-
1
-
-
33745820796
-
Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress
-
Back SH, Lee K, Vink E, Kaufman RJ. Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. J Biol Chem 281: 18691-18706, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 18691-18706
-
-
Back, S.H.1
Lee, K.2
Vink, E.3
Kaufman, R.J.4
-
3
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2: 326-332, 2000.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
4
-
-
0036312001
-
Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization
-
Boya P, Cohen I, Zamzami N, Vieira HL, Kroemer G. Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization. Cell Death Differ 9: 465-467, 2002.
-
(2002)
Cell Death Differ
, vol.9
, pp. 465-467
-
-
Boya, P.1
Cohen, I.2
Zamzami, N.3
Vieira, H.L.4
Kroemer, G.5
-
5
-
-
13644256191
-
A selective inhibitor of eIF2a dephosphorylation protects cells from ER stress
-
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2a dephosphorylation protects cells from ER stress. Science 307: 935-939, 2005.
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
Long, K.4
Harding, H.P.5
Scheuner, D.6
Kaufman, R.J.7
Ma, D.8
Coen, D.M.9
Ron, D.10
Yuan, J.11
-
6
-
-
0033739622
-
PERK mediates cell-cycle exit during the mammalian unfolded protein response
-
Brewer JW, Diehl JA. PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci USA 97: 12625-12630, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 12625-12630
-
-
Brewer, J.W.1
Diehl, J.A.2
-
7
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415: 92-96, 2002.
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
8
-
-
0037066741
-
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi
-
Chen X, Shen J, Prywes R. The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J Biol Chem 277: 13045-13052, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 13045-13052
-
-
Chen, X.1
Shen, J.2
Prywes, R.3
-
9
-
-
0034786019
-
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
-
Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 8: 705-711, 2001.
-
(2001)
Mol Cell
, vol.8
, pp. 705-711
-
-
Cheng, E.H.1
Wei, M.C.2
Weiler, S.3
Flavell, R.A.4
Mak, T.W.5
Lindsten, T.6
Korsmeyer, S.J.7
-
10
-
-
33947510911
-
Selective inhibition of eukaryotic translation initiation factor 2alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis
-
Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL. Selective inhibition of eukaryotic translation initiation factor 2alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem 282: 3989-3997, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 3989-3997
-
-
Cnop, M.1
Ladriere, L.2
Hekerman, P.3
Ortis, F.4
Cardozo, A.K.5
Dogusan, Z.6
Flamez, D.7
Boyce, M.8
Yuan, J.9
Eizirik, D.L.10
-
11
-
-
0027324844
-
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
-
Cox JS, Shamu CE, Walter P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73: 1197-1206, 1993.
-
(1993)
Cell
, vol.73
, pp. 1197-1206
-
-
Cox, J.S.1
Shamu, C.E.2
Walter, P.3
-
12
-
-
0030297537
-
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response
-
Cox JS, Walter P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87: 391-404, 1996.
-
(1996)
Cell
, vol.87
, pp. 391-404
-
-
Cox, J.S.1
Walter, P.2
-
13
-
-
30044432596
-
On the mechanism of sensing unfolded protein in the endoplasmic reticulum
-
Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci USA 102: 18773-18784, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 18773-18784
-
-
Credle, J.J.1
Finer-Moore, J.S.2
Papa, F.R.3
Stroud, R.M.4
Walter, P.5
-
14
-
-
0033565557
-
The mitochondrial permeability transition pore and its role in cell death
-
Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 341: 233-249, 1999.
-
(1999)
Biochem J
, vol.341
, pp. 233-249
-
-
Crompton, M.1
-
15
-
-
0034425698
-
EIF-2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome
-
Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, Julier C. EIF-2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet 25: 406-409, 2000.
-
(2000)
Nat Genet
, vol.25
, pp. 406-409
-
-
Delepine, M.1
Nicolino, M.2
Barrett, T.3
Golamaully, M.4
Lathrop, G.M.5
Julier, C.6
-
16
-
-
8644282751
-
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
-
Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol 24: 10161-10168, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10161-10168
-
-
Deng, J.1
Lu, P.D.2
Zhang, Y.3
Scheuner, D.4
Kaufman, R.J.5
Sonenberg, N.6
Harding, H.P.7
Ron, D.8
-
17
-
-
0036294646
-
Human caspase-12 has acquired deleterious mutations
-
Fischer H, Koenig U, Eckhart L, Tschachler E. Human caspase-12 has acquired deleterious mutations. Biochem Biophys Res Commun 293: 722-726, 2002.
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 722-726
-
-
Fischer, H.1
Koenig, U.2
Eckhart, L.3
Tschachler, E.4
-
18
-
-
33845399098
-
The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins
-
Goffin L, Vodala S, Fraser C, Ryan J, Timms M, Meusburger S, Catimel B, Nice EC, Silver PA, Xiao CY, Jans DA, Gething MJ. The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins. Mol Biol Cell 17: 5309-5323, 2006.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 5309-5323
-
-
Goffin, L.1
Vodala, S.2
Fraser, C.3
Ryan, J.4
Timms, M.5
Meusburger, S.6
Catimel, B.7
Nice, E.C.8
Silver, P.A.9
Xiao, C.Y.10
Jans, D.A.11
Gething, M.J.12
-
19
-
-
0034604033
-
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2
-
Hacki J, Egger L, Monney L, Conus S, Rosse T, Fellay I, Borner C. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene 19: 2286-2295, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 2286-2295
-
-
Hacki, J.1
Egger, L.2
Monney, L.3
Conus, S.4
Rosse, T.5
Fellay, I.6
Borner, C.7
-
20
-
-
0033634654
-
Regulated translation initiation controls stress-induced gene expression in mammalian cells
-
Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6: 1099-1108, 2000.
-
(2000)
Mol Cell
, vol.6
, pp. 1099-1108
-
-
Harding, H.P.1
Novoa, I.2
Zhang, Y.3
Zeng, H.4
Wek, R.5
Schapira, M.6
Ron, D.7
-
21
-
-
0034968330
-
-/- mice reveals a role for translational control in secretory cell survival
-
-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 7: 1153-1163, 2001.
-
(2001)
Mol Cell
, vol.7
, pp. 1153-1163
-
-
Harding, H.P.1
Zeng, H.2
Zhang, Y.3
Jungries, R.4
Chung, P.5
Plesken, H.6
Sabatini, D.D.7
Ron, D.8
-
22
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274, 1999.
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
23
-
-
0037353039
-
-
Harding HP, Zhang Y, Zeng H, Novoa I, PDL, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11: 619-633, 2003.
-
Harding HP, Zhang Y, Zeng H, Novoa I, PDL, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11: 619-633, 2003.
-
-
-
-
24
-
-
0035310752
-
Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response
-
Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem J 355: 19-28, 2001.
-
(2001)
Biochem J
, vol.355
, pp. 19-28
-
-
Haze, K.1
Okada, T.2
Yoshida, H.3
Yanagi, H.4
Yura, T.5
Negishi, M.6
Mori, K.7
-
25
-
-
0032693671
-
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
-
Haze K, Yoshida H, Yanagi H, Yura T, Mori K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell 10: 3787-3799, 1999.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 3787-3799
-
-
Haze, K.1
Yoshida, H.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
26
-
-
33646237823
-
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
-
Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312: 572-576, 2006.
-
(2006)
Science
, vol.312
, pp. 572-576
-
-
Hetz, C.1
Bernasconi, P.2
Fisher, J.3
Lee, A.H.4
Bassik, M.C.5
Antonsson, B.6
Brandt, G.S.7
Iwakoshi, N.N.8
Schinzel, A.9
Glimcher, L.H.10
Korsmeyer, S.J.11
-
27
-
-
2442432416
-
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and A-beta-induced cell death
-
Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, Tsujimoto Y, Tohyama M. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and A-beta-induced cell death. J Cell Biol 165: 347-356, 2004.
-
(2004)
J Cell Biol
, vol.165
, pp. 347-356
-
-
Hitomi, J.1
Katayama, T.2
Eguchi, Y.3
Kudo, T.4
Taniguchi, M.5
Koyama, Y.6
Manabe, T.7
Yamagishi, S.8
Bando, Y.9
Imaizumi, K.10
Tsujimoto, Y.11
Tohyama, M.12
-
28
-
-
33745893809
-
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
-
Hollien J, Weissman JS. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 313: 104-107, 2006.
-
(2006)
Science
, vol.313
, pp. 104-107
-
-
Hollien, J.1
Weissman, J.S.2
-
29
-
-
0035147411
-
Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress
-
Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C, Kimata Y, Tsuru A, Kohno K. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat Cell Biol 3: 158-164, 2001.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 158-164
-
-
Iwawaki, T.1
Hosoda, A.2
Okuda, T.3
Kamigori, Y.4
Nomura-Furuwatari, C.5
Kimata, Y.6
Tsuru, A.7
Kohno, K.8
-
30
-
-
0043133837
-
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses
-
Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC. Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol 23: 5651-5663, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 5651-5663
-
-
Jiang, H.Y.1
Wek, S.A.2
McGrath, B.C.3
Scheuner, D.4
Kaufman, R.J.5
Cavener, D.R.6
Wek, R.C.7
-
31
-
-
0027465942
-
-
Kohno K, Normington K, Sambrook J, MJG, Mori K. The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Mol Cell Biol 13: 877-890, 1993.
-
Kohno K, Normington K, Sambrook J, MJG, Mori K. The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Mol Cell Biol 13: 877-890, 1993.
-
-
-
-
32
-
-
0035937721
-
Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response
-
Kokame K, Kato H, Miyata T. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. J Biol Chem 276: 9199-9205, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 9199-9205
-
-
Kokame, K.1
Kato, H.2
Miyata, T.3
-
33
-
-
13944263299
-
OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes
-
Kondo S, Murakami T, Tatsumi K, Ogata M, Kanemoto S, Otori K, Iseki K, Wanaka A, Imaizumi K. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. Nat Cell Biol 7: 186-194, 2005.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 186-194
-
-
Kondo, S.1
Murakami, T.2
Tatsumi, K.3
Ogata, M.4
Kanemoto, S.5
Otori, K.6
Iseki, K.7
Wanaka, A.8
Imaizumi, K.9
-
34
-
-
0027362667
-
Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
-
Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 53: 4701-4714, 1993.
-
(1993)
Cancer Res
, vol.53
, pp. 4701-4714
-
-
Krajewski, S.1
Tanaka, S.2
Takayama, S.3
Schibler, M.J.4
Fenton, W.5
Reed, J.C.6
-
35
-
-
0142059951
-
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
-
Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23: 7448-7459, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7448-7459
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Glimcher, L.H.3
-
36
-
-
0037418238
-
JNK phosphorylation of Bim-related members of the Bcl2 family induces Baxdependent apoptosis
-
Lei K, Davis RJ. JNK phosphorylation of Bim-related members of the Bcl2 family induces Baxdependent apoptosis. Proc Natl Acad Sci USA 100: 2432-2437, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2432-2437
-
-
Lei, K.1
Davis, R.J.2
-
38
-
-
33747849846
-
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
-
Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, Bortell R, Rossini AA, Urano F. Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab 4: 245-254, 2006.
-
(2006)
Cell Metab
, vol.4
, pp. 245-254
-
-
Lipson, K.L.1
Fonseca, S.G.2
Ishigaki, S.3
Nguyen, L.X.4
Foss, E.5
Bortell, R.6
Rossini, A.A.7
Urano, F.8
-
39
-
-
0034637605
-
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
-
Liu CY, Schroder M, Kaufman RJ. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J Biol Chem 275: 24881-24885., 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 24881-24885
-
-
Liu, C.Y.1
Schroder, M.2
Kaufman, R.J.3
-
40
-
-
5444264022
-
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
-
Lu PD, Harding HP, Ron D. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. Mol Cell Biol 167: 27-33, 2004.
-
(2004)
Mol Cell Biol
, vol.167
, pp. 27-33
-
-
Lu, P.D.1
Harding, H.P.2
Ron, D.3
-
41
-
-
0037106329
-
Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: Activating transcription factor 6 as a target for stress-induced phosphorylation
-
Luo S, Lee AS. Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation. Biochem J 366: 787-795, 2002.
-
(2002)
Biochem J
, vol.366
, pp. 787-795
-
-
Luo, S.1
Lee, A.S.2
-
42
-
-
0036314984
-
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response
-
Ma Y, Brewer JW, Diehl JA, Hendershot LM. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol 318: 1351-1365, 2002.
-
(2002)
J Mol Biol
, vol.318
, pp. 1351-1365
-
-
Ma, Y.1
Brewer, J.W.2
Diehl, J.A.3
Hendershot, L.M.4
-
43
-
-
33749492425
-
Endoplasmic reticulum stress signaling in disease
-
Marciniak SJ, Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 86: 1133-1149, 2006.
-
(2006)
Physiol Rev
, vol.86
, pp. 1133-1149
-
-
Marciniak, S.J.1
Ron, D.2
-
44
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18: 3066-3077, 2004.
-
(2004)
Genes Dev
, vol.18
, pp. 3066-3077
-
-
Marciniak, S.J.1
Yun, C.Y.2
Oyadomari, S.3
Novoa, I.4
Zhang, Y.5
Jungreis, R.6
Nagata, K.7
Harding, H.P.8
Ron, D.9
-
45
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
-
McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.O.3
Aw, T.Y.4
Holbrook, N.J.5
-
46
-
-
23144451257
-
ERAD: The long road to destruction
-
Meusser B, Hirsch C, Jarosch E, Sommer T. ERAD: the long road to destruction. Nat Cell Biol 7: 766-772, 2005.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 766-772
-
-
Meusser, B.1
Hirsch, C.2
Jarosch, E.3
Sommer, T.4
-
47
-
-
0027305620
-
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus
-
Mori K, Ma W, Gething MJ, Sambrook J. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 74: 743-756, 1993.
-
(1993)
Cell
, vol.74
, pp. 743-756
-
-
Mori, K.1
Ma, W.2
Gething, M.J.3
Sambrook, J.4
-
48
-
-
0032540253
-
Palindrome with spacer of one nucleotide is characteristic of the cis-acting unfolded protein response element in Saccharomyces cerevisiae
-
Mori K, Ogawa N, Kawahara T, Yanagi H, Yura T. Palindrome with spacer of one nucleotide is characteristic of the cis-acting unfolded protein response element in Saccharomyces cerevisiae. J Biol Chem 273: 9912-9920, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 9912-9920
-
-
Mori, K.1
Ogawa, N.2
Kawahara, T.3
Yanagi, H.4
Yura, T.5
-
49
-
-
0026628290
-
A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins
-
Mori K, Sant A, Kohno K, Normington K, Gething MJ, Sambrook JF. A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins. EMBO J 11: 2583-2593, 1992.
-
(1992)
EMBO J
, vol.11
, pp. 2583-2593
-
-
Mori, K.1
Sant, A.2
Kohno, K.3
Normington, K.4
Gething, M.J.5
Sambrook, J.F.6
-
50
-
-
0037072937
-
An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12
-
Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277: 34287-34294, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 34287-34294
-
-
Morishima, N.1
Nakanishi, K.2
Takenouchi, H.3
Shibata, T.4
Yasuhiko, Y.5
-
51
-
-
33645107263
-
Cleavge of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress
-
Murakami T, Kondo S, Ogata M, Kanemoto S, Saito A, Wanaka A, Imaizumi K. Cleavge of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress. J Neurochem 96: 1090-1100, 2006.
-
(2006)
J Neurochem
, vol.96
, pp. 1090-1100
-
-
Murakami, T.1
Kondo, S.2
Ogata, M.3
Kanemoto, S.4
Saito, A.5
Wanaka, A.6
Imaizumi, K.7
-
52
-
-
33846223428
-
Role of disulfide bridges formed in the lumenal domain of ATF6 in sensing endoplasmic reticulum stress
-
Nadanaka S, Okada T, Yoshida H, Mori K. Role of disulfide bridges formed in the lumenal domain of ATF6 in sensing endoplasmic reticulum stress. Mol Cell Biol 27: 1027-1043, 2006.
-
(2006)
Mol Cell Biol
, vol.27
, pp. 1027-1043
-
-
Nadanaka, S.1
Okada, T.2
Yoshida, H.3
Mori, K.4
-
53
-
-
2542488276
-
Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum
-
Nadanaka S, Yoshida H, Kano F, Murata M, Mori K. Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum. Mol Biol Cell 15: 2537-2548, 2004.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 2537-2548
-
-
Nadanaka, S.1
Yoshida, H.2
Kano, F.3
Murata, M.4
Mori, K.5
-
54
-
-
33846201752
-
Analysis of ATF6 activation in site-2 protease-deficient Chinese hamster ovary cells
-
Nadanaka S, Yoshida H, Sato R, Mori K. Analysis of ATF6 activation in site-2 protease-deficient Chinese hamster ovary cells. Cell Struct Funct 31: 109-116, 2006.
-
(2006)
Cell Struct Funct
, vol.31
, pp. 109-116
-
-
Nadanaka, S.1
Yoshida, H.2
Sato, R.3
Mori, K.4
-
55
-
-
0034698878
-
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
-
Nakagawa T, Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol 150: 887-894, 2000.
-
(2000)
J Cell Biol
, vol.150
, pp. 887-894
-
-
Nakagawa, T.1
Yuan, J.2
-
56
-
-
0034610743
-
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
-
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403: 98-103, 2000.
-
(2000)
Nature
, vol.403
, pp. 98-103
-
-
Nakagawa, T.1
Zhu, H.2
Morishima, N.3
Li, E.4
Xu, J.5
Yankner, B.A.6
Yuan, J.7
-
57
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16: 1345-1355, 2002.
-
(2002)
Genes Dev
, vol.16
, pp. 1345-1355
-
-
Nishitoh, H.1
Matsuzawa, A.2
Tobiume, K.3
Saegusa, K.4
Takeda, K.5
Inoue, K.6
Hori, S.7
Kakizuka, A.8
Ichijo, H.9
-
58
-
-
0032158987
-
ASK1 is essential for JNK/SAPK activation by TRAF2
-
Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell 2: 389-395, 1998.
-
(1998)
Mol Cell
, vol.2
, pp. 389-395
-
-
Nishitoh, H.1
Saitoh, M.2
Mochida, Y.3
Takeda, K.4
Nakano, H.5
Rothe, M.6
Miyazono, K.7
Ichijo, H.8
-
59
-
-
0035947778
-
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
-
Novoa I, Zeng H, Harding HP, Ron D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol 153: 1011-1022, 2001.
-
(2001)
J Cell Biol
, vol.153
, pp. 1011-1022
-
-
Novoa, I.1
Zeng, H.2
Harding, H.P.3
Ron, D.4
-
60
-
-
0036713724
-
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
-
Okada T, Yoshida H, Akazawa R, Negishi M, Mori K. Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 366: 585-594, 2002.
-
(2002)
Biochem J
, vol.366
, pp. 585-594
-
-
Okada, T.1
Yoshida, H.2
Akazawa, R.3
Negishi, M.4
Mori, K.5
-
61
-
-
0036291139
-
OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain
-
Omori Y, Imai J, Suzuki Y, Wanaka S, Tanigami A, Sugano S. OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain. Biochem Biophys Res Commun 293: 470-477, 2002.
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 470-477
-
-
Omori, Y.1
Imai, J.2
Suzuki, Y.3
Wanaka, S.4
Tanigami, A.5
Sugano, S.6
-
62
-
-
0035873671
-
CREB-H: A novel mammalian transcription factor belonging to the CREB/ATF4 family and functioning via the box-B element with a liver-specific expression
-
Omori Y, Imai J, Wantanbe M, Komatsu T, Suzuki Y, Kataoka K, Watanabe S, Tanigami A, Sugano S. CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF4 family and functioning via the box-B element with a liver-specific expression. Nucleic Acids Res 29: 2154-2162, 2001.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 2154-2162
-
-
Omori, Y.1
Imai, J.2
Wantanbe, M.3
Komatsu, T.4
Suzuki, Y.5
Kataoka, K.6
Watanabe, S.7
Tanigami, A.8
Sugano, S.9
-
63
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109: 525-532, 2002.
-
(2002)
J Clin Invest
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
Gotoh, T.4
Akira, S.5
Araki, E.6
Mori, M.7
-
64
-
-
0035845568
-
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
-
Oyadomari S, Takeda K, Takiguchi M, Gotoh T, Matsumoto M, Wada I, Akira S, Araki E, Mori M. Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci USA 98: 10845-10850, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10845-10850
-
-
Oyadomari, S.1
Takeda, K.2
Takiguchi, M.3
Gotoh, T.4
Matsumoto, M.5
Wada, I.6
Akira, S.7
Araki, E.8
Mori, M.9
-
65
-
-
33747175431
-
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload
-
Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell 126: 727-739, 2006.
-
(2006)
Cell
, vol.126
, pp. 727-739
-
-
Oyadomari, S.1
Yun, C.2
Fisher, E.A.3
Kreglinger, N.4
Kreibich, G.5
Oyadomari, M.6
Harding, H.P.7
Goodman, A.G.8
Harant, H.9
Garrison, J.L.10
Taunton, J.11
Katze, M.G.12
Ron, D.13
-
66
-
-
0027729197
-
Reversible phosphorylation of eukaryotic initiation factor 2 alpha in response to endoplasmic reticular signaling
-
Prostko CR, Brostrom MA, Brostrom CO. Reversible phosphorylation of eukaryotic initiation factor 2 alpha in response to endoplasmic reticular signaling. Mol Cell Biochem 128: 255-265, 1993.
-
(1993)
Mol Cell Biochem
, vol.128
, pp. 255-265
-
-
Prostko, C.R.1
Brostrom, M.A.2
Brostrom, C.O.3
-
67
-
-
0033104996
-
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
-
Puthalakath H, Huang DCS, O'Reilly LA, King SM, Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 3: 287-296, 1999.
-
(1999)
Mol Cell
, vol.3
, pp. 287-296
-
-
Puthalakath, H.1
Huang, D.C.S.2
O'Reilly, L.A.3
King, S.M.4
Strasser, A.5
-
68
-
-
0036315042
-
Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis
-
Raggo C, Rapin N, Stirling J, Gobeil P, Smith-Windsor E, O'Hare P, Misra V. Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis. Mol Cell Biol 22: 5639-5649, 2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5639-5649
-
-
Raggo, C.1
Rapin, N.2
Stirling, J.3
Gobeil, P.4
Smith-Windsor, E.5
O'Hare, P.6
Misra, V.7
-
69
-
-
0035823579
-
Coupling endoplasmic reticulum stress to the cell death program: Mechanism of caspase activation
-
Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program: mechanism of caspase activation. J Biol Chem 276: 33869-33874, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 33869-33874
-
-
Rao, R.V.1
Hermel, E.2
Castro-Obregon, S.3
del Rio, G.4
Ellerby, L.M.5
Ellerby, H.M.6
Bredesen, D.E.7
-
70
-
-
0034650851
-
An essential role in liver development for transcription factor XBP-1
-
Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH. An essential role in liver development for transcription factor XBP-1. Genes Dev 14: 152-157, 2000.
-
(2000)
Genes Dev
, vol.14
, pp. 152-157
-
-
Reimold, A.M.1
Etkin, A.2
Clauss, I.3
Perkins, A.4
Friend, D.S.5
Zhang, J.6
Horton, H.F.7
Scott, A.8
Orkin, S.H.9
Byrne, M.C.10
Grusby, M.J.11
Glimcher, L.H.12
-
71
-
-
0035913294
-
Plasma cell differentiation requires the transcription factor XBP-1
-
Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. Plasma cell differentiation requires the transcription factor XBP-1. Nature 412: 300-307, 2001.
-
(2001)
Nature
, vol.412
, pp. 300-307
-
-
Reimold, A.M.1
Iwakoshi, N.N.2
Manis, J.3
Vallabhajosyula, P.4
Szomolanyi-Tsuda, E.5
Gravallese, E.M.6
Friend, D.7
Grusby, M.J.8
Alt, F.9
Glimcher, L.H.10
-
72
-
-
0036856008
-
Translational control in the endoplasmic reticulum stress response
-
Ron D. Translational control in the endoplasmic reticulum stress response. J Clin Invest 110: 1383-1388, 2002.
-
(2002)
J Clin Invest
, vol.110
, pp. 1383-1388
-
-
Ron, D.1
-
73
-
-
0026546365
-
-
Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6: 439-453, 1992.
-
Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6: 439-453, 1992.
-
-
-
-
74
-
-
0035812716
-
Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response
-
Ruegsegger U, Leber JH, Walter P. Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell 107: 103-114, 2001.
-
(2001)
Cell
, vol.107
, pp. 103-114
-
-
Ruegsegger, U.1
Leber, J.H.2
Walter, P.3
-
75
-
-
33646175602
-
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
-
Saleh M, Mathison JC, Wolinski MK, Bensinger SJ, Fitzgerald P, Droin N, Ulevitch RJ, Green DR, Nicholson DW. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 440: 1064-1068, 2006.
-
(2006)
Nature
, vol.440
, pp. 1064-1068
-
-
Saleh, M.1
Mathison, J.C.2
Wolinski, M.K.3
Bensinger, S.J.4
Fitzgerald, P.5
Droin, N.6
Ulevitch, R.J.7
Green, D.R.8
Nicholson, D.W.9
-
76
-
-
33747415096
-
Cross-talk between two apoptotic pathways activated by endoplasmic reticulum stress: Differential contribution of caspase-12 and AIF
-
Sanges D, Marigo V. Cross-talk between two apoptotic pathways activated by endoplasmic reticulum stress: differential contribution of caspase-12 and AIF. Apoptosis 11: 1629-1641, 2006.
-
(2006)
Apoptosis
, vol.11
, pp. 1629-1641
-
-
Sanges, D.1
Marigo, V.2
-
77
-
-
0034973982
-
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
-
Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 7: 1165-1176, 2001.
-
(2001)
Mol Cell
, vol.7
, pp. 1165-1176
-
-
Scheuner, D.1
Song, B.2
McEwen, E.3
Liu, C.4
Laybutt, R.5
Gillespie, P.6
Saunders, T.7
Bonner-Weir, S.8
Kaufman, R.J.9
-
78
-
-
0034643336
-
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
-
Schubert U, Anton LC, Gibbs J, Norbury CC, Yewdell JW, Bennink JR. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature 404: 770-774, 2000.
-
(2000)
Nature
, vol.404
, pp. 770-774
-
-
Schubert, U.1
Anton, L.C.2
Gibbs, J.3
Norbury, C.C.4
Yewdell, J.W.5
Bennink, J.R.6
-
79
-
-
0037418843
-
2+: A control point for apoptosis
-
2+: a control point for apoptosis. Science 300: 135-139, 2003.
-
(2003)
Science
, vol.300
, pp. 135-139
-
-
Scorrano, L.1
Oakes, S.A.2
Opferman, J.T.3
Cheng, E.H.4
Sorcinelli, M.D.5
Pozzan, T.6
Korsmeyer, S.J.7
-
80
-
-
0029903049
-
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
-
Shamu CE, Walter P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J 15: 3028-3039, 1996.
-
(1996)
EMBO J
, vol.15
, pp. 3028-3039
-
-
Shamu, C.E.1
Walter, P.2
-
81
-
-
0036069980
-
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
-
Shen J, Chen X, Hendershot L, Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell 3: 99-111, 2002.
-
(2002)
Dev Cell
, vol.3
, pp. 99-111
-
-
Shen, J.1
Chen, X.2
Hendershot, L.3
Prywes, R.4
-
82
-
-
5644244829
-
Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6
-
Shen J, Prywes R. Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6. J Biol Chem 279: 43046-43051, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 43046-43051
-
-
Shen, J.1
Prywes, R.2
-
83
-
-
0031755020
-
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
-
Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol 18: 7499-7509, 1998.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7499-7509
-
-
Shi, Y.1
Vattem, K.M.2
Sood, R.3
An, J.4
Liang, J.5
Stramm, L.6
Wek, R.C.7
-
84
-
-
33748862585
-
BH3-only proteins: Integrated control point of apoptosis
-
Shibue T, Taniguchi T. BH3-only proteins: integrated control point of apoptosis. Int J Cancer 119: 2036-2043, 2006.
-
(2006)
Int J Cancer
, vol.119
, pp. 2036-2043
-
-
Shibue, T.1
Taniguchi, T.2
-
85
-
-
0030297538
-
tRNA ligase is required for regulated mRNA splicing in the unfolded protein response
-
Sidrauski C, Cox JS, Walter P. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87: 405-413, 1996.
-
(1996)
Cell
, vol.87
, pp. 405-413
-
-
Sidrauski, C.1
Cox, J.S.2
Walter, P.3
-
86
-
-
0030954870
-
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
-
Sidrauski C, Walter P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90: 1031-1039, 1997.
-
(1997)
Cell
, vol.90
, pp. 1031-1039
-
-
Sidrauski, C.1
Walter, P.2
-
87
-
-
0032802315
-
2-terminal kinase activity, and apoptosis
-
2-terminal kinase activity, and apoptosis. Mol Cell Biol 19: 5659-5674, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5659-5674
-
-
Srivastava, R.K.1
Sollott, S.J.2
Khan, L.3
Hansford, R.4
Lakatta, E.G.5
Longo, D.L.6
-
88
-
-
30044441047
-
CREB4, a transmembrane bZIP transcription factor and potential new substrate for regulation and cleavage by S1P
-
Stirling J, O'Hare P. CREB4, a transmembrane bZIP transcription factor and potential new substrate for regulation and cleavage by S1P. Mol Biol Cell 17: 413-426, 2006.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 413-426
-
-
Stirling, J.1
O'Hare, P.2
-
89
-
-
33744918550
-
Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis
-
Tan Y, Dourdin N, Wu C, De Veyra T, Elce JS, Greer PA. Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis. J Biol Chem 281: 16016-16024, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 16016-16024
-
-
Tan, Y.1
Dourdin, N.2
Wu, C.3
De Veyra, T.4
Elce, J.S.5
Greer, P.A.6
-
90
-
-
0032525990
-
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
-
Tirasophon W, Welihinda AA, Kaufman RJ. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev 12: 1812-1824, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 1812-1824
-
-
Tirasophon, W.1
Welihinda, A.A.2
Kaufman, R.J.3
-
91
-
-
0034724520
-
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
-
Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101: 249-258, 2000.
-
(2000)
Cell
, vol.101
, pp. 249-258
-
-
Travers, K.J.1
Patil, C.K.2
Wodicka, L.3
Lockhart, D.J.4
Weissman, J.S.5
Walter, P.6
-
92
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664-666, 2000.
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Harding, H.P.6
Ron, D.7
-
93
-
-
0032190546
-
Cloning of mammalian Ire1 reveals diversity in the ER stress responses
-
Wang XZ, Harding HP, Zhang Y, Jolicoeur EM, Kuroda M, Ron D. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J 17: 5708-5717, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 5708-5717
-
-
Wang, X.Z.1
Harding, H.P.2
Zhang, Y.3
Jolicoeur, E.M.4
Kuroda, M.5
Ron, D.6
-
94
-
-
8944259440
-
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153)
-
Wang XZ, Lawson B, Brewer JW, Zinszner H, Sanjay A, Mi LJ, Boorstein R, Kreibich G, Hendershot LM, Ron D. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol 16: 4273-4280, 1996.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4273-4280
-
-
Wang, X.Z.1
Lawson, B.2
Brewer, J.W.3
Zinszner, H.4
Sanjay, A.5
Mi, L.J.6
Boorstein, R.7
Kreibich, G.8
Hendershot, L.M.9
Ron, D.10
-
95
-
-
0034282912
-
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
-
Wang Y, Shen J, Arenzana N, Tirasophon W, Kaufman RJ, Prywes R. Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. J Biol Chem 275: 27013-27020, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 27013-27020
-
-
Wang, Y.1
Shen, J.2
Arenzana, N.3
Tirasophon, W.4
Kaufman, R.J.5
Prywes, R.6
-
96
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730, 2001.
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
Roth, K.A.7
MacGregor, G.R.8
Thompson, C.B.9
Korsmeyer, S.J.10
-
97
-
-
0029892851
-
The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation
-
Welihinda AA, Kaufman RJ. The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation. J Biol Chem 271: 18181-18187, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 18181-18187
-
-
Welihinda, A.A.1
Kaufman, R.J.2
-
98
-
-
23144442469
-
A new pharmacology: Drugging stressed folding pathways
-
Wiseman RL, Balch WE. A new pharmacology: drugging stressed folding pathways. Trends Mol Med 11: 347-350, 2005.
-
(2005)
Trends Mol Med
, vol.11
, pp. 347-350
-
-
Wiseman, R.L.1
Balch, W.E.2
-
99
-
-
33645156429
-
From acute ER stress to physiological roles of the unfolded protein response
-
Wu J, Kaufman RJ. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ 13: 374-384, 2006.
-
(2006)
Cell Death Differ
, vol.13
, pp. 374-384
-
-
Wu, J.1
Kaufman, R.J.2
-
100
-
-
0033499801
-
BCL-2 is phosphorylated and inactivated by an ASK1/Jun Nterminal protein kinase pathway normally activated at G(2)/M
-
Yamamoto K, Ichijo H, Korsmeyer SJ. BCL-2 is phosphorylated and inactivated by an ASK1/Jun Nterminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19: 8469-8478, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8469-8478
-
-
Yamamoto, K.1
Ichijo, H.2
Korsmeyer, S.J.3
-
101
-
-
0034515724
-
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
-
Ye J, Rawson RB, Komuro R, Chen X, Dave UP, Prywes R, Brown MS, Goldstein JL. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell 6: 1355-1364, 2000.
-
(2000)
Mol Cell
, vol.6
, pp. 1355-1364
-
-
Ye, J.1
Rawson, R.B.2
Komuro, R.3
Chen, X.4
Dave, U.P.5
Prywes, R.6
Brown, M.S.7
Goldstein, J.L.8
-
102
-
-
33745833084
-
The DRiP hypothesis decennial: Support, controversy, refinement and extension
-
Yewdell JW, Nicchitta CV. The DRiP hypothesis decennial: support, controversy, refinement and extension. TRENDS Immunol 27: 368-373, 2006.
-
(2006)
TRENDS Immunol
, vol.27
, pp. 368-373
-
-
Yewdell, J.W.1
Nicchitta, C.V.2
-
103
-
-
0035957929
-
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
-
Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T, Tohyama M. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J Biol Chem 276: 13935-13940, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 13935-13940
-
-
Yoneda, T.1
Imaizumi, K.2
Oono, K.3
Yui, D.4
Gomi, F.5
Katayama, T.6
Tohyama, M.7
-
104
-
-
0032509216
-
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
-
Yoshida H, Haze K, Yanagi H, Yura T, Mori K. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J Biol Chem 273: 33741-33749, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 33741-33749
-
-
Yoshida, H.1
Haze, K.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
105
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881-891, 2001.
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
106
-
-
0033815971
-
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
-
Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol 20: 6755-6767, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6755-6767
-
-
Yoshida, H.1
Okada, T.2
Haze, K.3
Yanagi, H.4
Yura, T.5
Negishi, M.6
Mori, K.7
-
107
-
-
33749564033
-
Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest
-
Zhang F, Hamanaka RB, Bobrovnikova-Marjon E, Gordan JD, Dai MS, Lu H, Simon MC, Diehl JA. Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem 281: 30036-30045, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 30036-30045
-
-
Zhang, F.1
Hamanaka, R.B.2
Bobrovnikova-Marjon, E.3
Gordan, J.D.4
Dai, M.S.5
Lu, H.6
Simon, M.C.7
Diehl, J.A.8
-
108
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, Kaufman RJ. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124: 587-599, 2006.
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
Shen, X.2
Wu, J.3
Sakaki, K.4
Saunders, T.5
Rutkowski, D.T.6
Back, S.H.7
Kaufman, R.J.8
-
109
-
-
14944371187
-
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis
-
Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest 115: 268-281, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 268-281
-
-
Zhang, K.1
Wong, H.N.2
Song, B.3
Miller, C.N.4
Scheuner, D.5
Kaufman, R.J.6
-
110
-
-
0036091476
-
The PERK eukaryotic initiation factor 2alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
-
Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR. The PERK eukaryotic initiation factor 2alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol 22: 3864-3874, 2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3864-3874
-
-
Zhang, P.1
McGrath, B.2
Li, S.3
Frank, A.4
Zambito, F.5
Reinert, J.6
Gannon, M.7
Ma, K.8
McNaughton, K.9
Cavener, D.R.10
-
111
-
-
33751430251
-
-
Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR. PERK EIF2AK3 control of pancreatic b-cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab 4: 1-7, 2006.
-
Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR. PERK EIF2AK3 control of pancreatic b-cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab 4: 1-7, 2006.
-
-
-
-
112
-
-
33745844503
-
Endoplasmic reticulum stress in health and disease
-
Zhao L, Ackerman SL. Endoplasmic reticulum stress in health and disease. Curr Opin Cell Biol 18: 444-452, 2006.
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 444-452
-
-
Zhao, L.1
Ackerman, S.L.2
-
113
-
-
33749233991
-
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
-
Zhou J, Liu CY, Back SH, Clark RL, Peisach D, Xu Z, Kaufman RJ. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci USA 103: 14343-14348, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 14343-14348
-
-
Zhou, J.1
Liu, C.Y.2
Back, S.H.3
Clark, R.L.4
Peisach, D.5
Xu, Z.6
Kaufman, R.J.7
-
114
-
-
0032054744
-
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
-
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12: 982-995, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 982-995
-
-
Zinszner, H.1
Kuroda, M.2
Wang, X.3
Batchvarova, N.4
Lightfoot, R.T.5
Remotti, H.6
Stevens, J.L.7
Ron, D.8
-
115
-
-
0037810844
-
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
-
Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162: 59-69, 2003.
-
(2003)
J Cell Biol
, vol.162
, pp. 59-69
-
-
Zong, W.X.1
Li, C.2
Hatzivassiliou, G.3
Lindsten, T.4
Yu, Q.C.5
Yuan, J.6
Thompson, C.B.7
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