Neurotoxic traffic: Uncovering the mechanics of amyloid production in Alzheimer's disease

Traffic

Volumn 2, Issue 2, 2001, Pages 75-81

  Huse, J T ^a   Doms, R W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Site APP cleaving enzyme; Alzheimer's disease; Amyloid precursor protein; Amyloid ; Endosomes; Presenilin 1; Presenilin 2; Secretory pathway; Trans golgi network

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; ASPARTIC PROTEINASE; BETA SECRETASE; GAMMA SECRETASE; LEUCINE; MEMBRANE PROTEIN; NOTCH RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; BRAIN TISSUE; CARBOXY TERMINAL SEQUENCE; CELL PH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEMENTIA; DRUG TARGETING; ENDOSOME; ENZYME ACTIVITY; GENE MUTATION; GOLGI COMPLEX; MOUSE; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PROTEIN TRANSPORT;

EID: 0035102537     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.020201.x     Document Type: Review

References (84)

1. Translating cell biology into therapeutic advances in Alzheimer's disease
2. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
3. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
4. Amyloid plaque core protein in Alzheimer disease and Down syndrome
5. Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid plaque cores and blood vessels
6. Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence
7. The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
8. Solution structures of β peptide and its constituent fragments: Relation to amyloid deposition
9. Visualization of Aβ 42(43) and Aβ 40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ 42(43)
10. Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease
11. Amyloid β-peptide is produced by cultured cells during normal metabolism
12. Production of the Alzheimer amyloid β protein by normal proteolytic processing
13. Cleavage of amyloid β peptide during constitutive processing of its precursor
14. Evidence that tumor necrosis factor converting α enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor
15. Protein kinase C-dependent β-secretase competes with β-secretase for cleavage of amyloid-β precursor protein in the trans-Golgi network
16. Genetic risk factors in Alzheimer's disease
17. Amyloid, the presenilins and Alzheimer's disease
18. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
19. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
20. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
21. Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
22. Identification of a novel aspartic protease (Asp 2) as β-secretase
23. Purification and cloning of amyloid precursor protein β-secretase from human brain
24. Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
25. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
26. Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
27. β-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms
28. Cell-type and amyloid precursor protein-type specific inhibition of Aβ release by bafilomycin A1, a selective inhibitor of vacuolar ATPases
29. Maturation and pro-peptide cleavage of β-secretase
30. Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme: The Alzheimer's disease β-secretase
31. The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region
32. Expression analysis of BACE2 in brain and peripheral tissues
33. A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein β-secretase
34. BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein
35. Candidate gene for the chromosome 1 familial Alzheimer's disease locus
36. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
37. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
38. Protein topology of presenilin 1
39. Membrane topology of the C. elegans SEL-12 presenilin
40. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins
41. The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells
42. Evidence for a six-transmembrane domain structure of presenilin 1
43. Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins
44. Mutant genes in familial Alzheimer's disease and transgenic models
45. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
46. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
47. The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation
48. Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state
49. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
50. Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
51. Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
52. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
53. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
54. Presenilin is required for activity and nuclear access of Notch in Drosophila
55. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response
56. Targeting of cell-surface β-amyloid precursor protein to lysosomes: Alternative processing into amyloid bearing fragments
57. Evidence that production and release of amyloid β-protein involves the endocytic pathway
58. The swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway
59. Metabolism of the "Swedish" amyloid precursor protein variant in Neuro2a (N2a) cells
60. Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vescicle formation
61. Alzheimer's Aβ(1-42) is generated in the endoplasmic reticulum intermediate compartment of NT2N cells
62. Distinct sites of intracellular production for Alzheimer's disease Aβ40 42 amyloid peptides
63. Detection of a novel intra-neuronal pool of insoluble amyloid β protein that accumulates with time in culture
64. Intraneuronal Aβ42 accumulation in human brain
65. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase
66. Characterization of Alzheimer's β-secretase protein BACE
67. The cytoplasmic tail of the mannose 6-phosphate insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi
68. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
69. Endoproteolytic cleavage and proteosomal degradation of presenilin 2 in transfected cells
70. Endoproteolytic processing and stabalization of wild-type and mutant presenilin
71. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation
72. Expression and analysis of presenilin 1 in a human neuronal system: Localization in cell bodies and dendrites
73. Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
74. Presenilin 1 controls γ-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons
75. Presenilin 1 regulates the processing of β-amyloid precursor protein C-terminal fragments and the generation of amyloid β-protein in endoplasmic reticulum and Golgi
76. Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments
77. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
78. Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix
79. Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin
80. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
81. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin
82. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
83. Skeletal and CNS defects in presenilin-1-deficient mice
84. Presenilin is required for Notch1 and Dll1 expression in the paraxial mesoderm