Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP)

Journal of Biological Chemistry

Volumn 287, Issue 48, 2012, Pages 40629-40640

  Park, Hyo Jin ^a,b   Shabashvili, Daniil ^a   Nekorchuk, Michael D ^a   Shyqyriu, Eva ^a   Jung, Joo In ^b   Ladd, Thomas B ^b   Moore, Brenda D ^b   Felsenstein, Kevin M ^b   Golde, Todd E ^b   Kim, Seong Hun ^a,c  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; PEPTIDES; SUBSTRATES;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; BRAIN PARENCHYMA; ENDOPLASMIC RETICULUM; INTRACELLULAR TRAFFICKING; PRECURSOR PROTEINS; SECRETORY PATHWAYS; SURFACE ACCUMULATION;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; MEMBRANE PROTEIN; RETENTION IN ENDOPLASMIC RETICULUM 1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPARTMENTALIZATION; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT;

EID: 84869989388     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.418442     Document Type: Article

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