Genome-wide association study of pancreatic cancer in Japanese population

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Low, Siew Kee ^a,b   Kuchiba, Aya ^c   Zembutsu, Hitoshi ^a   Saito, Akira ^c,e   Takahashi, Atsushi ^d   Kubo, Michiaki ^d   Daigo, Yataro ^a,b   Kamatani, Naoyuki ^d   Chiku, Suenori ^c,f   Totsuka, Hirohiko ^c,g   Ohnami, Sumiko ^c   Hirose, Hiroshi ^h   Shimada, Kazuaki ⁱ   Okusaka, Takuji ⁱ   Yoshida, Teruhiko ^c   Nakamura, Yusuke ^a   Sakamoto, Hiromi ^c  

^a THE UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d RIKEN   (Japan)

^e Kuramae Orashion Bldg 9F   (Japan)

^f MIZUHO INFORMATION AND RESEARCH INSTITUTE   (Japan)

^g HITACHI LTD   (Japan)

^h KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

ⁱ NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHROMOSOME; CHROMOSOME 12P; CHROMOSOME 6P; CHROMOSOME 7Q; CONTROLLED STUDY; GENE FUNCTION; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; PANCREAS ADENOCARCINOMA; SINGLE NUCLEOTIDE POLYMORPHISM; ASIAN; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MALE; PANCREAS TUMOR;

ASIAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77955606616     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011824     Document Type: Article

References (39)

1. Kelsen DP, Portenoy R, Thaler H, Tao Y, Brennan M (1997) Pain as a predictor of outcome in patients with operable pancreatic carcinoma. Surgery 122: 53-59.
2. Catanzaro A, Richardson S, Veloso H, Isenberg GA, Wong RC, et al. (2003) Long-term follow-up of patients with clinically indeterminate suspicion of pancreatic cancer and normal EUS. Gastrointest Endosc 58: 836-840.
3. Anderson KE, Mack T, Silverman D (2006) Cancer of the pancreas. In: Schottenfeld D, Fraumeni JF, Jr., eds. Cancer Epidemiology and Prevention. New York: Oxford University Press. pp 721-762.
4. Stevens RJ, Roddam AW, Beral V (2007) Pancreatic cancer in type 1 and young-onset diabetes: systematic review and meta-analysis. Br J Cancer 96: 507-509.
5. Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, et al. (1993) Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med 328: 1433-1437.
6. Del Chiaro M, Zerbi A, Falconi M, Bertacca L, Polese M, et al. (2007) Cancer risk among the relatives of patients with pancreatic ductal adenocarcinoma. Pancreatology 7: 459-469.
7. McWilliams RR, Rabe KG, Olswold C, De Andrade M, Petersen GM (2005) Risk of malignancy in first-degree relatives of patients with pancreatic carcinoma. Cancer 104: 388-394.
8. Fernandez E, La Vecchia C, D'Avanzo B, Negri E, Franceschi S (1994) Family history and the risk of liver, gallbladder, and pancreatic cancer. Cancer Epidemiol Biomarkers Prev 3: 209-212.
9. Tersmette AC, Petersen GM, Offerhaus GJ, Falatko FC, Brune KA, et al. (2001) Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer. Clin Cancer Res 7: 738-744.
10. Yan L, McFaul C, Howes N, Leslie J, Lancaster G, et al. (2005) Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups. Gastroenterology 128: 2124-2130.
11. Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, et al. (1994) Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 8: 27-32.
12. Barton CM, Staddon SL, Hughes CM, Hall PA, O'Sullivan C, et al. (1991) Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. Br J Cancer 64: 1076-1082.
13. Berrozpe G, Schaeffer J, Peinado MA, Real FX, Perucho M (1994) Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer. Int J Cancer 58: 185-191.
14. Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, et al. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-3.
15. Hruban RH, Iacobuzio-Donahue C, Wilentz RE, Goggins M, Kern SE (2001) Molecular pathology of pancreatic cancer. Cancer J 7: 251-258.
16. Hahn SA, Greenhalf B, Ellis I, Sina-Frey M, Rieder H, et al. (2003) BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst 95: 214-221.
17. Wong T, Howes N, Threadgold J, Smart HL, Lombard MG, et al. (2001) Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients. Pancreatology 1: 486-509.
18. Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, et al. (2009) Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 324: 217.
19. MacLeod SL, Chowdhury P (2006) The genetics of nicotine dependence:relationship to pancreatic cancer. World J Gastroenterol 12: 7433-7439.
20. Milne RL, Greenhalf W, Murta-Nascimento C, Real FX, Malats N (2009) The inherited genetic component of sporadic pancreatic adenocarcinoma. Pancreatology 9: 206-214.
21. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, et al. (2009) Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 41: 986-990.
22. Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, et al. (2010) A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 42: 224-228.
23. Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-78.
24. Myatt SS, Lam EW (2007) The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 7: 847-859.
25. Hannenhalli S, Kaestner KH (2009) The evolution of Fox genes and their role in development and disease. Nat Rev Genet 10: 233-240.
26. Wang Z, Banerjee S, Kong D, Li Y, Sarkar FH (2007) Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells. Cancer Res 67: 8293-8300.
27. Cao D, Hustinx SR, Sui G, Bala P, Sato N, et al. (2004) Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags. Cancer Biol Ther 3: 1081-1089.
28. Askree SH, Yehuda T, Smolikov S, Gurevich R, Hawk J, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101: 8658-8663.
29. Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, et al. (2006) Telomere Length as a Quantitative Trait: Genome-Wide Survey and Genetic Mapping of Telomere Length-Control Genes in Yeast. PLoS Genet 2: e35. doi:10.1371/journal.pgen.0020035.
30. Rog O, Smolikov S, Krauskopf A, Kupiec M (2005) The yeast VPS genes affect telomere length regulation. Curr Genet 47: 18-28.
31. Mangino M, Brouilette S, Braund P, Tirmizi N, Vasa-Nicotera M, et al. (2008) A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans. Hum Mol Genet 17: 2518-2523.
32. Büchler P, Conejo-Garcia JR, Lehmann G, Müller M, Emrich T, et al. (2001) Real-time quantitative PCR of telomerase mRNA is useful for the differentiation of benign and malignant pancreatic disorders. Pancreas 22: 331-340.
33. Kobitsu K, Tsutsumi M, Tsujiuchi T, Suzuki F, Kido A, et al. (1997) Shortened telomere length and increased telomerase activity in hamster pancreatic duct adenocarcinomas and cell lines. Mol Carcinog 18: 153-159.
34. van Heek NT, Meeker AK, Kern SE, Yeo CJ, Lillemoe KD, et al. (2002) Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol 161: 1541-1547.
35. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806.
36. Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, et al. (2008) SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 40: 1098-1102.
37. Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, et al. (2008) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40: 1092-1097.
38. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, et al. (2008) Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 9: 356-369.
39. Yamaguchi-Kabata Y, Nakazono K, Takahashi A, Saito S, Hosono N, et al. (2008) Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies. Am J Hum Genet 83: 445-456.