ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells

Carcinogenesis

Volumn 27, Issue 3, 2006, Pages 437-445

  Xu, Changjiang ^a   Shen, Guoxiang ^a   Yuan, Xiaoling ^a   Kim, Jung Hwan ^a   Gopalkrishnan, Avantika ^a   Keum, Young Sam ^a   Nair, Sujit ^a   Kong, Ah Ng Tony ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALLYL ISOTHIOCYANATE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ISOTHIOCYANIC ACID DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHENETHYL ISOTHIOCYANATE; PROTEIN BCL 2; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; SULFORAPHANE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ELK 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTICARCINOGENIC AGENTS; APOPTOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOOD PRESERVATIVES; HUMANS; ISOTHIOCYANATES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; THIOCYANATES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 33644865443     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi251     Document Type: Article

References (41)

1. Chiao,J.W., Chung,F.L., Kancherla,R., Ahmed,T., Mittelman,A. and Conaway,C.C. (2002) Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int. J. Oncol., 20, 631-636.
2. Willis,M.S. and Wians,F.H. (2003) The role of nutrition in preventing prostate cancer: A review of the proposed mechanism of action of various dietary substances. Clin. Chim. Acta, 330, 57-83.
3. Talalay,P. and Fahey,J.W. (2001) Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J. Nutr., 131, 3027S-3033S.
4. Steinmetz,K.A. and Potter,J.D. (1996) Vegetables, fruit, and cancer prevention: A review. J. Am. Diet. Assoc., 96, 1027-1039.
5. Hecht,S.S. (2000) Inhibition of carcinogenesis by isothiocyanates. Drug Metab. Rev., 32, 395-411.
6. Kong,A.N., Yu,R., Hebbar,V., Chen,C., Owuor,E., Hu,R., Ee,R. and Mandlekar,S. (2001) Signal transduction events elicited by cancer prevention compounds. Mutat. Res., 480-481, 231-241.
7. Singh,A.V., Xiao,D., Lew,K.L., Dhir,R. and Singh,S.V. (2004) Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis, 25, 83-90.
8. Xiao,D. and Singh,S.V. (2002) Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases. Cancer Res., 62, 3615-3619.
9. Chen,Y.R., Han,J., Kori,R., Kong,A.N. and Tan,T.H. (2002) Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J. Biol. Chem., 277, 39334-39342.
10. Brooks,J.D., Paton,V.G. and Vidanes,G. (2001) Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol. Biomarkers Prev., 10, 949-954.
11. Srivastava,S.K., Xiao,D., Lew,K.L., Hershberger,P., Kokkinakis,D.M., Johnson,C.S., Trump,D.L. and Singh,S.V. (2003) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Carcinogenesis, 24, 1665-1670.
12. Xiao,D., Srivastava,S.K., Lew,K.L., Zeng,Y., Hershberger,P., Johnson,C.S., Trump,D.L. and Singh,S.V. (2003) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis. Carcinogenesis, 24, 891-897.
13. Xu,C., Shen,G., Chen,C., Gelinas,C. and Kong,A.N. (2005) Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene, 24, 4486-4495.
14. Hsu,T.C., Young,M.R., Cmarik,J. and Colbum,N.H. (2000) Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free. Radic. Biol. Med., 28, 1338-1348.
15. Shaulian,E. and Karin,M. (2002) AP-1 as a regulator of cell life and death. Nat. Cell. Biol., 4, E131-E136.
16. Amit,S. and Ben-Neriah,Y. (2003) NF-kappaB activation in cancer: A challenge for ubiquitination- and proteasome-based therapeutic approach. Semin. Cancer Biol., 13, 15-28.
17. Bremner,P. and Heinrich,M. (2002) Natural products as targeted modulators of the nuclear factor-kappaB pathway. J. Pharm. Pharmacol., 54, 453-472.
18. Heiss,E., Herhaus,C., Klimo,K., Bartsch,H. and Gerhauser,C. (2001) Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J. Biol. Chem., 276, 32008-32015.
19. Oya,M., Takayanagi,A., Horiguchi,A., Mizuno,R., Ohtsubo,M., Marumo,K., Shimizu,N. and Murai,M. (2003) Increased nuclear factor-kappa B activation is related to the tumor development of renal cell carcinoma. Carcinogenesis, 24, 377-384.
20. Kundu,J.K. and Surh,Y.J. (2004) Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets. Murat. Res., 555, 65-80.
21. Wisdom,R. (1999) AP-1: One switch for many signals. Exp. Cell Res., 253, 180-185.
22. Karin,M. (1995) The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem., 270, 16483-16486.
23. Deng,T. and Karin,M. (1994) c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature, 371, 171-175.
24. Yu,R., Hebbar,V., Kim,D.W., Mandlekar,S., Pezzuto,J.M. and Kong,A.N. (2001) Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways. Mol. Pharmacol., 60, 217-224.
25. Whitmarsh,A.J. and Davis,R.J. (1996) Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J. Mol. Med., 74, 589-607.
26. Barthelman,M., Bair,W.B.III, Stickland,K.K., Chen,W., Timmermann,B.N., Valcic,S., Dong,Z. and Bowden,G.T. (1998) (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity. Carcinogenesis, 19, 2201-2204.
27. Yoshioka,K., Deng,T., Cavigelli,M. and Karin,M. (1995) Antitumor promotion by phenolic antioxidants: Inhibition of AP-1 activity through induction of Fra expression. Proc. Natl. Acad. Sci. USA, 92, 4972-4976.
28. Nomura,M., Ma,W.Y., Huang,C., Yang,C.S., Bowden,G.T., Miyamoto,K. and Dong,Z. (2000) Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea. Mol. Carcinog., 28, 148-155.
29. Gonzales,M. and Bowden,G.T. (2002) Nordihydroguaiaretic acid-mediated inhibition of ultraviolet B-induced activator protein-1 activation in human keratinocytes. Mol. Carcinog., 34, 102-111.
30. Jeong,W.S., Kim,I.W., Hu,R. and Kong,A.N. (2004) Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line. Pharm. Res., 21, 649-660.
31. Hu,R., Kim,B.R., Chen,C., Hebbar,V. and Kong,A.N. (2003) The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. Carcinogenesis, 24, 1361-1367.
32. Yu,R., Mandlekar,S., Tan,T.H. and Kong,A.N. (2000) Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J. Blot. Chem., 275, 9612-9619.
33. Shen,G., Hebbar,V., Nair,S., Xu,C., Li,W., Lin,W., Keum,Y.S., Han,J., Gallo,M.A. and Kong,A.N. (2004) Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J. Biol. Chem., 279, 23052-23060.
34. Cohen,J.H., Kristal,A.R. and Stanford,J.L. (2000) Fruit and vegetable intakes and prostate cancer risk. J. Natl. Cancer Inst., 92, 61-68.
35. Kolonel,L.N., Hankin,J.H., Whittemore,A.S. et al. (2000) Vegetables, fruits, legumes and prostate cancer: A multiethnic case-control study. Cancer Epidemiol. Biomarkers Prev., 9, 795-804.
36. Brooks,J.D. and Paton,V. (1999) Potent induction of carcinogen defence enzymes with sulforaphane, a putative prostate cancer chemopreventive agent. Prostate Cancer Prostatic. Dis., 2, S8.
37. Chen,C. and Kong,A.N. (2005) Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol. Sci., 26, 318-326.
38. Hu,R., Hebbar,V., Kim,B.R., Chen,C., Winnik,B., Buckley,B., Soteropoulos,P., Tolias,P., Hart,R.P. and Kong,A.N. (2004) In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J. Pharmacol. Exp. Ther., 310, 263-271.
39. Chung,F.L., Conaway,C.C., Rao,C.V. and Reddy,B.S. (2000) Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis, 21, 2287-2291.
40. Chen,Y.R., Wang,W., Kong,A.N. and Tan,T.H. (1998) Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. J. Biol. Chem., 273, 1769-1775.
41. Cuadrado,A., Gonzalez,L., Suarez,Y., Martinez,T. and Munoz,A. (2004) JNK activation is critical for Aplidin-induced apoptosis. Oncogene, 23, 4673-4680.