Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways

International Journal of Oncology

Volumn 38, Issue 4, 2011, Pages 1067-1073

  Huang, Wen Wen ^a   Ko, Shih Wei ^a   Tsai, Huei Yann ^b,c   Chung, Jing Gung ^a   Chiang, Jo Hua ^d   Chen, Kuan Tin ^a   Chen, Yen Chen ^a   Chen, Hung Yi ^a   Chen, Yuh Fung ^b   Yang, Jai Sing ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Cantharidin; G2 M arrest; Human colorectal cancer colo 205 cells; Traditional Chinese medicine

Indexed keywords

ACETYLCYSTEINE; CANTHARIDIN; CASPASE 3; CASPASE 8; CASPASE 9; CHECKPOINT KINASE 1; CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; FAS ANTIGEN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL LEVEL; CELL VIABILITY; COLORECTAL CANCER; COLORIMETRY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; CANTHARIDIN; CASPASES; CDC2 PROTEIN KINASE; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; COLORECTAL NEOPLASMS; ENZYME ACTIVATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHATIDYLSERINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 79952327221     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.922     Document Type: Article

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