-
1
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991;12:383-388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
2
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001;81:741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
3
-
-
0036548070
-
Gamma-secretase, Notch, Abeta and Alzheimer's disease: Where do the presenilins fit in?
-
Sisodia SS, St George-Hyslop PH. Gamma-secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci 2002;3:281-290.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 281-290
-
-
Sisodia, S.S.1
St George-Hyslop, P.H.2
-
4
-
-
13944276825
-
Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
-
Tanzi RE, Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 2005;120:545-555.
-
(2005)
Cell
, vol.120
, pp. 545-555
-
-
Tanzi, R.E.1
Bertram, L.2
-
6
-
-
0029379605
-
Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease
-
Checler F. Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease. J Neurochem 1995;65:1431-1444.
-
(1995)
J Neurochem
, vol.65
, pp. 1431-1444
-
-
Checler, F.1
-
7
-
-
0033049442
-
Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism
-
Racchi M, Solano DC, Sironi M, Govoni S. Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism. J Neurochem 1999;72:2464-2470.
-
(1999)
J Neurochem
, vol.72
, pp. 2464-2470
-
-
Racchi, M.1
Solano, D.C.2
Sironi, M.3
Govoni, S.4
-
9
-
-
4344630985
-
BACE1: The beta-secretase enzyme in Alzheimer's disease
-
Vassar R. BACE1: the beta-secretase enzyme in Alzheimer's disease. J Mol Neurosci 2004;23:105-114.
-
(2004)
J Mol Neurosci
, vol.23
, pp. 105-114
-
-
Vassar, R.1
-
10
-
-
2942557122
-
Gamma-secretase: Proteasome of the membrane?
-
Kopan R, Ilagan MX. Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 2004;5:499-504.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 499-504
-
-
Kopan, R.1
Ilagan, M.X.2
-
11
-
-
13844299709
-
Presenilin attenuates receptor-mediated signaling and synaptic function
-
Parent AT, Barnes NY, Taniguchi Y, Thinakaran G, Sisodia SS. Presenilin attenuates receptor-mediated signaling and synaptic function. J Neurosci 2005;25:1540-1549.
-
(2005)
J Neurosci
, vol.25
, pp. 1540-1549
-
-
Parent, A.T.1
Barnes, N.Y.2
Taniguchi, Y.3
Thinakaran, G.4
Sisodia, S.S.5
-
12
-
-
4043052896
-
Identification of the role of presenilins beyond Alzheimer's disease
-
Thinakaran G, Parent AT. Identification of the role of presenilins beyond Alzheimer's disease. Pharmacol Res 2004;50:411-418.
-
(2004)
Pharmacol Res
, vol.50
, pp. 411-418
-
-
Thinakaran, G.1
Parent, A.T.2
-
13
-
-
0026721943
-
Beta-amyloid precursor protein cleavage by a membrane-bound protease
-
U S A
-
Sisodia SS. Beta-amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl Acad Sci U S A 1992;89:6075-6079.
-
(1992)
Proc Natl Acad Sci
, vol.89
, pp. 6075-6079
-
-
Sisodia, S.S.1
-
14
-
-
0028276801
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
-
Koo EH, Squazzo SL. Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J Biol Chem 1994;269:17386-17389.
-
(1994)
J Biol Chem
, vol.269
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
15
-
-
0030769092
-
Alzheimer's a beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
-
Cook DG, Forman MS, Sung JC, et al. Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nat Med 1997;3:1021-1023.
-
(1997)
Nat Med
, vol.3
, pp. 1021-1023
-
-
Cook, D.G.1
Forman, M.S.2
Sung, J.C.3
-
16
-
-
0033582159
-
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides
-
U S A
-
Greenfield JP, Tsai J, Gouras GK, et al. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc Natl Acad Sci U S A 1999;96:742-747.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 742-747
-
-
Greenfield, J.P.1
Tsai, J.2
Gouras, G.K.3
-
17
-
-
0036827031
-
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology
-
Takahashi RH, Milner TA, Li F, et al. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 2002;161:1869-1879.
-
(2002)
Am J Pathol
, vol.161
, pp. 1869-1879
-
-
Takahashi, R.H.1
Milner, T.A.2
Li, F.3
-
18
-
-
0030963605
-
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
-
U S A
-
Xu H, Sweeney D, Wang R, et al. Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc Natl Acad Sci U S A 1997;94:3748-3752.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 3748-3752
-
-
Xu, H.1
Sweeney, D.2
Wang, R.3
-
19
-
-
0036327098
-
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane
-
Kaether C, Lammich S, Edbauer D, et al. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. J Cell Biol 2002;158:551-561.
-
(2002)
J Cell Biol
, vol.158
, pp. 551-561
-
-
Kaether, C.1
Lammich, S.2
Edbauer, D.3
-
20
-
-
14244268498
-
Gamma -secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
-
Chyung JH, Raper DM, Selkoe DJ . gamma -secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. J Biol Chem 2005;280:4383-4392.
-
(2005)
J Biol Chem
, vol.280
, pp. 4383-4392
-
-
Chyung, J.H.1
Raper, D.M.2
Selkoe, D.J.3
-
21
-
-
7244258941
-
Association of g-secretase with lipid rafts in post-golgi and endosome membranes
-
Vetrivel KS, Cheng H, Lin W, et al. Association of g-secretase with lipid rafts in post-golgi and endosome membranes. J Biol Chem 2004;279:44945-44954.
-
(2004)
J Biol Chem
, vol.279
, pp. 44945-44954
-
-
Vetrivel, K.S.1
Cheng, H.2
Lin, W.3
-
22
-
-
0033516554
-
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42
-
Perez RG, Soriano S, Hayes JD, et al. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem 1999;274:18851-18856.
-
(1999)
J Biol Chem
, vol.274
, pp. 18851-18856
-
-
Perez, R.G.1
Soriano, S.2
Hayes, J.D.3
-
23
-
-
0345743462
-
Adaptor protein interactions: Modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?
-
King GD, Turner SR. Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk? Exp Neurol 2004;185:208-219.
-
(2004)
Exp Neurol
, vol.185
, pp. 208-219
-
-
King, G.D.1
Turner, S.R.2
-
24
-
-
2442498577
-
FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein
-
Pietrzik CU, Yoon IS, Jaeger S, Busse T, Weggen S, Koo EH. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci 2004;24:4259-4265.
-
(2004)
J Neurosci
, vol.24
, pp. 4259-4265
-
-
Pietrzik, C.U.1
Yoon, I.S.2
Jaeger, S.3
Busse, T.4
Weggen, S.5
Koo, E.H.6
-
25
-
-
0142123260
-
APP processing is regulated by cytoplasmic phosphorylation
-
Lee MS, Kao SC, Lemere CA, et al. APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol 2003;163:83-95.
-
(2003)
J Cell Biol
, vol.163
, pp. 83-95
-
-
Lee, M.S.1
Kao, S.C.2
Lemere, C.A.3
-
26
-
-
8744225623
-
Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport
-
Khvotchev M, Sudhof TC. Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport. J Biol Chem 2004;279:47101-47108.
-
(2004)
J Biol Chem
, vol.279
, pp. 47101-47108
-
-
Khvotchev, M.1
Sudhof, T.C.2
-
27
-
-
0035826909
-
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10
-
U S A
-
Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10. Proc Natl Acad Sci U S A 2001;98:5815-5820.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 5815-5820
-
-
Kojro, E.1
Gimpl, G.2
Lammich, S.3
Marz, W.4
Fahrenholz, F.5
-
28
-
-
10344263931
-
Neuronal membrane cholesterol loss enhances amyloid peptide generation
-
Abad-Rodriguez J, Ledesma MD, Craessaerts K, et al. Neuronal membrane cholesterol loss enhances amyloid peptide generation. J Cell Biol 2004;167:953-960.
-
(2004)
J Cell Biol
, vol.167
, pp. 953-960
-
-
Abad-Rodriguez, J.1
Ledesma, M.D.2
Craessaerts, K.3
-
30
-
-
0032421354
-
Functions of lipid rafts in biological membranes
-
Brown DA, London E. Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 1998;14:111-136.
-
(1998)
Annu Rev Cell Dev Biol
, vol.14
, pp. 111-136
-
-
Brown, D.A.1
London, E.2
-
31
-
-
0035928732
-
Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
-
Riddell DR, Christie G, Hussain I, Dingwall C. Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. Curr Biol 2001;11:1288-1293.
-
(2001)
Curr Biol
, vol.11
, pp. 1288-1293
-
-
Riddell, D.R.1
Christie, G.2
Hussain, I.3
Dingwall, C.4
-
32
-
-
0141482022
-
Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein
-
U S A
-
Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ. Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 2003;100:11735-11740.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 11735-11740
-
-
Cordy, J.M.1
Hussain, I.2
Dingwall, C.3
Hooper, N.M.4
Turner, A.J.5
-
33
-
-
0037421206
-
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
-
Ehehalt R, Keller P, Haass C, Thiele C, Simons K. Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 2003;160:113-123.
-
(2003)
J Cell Biol
, vol.160
, pp. 113-123
-
-
Ehehalt, R.1
Keller, P.2
Haass, C.3
Thiele, C.4
Simons, K.5
-
34
-
-
21844448354
-
Spatial segregation of g-secretase and substrates in distinct membrane domains
-
Vetrivel KS, Cheng H, Kim SH, et al. Spatial segregation of g-secretase and substrates in distinct membrane domains. J Biol Chem 2005;280:25892-25900.
-
(2005)
J Biol Chem
, vol.280
, pp. 25892-25900
-
-
Vetrivel, K.S.1
Cheng, H.2
Kim, S.H.3
-
35
-
-
0036797633
-
Inclusion-body myositis and myopathies: Different etiologies, possibly similar pathogenic mechanisms
-
Askanas V, Engel WK. Inclusion-body myositis and myopathies: different etiologies, possibly similar pathogenic mechanisms. Curr Opin Neurol 2002;15:525-531.
-
(2002)
Curr Opin Neurol
, vol.15
, pp. 525-531
-
-
Askanas, V.1
Engel, W.K.2
-
36
-
-
0742321934
-
Proposed pathogenetic cascade of inclusion-body myositis: Importance of amyloid-beta, misfolded proteins, predisposing genes, and aging
-
Askanas V, Engel WK. Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging. Curr Opin Rheumatol 2003;15:737-744.
-
(2003)
Curr Opin Rheumatol
, vol.15
, pp. 737-744
-
-
Askanas, V.1
Engel, W.K.2
-
37
-
-
1542784578
-
Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle
-
Vattemi G, Engel WK, McFerrin J, Askanas V. Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle. Am J Pathol 2004;164:1-7.
-
(2004)
Am J Pathol
, vol.164
, pp. 1-7
-
-
Vattemi, G.1
Engel, W.K.2
McFerrin, J.3
Askanas, V.4
-
38
-
-
17444418324
-
Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis
-
Ferrer I, Carmona M, Blanco R, Moreno D, Torrejon-Escribano B, Olive M. Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis. Brain Pathol 2005;15:101-108.
-
(2005)
Brain Pathol
, vol.15
, pp. 101-108
-
-
Ferrer, I.1
Carmona, M.2
Blanco, R.3
Moreno, D.4
Torrejon-Escribano, B.5
Olive, M.6
-
39
-
-
0037065833
-
Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle
-
Jaworska-Wilczynska M, Wilczynski GM, Engel WK, Strickland DK, Weisgraber KH, Askanas V. Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle. Neurology 2002;58:438-445.
-
(2002)
Neurology
, vol.58
, pp. 438-445
-
-
Jaworska-Wilczynska, M.1
Wilczynski, G.M.2
Engel, W.K.3
Strickland, D.K.4
Weisgraber, K.H.5
Askanas, V.6
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