The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells

Journal of Gastroenterology

Volumn 44, Issue 10, 2009, Pages 1055-1063

  Chou, Li Chen ^a   Yang, Jai Sing ^b   Huang, Li Jiau ^a   Wu, Hsi Chin ^b   Lu, Chi Cheng ^c   Chiang, Jo Hua ^c   Chen, Kuan Tin ^b   Kuo, Sheng Chu ^a   Chung, Jing Gung ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; CHM 1 and CHM 1 P; CT 26 colorectal adenocarcinoma cells; G2 Marrest; Orthotopic model

Indexed keywords

2 (2 FLUOROPHENYL) 6,7 METHYLENEDIOXYQUINOLIN 4 ONE; 2 (2 FLUOROPHENYL) 6,7 METHYLENEDIOXYQUINOLIN 4 YL DIHYDROGEN PHOSPHATE; ALLOGRAFT INFLAMMATORY FACTOR 1; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; FLUOROURACIL; PROCASPASE 3; PROCASPASE 9; PROTEIN BAD; PROTEIN BAX; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; COLORECTAL CANCER; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG STRUCTURE; ENZYME ACTIVITY; FLOW CYTOMETRY; IC 50; LIVER METASTASIS; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLENOMEGALY; SURVIVAL RATE; TUMOR GROWTH; WESTERN BLOTTING;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CDC2 PROTEIN KINASE; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL NEOPLASMS; CYCLIN A; CYCLIN B; DIOXOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; G2 PHASE; HUMANS; LIVER NEOPLASMS; MEIOSIS; MICE; MICE, INBRED BALB C; MITOCHONDRIA; QUINOLONES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 70350026142     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-009-0111-1     Document Type: Article

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