ERK-modulated intrinsic signaling and G2/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells

International Journal of Oncology

Volumn 41, Issue 6, 2012, Pages 2065-2072

  Tsai, Shih Chang ^a   Huang, Wen Wen ^a   Huang, Wei Chien ^a   Lu, Chi Cheng ^b   Chiang, Jo Hua ^b   Peng, Shu Fen ^a   Chung, Jing Gung ^a   Lin, Yu Hsin ^a   Hsu, Yuan Man ^a   Amagaya, Sakae ^a,c   Yang, Jai Sing ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

AITC; Apoptosis; ERK; G2 M phase arrest; Human breast cancer MDA MB 468 cells; Mitochondria

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALLYL ISOTHIOCYANATE; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TRYPAN BLUE;

APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL; CELL COUNT; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADENOCARCINOMA; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CASPASE 9; CDC2 PROTEIN KINASE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; ISOTHIOCYANATES; M PHASE CELL CYCLE CHECKPOINTS; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES;

EID: 84869768858     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1640     Document Type: Article

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