Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits Leukemic mice

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Lu, Chi Cheng ^a   Yang, Jai Sing ^b   Chiang, Jo Hua ^a   Hour, Mann Jen ^b   Lin, Kuei Li ^c   Lin, Jen Jyh ^b,d   Huang, Wen Wen ^b   Tsuzuki, Minoru ^b,e   Lee, Tsung Han ^a,b   Chung, Jing Gung ^b,f  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^f ASIA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; 6 PYRROLIDINYL 2 (2 HYDROXYPHENYL) 4 QUINAZOLINONE; CALCIUM ION; CALPAIN 1; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; LIPOCORTIN 5; MJ 29; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BODY WEIGHT; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANCER INHIBITION; CELL FATE; CELL INFILTRATION; CELL POPULATION; CELL STRAIN; CELL STRAIN WEHI 3; CELL VIABILITY; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LEUKEMIA CELL; LIVER; MACROPHAGE; MALE; MITOCHONDRION; MONOCYTE; MOUSE; MYELOBLAST; MYELOMONOCYTIC LEUKEMIA; NICK END LABELING; NONHUMAN; SPLEEN; STRUCTURE ANALYSIS; SURVIVAL RATE; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; ANTINEOPLASTIC AGENTS; APOPTOSIS; BODY WEIGHT; CALCIUM; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; LEUKEMIA; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MITOCHONDRIA; ORGAN SIZE; PHAGOCYTOSIS; QUINAZOLINONES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

MURINAE; MUS;

EID: 84861466040     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036831     Document Type: Article

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