MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 2, 2010, Pages 477-488

  Yang, Jai Sing ^a   Hour, Mann Jen ^a   Huang, Wen Wen ^a   Lin, Kuei Li ^b   Kuo, Sheng Chu ^a   Chung, Jing Gung ^a,c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

6 PYRROLIDINYL 2 (2 HYDROXYPHENYL) 4 QUINAZOLINONE; ALPHA TUBULIN; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BETA TUBULIN; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; MJ 29; PROCASPASE 9; PROTEIN BCL 2; ROSCOVITINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN U937; CELL VIABILITY; CONTROLLED STUDY; DNA CONTENT; ENZYME PHOSPHORYLATION; GROWTH INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROARRAY ANALYSIS; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOPOLYMERS; CASPASE 3; CASPASE 9; CDC2 PROTEIN KINASE; ENZYME INDUCTION; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOSIS; NEOPLASM TRANSPLANTATION; PHOSPHORYLATION; PILOT PROJECTS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; TUBULIN; TUBULIN MODULATORS; U937 CELLS;

EID: 77954910401     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.165415     Document Type: Article

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