Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: Frequent alterations in the APC/β-catenin pathway and chromosome 11p

American Journal of Pathology

Volumn 159, Issue 5, 2001, Pages 1619-1627

  Abraham, Susan C ^a   Wu, Tsung Teh ^a   Klimstra, David S ^a   Finn, Laura S ^b   Lee, Jae Hyuk ^a   Yeo, Charles J ^c   Cameron, John L ^c   Hruban, Ralph H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; DNA; GENE PRODUCT; PROTEIN P53; SMAD4 PROTEIN; UNCLASSIFIED DRUG;

ADENOMATOUS POLYP; ADOLESCENT; ADULT; ARTICLE; CARCINOGENESIS; CHILD; CHROMOSOME 11P; CHROMOSOME 5Q; CLINICAL ARTICLE; CLINICAL FEATURE; DNA SEQUENCE; EXON; FEMALE; GENE MUTATION; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREAS DUCT; PANCREATOBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR SUPPRESSOR GENE;

EID: 0035152551     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63008-8     Document Type: Article

References (61)

1. Non ductal adenocarcinoma neoplasms of the pancreas
2. Pancreatoblastoma. A clinicopathologic study and review of the literature
3. Pancreatoblastoma and solid and cystic papillary tumor: Two tumors related to pancreatic ontogeny
4. Pancreatoblastoma treated by delayed operation after effective chemotherapy
5. Pancreatoblastoma: A histochemical and immunohistochemical analysis
6. Pancreatoblastoma. A histochemical and ultrastructural analysis
7. Cytogenetic and flow cytometric analysis of a pancreatoblastoma
8. Pancreatoblastoma: A second report on cytogenetic findings
9. Pancreatoblastoma
10. Pancreatoblastoma: Case report and review of treatment in the literature
11. Pancreatoblastoma in a neonate with Wiedemann-Beckwith syndrome
12. Pancreatoblastoma in adults
13. Pancreatoblastoma in an adult
14. Pancreatoblastoma in an older adult
15. Pancreatoblastoma in an adult: Its separation from acinar cell carcinoma
16. Adult pancreatoblastoma: A case report and review of the literature
17. Mixed acinar-endocrine carcinomas of the pancreas
18. Mixed exocrine-endocrine tumors of the pancreas
19. Therapeutic management of rare malignant pancreatic tumors in children
20. Pancreatoblastoma. Three original cases and review of the literature
21. Loss of maternal alleles on chromosome arm 11p in hepatoblastoma
22. Three nonoverlapping regions of chromosome arm 11p allele loss identified in infantile tumors of adrenal and liver
23. Cytogenetic and molecular studies on six sporadic hepatoblastomas
24. Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism
25. Betacatenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma
26. Hepatoblastoma and APC gene mutation in familial adenomatcus polyposis
27. Risk of hepatoblastoma in familial adenomatous polyposis
28. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis
29. Biallelic inactivation of the APC gene in hepatoblastoma
30. Microdissection and polymerase chain reaction amplification of genomic DNA from histological tissue sections
31. Mutations of the adenomatous polyposis coli gene in the mutation cluster region: Comparison of human pancreatic and colorectal cancers
32. Genetic alterations in Barrett esophagus and adenocarcinomas of the esophagus and esophagogastric junction region
33. Molecular genetics of Beckwith-Wiedemann syndrome
34. Molecular genetics of Wiedemann-Beckwith syndrome
35. Somatic mutations of the APC gene in sporadic hepatoblastomas
36. Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene
37. Nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma
38. Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas
39. Somatic mutations of beat-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma
40. Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma
41. Cadherins, catenins, and APC protein: Interplay between cytoskeletal complexes and signaling pathways
42. Functional interaction of β-catenin with the transcriptional factor LEF-1
43. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly
44. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
45. β-catenin is a target for the ubiquitin-proteasome pathway
46. Serine phosphorylation-regulated ubiquitination and degradation of β-catenin
47. Activation of β-catenin-Tcf signaling in colon cancers by mutations in β-catenin or APC
48. -/- colon cancer
49. Lessons from hereditary colorectal cancer
50. Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer
51. Mutational activation of the β-catenin proto-oncogene is a common event in the development of Wilms' tumors
52. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
53. Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing
54. The K-ras mutation pattern in pancreatic ductal adenocarcinoma is usually identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium
55. Progression model for pancreatic cancer
56. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
57. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
58. Overexpression of p53 protein in adenocarcinoma of the pancreas
59. Pancreatic tumours: Molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis
60. DPC4 gene in various tumor types
61. DPC4, A candidate tumor suppressor gene at human chromosome 18q21.1