Function of Nuclear Factor κB in Pancreatic Cancer Metastasis

Clinical Cancer Research

Volumn 9, Issue 1, 2003, Pages 346-354

  Fujioka, Shuichi ^a   Sclabas, Guido M ^a   Schmidt, Christian ^a   Frederick, Wayne A ^a   Dong, Qiang G ^a   Abbruzzese, James L ^a   Evans, Douglas B ^a   Baker, Cheryl ^a   Chiao, Paul J ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; CANCER CELL; CELL FUNCTION; CELL IMMORTALIZATION; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MALIGNANT TRANSFORMATION; METASTASIS; MULTIGENE FAMILY; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR VASCULARIZATION;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; BORONIC ACIDS; ENZYME INHIBITORS; GENES, REPORTER; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-8; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM METASTASIS; NF-KAPPA B; PANCREATIC NEOPLASMS; PHENOTYPE; PYRAZINES; RETROVIRIDAE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0037242595     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Verma, I. M., Stevenson, J. K., Schwarz, E. M., Antwerp, D. V., and Miyamoto, S. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev., 9: 2723–2735, 1995.
2. Baldwin, A., Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol., 14: 694–681, 1996.
3. Gilmore, T. D., Koedood, M., Piffat, K. A., and White, D. Rel/NF- κB/IκB proteins and cancer. Oncogene, 14: 1367–1378, 1997.
4. Moore, B. E., and Bose, H. R. J. Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts. Virology, 162: 377–387, 1988.
5. Sylla, B. S., and Temin, H. M. Activation of oncogenicity of the c-rel proto-oncogene. Mol. Cell. Biol., 6: 4709–4716, 1986.
6. Kitajima, I., Shinohara, T., Bilakovics, J. D. A. B., Xu, X., and Nerenberg, M. Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-κB. Science (Wash. DC), 258: 1792–1795, 1992.
7. Neri, A., Chang, C. C., Lombardi, L., Salina, M., Corradini, P., Maiolo, A. T., Chaganti, R. S. K., and Dalla-Favera, R. B cell lymphoma- associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50. Cell, 67: 1075–1087, 1991.
8. Ohno, H., Takimoto, G., and McKeithan, T. W. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell, 60: 991–997, 1990.
9. Lu, D., Thompson, J. D., Gorski, G. K., Rice, N. R., Mayer, M. G., and Yunis, J. J. Alterations of the rel locus in human lymphoma. Oncogene, 6: 1235–1241, 1991.
10. Dejardin, E., Bonizzi, G., Bellahcene, A., Castronovo, V., Merville, M. P., and Bour, V. Highly-expressed p100/p52 (NF-κB2) sequesters other NF-κB-related proteins in the cytoplasm of human breast cancer cells. Oncogene, 11: 1835–1841, 1995.
11. Wang, W., Abbruzzese, J. L., Evans, D. B., Larry, L., Cleary, K. R., and Chiao, P. J. The nuclear factor-κ B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin. Cancer Res., 5: 119–127, 1999.
12. Wang, W., Abbruzzese, J. L., Evans, D. B., and Chiao, P. J. Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. Oncogene, 18: 4554–4563, 1999.
13. Yoshida, A., Yoshida, S., Ishibashi, T., Kuwano, M., and Inomata, H. Suppression of retinal neovascularization by the NF-κB inhibitor pyrrolidine dithiocarbamate in mice. Investig. Ophthalmol. Vis. Sci., 40: 1624–1629, 1999.
14. Huang, S., Robinson, J. B., DeGuzman, A., Bucana, C. D., and Fidler, I. J. Blockage of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res., 60: 5334–5339, 2000.
15. Huang, S., Pettaway, C. A., Uehara, H., Bucana, C. D., and Fidler, I. J. Blockage of NF-κB activity in human prostate cancer is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene, 20: 4188–4197, 2001.
16. Folkman, J., Watson, K., Ingber, D., and Hanahan, D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature (Lond.), 339: 58–61, 1989.
17. Folkman, J. What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst., 82: 4–6, 1990.
18. Folkman, J. The role of angiogenesis in tumor growth. Semin. Cancer Biol., 3: 65–71, 1992.
19. Liotta, L. A., Steeg, P. S., and Stetlet-Stevenson, W. G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell, 64: 327–336, 1991.
20. Ferrara, N. The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res. Treat., 36: 127–137, 1995.
21. Yoshimura, T., Matsushima, K., Oppenheim, J. J., and Leonard, E. J. Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL-1). J. Immunol., 139: 788–793, 1987.
22. Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., Elner, S. G., and Strieter, R. M. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science (Wash. DC), 258: 1798–1801, 1992.
23. Hu, D. E., Hori, Y., and Fan, T. P. Interleukin-8 stimulates angiogenesis in rats. Inflammation, 17: 135–143, 1993.
24. Strieter, R. M., Kunkel, S. L., Elner, V. M., Martonyi, C. L., Koch. A. E., Polverini, P. J., and Elner, S. G. Interleukin-8: a corneal factor that induces neovascularization. Am. J. Pathol., 141: 1279–1284, 1992.
25. Nitecki, S. S., Sarr, M. G., Colby, T. V., and van Heerden, J. A. Long-term survival after resection for ductal adenocarcinoma of the pancreas. Is it really improving? Ann. Surg., 221: 59–66, 1995.
26. Bramhall, S. R., Allum, W. H., Jones, A. G., Allwood, A., Cummins, C., and Neoptolemos, J. P. Treatment and survival in 13, 560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br. J. Surg., 82: 111–115, 1995.
27. Breslin, T. M., Hess, K. R., Harbison, D. B., Jean, M. E., Cleary, K. R., Dackiw, A. P., Wolff, R. A., Abbruzzese, J. L., Janjan, N. A., Crane, C. H., Vauthey, J. N., Lee, J. E., Pisters, P. W., and Evans, D. B. Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: treatment variables and survival duration. Ann. Surg. Oncol., 8: 123–132, 2001.
28. Naviaux, R. K., Costanzi, E., Haas, M., and Verma, I. M. The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J. Virol., 70: 5701–5705, 1996.
29. Chiao, P. J., Miyamoto, S., and Verma, I. M. Autoregulation of IkBk activity. Proc. Natl. Acad. Sci. USA, 91: 28–32, 1994.
30. Grau, A. M., Zhang, L., Wang, W., Ruan, S., Evans, D. B., Abbruzzese, L. L., Zhang, W., and Chiao, P. J. Induction of p21waf1 expression and growth inhibition by transforming growth factor involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. Cancer Res., 57: 3929–3934, 1997.
31. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680–685, 1970.
32. Weidner, N., Folkman, J., Pozza, F., Bevilacqua, P., Allred, E. N., Moore, D. H., Meli, S., and Gasparini, G. Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl. Cancer Inst., 84: 1875–1887, 1992.
33. Roebuck, K. A. Regulation of interleukin-8 gene expression. J. Interferon Cytokine Res., 19: 429–438, 1999.
34. Frater-Schroder, M., Risau, W., Hallmann, R., Gautschi, P., and Bohlen, P. Tumor necrosis factor type α, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proc. Natl. Acad. Sci. USA, 84: 5277–5281, 1987.
35. Yoshida, S., Ono, M., Shono, T., Izumi, H., Ishibashi, T., Suzuki, H., and Kuwano, M. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor α-dependent angiogenesis. Mol. Cell. Biol., 17: 4015–4023, 1997.
36. Leibovich, S. J., Polverini, P. J., Shepard, H. M., Wiseman, D. M., Shively, V., and Nuseir, N. Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α. Nature (Lond.), 329: 630–632, 1987.
37. Passaniti, A., Taylor, R. M., Pill, R., Guo, Y., Long, P. V., Haney, J. A., Pauly, R. R., Grant, D. S., and Martin, G. R. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab. Investig., 67: 519–528, 1992.
38. Shono, T., Ono, M., Izumi, H., Jimi, S., Matsushima, K., Okamoto, T., Kohno, K., and Kuwano, M. Involvement of the transcription factor NF-kB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress. Mol. Cell. Biol., 16: 4231–4239, 1996.
39. Leek, R. D., Lewis, C. E., Whitehouse, R., Greenall, M., Clarke, J., and Harris, A. L. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res., 56: 4625–4629, 1996.
40. Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., and Holash, J. Vascular-specific growth factors and blood vessel formation. Nature (Lond.), 407: 242–248, 2000.
41. Tang, R. F., Itakura, J., Aikawa, T., Matsuda, K., Fujii, H., Korc, M., and Matsumoto, Y. Overexpression of lymphangiogenic growth factor VEGF-C in human pancreatic cancer. Pancreas, 3: 285–292, 2001.
42. Itakura, J., Ishiwata, T., Friess, H., Fujii, H., Matsumoto, Y., Buchler, M. W., and Korc, M. Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clin. Cancer Res., 8: 1309–1316, 1997.
43. Luo, J., Guo, P., Matsuda, K., Truong, N., Lee, A., Chun, C., Cheng, S. Y., and Korc, M. Pancreatic cancer cell-derived vascular endothelial growth factor is biologically active in vitro and enhances tumorigenicity in vivo. Int. J. Cancer, 92: 361–369, 2001.
44. Tsuzuki, Y., Carreira, C. M., Bockhorn, M., Xu, L., Jain, R. K., and Fukumura, D. Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation. Lab. Investig., 81: 1439–1451, 2001.
45. Grisham, M. B., Palombella, V. J., Elliott, P. J., Conner, E. M., Brand, S., Wong, H. L., Pien, C., Mazzola, L. M., Destree, A., Parent, L., and Adams, J. Inhibition of NF-κ B activation in vitro and in vivo: role of 26S proteasome. Methods Enzymol., 300: 345–363, 1999.
46. Russo, S. M., Tepper, J. E., Baldwin, A. S. Jr., Liu, R., Adams, J., Elliott, P., and Cusack, J. C., Jr. Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-κB. Int. J. Radiat. Oncol. Biol. Phys., 50: 183-193, 2001.