Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32259-32267

  Geng, Feng ^a   Tang, Li ^a   Li, Yun ^a   Yang, Lu ^a   Choi, Kyoung Soo ^a   Kazim, A Latif ^a   Zhang, Yuesheng ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL ISOTHIOCYANATE; ANTI-CANCER MECHANISM; ANTICANCER ACTIVITIES; APOPTOSIS INDUCTION; BLADDER CANCERS; C-JUN N-TERMINAL KINASE; CANCER CELLS; CASPASE-3; CYSTEINE RESIDUES; CYTOCHROME C; HUMAN BLADDER CANCER; HUMAN DIET; HYDROXYUREA; MITOTIC ARREST; OVER-EXPRESSION; PROTEIN PHOSPHORYLATION; UBIQUITINATION;

AMINO ACIDS; CYTOTOXICITY; DISEASES; PHOSPHORYLATION;

CELL DEATH;

ALLYL ISOTHIOCYANATE; ALPHA TUBULIN; BETA TUBULIN; CASPASE 3; CASPASE 9; CYTOCHROME C; HYDROXYUREA; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRION; MITOSIS; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; UBIQUITINATION;

ALLYL COMPOUNDS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; ENZYME ACTIVATION; G1 PHASE; HUMANS; ISOCYANATES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOCHONDRIA; MITOSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TUBULIN; UBIQUITINATION; URINARY BLADDER NEOPLASMS;

EID: 80052782542     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.278127     Document Type: Article

References (29)

1. Zhang, Y. (2010) Mol. Nutr. Food Res. 54, 127-135
2. Bhattacharya, A., Tang, L., Li, Y., Geng, F., Paonessa, J. D., Chen, S. C., Wong, M. K., and Zhang, Y. (2010) Carcinogenesis 31, 281-286
3. Bhattacharya, A., Li, Y., Wade, K. L., Paonessa, J. D., Fahey, J. W., and Zhang, Y. (2010) Carcinogenesis 31, 2105-2110
4. Michaud, D. S., Spiegelman, D., Clinton, S. K., Rimm, E. B., Willett, W. C., and Giovannucci, E. L. (1999) J. Natl. Cancer Inst. 91, 605-613
5. Tang, L., Zirpoli, G. R., Guru, K., Moysich, K. B., Zhang, Y., Ambrosone, C. B., and McCann, S. E. (2008) Cancer Epidemiol. Biomarkers Prev. 17, 938-944
6. Tang, L., and Zhang, Y. (2004) J. Nutr. 134, 2004-2010
7. Tang, L., Li, G., Song, L., and Zhang, Y. (2006) Anticancer Drugs 17, 297-305
8. Yu, S. W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., and Dawson, V. L. (2002) Science 297, 259-263
9. Jo, H., Loison, F., Hattori, H., Silberstein, L. E., Yu, H., and Luo, H. R. (2010) PLoS One 5, e10318
10. Deng, X., Xiao, L., Lang, W., Gao, F., Ruvolo, P., and May, W. S., Jr. (2001) J. Biol. Chem. 276, 23681-23688
11. Castedo, M., Perfettini, J. L., Roumier, T., Andreau, K., Medema, R., and Kroemer, G. (2004) Oncogene 23, 2825-2837
12. Chang, B. S., Minn, A. J., Muchmore, S. W., Fesik, S. W., and Thompson, C. B. (1997) EMBO J. 16, 968-977
13. Srivastava, R. K., Mi, Q. S., Hardwick, J. M., and Longo, D. L. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 3775-3780
14. Hasegawa, T., Nishino, H., and Iwashima, A. (1993) Anticancer Drugs 4, 273-279
15. Smith, T. K., Lund, E. K., Parker, M. L., Clarke, R. G., and Johnson, I. T. (2004) Carcinogenesis 25, 1409-1415
16. Xiao, D., Srivastava, S. K., Lew, K. L., Zeng, Y., Hershberger, P., Johnson, C. S., Trump, D. L., and Singh, S. V. (2003) Carcinogenesis 24, 891-897
17. Mi, L., Xiao, Z., Hood, B. L., Dakshanamurthy, S., Wang, X., Govind, S., Conrads, T. P., Veenstra, T. D., and Chung, F. L. (2008) J. Biol. Chem. 283, 22136-22146
18. Mi, L., Gan, N., Cheema, A., Dakshanamurthy, S., Wang, X., Yang, D. C., and Chung, F. L. (2009) J. Biol. Chem. 284, 17039-17051
19. Xu, W., Xi, B., Wu, J., An, H., Zhu, J., Abassi, Y., Feinstein, S. C., Gaylord, M., Geng, B., Yan, H., Fan, W., Sui, M., Wang, X., and Xu, X. (2009) Mol. Cancer Ther. 8, 3318-3330
20. Zhang, X., Yang, F., Shim, J. Y., Kirk, K. L., Anderson, D. E., and Chen, X. (2007) Cancer Lett. 255, 95-106
21. Shan, B., Medina, J. C., Santha, E., Frankmoelle, W. P., Chou, T. C., Learned, R. M., Narbut, M. R., Stott, D., Wu, P., Jaen, J. C., Rosen, T., Timmermans, P. B., and Beckmann, H. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 5686-5691
22. Bai, R., Pei, X. F., Boyé, O., Getahun, Z., Grover, S., Bekisz, J., Nguyen, N. Y., Brossi, A., and Hamel, E. (1996) J. Biol. Chem. 271, 12639-12645
23. Bai, R., Covell, D. G., Pei, X. F., Ewell, J. B., Nguyen, N. Y., Brossi, A., and Hamel, E. (2000) J. Biol. Chem. 275, 40443-40452
24. Gupta, M. L., Jr., Bode, C. J., Dougherty, C. A., Marquez, R. T., and Himes, R. H. (2001) Cell Motil. Cytoskeleton 49, 67-77
25. Haldar, S., Chintapalli, J., and Croce, C. M. (1996) Cancer Res. 56, 1253-1255
26. Fan, M., Goodwin, M., Vu, T., Brantley-Finley, C., Gaarde, W. A., and Chambers, T. C. (2000) J. Biol. Chem. 275, 29980-29985
27. Yamamoto, K., Ichijo, H., and Korsmeyer, S. J. (1999) Mol. Cell. Biol. 19, 8469-8478
28. Haldar, S., Basu, A., and Croce, C. M. (1998) Cancer Res. 58, 1609-1615
29. Basu, A., and Haldar, S. (1998) Int. J. Oncol. 13, 659-664