Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo

Leukemia Research

Volumn 33, Issue 11, 2009, Pages 1505-1511

  Tsou, Mei Fen ^a   Peng, Ching Tien ^a,b   Shih, Mu Chin ^a   Yang, Jai Sing ^c   Lu, Chi Cheng ^d   Chiang, Jo Hua ^d   Wu, Chang Lin ^c   Lin, Jing Pin ^c   Lo, Chyi ^c   Fan, Ming Jen ^b   Chung, Jing Gung ^b,c  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

BALB c mice; Benzyl isothiocyanate (BITC); Cytotoxicity; Immune response; WEHI 3 leukemia cells

Indexed keywords

BENZYL ISOTHIOCYANATE; CASPASE 3; CD11B ANTIGEN; DIFFERENTIATION ANTIGEN; MACROPHAGE 3 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CANCER CELL; CANCER RISK; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; CRUCIFERA; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; FOOD INTAKE; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; LIVER WEIGHT; MACROPHAGE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MYELOMONOCYTIC LEUKEMIA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; RISK REDUCTION; SPLEEN WEIGHT; VEGETABLE; WEIGHT REDUCTION;

ANIMALS; CELL LINE, TUMOR; ISOTHIOCYANATES; LEUKEMIA, EXPERIMENTAL; MALE; MICE; MICE, INBRED BALB C; PHAGOCYTOSIS;

EID: 68649096111     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.01.030     Document Type: Article

References (34)

1. Jensen C.D., Block G., Buffler P., Ma X., Selvin S., and Month S. Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). Cancer Cause Control 15 (2004) 559-570
2. Cohen J.H., Kristal A.R., and Stanford J.L. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 92 (2000) 61-68
3. Verhoeven D.T., Goldbohm R.A., van Poppel G., Verhagen H., and van den Brandt P.A. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev 5 (1996) 733-748
4. Conaway C.C., Yang Y.M., and Chung F.L. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 3 (2002) 233-255
5. Ambrosone C.B., McCann S.E., Freudenheim J.L., Marshall J.R., Zhang Y., and Shields P.G. Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J Nutr 134 (2004) 1134-1138
6. Fowke J.H., Chung F.L., Jin F., Qi D., Cai Q., Conaway C., et al. Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res 63 (2003) 3980-3986
7. Lin J.M., Amin S., Trushin N., and Hecht S.S. Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models. Cancer Lett 74 (1993) 151-159
8. Wattenberg L.W. Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice. Carcinogenesis 8 (1987) 1971-1973
9. Wattenberg L.W. Inhibition of carcinogen-induced neoplasia by sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure. Cancer Res 41 (1981) 2991-2994
10. Wattenberg L.W. Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. J Natl Cancer Inst 58 (1977) 395-398
11. Sugie S., Okumura A., Tanaka T., and Mori H. Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats. Jpn J Cancer Res 84 (1993) 865-870
12. Yang Y.M., Conaway C.C., Chiao J.W., Wang C.X., Amin S., Whysner J., et al. Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis. Cancer Res 62 (2002) 2-7
13. Visanji J.M., Duthie S.J., Pirie L., Thompson D.G., and Padfield P.J. Dietary isothiocyanates inhibit Caco-2 cell proliferation and induce G2/M phase cell cycle arrest, DNA damage, and G2/M checkpoint activation. J Nutr 134 (2004) 3121-3126
14. Tseng E., Scott-Ramsay E.A., and Morris M.E. Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. Exp Biol Med (Maywood) 229 (2004) 835-842
15. Srivastava S.K., and Singh S.V. Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells. Carcinogenesis 25 (2004) 1701-1709
16. Miyoshi N., Uchida K., Osawa T., and Nakamura Y. A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. Cancer Res 64 (2004) 2134-2142
17. Nakamura Y., Kawakami M., Yoshihiro A., Miyoshi N., Ohigashi H., Kawai K., et al. Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. J Biol Chem 277 (2002) 8492-8499
18. Su C.C., Yang J.S., Lin S.Y., Lu H.F., Lin S.S., Chang Y.H., et al. Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo. In Vivo 22 (2008) 63-68
19. Hsu S.C., Lu J.H., Kuo C.L., Yang J.S., Lin M.W., Chen G.W., et al. Crude extracts of Solanum lyratum induced cytotoxicity and apoptosis in a human colon adenocarcinoma cell line (colo 205). Anticancer Res 28 (2008) 1045-1054
20. Zucker R.M., Elstein K.H., Easterling R.E., and Massaro E.J. Flow cytometric comparison of the effects of trialkyltins on the murine erythroleukemic cell. Toxicology 58 (1989) 107-119
21. Lu K.W., Tsai M.L., Chen J.C., Hsu S.C., Hsia T.C., Lin M.W., et al. Gypenosides inhibited invasion and migration of human tongue cancer SCC4 cells through down-regulation of NFkappaB and matrix metalloproteinase-9. Anticancer Res 28 (2008) 1093-1099
22. 2+-dependent mitochondrial death pathway in human nasopharyngeal carcinoma cells. Anticancer Res 27 (2007) 3313-3322
23. Yang J.S., Kok L.F., Lin Y.H., Kuo T.C., Yang J.L., Lin C.C., et al. Diallyl disulfide inhibits WEHI-3 leukemia cells in vivo. Anticancer Res 26 (2006) 219-225
24. Loken M.R., Green C.I., and Wells D.A. Immunofluorescence of surface markers. In: Ormerod M.G. (Ed). Flow cytometry: a practical approach (2000), Oxford University Press, Oxford pp. 61-82
25. He Q., and Na X. The effects and mechanisms of a novel 2-aminosteroid on murine WEHI-3B leukemia cells in vitro and in vivo. Leuk Res 25 (2001) 455-461
26. Lin J.G., Chen G.W., Li T.M., Chouh S.T., Tan T.W., and Chung J.G. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. J Urol 175 (2006) 343-347
27. Hsu M.H., Chen C.J., Kuo S.C., Chung J.G., Lai Y.Y., Teng C.M., et al. 2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells. Eur J Pharmacol 559 (2007) 14-20
28. Huang Y.T., Hwang J.J., Lee L.T., Liebow C., Lee P.P., Ke F.C., et al. Inhibitory effects of a luteinizing hormone-releasing hormone agonist on basal and epidermal growth factor-induced cell proliferation and metastasis-associated properties in human epidermoid carcinoma A431 cells. Int J Cancer 99 (2002) 505-513
29. Hsu S.C., Kuo C.L., Lin J.P., Lee J.H., Lin C.C., Su C.C., et al. Crude extracts of Euchresta formosana radix inhibit invasion and migration of human hepatocellular carcinoma cells. Anticancer Res 27 (2007) 2377-2384
30. Warner N.L., Moore M.A., and Metcalf D. A transplantable myelomonocytic leukemia in BALB-c mice: cytology, karyotype, and muramidase content. J Natl Cancer Inst 43 (1969) 963-982
31. Richards J., Zhang R., and Srivastava S.K. Benzyl isothiocyanate, a constituent of cruciferous vegetables, retards the growth of BxPC-3 human pancreatic cancer xenografts in vivo. Proc. Am Assoc Cancer Res (2006) 47
32. Abe J., Morikawa M., Miyamoto K., Kaiho S., Fukushima M., Miyaura C., et al. Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton. A trial of the development of vitamin D compounds which exhibit potent differentiation-inducing activity without inducing hypercalcemia. FEBS Lett 226 (1987) 58-62
33. Satchell D.P., and Norman A.W. Metabolism of the cell differentiating agent 1alpha,25(OH)2-16-ene-23-yne vitamin D3 by leukemic cells. J Steroid Biochem Mol Biol 57 (1996) 117-124
34. Wietrzyk J., Chodynski M., Fitak H., Wojdat E., Kutner A., and Opolski A. Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 (2007) 447-457