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Volumn 23, Issue 9, 2012, Pages 2223-2234

Targeting triple-negative breast cancer: Optimising therapeutic outcomes

Author keywords

Basal like; Breast cancer; Cancer treatment; Systematic review; Targeted therapy; Triple negative

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIRUBICIN; ERLOTINIB; EVEROLIMUS; GEMCITABINE; INIPARIB; IRINOTECAN; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; METHOTREXATE; NAVELBINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; PACLITAXEL; PLACEBO; SORAFENIB; SUNITINIB;

EID: 84865573852     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mds067     Document Type: Review
Times cited : (152)

References (119)
  • 1
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann BD, Bauer JA, Chen X et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011; 121: 2750-2767.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3
  • 2
    • 84863993236 scopus 로고    scopus 로고
    • Transcriptome analysis of triple negative breast cancers identifies six distinct biological subgroups and reveals therapeutic strategies
    • (Abstr PD01-07, presented data-SABCS 2010)
    • Lehmann BD, Bauer JA, Chen X et al. Transcriptome analysis of triple negative breast cancers identifies six distinct biological subgroups and reveals therapeutic strategies. Cancer Res 2010; 70: (Abstr PD01-07, presented data-SABCS 2010).
    • (2010) Cancer Res , pp. 70
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3
  • 3
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou CM, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001; 98: 10869-10874.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 4
    • 33646874546 scopus 로고    scopus 로고
    • The molecular portraits of breast tumors are conserved across microarray platforms
    • Hu Z, Fan C, Oh DS et al. The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 2006; 7: 96.
    • (2006) BMC Genomics , vol.7 , pp. 96
    • Hu, Z.1    Fan, C.2    Oh, D.S.3
  • 5
    • 79959520764 scopus 로고    scopus 로고
    • Molecular stratification of triple-negative breast cancers
    • Perou CM Molecular stratification of triple-negative breast cancers. Oncologist 2011; 16Suppl 161-70.
    • (2011) Oncologist , vol.16 , Issue.SUPPL. , pp. 161-170
    • Perou, C.M.1
  • 6
    • 4143150688 scopus 로고    scopus 로고
    • Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    • Nielsen TO, Hsu FD, Jensen K et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004; 10: 5367-5374.
    • (2004) Clin Cancer Res , vol.10 , pp. 5367-5374
    • Nielsen, T.O.1    Hsu, F.D.2    Jensen, K.3
  • 7
    • 43949095489 scopus 로고    scopus 로고
    • How basal are triple-negative breast cancers?
    • Bertucci F, Finetti P, Cervera N et al. How basal are triple-negative breast cancers?. Int J Cancer 2008; 123: 236-240.
    • (2008) Int J Cancer , vol.123 , pp. 236-240
    • Bertucci, F.1    Finetti, P.2    Cervera, N.3
  • 8
    • 36549004041 scopus 로고    scopus 로고
    • Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas
    • Kreike B, van Kouwenhove M, Horlings H et al. Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Res 2007; 9: R65.
    • (2007) Breast Cancer Res , vol.9
    • Kreike, B.1    van Kouwenhove, M.2    Horlings, H.3
  • 9
    • 78951482208 scopus 로고    scopus 로고
    • Perou CMDeconstructing the molecular portraits of breast cancer
    • Prat A, Perou CMDeconstructing the molecular portraits of breast cancer. Mol Oncol 2011; 5: 5-23.
    • (2011) Mol Oncol , vol.5 , pp. 5-23
    • Prat, A.1
  • 10
    • 52049086689 scopus 로고    scopus 로고
    • Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer
    • Atchley DP, Albarracin CT, Lopez A et al. Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer. J Clin Oncol 2008; 26: 4282-4288.
    • (2008) J Clin Oncol , vol.26 , pp. 4282-4288
    • Atchley, D.P.1    Albarracin, C.T.2    Lopez, A.3
  • 11
    • 79952253747 scopus 로고    scopus 로고
    • Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer
    • Gonzalez-Angulo AM, Timms KM, Liu S et al. Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer. Clin Cancer Res 2011; 17: 1082-1089.
    • (2011) Clin Cancer Res , vol.17 , pp. 1082-1089
    • Gonzalez-Angulo, A.M.1    Timms, K.M.2    Liu, S.3
  • 12
    • 4944229642 scopus 로고    scopus 로고
    • Ashworth AHallmarks of 'BRCAness' in sporadic cancers
    • Turner N, Tutt A, Ashworth AHallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 2004; 4: 814-819.
    • (2004) Nat Rev Cancer , vol.4 , pp. 814-819
    • Turner, N.1    Tutt, A.2
  • 13
    • 54849416387 scopus 로고    scopus 로고
    • Oh KBasal-like subtype and BRCA1 dysfunction in breast cancers
    • Miyoshi Y, Murase K, Oh KBasal-like subtype and BRCA1 dysfunction in breast cancers. Int J Clin Oncol 2008; 13: 395-400.
    • (2008) Int J Clin Oncol , vol.13 , pp. 395-400
    • Miyoshi, Y.1    Murase, K.2
  • 14
    • 22244449596 scopus 로고    scopus 로고
    • High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses
    • Abd El-Rehim DM, Ball G, Pinder SE et al. High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer 2005; 116: 340-350.
    • (2005) Int J Cancer , vol.116 , pp. 340-350
    • Abd El-Rehim, D.M.1    Ball, G.2    Pinder, S.E.3
  • 16
    • 33847022042 scopus 로고    scopus 로고
    • BRCA1 dysfunction in sporadic basal-like breast cancer
    • Turner NC, Reis-Filho JS, Russell AM et al. BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene 2007; 26: 2126-2132.
    • (2007) Oncogene , vol.26 , pp. 2126-2132
    • Turner, N.C.1    Reis-Filho, J.S.2    Russell, A.M.3
  • 17
    • 34247381115 scopus 로고    scopus 로고
    • Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    • Haffty BG, Yang Q, Reiss M et al. Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol 2006; 24: 5652-5657.
    • (2006) J Clin Oncol , vol.24 , pp. 5652-5657
    • Haffty, B.G.1    Yang, Q.2    Reiss, M.3
  • 18
    • 65649151690 scopus 로고    scopus 로고
    • Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design
    • Kassam F, Enright K, Dent R et al. Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design. Clin Breast Cancer 2009; 9: 29-33.
    • (2009) Clin Breast Cancer , vol.9 , pp. 29-33
    • Kassam, F.1    Enright, K.2    Dent, R.3
  • 19
    • 68249144780 scopus 로고    scopus 로고
    • Mukesh BNBreast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival
    • Onitilo AA, Engel JM, Greenlee RT, Mukesh BNBreast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival. Clin Med Res 2009; 7: 4-13.
    • (2009) Clin Med Res , vol.7 , pp. 4-13
    • Onitilo, A.A.1    Engel, J.M.2    Greenlee, R.T.3
  • 21
    • 41649102048 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    • Liedtke C, Mazouni C, Hess KR et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol 2008; 26: 1275-1281.
    • (2008) J Clin Oncol , vol.26 , pp. 1275-1281
    • Liedtke, C.1    Mazouni, C.2    Hess, K.R.3
  • 22
    • 34547661993 scopus 로고    scopus 로고
    • Triple-negative breast cancer: clinical features and patterns of recurrence
    • Dent R, Trudeau M, Pritchard KI et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 2007; 13: 4429-4434.
    • (2007) Clin Cancer Res , vol.13 , pp. 4429-4434
    • Dent, R.1    Trudeau, M.2    Pritchard, K.I.3
  • 23
    • 33744960226 scopus 로고    scopus 로고
    • Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    • Carey LA, Perou CM, Livasy CA et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 2006; 295: 2492-2502.
    • (2006) JAMA , vol.295 , pp. 2492-2502
    • Carey, L.A.1    Perou, C.M.2    Livasy, C.A.3
  • 24
    • 34247569300 scopus 로고    scopus 로고
    • Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California Cancer Registry
    • Bauer KR, Brown M, Cress RD et al. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California Cancer Registry. Cancer 2007; 109: 1721-1728.
    • (2007) Cancer , vol.109 , pp. 1721-1728
    • Bauer, K.R.1    Brown, M.2    Cress, R.D.3
  • 26
    • 62549091454 scopus 로고    scopus 로고
    • Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial
    • Hugh J, Hanson J, Cheang MC et al. Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. J Clin Oncol 2009; 27: 1168-1176.
    • (2009) J Clin Oncol , vol.27 , pp. 1168-1176
    • Hugh, J.1    Hanson, J.2    Cheang, M.C.3
  • 27
    • 44849114353 scopus 로고    scopus 로고
    • Subtypes of breast cancer show preferential site of relapse
    • Smid M, Wang Y, Zhang Y et al. Subtypes of breast cancer show preferential site of relapse. Cancer Res 2008; 68: 3108-3114.
    • (2008) Cancer Res , vol.68 , pp. 3108-3114
    • Smid, M.1    Wang, Y.2    Zhang, Y.3
  • 28
    • 70350008453 scopus 로고    scopus 로고
    • Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases
    • Heitz F, Harter P, Lueck HJ et al. Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases. Eur J Cancer 2009; 45: 2792-2798.
    • (2009) Eur J Cancer , vol.45 , pp. 2792-2798
    • Heitz, F.1    Harter, P.2    Lueck, H.J.3
  • 29
    • 41949104971 scopus 로고    scopus 로고
    • Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the arimidex, tamoxifen, alone or in combination trial
    • Dowsett M, Allred C, Knox J et al. Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the arimidex, tamoxifen, alone or in combination trial. J Clin Oncol 2008; 26: 1059-1065.
    • (2008) J Clin Oncol , vol.26 , pp. 1059-1065
    • Dowsett, M.1    Allred, C.2    Knox, J.3
  • 30
    • 79960834725 scopus 로고    scopus 로고
    • Relative contributions of BRCA1 and BRCA2 mutations to "triple-negative" breast cancer in Ashkenazi women
    • Comen E, Davids M, Kirchhoff T et al. Relative contributions of BRCA1 and BRCA2 mutations to "triple-negative" breast cancer in Ashkenazi women. Breast Cancer Res Treat 2011; 129: 185-190.
    • (2011) Breast Cancer Res Treat , vol.129 , pp. 185-190
    • Comen, E.1    Davids, M.2    Kirchhoff, T.3
  • 31
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple-negative breast cancer
    • O'Shaughnessy J, Osborne C, Pippen JE et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med 2011; 364: 205-214.
    • (2011) N Engl J Med , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.E.3
  • 32
    • 0035796042 scopus 로고    scopus 로고
    • Homologous recombinational repair of DNA ensures mammalian chromosome stability
    • Thompson LH, Schild D. Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutat Res 2001; 477: 131-153.
    • (2001) Mutat Res , vol.477 , pp. 131-153
    • Thompson, L.H.1    Schild, D.2
  • 33
    • 0034720734 scopus 로고    scopus 로고
    • Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1
    • Dantzer F, de La Rubia G, Menissier-De Murcia J et al. Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. Biochemistry (Mosc) 2000; 39: 7559-7569.
    • (2000) , vol.39 , pp. 7559-7569
    • Dantzer, F.1    de La Rubia, G.2    Menissier-De Murcia, J.3
  • 34
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature 2001; 411: 366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 35
    • 77957169419 scopus 로고    scopus 로고
    • Single institute phase II study of weekly cisplatinum and metronomic dosing of cyclophosphamide and methotrexate in second line metastatic breast cancer triple-negative
    • (Abstr 41LBA, presented data-ECCO 15-ESMO 34 2009)
    • Bhattacharyya GS, Basu S, Agarwal V et al. Single institute phase II study of weekly cisplatinum and metronomic dosing of cyclophosphamide and methotrexate in second line metastatic breast cancer triple-negative. Eur J Cancer 2009; 7: 18. (Abstr 41LBA, presented data-ECCO 15-ESMO 34 2009).
    • (2009) Eur J Cancer , vol.7 , pp. 18
    • Bhattacharyya, G.S.1    Basu, S.2    Agarwal, V.3
  • 36
    • 61349152550 scopus 로고    scopus 로고
    • TBCRC 001 EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer
    • (Abstr 1009, presented data-ASCO Annual Meeting 2008)
    • Carey LA, Rugo HS, Marcom PK et al. TBCRC 001: EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer. J Clin Oncol 2008; 26: (Abstr 1009, presented data-ASCO Annual Meeting 2008).
    • (2008) J Clin Oncol , pp. 26
    • Carey, L.A.1    Rugo, H.S.2    Marcom, P.K.3
  • 37
    • 80052330662 scopus 로고    scopus 로고
    • A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC)
    • (Abstr 1007, presented data-ASCO Annual Meeting 2011)
    • O'Shaughnessy J, Schwartzberg LS, Danso MA et al. A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC). J Clin Oncol 2011; 29: (Abstr 1007, presented data-ASCO Annual Meeting 2011).
    • (2011) J Clin Oncol , pp. 29
    • O'Shaughnessy, J.1    Schwartzberg, L.S.2    Danso, M.A.3
  • 38
    • 80051731918 scopus 로고    scopus 로고
    • Carboplatin and gemcitabine combination in metastatic triple-negative anthracycline- and taxane-pretreated breast cancer patients: a phase II study
    • Maisano R, Zavettieri M, Azzarello D et al. Carboplatin and gemcitabine combination in metastatic triple-negative anthracycline- and taxane-pretreated breast cancer patients: a phase II study. J Chemother 2011; 23: 40-43.
    • (2011) J Chemother , vol.23 , pp. 40-43
    • Maisano, R.1    Zavettieri, M.2    Azzarello, D.3
  • 39
    • 80054120482 scopus 로고    scopus 로고
    • Efficacy of gemcitabine and cisplatin (GP) as first-line combination therapy in patients with triple-negative metastatic breast cancer: preliminary results report of a phase II trial
    • (Abstr 1100)
    • Wang Z, Hu X, Chen L et al. Efficacy of gemcitabine and cisplatin (GP) as first-line combination therapy in patients with triple-negative metastatic breast cancer: preliminary results report of a phase II trial. J Clin Oncol 2010; 28: (Abstr 1100).
    • (2010) J Clin Oncol , pp. 28
    • Wang, Z.1    Hu, X.2    Chen, L.3
  • 40
    • 82155199636 scopus 로고    scopus 로고
    • Chemotherapy (CT) with or without carboplatin as neoadjuvant treatment in patients with basal-like breast cancer: GEICAM 2006-03-A multicenter, randomized phase II study
    • (Abstr 1015, presented data-ASCO Annual Meeting 2011)
    • Alba E, Chacon JI, Lluch A et al. Chemotherapy (CT) with or without carboplatin as neoadjuvant treatment in patients with basal-like breast cancer: GEICAM 2006-03-A multicenter, randomized phase II study. J Clin Oncol2011; 29: (Abstr 1015, presented data-ASCO Annual Meeting 2011).
    • (2011) J Clin Oncol , pp. 29
    • Alba, E.1    Chacon, J.I.2    Lluch, A.3
  • 41
    • 80054117561 scopus 로고    scopus 로고
    • TBCRC009: a multicenter phase II study of cisplatin or carboplatin for metastatic triple-negative breast cancer and evaluation of p63/p73 as a biomarker of response
    • 1025, presented data-ASCO Annual Meeting 2011)
    • Isakoff SJ, Goss PE, Mayer EL et al. TBCRC009: a multicenter phase II study of cisplatin or carboplatin for metastatic triple-negative breast cancer and evaluation of p63/p73 as a biomarker of response. J Clin Oncol 2011; 29: (Abstr 1025, presented data-ASCO Annual Meeting 2011).
    • (2011) J Clin Oncol (Abstr , pp. 29
    • Isakoff, S.J.1    Goss, P.E.2    Mayer, E.L.3
  • 42
    • 80054098596 scopus 로고    scopus 로고
    • The comparison of the benefits obtained from platinum-containing chemotherapy between triple-negative and non-triplenegative metastatic breast cancer
    • (Abstr 1071)
    • Kim T, Lee H, Han S et al. The comparison of the benefits obtained from platinum-containing chemotherapy between triple-negative and non-triplenegative metastatic breast cancer. J Clin Oncol 2010; 28: (Abstr 1071).
    • (2010) J Clin Oncol , pp. 28
    • Kim, T.1    Lee, H.2    Han, S.3
  • 43
    • 84860697370 scopus 로고    scopus 로고
    • Cetuximab + cisplatin in estrogen receptornegative, progesterone receptor-negative HER2-negative (triple-negative) metastatic breast cancer: results of the randomized phase II BALI-1 trial
    • (Abstr PD01-01, presented data-SABCS 2010)
    • Baselga J, Stemmer S, Pego A et al. Cetuximab + cisplatin in estrogen receptornegative, progesterone receptor-negative, HER2-negative (triple-negative) metastatic breast cancer: results of the randomized phase II BALI-1 trial. Cancer Res 2010; 70: (Abstr PD01-01, presented data-SABCS 2010).
    • (2010) Cancer Res , pp. 70
    • Baselga, J.1    Stemmer, S.2    Pego, A.3
  • 44
    • 84862000368 scopus 로고    scopus 로고
    • Use of SPARC, EGFR, and VEGFR expression to predict response to nab-paclitaxel (nabP)/carboplatin (C)/ bevacizumab (B) chemotherapy in triple-negative metastatic breast cancer (TNMBC)
    • (Abstr 1109)
    • Hamilton EP, Kimmick GG, Desai N et al. Use of SPARC, EGFR, and VEGFR expression to predict response to nab-paclitaxel (nabP)/carboplatin (C)/ bevacizumab (B) chemotherapy in triple-negative metastatic breast cancer (TNMBC). J Clin Oncol 2010; 28: (Abstr 1109).
    • (2010) J Clin Oncol , pp. 28
    • Hamilton, E.P.1    Kimmick, G.G.2    Desai, N.3
  • 45
    • 43549106185 scopus 로고    scopus 로고
    • Preliminary results of a randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer
    • (Abstr 308, presented data-SABCS 2007)
    • O'Shaughnessy J, Weckstein D, Vukelja S et al. Preliminary results of a randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer. Breast Cancer Res Treat 2007; 106: S32. (Abstr 308, presented data-SABCS 2007).
    • (2007) Breast Cancer Res Treat , vol.106
    • O'Shaughnessy, J.1    Weckstein, D.2    Vukelja, S.3
  • 46
    • 68149168181 scopus 로고    scopus 로고
    • Neoadjuvant cisplatin and bevacizumab in triple negative breast cancer (TNBC): safety and efficacy
    • (Abstr 551, presented data-ASCO Annual Meeting 2009)
    • Ryan PD, Tung NM, Isakoff SJ et al. Neoadjuvant cisplatin and bevacizumab in triple negative breast cancer (TNBC): safety and efficacy. J Clin Oncol 2009; 27: (Abstr 551, presented data-ASCO Annual Meeting 2009).
    • (2009) J Clin Oncol , pp. 27
    • Ryan, P.D.1    Tung, N.M.2    Isakoff, S.J.3
  • 47
    • 84872610136 scopus 로고    scopus 로고
    • Results of a phase II study of neoadjuvant platinum/taxane based chemotherapy and erlotinib for triple negative breast cancer
    • (Abstr P1-11-07, presented data-SABCS 2010)
    • Sharma P, Khan QJ, Kimler BF et al. Results of a phase II study of neoadjuvant platinum/taxane based chemotherapy and erlotinib for triple negative breast cancer. Cancer Res 2010; 70: (Abstr P1-11-07, presented data-SABCS 2010).
    • (2010) Cancer Res , pp. 70
    • Sharma, P.1    Khan, Q.J.2    Kimler, B.F.3
  • 48
    • 67650382241 scopus 로고    scopus 로고
    • Preoperative weekly cisplatin-epirubicin- paclitaxel with G-CSF support in triple-negative large operable breast cancer
    • Frasci G, Comella P, Rinaldo M et al. Preoperative weekly cisplatin-epirubicin- paclitaxel with G-CSF support in triple-negative large operable breast cancer. Ann Oncol 2009; 20: 1185-1192.
    • (2009) Ann Oncol , vol.20 , pp. 1185-1192
    • Frasci, G.1    Comella, P.2    Rinaldo, M.3
  • 49
    • 47549084272 scopus 로고    scopus 로고
    • Tailored preoperative treatment of locally advanced triple negative (hormone receptor negative and HER2 negative) breast cancer with epirubicin, cisplatin, and infusional fluorouracil followed by weekly paclitaxel
    • Torrisi R, Balduzzi A, Ghisini R et al. Tailored preoperative treatment of locally advanced triple negative (hormone receptor negative and HER2 negative) breast cancer with epirubicin, cisplatin, and infusional fluorouracil followed by weekly paclitaxel. Cancer Chemother Pharmacol 2008; 62: 667-672.
    • (2008) Cancer Chemother Pharmacol , vol.62 , pp. 667-672
    • Torrisi, R.1    Balduzzi, A.2    Ghisini, R.3
  • 50
    • 77953327187 scopus 로고    scopus 로고
    • Weekly paclitaxel plus carboplatin is an effective nonanthracycline-containing regimen as neoadjuvant chemotherapy for breast cancer
    • Chen XS, Nie XQ, Chen CM et al. Weekly paclitaxel plus carboplatin is an effective nonanthracycline-containing regimen as neoadjuvant chemotherapy for breast cancer. Ann Oncol 2010; 21: 961-967.
    • (2010) Ann Oncol , vol.21 , pp. 961-967
    • Chen, X.S.1    Nie, X.Q.2    Chen, C.M.3
  • 51
    • 84872601645 scopus 로고    scopus 로고
    • Phase II open, single-arm trial: cisplatin combined with paclitaxel and doxorubicin in operable or locally advanced triple-negative breast cancer
    • (Abstr 1135, presented data-ASCO Annual Meeting 2011)
    • Miranda AA, Lara Medina FU, Arce C et al. Phase II open, single-arm trial: cisplatin combined with paclitaxel and doxorubicin in operable or locally advanced triple-negative breast cancer. J Clin Oncol 2011; 29: (Abstr 1135, presented data-ASCO Annual Meeting 2011).
    • (2011) J Clin Oncol , pp. 29
    • Miranda, A.A.1    Lara Medina, F.U.2    Arce, C.3
  • 52
    • 6844222840 scopus 로고    scopus 로고
    • Anderson NCarboplatin versus cisplatin in solid tumors: an analysis of the literature
    • Lokich J, Anderson NCarboplatin versus cisplatin in solid tumors: an analysis of the literature. Ann Oncol 1998; 9: 13-21.
    • (1998) Ann Oncol , vol.9 , pp. 13-21
    • Lokich, J.1
  • 53
    • 70249143282 scopus 로고    scopus 로고
    • Cisplatin versus carboplatin in NSCLC: is there one "best" answer?
    • Sanborn RE. Cisplatin versus carboplatin in NSCLC: is there one "best" answer?. Curr Treat Options Oncol 2008; 9: 326-342.
    • (2008) Curr Treat Options Oncol , vol.9 , pp. 326-342
    • Sanborn, R.E.1
  • 54
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361: 123-134.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 55
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial
    • Tutt A, Robson M, Garber JE et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 2010; 376: 235-244.
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 56
    • 77955877185 scopus 로고    scopus 로고
    • A phase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer
    • (Abstr 1019, presented data-ASCO Annual Meeting 2010)
    • Isakoff SJ, Overmoyer B, Tung NM et al. A phase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer. J Clin Oncol 2010; 28: (Abstr 1019, presented data-ASCO Annual Meeting 2010).
    • (2010) J Clin Oncol , pp. 28
    • Isakoff, S.J.1    Overmoyer, B.2    Tung, N.M.3
  • 57
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
    • Gelmon KA, Tischkowitz M, Mackay H et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 2011; 12: 852-861.
    • (2011) Lancet Oncol , vol.12 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3
  • 58
    • 77955856734 scopus 로고    scopus 로고
    • Safety and efficacy of the oral PARP inhibitor olaparib (AZD2281) in combination with paclitaxel for the first- or second-line treatment of patients with metastatic triple-negative breast cancer: results from the safety cohort of a phase I/II multicenter trial
    • (Abstr 1018, presented data-ASCO Annual Meeting 2010)
    • Dent RA, Lindeman GJ, Clemons M et al. Safety and efficacy of the oral PARP inhibitor olaparib (AZD2281) in combination with paclitaxel for the first- or second-line treatment of patients with metastatic triple-negative breast cancer: results from the safety cohort of a phase I/II multicenter trial. J Clin Oncol 2010; 28: (Abstr 1018, presented data-ASCO Annual Meeting 2010).
    • (2010) J Clin Oncol , pp. 28
    • Dent, R.A.1    Lindeman, G.J.2    Clemons, M.3
  • 59
    • 43249090316 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine/carboplatin (plus trastuzumab in HER2-positive disease) in patients with metastatic breast cancer
    • Loesch D, Asmar L, McIntyre K et al. Phase II trial of gemcitabine/carboplatin (plus trastuzumab in HER2-positive disease) in patients with metastatic breast cancer. Clin Breast Cancer 2008; 8: 178-186.
    • (2008) Clin Breast Cancer , vol.8 , pp. 178-186
    • Loesch, D.1    Asmar, L.2    McIntyre, K.3
  • 60
    • 70649087117 scopus 로고    scopus 로고
    • A phase I combination study of AZD2281 and cisplatin plus gemcitabine in adults with solid tumors
    • (Abstr G04, presented data-7th International Symposium on Targeted Anticancer Therapies)
    • Rajan A, Gutierrez M, Kummar S et al. A phase I combination study of AZD2281 and cisplatin plus gemcitabine in adults with solid tumors. Ann Oncol 2009; 20: (Abstr G04, presented data-7th International Symposium on Targeted Anticancer Therapies).
    • (2009) Ann Oncol , pp. 20
    • Rajan, A.1    Gutierrez, M.2    Kummar, S.3
  • 61
    • 79959256086 scopus 로고    scopus 로고
    • A phase I combination study of olaparib (AZD2281; KU-0059436) and cisplatin (C) plus gemcitabine (G) in adults with solid tumors
    • (Abstr 3027, presented data-ASCO Annual Meeting 2010)
    • Giaccone G, Rajan A, Kelly RJ et al. A phase I combination study of olaparib (AZD2281; KU-0059436) and cisplatin (C) plus gemcitabine (G) in adults with solid tumors. J Clin Oncol 2010; 28: (Abstr 3027, presented data-ASCO Annual Meeting 2010).
    • (2010) J Clin Oncol , pp. 28
    • Giaccone, G.1    Rajan, A.2    Kelly, R.J.3
  • 62
    • 77956300908 scopus 로고    scopus 로고
    • Preliminary results of a phase I trial of ABT-888, a poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with cyclophosphamide
    • (Abstr 3000, presented data-ASCO Annual Meeting 2010)
    • Tan AR, Gibbon D, Stein MN et al. Preliminary results of a phase I trial of ABT-888, a poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with cyclophosphamide. J Clin Oncol 2010; 28: (Abstr 3000, presented data-ASCO Annual Meeting 2010).
    • (2010) J Clin Oncol , pp. 28
    • Tan, A.R.1    Gibbon, D.2    Stein, M.N.3
  • 63
    • 79956209286 scopus 로고    scopus 로고
    • A phase I study of ABT-888 (A) in combination with metronomic cyclophosphamide (C) in adults with refractory solid tumors and lymphomas
    • (Abstr 2605)
    • Kummar S, Chen AP, Ji JJ et al. A phase I study of ABT-888 (A) in combination with metronomic cyclophosphamide (C) in adults with refractory solid tumors and lymphomas. J Clin Oncol 2010; 28: (Abstr 2605).
    • (2010) J Clin Oncol , vol.28
    • Kummar, S.1    Chen, A.P.2    Ji, J.J.3
  • 64
    • 70349642532 scopus 로고    scopus 로고
    • Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast cancer
    • Linderholm BK, Hellborg H, Johansson U et al. Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast cancer. Ann Oncol 2009; 20: 1639-1646.
    • (2009) Ann Oncol , vol.20 , pp. 1639-1646
    • Linderholm, B.K.1    Hellborg, H.2    Johansson, U.3
  • 65
    • 77949686134 scopus 로고    scopus 로고
    • Comparison of subgroup analyses of PFS from three phase III studies of bevacizumab in combination with chemotherapy in patients with HER2-negative metastatic breast cancer (MBC)
    • (Abstr 207, presented data-SABCS 2009)
    • O'Shaughnessy J, Dieras V, Glaspy J et al. Comparison of subgroup analyses of PFS from three phase III studies of bevacizumab in combination with chemotherapy in patients with HER2-negative metastatic breast cancer (MBC). Cancer Res 2009; 69: (Abstr 207, presented data-SABCS 2009).
    • (2009) Cancer Res , vol.69
    • O'Shaughnessy, J.1    Dieras, V.2    Glaspy, J.3
  • 66
    • 82455194681 scopus 로고    scopus 로고
    • Impact of bevacizumab (BEV) on efficacy of second-line chemotherapy (CT) for triple-negative breast cancer (TNBC): analysis of RIBBON-2
    • (Abstr 1010, presented data-ASCO Annual Meeting 2011)
    • Brufsky A, Valero V, Tiangco B et al. Impact of bevacizumab (BEV) on efficacy of second-line chemotherapy (CT) for triple-negative breast cancer (TNBC): analysis of RIBBON-2. J Clin Oncol 2011; 29: (Abstr 1010, presented data-ASCO Annual Meeting 2011).
    • (2011) J Clin Oncol , pp. 29
    • Brufsky, A.1    Valero, V.2    Tiangco, B.3
  • 67
    • 84863799879 scopus 로고    scopus 로고
    • A randomized phase II study of sunitinib vs. standard of care for patients with previously treated advanced triple-negative breast cancer
    • (Abstr P6-12-02, presented data-SABCS 2010)
    • Curigliano G, Pivot X, Cortes J et al. A randomized phase II study of sunitinib vs. standard of care for patients with previously treated advanced triple-negative breast cancer. Cancer Res 2010; 70: (Abstr P6-12-02, presented data-SABCS 2010).
    • (2010) Cancer Res , pp. 70
    • Curigliano, G.1    Pivot, X.2    Cortes, J.3
  • 68
    • 84861711824 scopus 로고    scopus 로고
    • Overall survival data from SOLTI-0701: a multinational, double-blind, placebo-controlled, randomized phase 2b study evaluating the oral combination of sorafenib and capecitabine in patients with locally advanced or metastatic HER2-negative breast cancer
    • (Abstr P2-16-01, presented data-SABCS 2010)
    • Gomez P, Roche H, Costa F et al. Overall survival data from SOLTI-0701: a multinational, double-blind, placebo-controlled, randomized phase 2b study evaluating the oral combination of sorafenib and capecitabine in patients with locally advanced or metastatic HER2-negative breast cancer. Cancer Res 2010; 70: (Abstr P2-16-01, presented data-SABCS 2010).
    • (2010) Cancer Res , vol.70
    • Gomez, P.1    Roche, H.2    Costa, F.3
  • 69
    • 77949769826 scopus 로고    scopus 로고
    • SOLTI-0701: a multinational double-blind, randomized phase 2b study evaluating the efficacy and safety of sorafenib compared to placebo when administered in combination with capecitabine in patients with locally advanced or metastatic breast cancer (BC)
    • (Abstr 45, presented data-SABCS 2009)
    • Baselga J, Roche H, Costa F et al. SOLTI-0701: a multinational double-blind, randomized phase 2b study evaluating the efficacy and safety of sorafenib compared to placebo when administered in combination with capecitabine in patients with locally advanced or metastatic breast cancer (BC). Cancer Res 2009; 69: (Abstr 45, presented data-SABCS 2009).
    • (2009) Cancer Res , vol.69
    • Baselga, J.1    Roche, H.2    Costa, F.3
  • 70
    • 84858642912 scopus 로고    scopus 로고
    • Sorafenib (SOR) plus chemotherapy (CRx) for patients (pts) with advanced (adv) breast cancer (BC) previously treated with bevacizumab (BEV)
    • (Abstr 1009, presented data-ASCO Annual Meeting 2011)
    • Hudis C, Tauer KW, Hermann RC et al. Sorafenib (SOR) plus chemotherapy (CRx) for patients (pts) with advanced (adv) breast cancer (BC) previously treated with bevacizumab (BEV). J Clin Oncol 2011; 29: (Abstr 1009, presented data-ASCO Annual Meeting 2011).
    • (2011) J Clin Oncol , vol.29
    • Hudis, C.1    Tauer, K.W.2    Hermann, R.C.3
  • 71
    • 69849105168 scopus 로고    scopus 로고
    • Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer
    • Finn RS, Press MF, Dering J et al. Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer. J Clin Oncol 2009; 27: 3908-3915.
    • (2009) J Clin Oncol , vol.27 , pp. 3908-3915
    • Finn, R.S.1    Press, M.F.2    Dering, J.3
  • 72
    • 79959876844 scopus 로고    scopus 로고
    • Meta-analysis of patients with triplenegative breast cancer (TNBC) from three randomized trials of first-line bevacizumab (BV) and chemotherapy treatment for metastatic breast cancer (MBC)
    • (Abstr P6-12-03, presented data-SABCS 2010)
    • O'Shaughnessy J, Romieu G, Diéras V et al. Meta-analysis of patients with triplenegative breast cancer (TNBC) from three randomized trials of first-line bevacizumab (BV) and chemotherapy treatment for metastatic breast cancer (MBC). Cancer Res 2010; 70: (Abstr P6-12-03, presented data-SABCS 2010).
    • (2010) Cancer Res , vol.70
    • O'Shaughnessy, J.1    Romieu, G.2    Diéras, V.3
  • 73
    • 79952083872 scopus 로고    scopus 로고
    • Congestive heart failure risk in patients with breast cancer treated with bevacizumab
    • Choueiri TK, Mayer EL, Je Y et al. Congestive heart failure risk in patients with breast cancer treated with bevacizumab. J Clin Oncol 2011; 29: 632-638.
    • (2011) J Clin Oncol , vol.29 , pp. 632-638
    • Choueiri, T.K.1    Mayer, E.L.2    Je, Y.3
  • 74
    • 84872595433 scopus 로고    scopus 로고
    • Magnitude of risks and benefits of the addition of bevacizumab (BEVA) to chemotherapy (CT) for patients (pts) with advanced breast cancer (ABC): metaregression analysis of randomized trials (RCT)
    • (Abstr 1045, presented data-ASCO Annual Meeting 2010)
    • Cuppone F, Bria E, Sperduti I et al. Magnitude of risks and benefits of the addition of bevacizumab (BEVA) to chemotherapy (CT) for patients (pts) with advanced breast cancer (ABC): metaregression analysis of randomized trials (RCT). J Clin Oncol 2010; 28: (Abstr 1045, presented data-ASCO Annual Meeting 2010).
    • (2010) J Clin Oncol , vol.28
    • Cuppone, F.1    Bria, E.2    Sperduti, I.3
  • 75
    • 80053069130 scopus 로고    scopus 로고
    • Avastin hearing leads to more uncertainty over drug's future
    • Goozner MAvastin hearing leads to more uncertainty over drug's future. J Natl Cancer Inst 2011; 103: 1148-1150.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1148-1150
    • Goozner, M.1
  • 76
    • 84856291930 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer
    • von Minckwitz G, Eidtmann H, Rezai M et al. Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer. N Engl J Med 2012; 366: 299-309.
    • (2012) N Engl J Med , vol.366 , pp. 299-309
    • von Minckwitz, G.1    Eidtmann, H.2    Rezai, M.3
  • 77
    • 80052882569 scopus 로고    scopus 로고
    • The effect on pCR of bevacizumab and/or antimetabolites added to standard neoadjuvant chemotherapy: NSABP protocol B-40
    • (Abstr LBA 1005 presented data-ASCO Annual Meeting 2011)
    • Bear HD, Tang G, Rastogi P et al. The effect on pCR of bevacizumab and/or antimetabolites added to standard neoadjuvant chemotherapy: NSABP protocol B-40. J Clin Oncol 2011; 29: (Abstr LBA 1005, presented data-ASCO Annual Meeting 2011).
    • (2011) J Clin Oncol , vol.29
    • Bear, H.D.1    Tang, G.2    Rastogi, P.3
  • 78
    • 51849134272 scopus 로고    scopus 로고
    • Phase II feasibility trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node-positive breast cancer: a trial of the Eastern Cooperative Oncology Group (E2104)
    • Miller KD, O'Neill A, Perez EA et al. Phase II feasibility trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node-positive breast cancer: a trial of the Eastern Cooperative Oncology Group (E2104). J Clin Oncol 2008; 26: 520.
    • (2008) J Clin Oncol , vol.26 , pp. 520
    • Miller, K.D.1    O'Neill, A.2    Perez, E.A.3
  • 79
    • 69949109089 scopus 로고    scopus 로고
    • Cardiac safety of adjuvant bevacizumab (B) plus dose-dense doxorubicin/cyclophosphamide (AC) followed by nanoparticle albumin-bound paclitaxel (nab-P) in patients with early stage breast cancer. Cancer Res
    • (Abstr 4104, presented data-SABCS 2008)
    • McArthur HL, Rugo H, Nulsen B et al. Cardiac safety of adjuvant bevacizumab (B) plus dose-dense doxorubicin/cyclophosphamide (AC) followed by nanoparticle albumin-bound paclitaxel (nab-P) in patients with early stage breast cancer. Cancer Res 2009; 69: 281S-282S: (Abstr 4104, presented data-SABCS 2008).
    • (2009) , vol.69
    • McArthur, H.L.1    Rugo, H.2    Nulsen, B.3
  • 80
    • 74949098887 scopus 로고    scopus 로고
    • Dose-dense adjuvant doxorubicin and cyclophosphamide is not associated with frequent short-term changes in left ventricular ejection fraction
    • Morris PG, Dickler M, McArthur HL et al. Dose-dense adjuvant doxorubicin and cyclophosphamide is not associated with frequent short-term changes in left ventricular ejection fraction. J Clin Oncol 2009; 27: 6117-6123.
    • (2009) J Clin Oncol , vol.27 , pp. 6117-6123
    • Morris, P.G.1    Dickler, M.2    McArthur, H.L.3
  • 81
    • 84856325150 scopus 로고    scopus 로고
    • A phase II pilot trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node positive breast cancer: a trial coordinated by the Eastern Cooperative Oncology Group
    • Miller KD, O'Neill A, Perez EA et al. A phase II pilot trial incorporating bevacizumab into dose-dense doxorubicin and cyclophosphamide followed by paclitaxel in patients with lymph node positive breast cancer: a trial coordinated by the Eastern Cooperative Oncology Group. Ann Oncol 2012; 23: 331-337.
    • (2012) Ann Oncol , vol.23 , pp. 331-337
    • Miller, K.D.1    O'Neill, A.2    Perez, E.A.3
  • 82
    • 84865571445 scopus 로고    scopus 로고
    • Cancernetwork., comAvastin breast Rx trial enrollment halted due to cardiotoxicity, cases
    • Cancernetwork. comAvastin breast Rx trial enrollment halted due to cardiotoxicity cases. Oncology NEWS International 2009; 18: 10.
    • (2009) Oncology, NEWS., International , vol.18 , pp. 10
  • 83
    • 77951296573 scopus 로고    scopus 로고
    • Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer
    • Barrios CH, Liu MC, Lee SC et al. Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer. Breast Cancer Res Treat 2010; 121: 121-131.
    • (2010) Breast Cancer Res Treat , vol.121 , pp. 121-131
    • Barrios, C.H.1    Liu, M.C.2    Lee, S.C.3
  • 84
    • 77956187531 scopus 로고    scopus 로고
    • Multicenter phase II randomized trial evaluating antiangiogenic therapy with sunitinib as consolidation after objective response to taxane chemotherapy in women with HER2-negative metastatic breast cancer
    • Wildiers H, Fontaine C, Vuylsteke P et al. Multicenter phase II randomized trial evaluating antiangiogenic therapy with sunitinib as consolidation after objective response to taxane chemotherapy in women with HER2-negative metastatic breast cancer. Breast Cancer Res Treat 2010; 123: 463-469.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 463-469
    • Wildiers, H.1    Fontaine, C.2    Vuylsteke, P.3
  • 85
    • 42949148257 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Burstein HJ, Elias AD, Rugo HS et al. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2008; 26: 1810-1816.
    • (2008) J Clin Oncol , vol.26 , pp. 1810-1816
    • Burstein, H.J.1    Elias, A.D.2    Rugo, H.S.3
  • 86
    • 77957604275 scopus 로고    scopus 로고
    • SABRE-B: an evaluation of paclitaxel and bevacizumab with or without sunitinib as first-line treatment of metastatic breast cancer
    • Mayer EL, Dhakil S, Patel T et al. SABRE-B: an evaluation of paclitaxel and bevacizumab with or without sunitinib as first-line treatment of metastatic breast cancer. Ann Oncol 2010; 21: 2370-2376.
    • (2010) Ann Oncol , vol.21 , pp. 2370-2376
    • Mayer, E.L.1    Dhakil, S.2    Patel, T.3
  • 87
    • 78651347654 scopus 로고    scopus 로고
    • Phase III trial of sunitinib (SU) in combination with capecitabine (C) versus C in previously treated advanced breast cancer (ABC). J Clin Oncol (Abstr LBA1011
    • (Abstr LBA1011, presented data-ASCO Annual Meeting 2010)
    • Crown J, Dieras V, Staroslawska E et al. Phase III trial of sunitinib (SU) in combination with capecitabine (C) versus C in previously treated advanced breast cancer (ABC). J Clin Oncol 2010; 28: (Abstr LBA1011, presented data-ASCO Annual Meeting 2010).
    • (2010) presented data-ASCO Annual Meeting 2010) , vol.28
    • Crown, J.1    Dieras, V.2    Staroslawska, E.3
  • 88
    • 77955911251 scopus 로고    scopus 로고
    • Sunitinib (SU) in combination with docetaxel (D) versus D alone for the first-line treatment of advanced breast cancer (ABC)
    • (Abstr LBA1010, presented data-ASCO Annual Meeting 2010)
    • Bergh J, Greil R, Voytko N et al. Sunitinib (SU) in combination with docetaxel (D) versus D alone for the first-line treatment of advanced breast cancer (ABC). J Clin Oncol 2010; 28: (Abstr LBA1010, presented data-ASCO Annual Meeting 2010).
    • (2010) J Clin Oncol , vol.28
    • Bergh, J.1    Greil, R.2    Voytko, N.3
  • 89
    • 58149335533 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment Group and Mayo Clinic Trial N0336
    • Moreno-Aspitia A, Morton RF, Hillman DW et al. Phase II trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment Group and Mayo Clinic Trial N0336. J Clin Oncol 2009; 27: 11-15.
    • (2009) J Clin Oncol , vol.27 , pp. 11-15
    • Moreno-Aspitia, A.1    Morton, R.F.2    Hillman, D.W.3
  • 90
    • 70149087258 scopus 로고    scopus 로고
    • Phase II multicenter, uncontrolled trial of sorafenib in patients with metastatic breast cancer
    • Bianchi G, Loibl S, Zamagni C et al. Phase II multicenter, uncontrolled trial of sorafenib in patients with metastatic breast cancer. Anticancer Drugs 2009; 20: 616-624.
    • (2009) Anticancer Drugs , vol.20 , pp. 616-624
    • Bianchi, G.1    Loibl, S.2    Zamagni, C.3
  • 91
    • 84872615056 scopus 로고    scopus 로고
    • Sorafenib in combination with paclitaxel as a first-line therapy in patients with locally recurrent or metastatic breast cancer: overall survival results from a double-blind, randomized, placebocontrolled, phase 2b trial
    • (Abstr P2-16-03, presented data-SABCS 2010)
    • Bondarde S, Kaklamani V, Prasad Sahoo T et al. Sorafenib in combination with paclitaxel as a first-line therapy in patients with locally recurrent or metastatic breast cancer: overall survival results from a double-blind, randomized, placebocontrolled, phase 2b trial. Cancer Res 2010; 70: (Abstr P2-16-03, presented data-SABCS 2010).
    • (2010) Cancer Res , vol.70
    • Bondarde, S.1    Kaklamani, V.2    Prasad Sahoo, T.3
  • 92
    • 84872603293 scopus 로고    scopus 로고
    • Neoadjuvant bevacizumab and anthracycline-taxane-based chemotherapy in 686 triple-negative primary breast cancers: secondary endpoint analysis of the GeparQuinto study (GBG 44)
    • (Abstr 1006, presented data-ASCO Annual Meeting 2011)
    • Gerber B, Eidtmann H, Rezai M et al. Neoadjuvant bevacizumab and anthracycline-taxane-based chemotherapy in 686 triple-negative primary breast cancers: secondary endpoint analysis of the GeparQuinto study (GBG 44). ASCO Meeting Abstracts 2011; 29: (Abstr 1006, presented data-ASCO Annual Meeting 2011).
    • (2011) ASCO Meeting Abstracts , pp. 29
    • Gerber, B.1    Eidtmann, H.2    Rezai, M.3
  • 93
    • 47549107072 scopus 로고    scopus 로고
    • Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients
    • Tan DSP, Marchió C, Jones RL et al. Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients. Breast Cancer Res Treat 2008; 111: 27-44.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 27-44
    • Tan, D.S.P.1    Marchió, C.2    Jones, R.L.3
  • 94
    • 67649211199 scopus 로고    scopus 로고
    • Invasive ductal carcinoma of the breast with the "triple-negative" phenotype: prognostic implications of EGFR immunoreactivity
    • Viale G, Rotmensz N, Maisonneuve P et al. Invasive ductal carcinoma of the breast with the "triple-negative" phenotype: prognostic implications of EGFR immunoreactivity. Breast Cancer Res Treat 2009; 116: 317-328.
    • (2009) Breast Cancer Res Treat , vol.116 , pp. 317-328
    • Viale, G.1    Rotmensz, N.2    Maisonneuve, P.3
  • 95
    • 33846266252 scopus 로고    scopus 로고
    • Prognostic markers in triple-negative breast cancer
    • Rakha EA, El-Sayed ME, Green AR et al. Prognostic markers in triple-negative breast cancer. Cancer 2007; 109: 25-32.
    • (2007) Cancer , vol.109 , pp. 25-32
    • Rakha, E.A.1    El-Sayed, M.E.2    Green, A.R.3
  • 96
    • 79958711331 scopus 로고    scopus 로고
    • Effect of adding gefitinib to neoadjuvant chemotherapy in estrogen receptor negative early breast cancer in a randomized phase II trial
    • Bernsdorf M, Ingvar C, Jorgensen L et al. Effect of adding gefitinib to neoadjuvant chemotherapy in estrogen receptor negative early breast cancer in a randomized phase II trial. Breast Cancer Res Treat 2011; 126: 463-470.
    • (2011) Breast Cancer Res Treat , vol.126 , pp. 463-470
    • Bernsdorf, M.1    Ingvar, C.2    Jorgensen, L.3
  • 97
    • 1042267229 scopus 로고    scopus 로고
    • Determinants of rapamycin sensitivity in breast cancer cells
    • Noh WC, Mondesire WH, Peng J et al. Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res 2004; 10: 1013-1023.
    • (2004) Clin Cancer Res , vol.10 , pp. 1013-1023
    • Noh, W.C.1    Mondesire, W.H.2    Peng, J.3
  • 98
    • 0034790016 scopus 로고    scopus 로고
    • mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
    • Yu K, Toral-Barza L, Discafani C et al. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 2001; 8: 249-258.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3
  • 99
    • 80755185886 scopus 로고    scopus 로고
    • A phase Ib trial of RAD001, an mTOR inhibitor, with weekly cisplatin and paclitaxel in patients with HER2-negative metastatic breast cancer
    • (Abstr 3093, presented data-SABCS 2009)
    • Mayer I, Burris H, Bendell J et al. A phase Ib trial of RAD001, an mTOR inhibitor, with weekly cisplatin and paclitaxel in patients with HER2-negative metastatic breast cancer. Cancer Res 2009; 69: (Abstr 3093, presented data-SABCS 2009).
    • (2009) Cancer Res , vol.69
    • Mayer, I.1    Burris, H.2    Bendell, J.3
  • 100
    • 78650984926 scopus 로고    scopus 로고
    • Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab
    • Andre F, Campone M, O'Regan R et al. Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol 2010; 28: 5110-5115.
    • (2010) J Clin Oncol , vol.28 , pp. 5110-5115
    • Andre, F.1    Campone, M.2    O'Regan, R.3
  • 101
    • 84863617329 scopus 로고    scopus 로고
    • Open label, randomized clinical trial of standard neoadjuvant chemotherapy with paclitaxel followed by FEC (T-FEC) versus the combination of paclitaxel and RAD001 followed by FEC (TR-FEC) in women with triple receptor-negative breast cancer (TNBC)
    • (Abstr 1016, presented data-ASCO Annual Meeting 2011)
    • Gonzalez-Angulo AM, Green MC, Murray JL et al. Open label, randomized clinical trial of standard neoadjuvant chemotherapy with paclitaxel followed by FEC (T-FEC) versus the combination of paclitaxel and RAD001 followed by FEC (TR-FEC) in women with triple receptor-negative breast cancer (TNBC). J Clin Oncol 2011; 29: (Abstr 1016, presented data-ASCO Annual Meeting 2011).
    • (2011) J Clin Oncol , pp. 29
    • Gonzalez-Angulo, A.M.1    Green, M.C.2    Murray, J.L.3
  • 102
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357: 2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 103
    • 68449096428 scopus 로고    scopus 로고
    • Efficacy of BSI-201, a poly (ADPribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/ carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): results of a randomized phase II trial
    • (Abstr 3, presented data-ASCO Annual Meeting 2009)
    • O'Shaughnessy J, Osborne C, Pippen J et al. Efficacy of BSI-201, a poly (ADPribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/ carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): results of a randomized phase II trial. J Clin Oncol 2009; 27: (Abstr 3, presented data-ASCO Annual Meeting 2009).
    • (2009) J Clin Oncol , pp. 27
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.3
  • 104
    • 79151476662 scopus 로고    scopus 로고
    • Pegram MTriple negative breast cancer: unmet medical needs
    • Pal SK, Childs BH, Pegram MTriple negative breast cancer: unmet medical needs. Breast Cancer Res Treat 2011; 125: 627-636.
    • (2011) Breast Cancer Res Treat , vol.125 , pp. 627-636
    • Pal, S.K.1    Childs, B.H.2
  • 105
    • 78649459901 scopus 로고    scopus 로고
    • Potential predictive markers of benefit from cetuximab in metastatic breast cancer: an analysis of two randomized phase 2 trials
    • (Abstr presented data -SABCS 2009)
    • Carey L, O'Shaughnessy J, Hoadley K et al. Potential predictive markers of benefit from cetuximab in metastatic breast cancer: an analysis of two randomized phase 2 trials. Cancer Res 2009; 69: (Abstr 2014, presented data -SABCS 2009).
    • (2014) Cancer Res 2009 , vol.69
    • Carey, L.1    O'Shaughnessy, J.2    Hoadley, K.3
  • 106
    • 77949908546 scopus 로고    scopus 로고
    • Efficacy of neoadjuvant cisplatin in triple-negative breast cancer
    • Silver DP, Richardson AL, Eklund AC et al. Efficacy of neoadjuvant cisplatin in triple-negative breast cancer. J Clin Oncol 2010; 28: 1145-1153.
    • (2010) J Clin Oncol , vol.28 , pp. 1145-1153
    • Silver, D.P.1    Richardson, A.L.2    Eklund, A.C.3
  • 107
    • 54949097426 scopus 로고    scopus 로고
    • Platinum-based chemotherapy in triplenegative breast cancer
    • Sirohi B, Arnedos M, Popat S et al. Platinum-based chemotherapy in triplenegative breast cancer. Ann Oncol 2008; 19: 1847-1852.
    • (2008) Ann Oncol , vol.19 , pp. 1847-1852
    • Sirohi, B.1    Arnedos, M.2    Popat, S.3
  • 108
    • 10744223743 scopus 로고    scopus 로고
    • The prognostic implication of the basal-like (cyclin E high/p27 low/p53 + /glomeruloid-microvascular-proliferation +) phenotype of BRCA1-related breast cancer
    • Foulkes WD, Brunet JS, Stefansson IM et al. The prognostic implication of the basal-like (cyclin E high/p27 low/p53 + /glomeruloid-microvascular-proliferation +) phenotype of BRCA1-related breast cancer. Cancer Res 2004; 64: 830-835.
    • (2004) Cancer Res , vol.64 , pp. 830-835
    • Foulkes, W.D.1    Brunet, J.S.2    Stefansson, I.M.3
  • 109
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie T, Tibshirani R, Parker J et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 2003; 100: 8418-8423.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 111
    • 67349284098 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
    • Byrski T, Huzarski T, Dent R et al. Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 2009; 115: 359-363.
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 359-363
    • Byrski, T.1    Huzarski, T.2    Dent, R.3
  • 112
    • 75749143502 scopus 로고    scopus 로고
    • Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy
    • Byrski T, Gronwald J, Huzarski T et al. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 2010; 28: 375-379.
    • (2010) J Clin Oncol , vol.28 , pp. 375-379
    • Byrski, T.1    Gronwald, J.2    Huzarski, T.3
  • 113
    • 31044446360 scopus 로고    scopus 로고
    • JPARP inhibitors for cancer therapy
    • Curtin N. JPARP inhibitors for cancer therapy. Expert Rev Mol Med 2005; 7: 1-20.
    • (2005) Expert Rev Mol Med , vol.7 , pp. 1-20
    • Curtin, N.1
  • 115
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T, Butterfield CE, Kraling BM et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 2000; 60: 1878-1886.
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3
  • 116
    • 74549208007 scopus 로고    scopus 로고
    • Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?
    • Shen FZ, Wang J, Liang J et al. Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?. Int J Exp Pathol 2010; 91: 10-16.
    • (2010) Int J Exp Pathol , vol.91 , pp. 10-16
    • Shen, F.Z.1    Wang, J.2    Liang, J.3
  • 117
    • 53749093040 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
    • Schneider BP, Wang M, Radovich M et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 2008; 26: 4672-4678.
    • (2008) J Clin Oncol , vol.26 , pp. 4672-4678
    • Schneider, B.P.1    Wang, M.2    Radovich, M.3
  • 118
    • 79251473728 scopus 로고    scopus 로고
    • Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer
    • Jubb AM, Miller KD, Rugo HS et al. Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer. Clin Cancer Res 2011; 17: 372-381.
    • (2011) Clin Cancer Res , vol.17 , pp. 372-381
    • Jubb, A.M.1    Miller, K.D.2    Rugo, H.S.3
  • 119
    • 77149157867 scopus 로고    scopus 로고
    • Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
    • Mendes-Pereira AM, Martin SA, Brough R et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med 2009; 1: 315-322.
    • (2009) EMBO Mol Med , vol.1 , pp. 315-322
    • Mendes-Pereira, A.M.1    Martin, S.A.2    Brough, R.3


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