Histone deacetylase inhibitors in cancer treatment: A review of the clinical toxicity and the modulation of gene expression in cancer cells

Current Pharmaceutical Biotechnology

Volumn 8, Issue 6, 2007, Pages 388-400

  Bruserud, Øystein ^a   Stapnes, C ^a   Ersvaer E ^a   Gjertsen, B T ^a   Ryningen, A ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

Cancer; Histone deacetylase; Protein acetylation

Indexed keywords

4 N ACETYLDINALINE; AMINOPHYLLINE; ARYLBUTYRIC ACID DERIVATIVE; CARBOPLATIN; CD9 ANTIGEN; CYCLIN A; CYCLIN DEPENDENT KINASE INHIBITOR 1; DEPSIPEPTIDE; GAMMA INTERFERON; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HLA ANTIGEN CLASS 2; LACTOFERRIN; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; ONCOPROTEIN; PACLITAXEL; PROTEIN P21; PROTEIN P300; RETINOIC ACID; ROMIDEPSIN; TRANSCRIPTION FACTOR; TRICHOSTATIN A; UNINDEXED DRUG; VALPROIC ACID; VORINOSTAT;

ACETYLATION; ACUTE GRANULOCYTIC LEUKEMIA; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ANOREXIA; APOPTOSIS; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BONE MARROW DISEASE; BONE PAIN; CANCER CELL; CANCER PAIN; CARCINOGENESIS; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL TRIAL; CONFUSION; CONSTIPATION; CREATININE BLOOD LEVEL; DIARRHEA; DIETARY INTAKE; DYSPEPSIA; EDEMA; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPHY; ELECTROLYTE DISTURBANCE; ENZYME INHIBITION; EPIGENETICS; FATIGUE; FEVER; GASTROINTESTINAL DISEASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; HEADACHE; HEARING IMPAIRMENT; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART LEFT BUNDLE BRANCH BLOCK; HEART VENTRICLE TACHYCARDIA; HEMATOLOGIC DISEASE; HEMATOPOIESIS; HUMAN; HYPERCALCEMIA; HYPERGLYCEMIA; HYPERKALEMIA; HYPERPHOSPHATEMIA; HYPERURICEMIA; HYPOALBUMINEMIA; HYPOCALCEMIA; HYPOKALEMIA; HYPONATREMIA; HYPOPHOSPHATEMIA; HYPOTENSION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FAILURE; LIVER DYSFUNCTION; LYMPHOCYTOPENIA; MALIGNANT NEOPLASTIC DISEASE; MEDICAL RESEARCH; NAUSEA; NAUSEA AND VOMITING; NEUROLOGIC DISEASE; NEUTROPENIA; PROTEIN EXPRESSION; PROTEIN PROCESSING; RESPIRATORY FAILURE; REVIEW; SIDE EFFECT; ST SEGMENT; SUPRAVENTRICULAR TACHYCARDIA; T WAVE; TASTE DISORDER; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TINNITUS; TREATMENT OUTCOME; TUMOR LYSIS SYNDROME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CLINICAL TRIALS AS TOPIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HUMANS; NEOPLASMS; TREATMENT OUTCOME;

EID: 37249071337     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920107783018417     Document Type: Review

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