Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways

Chemical Research in Toxicology

Volumn 24, Issue 1, 2011, Pages 20-29

  Chiang, Jo Hua ^a   Yang, Jai Sing ^b   Ma, Chia Yu ^c   Yang, Mei Due ^d   Huang, Hui Ying ^b   Hsia, Te Chun ^b,d   Kuo, Hsiu Maan ^b   Wu, Ping Ping ^b   Lee, Tsung Han ^a   Chung, Jing Gung ^b,e  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TECHNOLOGY AND SCIENCE INSTITUTE OF NORTHERN TAIWAN   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE DERIVATIVE; APOPTOSIS INDUCING FACTOR; CALCIUM; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DANTRON; ENDONUCLEASE G; LIPOCORTIN 5; NUCLEIC ACID; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL MEMBRANE PERMEABILITY; CELL STRUCTURE; CELL VIABILITY; CHROMATIN CONDENSATION; DNA DAMAGE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; MEMBRANE DEPOLARIZATION; MITOCHONDRION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; UPREGULATION; WESTERN BLOTTING;

ANNEXIN A5; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELL MEMBRANE PERMEABILITY; DNA DAMAGE; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; PROPIDIUM; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 78651497947     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100248s     Document Type: Article

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