Discovery of novel arylethynyltriazole ribonucleosides with selective and effective antiviral and antiproliferative activity

Journal of Medicinal Chemistry

Volumn 52, Issue 4, 2009, Pages 1144-1155

  Wan, Jinqiao ^a   Xia, Yi ^b   Liu, Yang ^a   Wang, Menghua ^a   Rocchi, Palma ^c   Yao, Jianhua ^d   Qu, Fanqi ^a   Neyts, Johan ^e   Iovanna, Juan L ^c   Peng, Ling ^a,b  

^a WUHAN UNIVERSITY   (China)

^b Univ de la Mediter   (France)

^c INSERM   (France)

^d SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^e REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; ACICLOVIR; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CARBOHYDRATE DERIVATIVE; CLADRIBINE; ETHYNYLTRIAZOLE RIBONUCLEOSIDE; GEMCITABINE; NUCLEIC ACID BASE; PURINE NUCLEOSIDE DERIVATIVE; RIBAVIRIN; RIBOSE; TRIFLUOROMETHYLPHENYLETHYNYLTRIAZOLE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN MIAPACA 2; CONTROLLED STUDY; DRUG EFFICACY; DRUG SELECTIVITY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LABELING INDEX; MALE; MOUSE; NONHUMAN; PANCREAS CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; APOPTOSIS; CELL LINE, TUMOR; HEPACIVIRUS; HUMANS; MOLECULAR CONFORMATION; PANCREATIC NEOPLASMS; RIBONUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; VIRUS REPLICATION;

EID: 64349110092     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800927r     Document Type: Article

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