shishodia, S.3    Abbruzzese, J.4    Kurzrock, R.5
  • 109
    • 2942690157 scopus 로고    scopus 로고
    • Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-κB in BxPC-3 pancreatic cancer cell line
    • Li, Y., Ellis, K. L., Ali, S., El-Rayes, B. F., Nedeljkovic-Kurepa, A., Kucuk, O., Philip, P. A., and Sarkar, F. H. (2004b). Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-κB in BxPC-3 pancreatic cancer cell line. Pancreas 28, e90-e95.
    • (2004) Pancreas , vol.28
    • Li, Y.1    Ellis, K.L.2    Ali, S.3    El-Rayes, B.F.4    Nedeljkovic-Kurepa, A.5    Kucuk, O.6    Philip, P.A.7    Sarkar, F.H.8
  • 110
    • 23044498269 scopus 로고    scopus 로고
    • Inactivation of nuclear factor κB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
    • Li, Y., Ahmed, F., Ali, S., Philip, P. A., Kucuk, O., and Sarkar, F. H. (2005). Inactivation of nuclear factor κB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res. 65, 6934-6942.
    • (2005) Cancer Res. , vol.65 , pp. 6934-6942
    • Li, Y.1    Ahmed, F.2    Ali, S.3    Philip, P.A.4    Kucuk, O.5    Sarkar, F.H.6
  • 111
  • 112
    • 33646397565 scopus 로고    scopus 로고
    • Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-κB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer
    • Li, Y., Kucuk, O., Hussain, M., Abrams, J., Cher, M. L., and Sarkar, F. H. (2006). Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-κB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer. Cancer Res. 66, 4816-4825.
    • (2006) Cancer Res. , vol.66 , pp. 4816-4825
    • Li, Y.1    Kucuk, O.2    Hussain, M.3    Abrams, J.4    Cher, M.L.5    Sarkar, F.H.6
  • 113
    • 1442277094 scopus 로고    scopus 로고
    • Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein
    • Lian, J. P., Word, B., Taylor, S., Hammons, G. J., and Lyn-Cook, B. D. (2004). Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein. Anticancer Res. 24, 133-137.
    • (2004) Anticancer Res. , vol.24 , pp. 133-137
    • Lian, J.P.1    Word, B.2    Taylor, S.3    Hammons, G.J.4    Lyn-Cook, B.D.5
  • 114
    • 33750986493 scopus 로고    scopus 로고
    • Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma
    • discussion 1263
    • Liau, S. S., Ashley, S. W., and Whang, E. E. (2006). Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma. J. Gastrointest. Surg. 10, 1254-1262; discussion 1263.
    • (2006) J. Gastrointest. Surg. , vol.10 , pp. 1254-1262
    • Liau, S.S.1    Ashley, S.W.2    Whang, E.E.3
  • 115
    • 40949087142 scopus 로고    scopus 로고
    • HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma
    • Liau, S. S., and Whang, E. (2008). HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma. Clin. Cancer Res. 14, 1470-1477.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 1470-1477
    • Liau, S.S.1    Whang, E.2
  • 116
    • 0037780982 scopus 로고    scopus 로고
    • Mitogenic and antiapoptotic role of constitutive NF-κB/Rel activity in pancreatic cancer
    • Liptay, S., Weber, C. K., Ludwig, L., Wagner, M., Adler, G., and Schmid, R. M. (2003). Mitogenic and antiapoptotic role of constitutive NF-κB/Rel activity in pancreatic cancer. Int. J. Cancer 105, 735-746.
    • (2003) Int. J. Cancer , vol.105 , pp. 735-746
    • Liptay, S.1    Weber, C.K.2    Ludwig, L.3    Wagner, M.4    Adler, G.5    Schmid, R.M.6
  • 117
    • 46949105858 scopus 로고    scopus 로고
    • FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells
    • Liu, W., Bloom, D. A., Cance, W. G., Kurenova, E. V., Golubovskaya, V. M., and Hochwald, S. N. (2008). FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 29, 1096-1107.
    • (2008) Carcinogenesis , vol.29 , pp. 1096-1107
    • Liu, W.1    Bloom, D.A.2    Cance, W.G.3    Kurenova, E.V.4    Golubovskaya, V.M.5    Hochwald, S.N.6
  • 118
    • 34248136479 scopus 로고    scopus 로고
    • Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo
    • Liu, T. J., LaFortune, T., Honda, T., Ohmori, O., Hatakeyama, S., Meyer, T., Jackson, D., de Groot, J., and Yung, W. K. (2007). Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol. Cancer Ther. 6, 1357-1367.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1357-1367
    • Liu, T.J.1    LaFortune, T.2    Honda, T.3    Ohmori, O.4    Hatakeyama, S.5    Meyer, T.6    Jackson, D.7    de Groot, J.8    Yung, W.K.9
  • 119
    • 0035875112 scopus 로고    scopus 로고
    • Survey and summary: the applications of universal DNA base analogues
    • Loakes, D. (2001). Survey and summary: the applications of universal DNA base analogues. Nucleic Acids Res. 29, 2437-2447.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 2437-2447
    • Loakes, D.1
  • 120
  • 122
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial
    • GERCOR, and GISCAD.
    • Louvet, C., Labianca, R., Hammel, P., Lledo, G., Zampino, M. G., Andre, T., Zaniboni, A., Ducreux, M., Aitini, E., Taieb, J., Faroux, R., Lepere, C., de Gramont, A., GERCOR, and GISCAD. (2005). Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J. Clin. Oncol. 23, 3509-3516.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3    Lledo, G.4    Zampino, M.G.5    Andre, T.6    Zaniboni, A.7    Ducreux, M.8    Aitini, E.9    Taieb, J.10    Faroux, R.11    Lepere, C.12    de Gramont, A.13
  • 126
    • 77954407332 scopus 로고    scopus 로고
    • Genomewide association studies and assessment of the risk of disease
    • Manolio, T. A. (2010). Genomewide association studies and assessment of the risk of disease. N. Engl. J. Med. 363, 166-176.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 166-176
    • Manolio, T.A.1
  • 127
    • 0014508589 scopus 로고
    • The ABO and Lewis blood-group system. Immunochemistry, genetics and relation to human disease
    • Marcus, D. M. (1969). The ABO and Lewis blood-group system. Immunochemistry, genetics and relation to human disease. N. Engl. J. Med. 280, 994-1006.
    • (1969) N. Engl. J. Med. , vol.280 , pp. 994-1006
    • Marcus, D.M.1
  • 129
    • 0001294157 scopus 로고
    • The stability of broken ends of chromosomes in Zea mays
    • McClintock, B. (1941). The stability of broken ends of chromosomes in Zea mays. Genetics 26, 234-282.
    • (1941) Genetics , vol.26 , pp. 234-282
    • McClintock, B.1
  • 131
    • 27644549557 scopus 로고    scopus 로고
    • Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies
    • Mimeault, M., Brand, R. E., Sasson, A. A., and Batra, S. K. (2005). Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies. Pancreas 31, 301-316.
    • (2005) Pancreas , vol.31 , pp. 301-316
    • Mimeault, M.1    Brand, R.E.2    Sasson, A.A.3    Batra, S.K.4
  • 133
    • 33644834505 scopus 로고    scopus 로고
    • Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts
    • Mohammad, R. M., Banerjee, S., Li, Y., Aboukameel, A., Kucuk, O., and Sarkar, F. H. (2006). Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts. Cancer 106, 1260-1268.
    • (2006) Cancer , vol.106 , pp. 1260-1268
    • Mohammad, R.M.1    Banerjee, S.2    Li, Y.3    Aboukameel, A.4    Kucuk, O.5    Sarkar, F.H.6
  • 134
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • National Cancer Institute of Canada Clinical Trials Group.
    • Moore, M. J., Goldstein, D., Hamm, J., Figer, A., Hecht, J. R., Gallinger, S., Au, H. J., Murawa, P., Walde, D., Wolff, R. A., Campos, D., Lim, R., Ding, K., Clark, G., Voskoglou-Nomikos, T., Ptasynski, M., Parulekar, W., and National Cancer Institute of Canada Clinical Trials Group. (2007). Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 25, 1960-1966.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6    Au, H.J.7    Murawa, P.8    Walde, D.9    Wolff, R.A.10    Campos, D.11    Lim, R.12    Ding, K.13    Clark, G.14    Voskoglou-Nomikos, T.15    Ptasynski, M.16    Parulekar, W.17
  • 135
    • 0141688333 scopus 로고    scopus 로고
    • Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • National Cancer Institute of Canada Clinical Trials Group.
    • Moore, M. J., Hamm, J., Dancey, J., Eisenberg, P. D., Dagenais, M., Fields, A., Hagan, K., Greenberg, B., Colwell, B., Zee, B., Tu, D., Ottaway, J., Humphrey, R., Seymour, L., National Cancer Institute of Canada Clinical Trials Group. (2003). Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 21, 3296-3302.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3296-3302
    • Moore, M.J.1    Hamm, J.2    Dancey, J.3    Eisenberg, P.D.4    Dagenais, M.5    Fields, A.6    Hagan, K.7    Greenberg, B.8    Colwell, B.9    Zee, B.10    Tu, D.11    Ottaway, J.12    Humphrey, R.13    Seymour, L.14
  • 140
    • 0033391076 scopus 로고    scopus 로고
    • Green tea in chemoprevention of cancer
    • Mukhtar, H., and Ahmad, N. (1999). Green tea in chemoprevention of cancer. Toxicol. Sci. 52, 111-117.
    • (1999) Toxicol. Sci. , vol.52 , pp. 111-117
    • Mukhtar, H.1    Ahmad, N.2
  • 141
    • 38449106861 scopus 로고    scopus 로고
    • Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications
    • Mund, C., Brueckner, B., and Lyko, F. (2006). Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications. Epigenetics 1, 7-13.
    • (2006) Epigenetics , vol.1 , pp. 7-13
    • Mund, C.1    Brueckner, B.2    Lyko, F.3
  • 145
    • 55349119506 scopus 로고    scopus 로고
    • Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
    • doi:10.1371/journal.pone.0000392
    • Nawroth, R., van Zante, A., Cervantes, S., McManus, M., Hebrok, M., and Rosen, S. D. (2007). Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS ONE 2, e392. doi:10.1371/journal.pone.0000392
    • (2007) PLoS ONE , vol.2
    • Nawroth, R.1    van Zante, A.2    Cervantes, S.3    McManus, M.4    Hebrok, M.5    Rosen, S.D.6
  • 147
    • 14944380596 scopus 로고    scopus 로고
    • Dietary intake of lycopene is associated with reduced pancreatic cancer risk
    • Nkondjock, A., Ghadirian, P., Johnson, K. C., and Krewski, D. (2005). Dietary intake of lycopene is associated with reduced pancreatic cancer risk. J. Nutr. 135, 592-597.
    • (2005) J. Nutr. , vol.135 , pp. 592-597
    • Nkondjock, A.1    Ghadirian, P.2    Johnson, K.C.3    Krewski, D.4
  • 149
    • 33645880761 scopus 로고    scopus 로고
    • Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival
    • Ogura, Y., Mizumoto, K., Nagai, E., Murakami, M., Inadome, N., Saimura, M., Matsumoto, K., Nakamura, T., Maemondo, M., Nukiwa, T., and Tanaka, M. (2006). Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival. Cancer Gene Ther. 13, 520-529.
    • (2006) Cancer Gene Ther. , vol.13 , pp. 520-529
    • Ogura, Y.1    Mizumoto, K.2    Nagai, E.3    Murakami, M.4    Inadome, N.5    Saimura, M.6    Matsumoto, K.7    Nakamura, T.8    Maemondo, M.9    Nukiwa, T.10    Tanaka, M.11
  • 153
    • 58149214373 scopus 로고    scopus 로고
    • Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2
    • Ougolkov, A. V., Bilim, V. N., and Billadeau, D. D. (2008). Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clin. Cancer Res. 14, 6790-6796.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6790-6796
    • Ougolkov, A.V.1    Bilim, V.N.2    Billadeau, D.D.3
  • 154
    • 34250816847 scopus 로고    scopus 로고
    • A randomized phase 2 trial of neoadjuvant chemotherapy in resectable pancreatic cancer: gemcitabine alone versus gemcitabine combined with cisplatin
    • Palmer, D. H., Stocken, D. D., Hewitt, H., Markham, C. E., Hassan, A. B., Johnson, P. J., Buckels, J. A., and Bramhall, S. R. (2007). A randomized phase 2 trial of neoadjuvant chemotherapy in resectable pancreatic cancer: gemcitabine alone versus gemcitabine combined with cisplatin. Ann. Surg. Oncol. 14, 2088-2096.
    • (2007) Ann. Surg. Oncol. , vol.14 , pp. 2088-2096
    • Palmer, D.H.1    Stocken, D.D.2    Hewitt, H.3    Markham, C.E.4    Hassan, A.B.5    Johnson, P.J.6    Buckels, J.A.7    Bramhall, S.R.8
  • 155
    • 39149114438 scopus 로고    scopus 로고
    • HDAC inhibitors: a potential new category of anti-tumor agents
    • Pan, L. N., Lu, J., and Huang, B. (2007). HDAC inhibitors: a potential new category of anti-tumor agents. Cell. Mol. Immunol. 4, 337-343.
    • (2007) Cell. Mol. Immunol. , vol.4 , pp. 337-343
    • Pan, L.N.1    Lu, J.2    Huang, B.3
  • 162
    • 68949114505 scopus 로고    scopus 로고
    • Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group
    • Poplin, E., Feng, Y., Berlin, J., Rothenberg, M. L., Hochster, H., Mitchell, E., Alberts, S., O'Dwyer, P., Haller, D., Catalano, P., Cella, D., and Benson, A. B. III. (2009). Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J. Clin. Oncol. 27, 3778-3785.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3778-3785
    • Poplin, E.1    Feng, Y.2    Berlin, J.3    Rothenberg, M.L.4    Hochster, H.5    Mitchell, E.6    Alberts, S.7    O'Dwyer, P.8    Haller, D.9    Catalano, P.10    Cella, D.11    Benson III, A.B.12
  • 163
    • 19844374460 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells
    • Qanungo, S., Das, M., Haldar, S., and Basu, A. (2005). Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis 26, 958-967.
    • (2005) Carcinogenesis , vol.26 , pp. 958-967
    • Qanungo, S.1    Das, M.2    Haldar, S.3    Basu, A.4
  • 164
    • 59449094255 scopus 로고    scopus 로고
    • Volociximab, a chimeric monoclonal antibody that specifically binds α5β1 integrin: a phase I, pharmacokinetic, and biological correlative study
    • Ricart, A. D., Tolcher, A. W., Liu, G., Holen, K., Schwartz, G., Albertini, M., Weiss, G., Yazji, S., Ng, C., and Wilding, G. (2008). Volociximab, a chimeric monoclonal antibody that specifically binds α5β1 integrin: a phase I, pharmacokinetic, and biological correlative study. Clin. Cancer Res. 14, 7924-7929.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7924-7929
    • Ricart, A.D.1    Tolcher, A.W.2    Liu, G.3    Holen, K.4    Schwartz, G.5    Albertini, M.6    Weiss, G.7    Yazji, S.8    Ng, C.9    Wilding, G.10
  • 166
    • 34250218900 scopus 로고    scopus 로고
    • Polycomb comes of age: genome-wide profiling of target sites
    • Ringrose, L. (2007). Polycomb comes of age: genome-wide profiling of target sites. Curr. Opin. Cell Biol. 19, 290-297.
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 290-297
    • Ringrose, L.1
  • 167
    • 28244456529 scopus 로고    scopus 로고
    • Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis
    • Rocchi, P., Beraldi, E., Ettinger, S., Fazli, L., Vessella, R. L., Nelson, C., and Gleave, M. (2005). Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis. Cancer Res. 65, 11083-11093.
    • (2005) Cancer Res. , vol.65 , pp. 11083-11093
    • Rocchi, P.1    Beraldi, E.2    Ettinger, S.3    Fazli, L.4    Vessella, R.L.5    Nelson, C.6    Gleave, M.7
  • 168
    • 4644237335 scopus 로고    scopus 로고
    • Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer
    • Rocchi, P., So, A., Kojima, S., Signaevsky, M., Beraldi, E., Fazli, L., Hurtado-Coll, A., Yamanaka, K., and Gleave, M. (2004). Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res. 64, 6595-6602.
    • (2004) Cancer Res. , vol.64 , pp. 6595-6602
    • Rocchi, P.1    So, A.2    Kojima, S.3    Signaevsky, M.4    Beraldi, E.5    Fazli, L.6    Hurtado-Coll, A.7    Yamanaka, K.8    Gleave, M.9
  • 169
    • 33750600178 scopus 로고    scopus 로고
    • MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior
    • Roldo, C., Missiaglia, E., Hagan, J. P., Falconi, M., Capelli, P., Bersani, S., Calin, G. A., Volinia, S., Liu, C. G., Scarpa, A., and Croce, C. M. (2006). MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J. Clin. Oncol. 24, 4677-4684.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 4677-4684
    • Roldo, C.1    Missiaglia, E.2    Hagan, J.P.3    Falconi, M.4    Capelli, P.5    Bersani, S.6    Calin, G.A.7    Volinia, S.8    Liu, C.G.9    Scarpa, A.10    Croce, C.M.11
  • 170
    • 47249108568 scopus 로고    scopus 로고
    • Functional blockade of Smad4 leads to a decrease in β-catenin levels and signaling activity in human pancreatic carcinoma cells
    • Romero, D., Iglesias, M., Vary, C. P., and Quintanilla, M. (2008). Functional blockade of Smad4 leads to a decrease in β-catenin levels and signaling activity in human pancreatic carcinoma cells. Carcinogenesis 29, 1070-1076.
    • (2008) Carcinogenesis , vol.29 , pp. 1070-1076
    • Romero, D.1    Iglesias, M.2    Vary, C.P.3    Quintanilla, M.4
  • 171
    • 0031936947 scopus 로고    scopus 로고
    • Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
    • Ruggeri, B. A., Huang, L., Wood, M., Cheng, J. Q., and Testa, J. R. (1998). Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol. Carcinog. 21, 81-86.
    • (1998) Mol. Carcinog. , vol.21 , pp. 81-86
    • Ruggeri, B.A.1    Huang, L.2    Wood, M.3    Cheng, J.Q.4    Testa, J.R.5
  • 172
    • 0037742210 scopus 로고    scopus 로고
    • Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays
    • Sato, N., Fukushima, N., Maitra, A., Matsubayashi, H., Yeo, C. J., Cameron, J. L., Hruban, R. H., and Goggins, M. (2003). Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res. 63, 3735-3742.
    • (2003) Cancer Res. , vol.63 , pp. 3735-3742
    • Sato, N.1    Fukushima, N.2    Maitra, A.3    Matsubayashi, H.4    Yeo, C.J.5    Cameron, J.L.6    Hruban, R.H.7    Goggins, M.8
  • 173
    • 0348049845 scopus 로고    scopus 로고
    • Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
    • Schlieman, M. G., Fahy, B. N., Ramsamooj, R., Beckett, L., and Bold, R. J. (2003). Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br. J. Cancer 89, 2110-2115.
    • (2003) Br. J. Cancer , vol.89 , pp. 2110-2115
    • Schlieman, M.G.1    Fahy, B.N.2    Ramsamooj, R.3    Beckett, L.4    Bold, R.J.5
  • 176
    • 34147189720 scopus 로고    scopus 로고
    • Familial and sporadic pancreatic carcinoma, epidemiologic concordance
    • Schwartz, A. M., and Henson, D. E. (2007). Familial and sporadic pancreatic carcinoma, epidemiologic concordance. Am. J. Surg. Pathol. 31, 645-646.
    • (2007) Am. J. Surg. Pathol. , vol.31 , pp. 645-646
    • Schwartz, A.M.1    Henson, D.E.2
  • 177
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo, Y., Baba, H., Fukuda, T., Takashima, M., and Sugimachi, K. (2000). High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 88, 2239-2245.
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3    Takashima, M.4    Sugimachi, K.5
  • 178
    • 33748469128 scopus 로고    scopus 로고
    • Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells
    • Shafaee, Z., Schmidt, H., Du, W., Posner, M., and Weichselbaum, R. (2006). Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells. Cancer Chemother. Pharmacol. 58, 765-770.
    • (2006) Cancer Chemother. Pharmacol. , vol.58 , pp. 765-770
    • Shafaee, Z.1    Schmidt, H.2    Du, W.3    Posner, M.4    Weichselbaum, R.5
  • 179
    • 58149241090 scopus 로고    scopus 로고
    • Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides
    • Shen, Y. M., Yang, X. C., Yang, C., and Shen, J. K. (2008). Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides. World J. Gastroenterol. 14, 5176-5185.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 5176-5185
    • Shen, Y.M.1    Yang, X.C.2    Yang, C.3    Shen, J.K.4
  • 181
    • 34248204213 scopus 로고    scopus 로고
    • Precursor lesions of pancreatic cancer: molecular pathology and clinical implications
    • Singh, M., and Maitra, A. (2007). Precursor lesions of pancreatic cancer: molecular pathology and clinical implications. Pancreatology 7, 9-19.
    • (2007) Pancreatology , vol.7 , pp. 9-19
    • Singh, M.1    Maitra, A.2
  • 182
    • 0034857973 scopus 로고    scopus 로고
    • Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entity
    • discussion 321-312
    • Sohn, T. A., Yeo, C. J., Cameron, J. L., Iacobuzio-Donahue, C. A., Hruban, R. H., and Lillemoe, K. D. (2001). Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entity. Ann. Surg. 234, 313-321; discussion 321-312.
    • (2001) Ann. Surg. , vol.234 , pp. 313-321
    • Sohn, T.A.1    Yeo, C.J.2    Cameron, J.L.3    Iacobuzio-Donahue, C.A.4    Hruban, R.H.5    Lillemoe, K.D.6
  • 186
    • 34248200155 scopus 로고    scopus 로고
    • MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
    • Szafranska, A. E., Davison, T. S., John, J., Cannon, T., Sipos, B., Maghnouj, A., Labourier, E., and Hahn, S. A. (2007). MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 26, 4442-4452.
    • (2007) Oncogene , vol.26 , pp. 4442-4452
    • Szafranska, A.E.1    Davison, T.S.2    John, J.3    Cannon, T.4    Sipos, B.5    Maghnouj, A.6    Labourier, E.7    Hahn, S.A.8
  • 187
    • 42749091401 scopus 로고    scopus 로고
    • MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth
    • Takayama, Y., Kokuryo, T., Yokoyama, Y., Nagino, M., Nimura, Y., Senga, T., and Hamaguchi, M. (2008). MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth. Cancer Lett. 264, 241-249.
    • (2008) Cancer Lett. , vol.264 , pp. 241-249
    • Takayama, Y.1    Kokuryo, T.2    Yokoyama, Y.3    Nagino, M.4    Nimura, Y.5    Senga, T.6    Hamaguchi, M.7
  • 188
    • 33748540080 scopus 로고    scopus 로고
    • Molecular pathogenesis of pancreatic adenocarcinoma: potential clinical implications
    • Talar-Wojnarowska, R., and Malecka-Panas, E. (2006). Molecular pathogenesis of pancreatic adenocarcinoma: potential clinical implications. Med. Sci. Monit. 12, RA186-RA193.
    • (2006) Med. Sci. Monit. , vol.12
    • Talar-Wojnarowska, R.1    Malecka-Panas, E.2
  • 190
    • 0035887435 scopus 로고    scopus 로고
    • Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model
    • Tomioka, D., Maehara, N., Kuba, K., Mizumoto, K., Tanaka, M., Matsumoto, K., and Nakamura, T. (2001). Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model. Cancer Res. 61, 7518-7524.
    • (2001) Cancer Res. , vol.61 , pp. 7518-7524
    • Tomioka, D.1    Maehara, N.2    Kuba, K.3    Mizumoto, K.4    Tanaka, M.5    Matsumoto, K.6    Nakamura, T.7
  • 193
    • 33644647192 scopus 로고    scopus 로고
    • Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model
    • Trevino, J. G., Summy, J. M., Lesslie, D. P., Parikh, N. U., Hong, D. S., Lee, F. Y., Donato, N. J., Abbruzzese, J. L., Baker, C. H., and Gallick, G. E. (2006). Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. Am. J. Pathol. 168, 962-972.
    • (2006) Am. J. Pathol. , vol.168 , pp. 962-972
    • Trevino, J.G.1    Summy, J.M.2    Lesslie, D.P.3    Parikh, N.U.4    Hong, D.S.5    Lee, F.Y.6    Donato, N.J.7    Abbruzzese, J.L.8    Baker, C.H.9    Gallick, G.E.10
  • 194
    • 33751264968 scopus 로고    scopus 로고
    • Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells
    • Tsuda, N., Ishiyama, S., Li, Y., Ioannides, C. G., Abbruzzese, J. L., and Chang, D. Z. (2006). Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells. Clin. Cancer Res. 12, 6557-6564.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6557-6564
    • Tsuda, N.1    Ishiyama, S.2    Li, Y.3    Ioannides, C.G.4    Abbruzzese, J.L.5    Chang, D.Z.6
  • 200
    • 64349110092 scopus 로고    scopus 로고
    • Discovery of novel arylethynyltriazole ribonucleosides with selective and effective antiviral and antiproliferative activity
    • Wan, J., Xia, Y., Liu, Y., Wang, M., Rocchi, P., Yao, J., Qu, F., Neyts, J., Iovanna, J. L., and Peng, L. (2009). Discovery of novel arylethynyltriazole ribonucleosides with selective and effective antiviral and antiproliferative activity. J. Med. Chem. 52, 1144-1155.
    • (2009) J. Med. Chem. , vol.52 , pp. 1144-1155
    • Wan, J.1    Xia, Y.2    Liu, Y.3    Wang, M.4    Rocchi, P.5    Yao, J.6    Qu, F.7    Neyts, J.8    Iovanna, J.L.9    Peng, L.10
  • 201
    • 0033549875 scopus 로고    scopus 로고
    • Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA
    • Wang, W., Abbruzzese, J. L., Evans, D. B., and Chiao, P. J. (1999). Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. Oncogene 18, 4554-4563.
    • (1999) Oncogene , vol.18 , pp. 4554-4563
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Chiao, P.J.4
  • 202
    • 34248210562 scopus 로고    scopus 로고
    • PancPRO: risk assessment for individuals with a family history of pancreatic cancer
    • Wang, W., Chen, S., Brune, K. A., Hruban, R. H., Parmigiani, G., and Klein, A. P. (2007). PancPRO: risk assessment for individuals with a family history of pancreatic cancer. J. Clin. Oncol. 25, 1417-1422.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1417-1422
    • Wang, W.1    Chen, S.2    Brune, K.A.3    Hruban, R.H.4    Parmigiani, G.5    Klein, A.P.6
  • 203
    • 33645049305 scopus 로고    scopus 로고
    • Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-κB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
    • Wang, Z., Banerjee, S., Li, Y., Rahman, K. M., Zhang, Y., and Sarkar, F. H. (2006a). Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-κB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res. 66, 2778-2784.
    • (2006) Cancer Res. , vol.66 , pp. 2778-2784
    • Wang, Z.1    Banerjee, S.2    Li, Y.3    Rahman, K.M.4    Zhang, Y.5    Sarkar, F.H.6
  • 205
    • 33645064160 scopus 로고    scopus 로고
    • Inhibition of nuclear factor κB activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells
    • Wang, Z., Zhang, Y., Banerjee, S., Li, Y., and Sarkar, F. H. (2006c). Inhibition of nuclear factor κB activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells. Int. J. Cancer 118, 1930-1936.
    • (2006) Int. J. Cancer , vol.118 , pp. 1930-1936
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 206
    • 33646877856 scopus 로고    scopus 로고
    • Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
    • Wang, Z., Zhang, Y., Banerjee, S., Li, Y., and Sarkar, F. H. (2006d). Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 106, 2503-2513.
    • (2006) Cancer , vol.106 , pp. 2503-2513
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 207
    • 33645473185 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
    • Wang, Z., Zhang, Y., Li, Y., Banerjee, S., Liao, J., and Sarkar, F. H. (2006e). Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol. Cancer Ther. 5, 483-493.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 483-493
    • Wang, Z.1    Zhang, Y.2    Li, Y.3    Banerjee, S.4    Liao, J.5    Sarkar, F.H.6
  • 208
    • 55949116428 scopus 로고    scopus 로고
    • Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway
    • Wang, Z., Ma, Q., Liu, Q., Yu, H., Zhao, L., Shen, S., and Yao, J. (2008). Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway. Br. J. Cancer 99, 1695-1703.
    • (2008) Br. J. Cancer , vol.99 , pp. 1695-1703
    • Wang, Z.1    Ma, Q.2    Liu, Q.3    Yu, H.4    Zhao, L.5    Shen, S.6    Yao, J.7
  • 209
    • 62549159932 scopus 로고    scopus 로고
    • HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells
    • Watanabe, S., Ueda, Y., Akaboshi, S., Hino, Y., Sekita, Y., and Nakao, M. (2009). HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. Am. J. Pathol. 174, 854-868.
    • (2009) Am. J. Pathol. , vol.174 , pp. 854-868
    • Watanabe, S.1    Ueda, Y.2    Akaboshi, S.3    Hino, Y.4    Sekita, Y.5    Nakao, M.6
  • 210
    • 1542615084 scopus 로고    scopus 로고
    • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity
    • Wei, D., Wang, L., He, Y., Xiong, H. Q., Abbruzzese, J. L., and Xie, K. (2004). Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. Cancer Res. 64, 2030-2038.
    • (2004) Cancer Res. , vol.64 , pp. 2030-2038
    • Wei, D.1    Wang, L.2    He, Y.3    Xiong, H.Q.4    Abbruzzese, J.L.5    Xie, K.6
  • 216
    • 70349650214 scopus 로고    scopus 로고
    • Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer
    • Xia, Y., Liu, Y., Wan, J., Wang, M., Rocchi, P., Qu, F., Iovanna, J. L., and Peng, L. (2009). Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer. J. Med. Chem. 52, 6083-6096.
    • (2009) J. Med. Chem. , vol.52 , pp. 6083-6096
    • Xia, Y.1    Liu, Y.2    Wan, J.3    Wang, M.4    Rocchi, P.5    Qu, F.6    Iovanna, J.L.7    Peng, L.8
  • 218
    • 0035300547 scopus 로고    scopus 로고
    • Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability
    • Yamamoto, H., Itoh, F., Nakamura, H., Fukushima, H., Sasaki, S., Perucho, M., and Imai, K. (2001). Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability. Cancer Res. 61, 3139-3144.
    • (2001) Cancer Res. , vol.61 , pp. 3139-3144
    • Yamamoto, H.1    Itoh, F.2    Nakamura, H.3    Fukushima, H.4    Sasaki, S.5    Perucho, M.6    Imai, K.7
  • 220
    • 0037960266 scopus 로고    scopus 로고
    • PSK-mediated NF-κB inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells NOR-P1
    • Zhang, H., Morisaki, T., Nakahara, C., Matsunaga, H., Sato, N., Nagumo, F., Tadano, J., and Katano, M. (2003). PSK-mediated NF-κB inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells NOR-P1. Oncogene 22, 2088-2096.
    • (2003) Oncogene , vol.22 , pp. 2088-2096
    • Zhang, H.1    Morisaki, T.2    Nakahara, C.3    Matsunaga, H.4    Sato, N.5    Nagumo, F.6    Tadano, J.7    Katano, M.8
  • 221
    • 31544436862 scopus 로고    scopus 로고
    • Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-κB in pancreatic cancer
    • Zhang, Y., Banerjee, S., Wang, Z., Xu, H., Zhang, L., Mohammad, R., Aboukameel, A., Adsay, N. V., Che, M., Abbruzzese, J. L., Majumdar, A. P., and Sarkar, F. H. (2006). Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-κB in pancreatic cancer. Cancer Res. 66, 1025-1032.
    • (2006) Cancer Res. , vol.66 , pp. 1025-1032
    • Zhang, Y.1    Banerjee, S.2    Wang, Z.3    Xu, H.4    Zhang, L.5    Mohammad, R.6    Aboukameel, A.7    Adsay, N.V.8    Che, M.9    Abbruzzese, J.L.10    Majumdar, A.P.11    Sarkar, F.H.12
  • 222
    • 18144409431 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-related protein inhibits cell growth and induces apoptosis of BxPC3 pancreatic cancer cells
    • Zhang, Y., Banerjee, S., Wang, Z. W., Marciniak, D. J., Majumdar, A. P., and Sarkar, F. H. (2005). Epidermal growth factor receptor-related protein inhibits cell growth and induces apoptosis of BxPC3 pancreatic cancer cells. Cancer Res. 65, 3877-3882.
    • (2005) Cancer Res. , vol.65 , pp. 3877-3882
    • Zhang, Y.1    Banerjee, S.2    Wang, Z.W.3    Marciniak, D.J.4    Majumdar, A.P.5    Sarkar, F.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.