Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in hedgehog expressing pancreatic cancer cells

Cancer Chemotherapy and Pharmacology

Volumn 58, Issue 6, 2006, Pages 765-770

  Shafaee, Z ^a   Schmidt, H ^a   Du, W ^a   Posner, M ^a   Weichselbaum, R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Cyclopamine; Hedgehog; Paclitaxel; Pancreatic cancer

Indexed keywords

CISPLATIN; CYCLOPAMINE; GEMCITABINE; LIPOCORTIN 5; PACLITAXEL; SONIC HEDGEHOG PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; IONIZING RADIATION; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; COLORECTAL NEOPLASMS; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HCT116 CELLS; HEDGEHOG PROTEINS; HUMANS; PACLITAXEL; PANCREATIC NEOPLASMS; RADIATION, IONIZING; TIME FACTORS; VERATRUM ALKALOIDS;

EID: 33748469128     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-006-0227-4     Document Type: Article

References (20)

1. American Cancer Society (2005) Cancer facts and figures 2005. American Cancer Society, Atlanta
2. Gastrointestinal Tumor Study Group (1987) Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59:2006
3. Neoptolemos JP, Stocken D, Friess H et al (2004) European Study Group for Pancreatic Cancer, a randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350:1200-1210
4. Breslin TM, Hess KR, Harbison DB et al (2001) Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: treatment variables and survival duration. Ann Surg Oncol 8:123-132
5. Fogelman DR, Chen J, Chabot JA, Allendorf JD, Schrope BA, Ennis RD, Schreibman SM, Fine RL (2004) The evolution of adjuvant and neoadjuvant chemotherapy and radiation for advanced pancreatic cancer: from 5-FU to GTX. Surg Oncol Clin N Am 13(4):711-735
6. Klinkenbijl JH, Jeekel J, Sahmoud T et al (1999) Adjuvant radiotherapy and 5- fluorouracil after curative resection of cancer of the pancreas and peri-ampullary region. Phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group. Ann Surg 230(6):776-784
7. Thayer S, di Magliano M, Heiser P et al (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425:851-856
8. Hooper JE, Scott MP (2005) Communicating with Hedgehogs. Nat Rev Mol Cell Biol 6:306-317
9. Taipale J, Chen J, Cooper M et al (2000) Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine. Nature 406:1005-9
10. Karhadkhar S, Bova G, Abdallah N et al (2004) Hedgehog signaling in prostate regeneration, neoplasia and metastasis. Nature 431:707-712
11. Berman DM, Karhadkar SS, Hallahan AR et al (2002) Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297(5586):1559-1561
12. Howard Hughes (2002) Medical Institute Newsletter, August 30
13. Kayed H, Kleeff J, Keleg S et al (2004) Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer. Int J Cancer 110:668-676
14. Berman D, Karhadkar S, Maitra A et al (2003) Widespread requirement for Hedgehog ligand stimulation In growth of digestive tract tumors. Nature 425:846-851
15. Weichselbaum R, Dahlberg W, Little JB, Ervin TJ, Miller D, Hellman S, Rheinwald JG (1984) Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy. Br J Cancer 49(5):595-601
16. Weichselbaum R, Dahlberg W, Little JB (1985) Inherently radioresistant cells exist in some human tumors. Proc Natl Acad Sci USA 82(14):4732-4735
17. Weichselbaum RR (1984) The role of DNA repair processes in the response of human tumors to fractionated radiotherapy. Int J Radiat Oncol Biol Phys 10(7):1127-1134
18. Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, Therond PP (1997) Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal2. Cell 90:225-234
19. Ogden SK, Ascano M Jr, Stegman MA, Suber LM, Hooper JE, Robbins DJ (2003) Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr Biol 13(22):1998-2003
20. Kroft T, Patterson J, Won Yoon J et al (2001) GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: up regulation in transgenic mice blocks spermatogenesis in pachytene. Biol Reprod 65:1663-1671