-
1
-
-
22844457491
-
DNA methylation and human disease
-
DOI 10.1038/nrg1655
-
Robertson KD (2005) DNA methylation and human disease. Nat Rev Genet 6(8):597-610 (Pubitemid 41044297)
-
(2005)
Nature Reviews Genetics
, vol.6
, Issue.8
, pp. 597-610
-
-
Robertson, K.D.1
-
2
-
-
33748740832
-
Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L
-
DOI 10.1074/jbc.M603140200
-
Kareta MS, Botello ZM, Ennis JJ, Chou C, Chedin F (2006) Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L. J Biol Chem 281(36): 25893-25902 (Pubitemid 44401795)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.36
, pp. 25893-25902
-
-
Kareta, M.S.1
Botello, Z.M.2
Ennis, J.J.3
Chou, C.4
Chedin, F.5
-
3
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
DOI 10.1016/S0092-8674(00)81656-6
-
Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99(3):247-257 (Pubitemid 29519904)
-
(1999)
Cell
, vol.99
, Issue.3
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
4
-
-
0031860739
-
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [1]
-
DOI 10.1038/890
-
Okano M, Xie S, Li E (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 19(3):219-220 (Pubitemid 28309328)
-
(1998)
Nature Genetics
, vol.19
, Issue.3
, pp. 219-220
-
-
Okano, M.1
Xie, S.2
Li, E.3
-
5
-
-
33748998743
-
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival
-
DOI 10.1073/pnas.0604602103
-
Egger G, Jeong S, Escobar SG et al (2006) Identi fi cation of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc Natl Acad Sci USA 103(38):14080-14085 (Pubitemid 44452983)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.38
, pp. 14080-14085
-
-
Egger, G.1
Jeong, S.2
Escobar, S.G.3
Cortez, C.C.4
Li, T.W.H.5
Saito, Y.6
Yoo, C.B.7
Jones, P.A.8
Liang, G.9
-
6
-
-
0347719444
-
Methylation and epigenetic fi delity
-
Riggs AD, Xiong Z (2004) Methylation and epigenetic fi delity. Proc Natl Acad Sci USA 101(1):4-5
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.1
, pp. 4-5
-
-
Riggs, A.D.1
Xiong, Z.2
-
7
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
Li E, Bestor TH, Jaenisch R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69(6):915-926
-
(1992)
Cell
, vol.69
, Issue.6
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
8
-
-
0029803192
-
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
-
Lei H, Oh SP, Okano M et al (1996) De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122(10):3195-3205
-
(1996)
Development
, vol.122
, Issue.10
, pp. 3195-3205
-
-
Lei, H.1
Oh, S.P.2
Okano, M.3
-
9
-
-
0036733675
-
Chromatin modification and epigenetic reprogramming in mammalian development
-
DOI 10.1038/nrg887
-
Li E (2002) Chromatin modi fi cation and epigenetic reprogramming in mammalian development. Nat Rev Genet 3(9):662-673 (Pubitemid 34984255)
-
(2002)
Nature Reviews Genetics
, vol.3
, Issue.9
, pp. 662-673
-
-
Li, E.1
-
10
-
-
0030840954
-
Cytosine methylation and the ecology of intragenomic parasites
-
DOI 10.1016/S0168-9525(97)01181-5, PII S0168952597011815
-
Yoder JA, Walsh CP, Bestor TH (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 13(8):335-340 (Pubitemid 27309911)
-
(1997)
Trends in Genetics
, vol.13
, Issue.8
, pp. 335-340
-
-
Yoder, J.A.1
Walsh, C.P.2
Bestor, T.H.3
-
11
-
-
33645702660
-
DNA methyltransferases control telomere length and telomere recombination in mammalian cells
-
Gonzalo S, Jaco I, Fraga MF et al (2006) DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol 8(4):416-424
-
(2006)
Nat Cell Biol
, vol.8
, Issue.4
, pp. 416-424
-
-
Gonzalo, S.1
Jaco, I.2
Fraga, M.F.3
-
12
-
-
0033547330
-
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
-
Xu GL, Bestor TH, Bourc'his D et al (1999) Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402(6758): 187-191
-
(1999)
Nature
, vol.402
, Issue.6758
, pp. 187-191
-
-
Xu, G.L.1
Bestor, T.H.2
Bourc'his, D.3
-
13
-
-
3042531072
-
Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells
-
DOI 10.1038/nature02653
-
Guo G, Wang W, Bradley A (2004) Mismatch repair genes identi fi ed using genetic screens in Blm-deficient embryonic stem cells. Nature 429(6994):891-895 (Pubitemid 38843302)
-
(2004)
Nature
, vol.429
, Issue.6994
, pp. 891-895
-
-
Guo, G.1
Wang, W.2
Bradley, A.3
-
14
-
-
10244278087
-
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells
-
DOI 10.1093/nar/gkh912
-
Kim M, Trinh BN, Long TI, Oghamian S, Laird PW (2004) Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells. Nucleic Acids Res 32(19): 5742-5749 (Pubitemid 39619157)
-
(2004)
Nucleic Acids Research
, vol.32
, Issue.19
, pp. 5742-5749
-
-
Kim, M.1
Trinh, B.N.2
Long, T.I.3
Oghamian, S.4
Laird, P.W.5
-
15
-
-
7644244043
-
DNA methyltransferase Dnmt1 and mismatch repair
-
Wang KY, James Shen CK (2004) DNA methyltransferase Dnmt1 and mismatch repair. Oncogene 23(47):7898-7902
-
(2004)
Oncogene
, vol.23
, Issue.47
, pp. 7898-7902
-
-
Wang, K.Y.1
James Shen, C.K.2
-
16
-
-
42449090287
-
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline
-
DOI 10.1093/hmg/ddn019
-
Dion V, Lin Y, Hubert L Jr, Waterland RA, Wilson JH (2008) Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. Hum Mol Genet 17(9):1306-1317 (Pubitemid 351566967)
-
(2008)
Human Molecular Genetics
, vol.17
, Issue.9
, pp. 1306-1317
-
-
Dion, V.1
Lin, Y.2
Hubert Jr., L.3
Waterland, R.A.4
Wilson, J.H.5
-
17
-
-
79960805226
-
DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response
-
Loughery JE, Dunne PD, O'Neill KM, Meehan RR, McDaid JR, Walsh CP (2011) DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response. Hum Mol Genet 20(16): 3241-3255
-
(2011)
Hum Mol Genet
, vol.20
, Issue.16
, pp. 3241-3255
-
-
Loughery, J.E.1
Dunne, P.D.2
O'Neill, K.M.3
Meehan, R.R.4
McDaid, J.R.5
Walsh, C.P.6
-
18
-
-
25444475765
-
Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells
-
DOI 10.1158/0008-5472.CAN-05-1961
-
Karpf AR, Matsui S (2005) Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res 65(19):8635-8639 (Pubitemid 41377349)
-
(2005)
Cancer Research
, vol.65
, Issue.19
, pp. 8635-8639
-
-
Karpf, A.R.1
Matsui, S.-I.2
-
19
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson SP, Bartek J (2009) The DNA-damage response in human biology and disease. Nature 461(7267):1071-1078
-
(2009)
Nature
, vol.461
, Issue.7267
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
20
-
-
34447104563
-
Mutator pathways unleashed by epigenetic silencing in human cancer
-
DOI 10.1093/mutage/gem009
-
Jacinto FV, Esteller M (2007) Mutator pathways unleashed by epigenetic silencing in human cancer. Mutagenesis 22(4):247-253 (Pubitemid 47216613)
-
(2007)
Mutagenesis
, vol.22
, Issue.4
, pp. 247-253
-
-
Jacinto, F.V.1
Esteller, M.2
-
21
-
-
79956304468
-
Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery
-
Ha K, Lee GE, Palii SS et al (2011) Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery. Hum Mol Genet 20(1):126-140
-
(2011)
Hum Mol Genet
, vol.20
, Issue.1
, pp. 126-140
-
-
Ha, K.1
Lee, G.E.2
Palii, S.S.3
-
22
-
-
0038341137
-
Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes
-
DOI 10.1074/jbc.M213219200
-
Milutinovic S, Zhuang Q, Niveleau A, Szyf M (2003) Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes. J Biol Chem 278(17):14985-14995 (Pubitemid 36799830)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.17
, pp. 14985-14995
-
-
Milutinovic, S.1
Zhuang, Q.2
Niveleau, A.3
Szyf, M.4
-
23
-
-
33749594205
-
DNA methyltransferase 1 knockdown activates a replication stress checkpoint
-
DOI 10.1128/MCB.01887-05
-
Unterberger A, Andrews SD, Weaver IC, Szyf M (2006) DNA methyltransferase 1 knockdown activates a replication stress checkpoint. Mol Cell Biol 26(20):7575-7586 (Pubitemid 44547707)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.20
, pp. 7575-7586
-
-
Unterberger, A.1
Andrews, S.D.2
Weaver, I.C.G.3
Szyf, M.4
-
24
-
-
21144433566
-
Recruitment of DNA methyltransferase I to DNA repair sites
-
DOI 10.1073/pnas.0501034102
-
Mortusewicz O, Schermelleh L, Walter J, Cardoso MC, Leonhardt H (2005) Recruitment of DNA methyltransferase I to DNA repair sites. Proc Natl Acad Sci USA 102(25):8905-8909 (Pubitemid 40881051)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.25
, pp. 8905-8909
-
-
Mortusewicz, O.1
Schermelleh, L.2
Walter, J.3
Cardoso, M.C.4
Leonhardt, H.5
-
25
-
-
54549099260
-
Differences and evolution of the methods for the assessment of microsatellite instability
-
Laghi L, Bianchi P, Malesci A (2008) Differences and evolution of the methods for the assessment of microsatellite instability. Oncogene 27(49):6313-6321
-
(2008)
Oncogene
, vol.27
, Issue.49
, pp. 6313-6321
-
-
Laghi, L.1
Bianchi, P.2
Malesci, A.3
-
27
-
-
0037077309
-
Mutations within the hMLH1 and hPMS2 subunits of the human MutLα mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSα
-
DOI 10.1074/jbc.M108787200
-
Raschle M, Dufner P, Marra G, Jiricny J (2002) Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha. J Biol Chem 277(24):21810-21820 (Pubitemid 34952333)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.24
, pp. 21810-21820
-
-
Raschle, M.1
Dufner, P.2
Marra, G.3
Jiricny, J.4
-
28
-
-
77949541656
-
MutSbeta exceeds MutSalpha in dinucleotide loop repair
-
Kantelinen J, Kansikas M, Korhonen MK et al (2010) MutSbeta exceeds MutSalpha in dinucleotide loop repair. Br J Cancer 102(6):1068-1073
-
(2010)
Br J Cancer
, vol.102
, Issue.6
, pp. 1068-1073
-
-
Kantelinen, J.1
Kansikas, M.2
Korhonen, M.K.3
-
29
-
-
0032522658
-
Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principal involvement of hMLH1
-
Thibodeau SN, French AJ, Cunningham JM et al (1998) Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res 58(8):1713-1718 (Pubitemid 28215098)
-
(1998)
Cancer Research
, vol.58
, Issue.8
, pp. 1713-1718
-
-
Thibodeau, S.N.1
French, A.J.2
Cunningham, J.M.3
Tester, D.4
Burgart, L.J.5
Roche, P.C.6
McDonnell, S.K.7
Schaid, D.J.8
Vockley, C.W.9
Michels, V.V.10
Farr Jr., G.H.11
O'Connell, M.J.12
-
30
-
-
0345269743
-
Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma
-
DOI 10.1002/ijc.11028
-
Viswanathan M, Tsuchida N, Shanmugam G (2003) Promoter hypermethylation pro fi le of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma. Int J Cancer 105(1):41-46 (Pubitemid 36418483)
-
(2003)
International Journal of Cancer
, vol.105
, Issue.1
, pp. 41-46
-
-
Viswanathan, M.1
Tsuchida, N.2
Shanmugam, G.3
-
31
-
-
74049091691
-
Aberrant methylation of DNA mismatch repair genes in elderly patients with sporadic gastric carcinoma: A comparison with younger patients
-
Kim HG, Lee S, Kim DY et al (2010) Aberrant methylation of DNA mismatch repair genes in elderly patients with sporadic gastric carcinoma: A comparison with younger patients. J Surg Oncol 101(1):28-35
-
(2010)
J Surg Oncol
, vol.101
, Issue.1
, pp. 28-35
-
-
Kim, H.G.1
Lee, S.2
Kim, D.Y.3
-
32
-
-
33745693216
-
INK4A and APC in primary adenocarcinomas of the small bowel
-
DOI 10.1002/ijc.21990
-
Brucher BL, Geddert H, Langner C et al (2006) Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel. Int J Cancer 119(6):1298-1302 (Pubitemid 44258803)
-
(2006)
International Journal of Cancer
, vol.119
, Issue.6
, pp. 1298-1302
-
-
Brucher, B.L.D.M.1
Geddert, H.2
Langner, C.3
Hofler, H.4
Fink, U.5
Siewert, J.R.6
Sarbia, M.7
-
33
-
-
85047688675
-
Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples
-
Wang YC, Lu YP, Tseng RC et al (2003) Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples. J Clin Invest 111(6):887-895
-
(2003)
J Clin Invest
, vol.111
, Issue.6
, pp. 887-895
-
-
Wang, Y.C.1
Lu, Y.P.2
Tseng, R.C.3
-
34
-
-
80052035210
-
Frequency of mismatch repair deficiency in ovarian cancer: A systematic review
-
Murphy MA, Wentzensen N (2011) Frequency of mismatch repair deficiency in ovarian cancer: a systematic review. Int J Cancer 129:1914-1922
-
(2011)
Int J Cancer
, vol.129
, pp. 1914-1922
-
-
Murphy, M.A.1
Wentzensen, N.2
-
35
-
-
0037269185
-
Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia
-
DOI 10.1038/sj.leu.2402747
-
Seedhouse CH, Das-Gupta EP, Russell NH (2003) Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia. Leukemia 17(1):83-88 (Pubitemid 36175892)
-
(2003)
Leukemia
, vol.17
, Issue.1
, pp. 83-88
-
-
Seedhouse, C.H.1
Das-Gupta, E.P.2
Russell, N.H.3
-
36
-
-
4844221344
-
Promoter methylation and expression of DNA repair genes hMLH1 and MGMT in acute myeloid leukemia
-
DOI 10.1007/s00277-004-0925-0
-
Lenz G, Hutter G, Hiddemann W, Dreyling M (2004) Promoter methylation and expression of DNA repair genes hMLH1 and MGMT in acute myeloid leukemia. Ann Hematol 83(10):628-633 (Pubitemid 39317487)
-
(2004)
Annals of Hematology
, vol.83
, Issue.10
, pp. 628-633
-
-
Lenz, G.1
Hutter, G.2
Hiddemann, W.3
Dreyling, M.4
-
37
-
-
20444497374
-
Microsatellite instability is not an uncommon finding in adult de novo acute myeloid leukemia
-
DOI 10.1007/s00277-005-1035-3
-
Nomdedeu JF, Perea G, Estivill C et al (2005) Microsatellite instability is not an uncommon fi nding in adult de novo acute myeloid leukemia. Ann Hematol 84(6):368-375 (Pubitemid 40823350)
-
(2005)
Annals of Hematology
, vol.84
, Issue.6
, pp. 368-375
-
-
Nomdedeu, J.F.1
Perea, G.2
Estivill, C.3
Lasa, A.4
Carnicer, M.J.5
Brunet, S.6
Aventin, A.7
Sierra, J.8
-
38
-
-
80055062300
-
Head and neck squamous cell carcinoma: Mismatch repair immunohistochemistry and promoter hypermethylation of hMLH1 gene
-
Taw fi k HM, El-Maqsoud NM, Hak BH, El-Sherbiny YM (2011) Head and neck squamous cell carcinoma: mismatch repair immunohistochemistry and promoter hypermethylation of hMLH1 gene. Am J Otolaryngol 32(6):528-36
-
(2011)
Am J Otolaryngol
, vol.32
, Issue.6
, pp. 528-536
-
-
Tawfik, H.M.1
El-Maqsoud, N.M.2
Hak, B.H.3
El-Sherbiny, Y.M.4
-
39
-
-
79951470643
-
Epigenetic changes of DNA repair genes in cancer
-
Lahtz C, Pfeifer GP (2011) Epigenetic changes of DNA repair genes in cancer. J Mol Cell Biol 3(1):51-58
-
(2011)
J Mol Cell Biol
, vol.3
, Issue.1
, pp. 51-58
-
-
Lahtz, C.1
Pfeifer, G.P.2
-
40
-
-
33847259206
-
MLH1 germline epimutations in selected patients with early-onset non-polyposis colorectal cancer
-
DOI 10.1111/j.1399-0004.2007.00751.x
-
Valle L, Carbonell P, Fernandez V et al (2007) MLH1 germline epimutations in selected patients with early-onset non-polyposis colorectal cancer. Clin Genet 71(3):232-237 (Pubitemid 46322661)
-
(2007)
Clinical Genetics
, vol.71
, Issue.3
, pp. 232-237
-
-
Valle, L.1
Carbonell, P.2
Fernandez, V.3
Dotor, A.M.4
Sanz, M.5
Benitez, J.6
Urioste, M.7
-
41
-
-
0037099602
-
A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor
-
Gazzoli I, Loda M, Garber J, Syngal S, Kolodner RD (2002) A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability- high tumor. Cancer Res 62(14):3925-3928 (Pubitemid 34791053)
-
(2002)
Cancer Research
, vol.62
, Issue.14
, pp. 3925-3928
-
-
Gazzoli, I.1
Loda, M.2
Garber, J.3
Syngal, S.4
Kolodner, R.D.5
-
42
-
-
13144266670
-
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
-
DOI 10.1073/pnas.95.12.6870
-
Herman JG, Umar A, Polyak K et al (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 95(12):6870-6875 (Pubitemid 28278073)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.12
, pp. 6870-6875
-
-
Herman, J.G.1
Umar, A.2
Polyak, K.3
Graff, J.R.4
Ahuja, N.5
Issa, J.-P.J.6
Markowitz, S.7
Willson, J.K.V.8
Hamilton, S.R.9
Kinzler, K.W.10
Kane, M.F.11
Kolodner, R.D.12
Vogelstein, B.13
Kunkel, T.A.14
Baylin, S.B.15
-
43
-
-
0035477897
-
Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development
-
Nakagawa H, Nuovo GJ, Zervos EE et al (2001) Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res 61(19):6991-6995 (Pubitemid 32946483)
-
(2001)
Cancer Research
, vol.61
, Issue.19
, pp. 6991-6995
-
-
Nakagawa, H.1
Nuovo, G.J.2
Zervos, E.E.3
Martin Jr., E.W.4
Salovaara, R.5
Aaltonen, L.A.6
De La Chapelle, A.7
-
44
-
-
0033607285
-
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers
-
DOI 10.1073/pnas.96.22.12661
-
Kuismanen SA, Holmberg MT, Salovaara R et al (1999) Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers. Proc Natl Acad Sci USA 96(22): 12661-12666 (Pubitemid 29513559)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.22
, pp. 12661-12666
-
-
Kuismanen, S.A.1
Holmberg, M.T.2
Salovaara, R.3
Schweizer, P.4
Aaltonen, L.A.5
De La Chapelle, A.6
Nystrom-Lahti, M.7
Peltomaki, P.8
-
45
-
-
0033621170
-
Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1
-
DOI 10.1073/pnas.96.18.10296
-
Wheeler JM, Beck NE, Kim HC, Tomlinson IP, Mortensen NJ, Bodmer WF (1999) Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1. Proc Natl Acad Sci USA 96(18):10296-10301 (Pubitemid 29422552)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.18
, pp. 10296-10301
-
-
Wheeler, J.M.D.1
Beck, N.E.2
Kim, H.C.3
Tomlinson, I.P.M.4
Mortensen, N.J.McC.5
Bodmer, W.F.6
-
46
-
-
78650947025
-
Intensity-dependent constitutional MLH1 promoter methylation leads to early onset of colorectal cancer by affecting both alleles
-
Auclair J, Vaissiere T, Desseigne F et al (2011) Intensity-dependent constitutional MLH1 promoter methylation leads to early onset of colorectal cancer by affecting both alleles. Genes Chromosomes Cancer 50(3):178-185
-
(2011)
Genes Chromosomes Cancer
, vol.50
, Issue.3
, pp. 178-185
-
-
Auclair, J.1
Vaissiere, T.2
Desseigne, F.3
-
47
-
-
54349126239
-
Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer
-
Zhang H, Zhang S, Cui J, Zhang A, Shen L, Yu H (2008) Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer. Aust N Z J Obstet Gynaecol 48(5):505-509
-
(2008)
Aust N Z J Obstet Gynaecol
, vol.48
, Issue.5
, pp. 505-509
-
-
Zhang, H.1
Zhang, S.2
Cui, J.3
Zhang, A.4
Shen, L.5
Yu, H.6
-
48
-
-
79960260695
-
Microsatellite instability and promoter hypermethylation of MLH1 and MSH2 in patients with sporadic colorectal cancer
-
Vlaykova T, Mitkova A, Stancheva G et al (2011) Microsatellite instability and promoter hypermethylation of MLH1 and MSH2 in patients with sporadic colorectal cancer. J BUON 16(2):265-273
-
(2011)
J BUON
, vol.16
, Issue.2
, pp. 265-273
-
-
Vlaykova, T.1
Mitkova, A.2
Stancheva, G.3
-
49
-
-
77951049336
-
Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers
-
Nagasaka T, Rhees J, Kloor M et al (2010) Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers. Cancer Res 70(8):3098-3108
-
(2010)
Cancer Res
, vol.70
, Issue.8
, pp. 3098-3108
-
-
Nagasaka, T.1
Rhees, J.2
Kloor, M.3
-
50
-
-
58149144567
-
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1
-
Ligtenberg MJ, Kuiper RP, Chan TL et al (2009) Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1. Nat Genet 41(1):112-117
-
(2009)
Nat Genet
, vol.41
, Issue.1
, pp. 112-117
-
-
Ligtenberg, M.J.1
Kuiper, R.P.2
Chan, T.L.3
-
51
-
-
80052429650
-
Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer
-
Moelans CB, Verschuur-Maes AH, van Diest PJ (2011) Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer. J Pathol 225(2):222-231
-
(2011)
J Pathol
, vol.225
, Issue.2
, pp. 222-231
-
-
Moelans, C.B.1
Verschuur-Maes, A.H.2
Van Diest, P.J.3
-
52
-
-
34250900982
-
Base-excision repair of oxidative DNA damage
-
DOI 10.1038/nature05978, PII NATURE05978
-
David SS, O'Shea VL, Kundu S (2007) Base-excision repair of oxidative DNA damage. Nature 447(7147):941-950 (Pubitemid 46975761)
-
(2007)
Nature
, vol.447
, Issue.7147
, pp. 941-950
-
-
David, S.S.1
O'Shea, V.L.2
Kundu, S.3
-
53
-
-
38449108245
-
DNA hypermethylation and partial gene silencing of human thymine- DNA glycosylase in multiple myeloma cell lines
-
Peng B, Hurt EM, Hodge DR, Thomas SB, Farrar WL (2006) DNA hypermethylation and partial gene silencing of human thymine- DNA glycosylase in multiple myeloma cell lines. Epigenetics 1(3):138-145
-
(2006)
Epigenetics
, vol.1
, Issue.3
, pp. 138-145
-
-
Peng, B.1
Hurt, E.M.2
Hodge, D.R.3
Thomas, S.B.4
Farrar, W.L.5
-
54
-
-
58749100088
-
Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer
-
Howard JH, Frolov A, Tzeng CW et al (2009) Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer. Cancer Biol Ther 8(1):94-100
-
(2009)
Cancer Biol Ther
, vol.8
, Issue.1
, pp. 94-100
-
-
Howard, J.H.1
Frolov, A.2
Tzeng, C.W.3
-
55
-
-
48249084096
-
Hypermethylation of the DNA mismatch repair gene hMLH1 and its association with lymph node metastasis and T1799A BRAF mutation in patients with papillary thyroid cancer
-
Guan H, Ji M, Hou P et al (2008) Hypermethylation of the DNA mismatch repair gene hMLH1 and its association with lymph node metastasis and T1799A BRAF mutation in patients with papillary thyroid cancer. Cancer 113(2):247-255
-
(2008)
Cancer
, vol.113
, Issue.2
, pp. 247-255
-
-
Guan, H.1
Ji, M.2
Hou, P.3
-
56
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
DOI 10.1038/35077232
-
Hoeijmakers JH (2001) Genome maintenance mechanisms for preventing cancer. Nature 411(6835):366-374 (Pubitemid 32467046)
-
(2001)
Nature
, vol.411
, Issue.6835
, pp. 366-374
-
-
Hoeijmakers, J.H.J.1
-
57
-
-
77953123549
-
XPC epigenetic silence coupled with p53 alteration has a signi fi cant impact on bladder cancer outcome
-
Yang J, Xu Z, Li J et al (2010) XPC epigenetic silence coupled with p53 alteration has a signi fi cant impact on bladder cancer outcome. J Urol 184(1):336-343
-
(2010)
J Urol
, vol.184
, Issue.1
, pp. 336-343
-
-
Yang, J.1
Xu, Z.2
Li, J.3
-
58
-
-
77949895970
-
Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas
-
Chen HY, Shao CJ, Chen FR, Kwan AL, Chen ZP (2010) Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas. Int J Cancer 126(8):1944-1954
-
(2010)
Int J Cancer
, vol.126
, Issue.8
, pp. 1944-1954
-
-
Chen, H.Y.1
Shao, C.J.2
Chen, F.R.3
Kwan, A.L.4
Chen, Z.P.5
-
59
-
-
79956187549
-
Molecular analysis of DNA repair gene methylation and protein expression during chemical-induced rat lung carcinogenesis
-
Liu WB, Ao L, Cui ZH et al (2011) Molecular analysis of DNA repair gene methylation and protein expression during chemical-induced rat lung carcinogenesis. Biochem Biophys Res Commun 408(4):595-601
-
(2011)
Biochem Biophys Res Commun
, vol.408
, Issue.4
, pp. 595-601
-
-
Liu, W.B.1
Ao, L.2
Cui, Z.H.3
-
60
-
-
78149437505
-
DNA repair gene X-ray repair cross complementing group 1 Arg194Trp polymorphism on the risk of lung cancer: A meta-analysis on 22 studies
-
Jiang J, Liang X, Zhou X et al (2010) DNA repair gene X-ray repair cross complementing group 1 Arg194Trp polymorphism on the risk of lung cancer: a meta-analysis on 22 studies. J Thorac Oncol 5(11):1741-1747
-
(2010)
J Thorac Oncol
, vol.5
, Issue.11
, pp. 1741-1747
-
-
Jiang, J.1
Liang, X.2
Zhou, X.3
-
61
-
-
78649615250
-
XRCC1 downregulated through promoter hypermethylation is involved in human gastric carcinogenesis
-
Wang P, Tang JT, Peng YS, Chen XY, Zhang YJ, Fang JY (2010) XRCC1 downregulated through promoter hypermethylation is involved in human gastric carcinogenesis. J Dig Dis 11(6):343-351
-
(2010)
J Dig Dis
, vol.11
, Issue.6
, pp. 343-351
-
-
Wang, P.1
Tang, J.T.2
Peng, Y.S.3
Chen, X.Y.4
Zhang, Y.J.5
Fang, J.Y.6
-
62
-
-
14244259066
-
Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells
-
DOI 10.1074/jbc.M412566200
-
Peng B, Hodge DR, Thomas SB et al (2005) Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells. J Biol Chem 280(6):4182-4187 (Pubitemid 40288583)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.6
, pp. 4182-4187
-
-
Peng, B.1
Hodge, D.R.2
Thomas, S.B.3
Cherry, J.M.4
Munroe, D.J.5
Pompeia, C.6
Xiao, W.7
Farrar, W.L.8
-
63
-
-
77649131406
-
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
-
Moynahan ME, Jasin M (2010) Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol 11(3):196-207
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, Issue.3
, pp. 196-207
-
-
Moynahan, M.E.1
Jasin, M.2
-
64
-
-
77956624553
-
SnapShot: Homologous recombination in DNA double- strand break repair
-
646.e1
-
Mazon G, Mimitou EP, Symington LS. SnapShot: homologous recombination in DNA double- strand break repair. Cell . 2010;142(4):646, 646.e1.
-
(2010)
Cell
, vol.142
, Issue.4
, pp. 646
-
-
Mazon, G.1
Mimitou, E.P.2
Symington, L.S.3
-
65
-
-
0034607234
-
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
-
Esteller M, Silva JM, Dominguez G et al (2000) Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 92(7):564-569 (Pubitemid 30212318)
-
(2000)
Journal of the National Cancer Institute
, vol.92
, Issue.7
, pp. 564-569
-
-
Esteller, M.1
Silva, J.M.2
Dominguez, G.3
Bonilla, F.4
Matias-Guiu, X.5
Lerma, E.6
Bussaglia, E.7
Prat, J.8
Harkes, I.C.9
Repasky, E.A.10
Gabrielson, E.11
Schutte, M.12
Baylin, S.B.13
Herman, J.G.14
-
66
-
-
0035874892
-
6- methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis
-
Esteller M, Risques RA, Toyota M et al (2001) Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res 61(12): 4689-4692 (Pubitemid 32691877)
-
(2001)
Cancer Research
, vol.61
, Issue.12
, pp. 4689-4692
-
-
Esteller, M.1
Risques, R.-A.2
Toyota, M.3
Capella, G.4
Moreno, V.5
Peinado, M.A.6
Baylin, S.B.7
Herman, J.G.8
-
67
-
-
0034307160
-
BRCA1 promoter region hypermethylation in ovarian carcinoma: A population-based study
-
Baldwin RL, Nemeth E, Tran H et al (2000) BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study. Cancer Res 60(19):5329-5333
-
(2000)
Cancer Res
, vol.60
, Issue.19
, pp. 5329-5333
-
-
Baldwin, R.L.1
Nemeth, E.2
Tran, H.3
-
68
-
-
65949096092
-
DNA methylation pro fi le in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis
-
Bernal C, Vargas M, Ossandon F et al (2008) DNA methylation pro fi le in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis. Biol Res 41(3):303-315
-
(2008)
Biol Res
, vol.41
, Issue.3
, pp. 303-315
-
-
Bernal, C.1
Vargas, M.2
Ossandon, F.3
-
69
-
-
78651087385
-
Multiplexed methylation pro fi les of tumor suppressor genes in bladder cancer
-
Cabello MJ, Grau L, Franco N et al (2011) Multiplexed methylation pro fi les of tumor suppressor genes in bladder cancer. J Mol Diagn 13(1):29-40
-
(2011)
J Mol Diagn
, vol.13
, Issue.1
, pp. 29-40
-
-
Cabello, M.J.1
Grau, L.2
Franco, N.3
-
70
-
-
33847355994
-
Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer
-
Lee MN, Tseng RC, Hsu HS et al (2007) Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. Clin Cancer Res 13(3):832-838
-
(2007)
Clin Cancer Res
, vol.13
, Issue.3
, pp. 832-838
-
-
Lee, M.N.1
Tseng, R.C.2
Hsu, H.S.3
-
71
-
-
18244388241
-
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis
-
Esteller M, Fraga MF, Guo M et al (2001) DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet 10(26):3001-3007 (Pubitemid 34083486)
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.26
, pp. 3001-3007
-
-
Esteller, M.1
Fraga, M.F.2
Guo, M.3
Garcia-Foncillas, J.4
Hedenfalk, I.5
Godwin, A.K.6
Trojan, J.7
Vaurs-Barriere, C.8
Bignon, Y.-J.9
Ramus, S.10
Benitez, J.11
Caldes, T.12
Akiyama, Y.13
Yuasa, Y.14
Launonen, V.15
Canal, M.J.16
Rodriguez, R.17
Capella, G.18
Peinado, M.A.19
Borg, A.20
Aaltonen, L.A.21
Ponder, B.A.22
Baylin, S.B.23
Herman, J.G.24
more..
-
72
-
-
0030924656
-
Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos
-
Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A (1997) Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev 11(10): 1226-1241 (Pubitemid 27235356)
-
(1997)
Genes and Development
, vol.11
, Issue.10
, pp. 1226-1241
-
-
Ludwig, T.1
Chapman, D.L.2
Papaioannou, V.E.3
Efstratiadis, A.4
-
73
-
-
77955889790
-
Expanded roles of the Fanconi anemia pathway in preserving genomic stability
-
Kee Y, D'Andrea AD (2010) Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev 24(16):1680-1694
-
(2010)
Genes Dev
, vol.24
, Issue.16
, pp. 1680-1694
-
-
Kee, Y.1
D'Andrea, A.D.2
-
74
-
-
79961040243
-
Fanconi anemia core complex gene promoters harbor conserved transcription regulatory elements
-
Meier D, Schindler D (2011) Fanconi anemia core complex gene promoters harbor conserved transcription regulatory elements. PLoS One 6(8):e22911
-
(2011)
PLoS One
, vol.6
, Issue.8
-
-
Meier, D.1
Schindler, D.2
-
75
-
-
47749098040
-
Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia
-
DOI 10.3233/CLO-2008-0426
-
Hess CJ, Ameziane N, Schuurhuis GJ et al (2008) Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia. Cell Oncol 30(4):299-306 (Pubitemid 352032906)
-
(2008)
Cellular Oncology
, vol.30
, Issue.4
, pp. 299-306
-
-
Hess, C.J.1
Ameziane, N.2
Schuurhuis, G.J.3
Errami, A.4
Denkers, F.5
Kaspers, G.J.L.6
Cloos, J.7
Joenje, H.8
Reinhardt, D.9
Ossenkoppele, G.J.10
Zwaan, C.M.11
Waisfisz, Q.12
-
76
-
-
1342301467
-
Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: Implications for treatment and survival
-
DOI 10.1038/sj.onc.1207256
-
Marsit CJ, Liu M, Nelson HH, Posner M, Suzuki M, Kelsey KT (2004) Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene 23(4):1000-1004 (Pubitemid 38250946)
-
(2004)
Oncogene
, vol.23
, Issue.4
, pp. 1000-1004
-
-
Marsit, C.J.1
Liu, M.2
Nelson, H.H.3
Posner, M.4
Suzuki, M.5
Kelsey, K.T.6
-
77
-
-
2342633174
-
Promoter hypermethylation of FANCF: Disruption of fanconi anemia-BRCA pathway in cervical cancer
-
DOI 10.1158/0008-5472.CAN-04-0245
-
Narayan G, Arias-Pulido H, Nandula SV et al (2004) Promoter hypermethylation of FANCF: disruption of Fanconi anemia-BRCA pathway in cervical cancer. Cancer Res 64(9): 2994-2997 (Pubitemid 38581394)
-
(2004)
Cancer Research
, vol.64
, Issue.9
, pp. 2994-2997
-
-
Narayan, G.1
Arias-Pulido, H.2
Nandula, S.V.3
Basso, K.4
Sugirtharaj, D.D.5
Vargas, H.6
Mansukhani, M.7
Villella, J.8
Meyer, L.9
Schneider, A.10
Gissmann, L.11
Durst, M.12
Pothuri, B.13
Murty, V.V.V.S.14
-
78
-
-
42149144580
-
Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer
-
DOI 10.1038/sj.bjc.6604325, PII 6604325
-
Lim SL, Smith P, Syed N et al (2008) Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer. Br J Cancer 98(8):1452-1456 (Pubitemid 351543586)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.8
, pp. 1452-1456
-
-
Lim, S.L.1
Smith, P.2
Syed, N.3
Coens, C.4
Wong, H.5
Van Der Burg, M.6
Szlosarek, P.7
Crook, T.8
Green, J.A.9
-
79
-
-
0028794564
-
Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase
-
Pegg AE, Dolan ME, Moschel RC (1995) Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase. Prog Nucleic Acid Res Mol Biol 51:167-223
-
(1995)
Prog Nucleic Acid Res Mol Biol
, vol.51
, pp. 167-223
-
-
Pegg, A.E.1
Dolan, M.E.2
Moschel, R.C.3
-
80
-
-
1942469956
-
MGMT: Its role in cancer aetiology and cancer therapeutics
-
Gerson SL (2004) MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4(4):296-307 (Pubitemid 38525285)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.4
, pp. 296-307
-
-
Gerson, S.L.1
-
81
-
-
0033557903
-
Inactivation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
-
Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG (1999) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59(4):793-797 (Pubitemid 29086728)
-
(1999)
Cancer Research
, vol.59
, Issue.4
, pp. 793-797
-
-
Esteller, M.1
Hamilton, S.R.2
Burger, P.C.3
Baylin, S.B.4
Herman, J.G.5
-
82
-
-
75149166496
-
MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?
-
Weller M, Stupp R, Reifenberger G et al (2010) MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol 6(1):39-51
-
(2010)
Nat Rev Neurol
, vol.6
, Issue.1
, pp. 39-51
-
-
Weller, M.1
Stupp, R.2
Reifenberger, G.3
-
83
-
-
0035117307
-
Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability
-
Whitehall VL, Walsh MD, Young J, Leggett BA, Jass JR (2001) Methylation of O-6- methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with lowlevel DNA microsatellite instability. Cancer Res 61(3):827-830 (Pubitemid 32174386)
-
(2001)
Cancer Research
, vol.61
, Issue.3
, pp. 827-830
-
-
Whitehall, V.L.J.1
Walsh, M.D.2
Young, J.3
Leggett, B.A.4
Jass, J.R.5
-
84
-
-
0035575781
-
6-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma
-
DOI 10.1002/1097-0142(20011201)92:11<2760::AID-CNCR10123>3.0.CO;2-8
-
Park TJ, Han SU, Cho YK, Paik WK, Kim YB, Lim IK (2001) Methylation of O(6)- methylguanine-DNA methyltransferase gene is associated signi fi cantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma. Cancer 92(11):2760-2768 (Pubitemid 33091912)
-
(2001)
Cancer
, vol.92
, Issue.11
, pp. 2760-2768
-
-
Park, T.J.1
Han, S.-U.2
Cho, Y.-K.3
Paik, W.K.4
Kim, Y.B.5
Lim, I.K.6
-
85
-
-
0028071555
-
Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
-
Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54(18): 4855-4878 (Pubitemid 24289415)
-
(1994)
Cancer Research
, vol.54
, Issue.18
, pp. 4855-4878
-
-
Greenblatt, M.S.1
Bennett, W.P.2
Hollstein, M.3
Harris, C.C.4
-
86
-
-
0037428664
-
1-DNA adducts and p53 mutation in hepatocellular carcinoma
-
DOI 10.1002/ijc.10852
-
Zhang YJ, Chen Y, Ahsan H et al (2003) Inactivation of the DNA repair gene O6-methylguanine- DNA methyltransferase by promoter hypermethylation and its relationship to a fl atoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma. Int J Cancer 103(4): 440-444 (Pubitemid 36020217)
-
(2003)
International Journal of Cancer
, vol.103
, Issue.4
, pp. 440-444
-
-
Zhang, Y.-J.1
Chen, Y.2
Ahsan, H.3
Lunn, R.M.4
Lee, P.-H.5
Chen, C.-J.6
Santella, R.M.7
-
87
-
-
0035890742
-
6-methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer
-
Wolf P, Hu YC, Doffek K, Sidransky D, Ahrendt SA (2001) O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in nonsmall cell lung cancer. Cancer Res 61(22):8113-8117 (Pubitemid 33091600)
-
(2001)
Cancer Research
, vol.61
, Issue.22
, pp. 8113-8117
-
-
Wolf, P.1
Hu, Y.C.2
Doffek, K.3
Sidransky, D.4
Ahrendt, S.A.5
-
88
-
-
0038687773
-
6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relation to p53 mutations in esophageal squamous cell carcinoma
-
Zhang L, Lu W, Miao X, Xing D, Tan W, Lin D (2003) Inactivation of DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relation to p53 mutations in esophageal squamous cell carcinoma. Carcinogenesis 24(6):1039-1044 (Pubitemid 36827255)
-
(2003)
Carcinogenesis
, vol.24
, Issue.6
, pp. 1039-1044
-
-
Zhang, L.1
Lu, W.2
Miao, X.3
Xing, D.4
Tan, W.5
Lin, D.6
-
89
-
-
0034795045
-
Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C → A:T mutations of the TP53 tumor suppressor gene
-
Nakamura M, Watanabe T, Yonekawa Y, Kleihues P, Ohgaki H (2001) Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C -> A:T mutations of the TP53 tumor suppressor gene. Carcinogenesis 22(10):1715-1719 (Pubitemid 32952152)
-
(2001)
Carcinogenesis
, vol.22
, Issue.10
, pp. 1715-1719
-
-
Nakamura, M.1
Watanabe, T.2
Yonekawa, Y.3
Kleihues, P.4
Ohgaki, H.5
-
90
-
-
33745686030
-
Exploiting the role of O6-methylguanine-DNAmethyltransferase (MGMT) in cancer therapy
-
Sabharwal A, Middleton MR (2006) Exploiting the role of O6-methylguanine-DNAmethyltransferase (MGMT) in cancer therapy. Curr Opin Pharmacol 6(4):355-363
-
(2006)
Curr Opin Pharmacol
, vol.6
, Issue.4
, pp. 355-363
-
-
Sabharwal, A.1
Middleton, M.R.2
-
91
-
-
75849122854
-
Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN
-
Kitano K, Kim SY, Hakoshima T (2010) Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN. Structure 18(2):177-187
-
(2010)
Structure
, vol.18
, Issue.2
, pp. 177-187
-
-
Kitano, K.1
Kim, S.Y.2
Hakoshima, T.3
-
92
-
-
38949094875
-
Telomere ResQue and preservation-Roles for the Werner syndrome protein and other RecQ helicases
-
DOI 10.1016/j.mad.2007.10.007, PII S0047637407001686
-
Opresko PL (2008) Telomere ResQue and preservation - roles for the Werner syndrome protein and other RecQ helicases. Mech Ageing Dev 129(1-2):79-90 (Pubitemid 351210677)
-
(2008)
Mechanisms of Ageing and Development
, vol.129
, Issue.1-2
, pp. 79-90
-
-
Opresko, P.L.1
-
93
-
-
33745056414
-
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
-
DOI 10.1073/pnas.0600645103
-
Agrelo R, Cheng WH, Setien F et al (2006) Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci USA 103(23):8822-8827 (Pubitemid 43878103)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.23
, pp. 8822-8827
-
-
Agrelo, R.1
Cheng, W.-H.2
Setien, F.3
Ropero, S.4
Espada, J.5
Fraga, M.F.6
Herranz, M.7
Paz, M.F.8
Sanchez-Cespedes, M.9
Artiga, M.J.10
Guerrero, D.11
Castells, A.12
Von Kobbe, C.13
Bohr, V.A.14
Esteller, M.15
-
94
-
-
38649135425
-
WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer
-
DOI 10.1038/modpathol.3800996, PII 3800996
-
Kawasaki T, Ohnishi M, Suemoto Y et al (2008) WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol 21(2):150-158 (Pubitemid 351172166)
-
(2008)
Modern Pathology
, vol.21
, Issue.2
, pp. 150-158
-
-
Kawasaki, T.1
Ohnishi, M.2
Suemoto, Y.3
Kirkner, G.J.4
Liu, Z.5
Yamamoto, H.6
Loda, M.7
Fuchs, C.S.8
Ogino, S.9
-
95
-
-
77957752456
-
A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4
-
Smith JA, Ndoye AM, Geary K, Lisanti MP, Igoucheva O, Daniel R (2010) A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4. Aging Cell 9(4):580-591
-
(2010)
Aging Cell
, vol.9
, Issue.4
, pp. 580-591
-
-
Smith, J.A.1
Ndoye, A.M.2
Geary, K.3
Lisanti, M.P.4
Igoucheva, O.5
Daniel, R.6
-
96
-
-
79952235291
-
Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modi fi cations
-
Polo SE, Jackson SP (2011) Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modi fi cations. Genes Dev 25(5):409-433
-
(2011)
Genes Dev
, vol.25
, Issue.5
, pp. 409-433
-
-
Polo, S.E.1
Jackson, S.P.2
-
97
-
-
33751419716
-
Surviving the breakup: The DNA damage checkpoint
-
DOI 10.1146/annurev.genet.40.051206.105231
-
Harrison JC, Haber JE (2006) Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet 40:209-235 (Pubitemid 44956785)
-
(2006)
Annual Review of Genetics
, vol.40
, pp. 209-235
-
-
Harrison, J.C.1
Haber, J.E.2
-
98
-
-
68249091647
-
Checkpoint mechanisms at the intersection between DNA damage and repair
-
Lazzaro F, Giannattasio M, Puddu F et al (2009) Checkpoint mechanisms at the intersection between DNA damage and repair. DNA Repair (Amst) 8(9):1055-1067
-
(2009)
DNA Repair (Amst)
, vol.8
, Issue.9
, pp. 1055-1067
-
-
Lazzaro, F.1
Giannattasio, M.2
Puddu, F.3
-
99
-
-
34250743173
-
Systematic discovery of in vivo phosphorylation networks
-
DOI 10.1016/j.cell.2007.05.052, PII S0092867407007271
-
Linding R, Jensen LJ, Ostheimer GJ et al (2007) Systematic discovery of in vivo phosphorylation networks. Cell 129(7):1415-1426 (Pubitemid 46962092)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1415-1426
-
-
Linding, R.1
Jensen, L.J.2
Ostheimer, G.J.3
Van Vugt, M.A.T.M.4
Jorgensen, C.5
Miron, I.M.6
Diella, F.7
Colwill, K.8
Taylor, L.9
Elder, K.10
Metalnikov, P.11
Nguyen, V.12
Pasculescu, A.13
Jin, J.14
Park, J.G.15
Samson, L.D.16
Woodgett, J.R.17
Russell, RobertB.18
Bork, P.19
Yaffe, M.B.20
Pawson, T.21
more..
-
100
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
DOI 10.1126/science.1140321
-
Matsuoka S, Ballif BA, Smogorzewska A et al (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316(5828): 1160-1166 (Pubitemid 46877472)
-
(2007)
Science
, vol.316
, Issue.5828
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald III, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
Shiloh, Y.11
Gygi, S.P.12
Elledge, S.J.13
-
101
-
-
85047697132
-
Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line
-
DOI 10.1038/sj/onc/1205485
-
Kim WJ, Vo QN, Shrivastav M, Lataxes TA, Brown KD (2002) Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line. Oncogene 21(24):3864-3871 (Pubitemid 34620854)
-
(2002)
Oncogene
, vol.21
, Issue.24
, pp. 3864-3871
-
-
Kim, W.-J.1
Vo, Q.N.2
Shrivastav, M.3
Lataxes, T.A.4
Brown, K.D.5
-
102
-
-
11244335534
-
The ATM gene is a target for epigenetic silencing in locally advanced breast cancer
-
DOI 10.1038/sj.onc.1208092
-
Vo QN, Kim WJ, Cvitanovic L, Boudreau DA, Ginzinger DG, Brown KD (2004) The ATM gene is a target for epigenetic silencing in locally advanced breast cancer. Oncogene 23(58): 9432-9437 (Pubitemid 40069676)
-
(2004)
Oncogene
, vol.23
, Issue.58
, pp. 9432-9437
-
-
Vo, Q.N.1
Kim, W.-J.2
Cvitanovic, L.3
Boudreau, D.A.4
Ginzinger, D.G.5
Brown, K.D.6
-
103
-
-
1642568676
-
Ataxia-Telangiectasia-Mutated (ATM) Gene in Head and Neck Squamous Cell Carcinoma: Promoter Hypermethylation with Clinical Correlation in 100 Cases
-
DOI 10.1158/1055-9965.EPI-082-3
-
Ai L, Vo QN, Zuo C et al (2004) Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma: promoter hypermethylation with clinical correlation in 100 cases. Cancer Epidemiol Biomarkers Prev 13(1):150-156 (Pubitemid 38116634)
-
(2004)
Cancer Epidemiology Biomarkers and Prevention
, vol.13
, Issue.1
, pp. 150-156
-
-
Ai, L.1
Vo, Q.N.2
Zuo, C.3
Li, L.4
Ling, W.5
Suen, J.Y.6
Hanna, E.7
Brown, K.D.8
Fan, C.-Y.9
-
105
-
-
0033601346
-
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
-
Bell DW, Varley JM, Szydlo TE et al (1999) Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286(5449):2528-2531
-
(1999)
Science
, vol.286
, Issue.5449
, pp. 2528-2531
-
-
Bell, D.W.1
Varley, J.M.2
Szydlo, T.E.3
-
106
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
DOI 10.1016/S1535-6108(03)00110-7, PII S1535610803001107
-
Bartek J, Lukas J (2003) Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3(5):421-429 (Pubitemid 38340288)
-
(2003)
Cancer Cell
, vol.3
, Issue.5
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
107
-
-
19944433702
-
Regulation of Chk2 gene expression in lymphoid malignancies: Involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines
-
Kato N, Fujimoto H, Yoda A et al (2004) Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines. Cell Death Differ 11(Suppl 2):S153-161
-
(2004)
Cell Death Differ
, vol.11
, Issue.SUPPL. 2
-
-
Kato, N.1
Fujimoto, H.2
Yoda, A.3
-
108
-
-
67449123065
-
Epigenetic inactivation of checkpoint kinase 2 gene in non-small cell lung cancer and its relationship with clinicopathological features
-
Kim DS, Kim MJ, Lee JY et al (2009) Epigenetic inactivation of checkpoint kinase 2 gene in non-small cell lung cancer and its relationship with clinicopathological features. Lung Cancer 65(2):247-250
-
(2009)
Lung Cancer
, vol.65
, Issue.2
, pp. 247-250
-
-
Kim, D.S.1
Kim, M.J.2
Lee, J.Y.3
-
109
-
-
74749085364
-
Chk2 down-regulation by promoter hypermethylation in human bulk gliomas
-
Wang H, Wang S, Shen L et al (2010) Chk2 down-regulation by promoter hypermethylation in human bulk gliomas. Life Sci 86(5-6):185-191
-
(2010)
Life Sci
, vol.86
, Issue.5-6
, pp. 185-191
-
-
Wang, H.1
Wang, S.2
Shen, L.3
-
110
-
-
85047695017
-
Concomitant inactivation of p53 and Chk2 in breast cancer
-
DOI 10.1038/sj/onc/1205207
-
Sullivan A, Yuille M, Repellin C et al (2002) Concomitant inactivation of p53 and Chk2 in breast cancer. Oncogene 21(9):1316-1324 (Pubitemid 34214497)
-
(2002)
Oncogene
, vol.21
, Issue.9
, pp. 1316-1324
-
-
Sullivan, A.1
Yuille, M.2
Repellin, C.3
Reddy, A.4
Reelfs, O.5
Bell, A.6
Dunne, B.7
Gusterson, B.A.8
Osin, P.9
Farrell, P.J.10
Yulug, I.11
Evans, A.12
Ozcelik, T.13
Gasco, M.14
Crook, T.15
-
111
-
-
33845780616
-
Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers
-
DOI 10.1158/1078-0432.CCR-06-1770
-
Williams LH, Choong D, Johnson SA, Campbell IG (2006) Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers. Clin Cancer Res 12(23):6967-6972 (Pubitemid 44974490)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.23
, pp. 6967-6972
-
-
Williams, L.H.1
Choong, D.2
Johnson, S.A.3
Campbell, I.G.4
-
112
-
-
33748855364
-
Structure and function of the components of the human DNA mismatch repair system
-
DOI 10.1002/ijc.22023
-
Jascur T, Boland CR (2006) Structure and function of the components of the human DNA mismatch repair system. Int J Cancer 119(9):2030-2035 (Pubitemid 44423658)
-
(2006)
International Journal of Cancer
, vol.119
, Issue.9
, pp. 2030-2035
-
-
Jascur, T.1
Boland, C.R.2
-
114
-
-
67650573173
-
Diverse effects of individual mismatch repair components on transcription- induced CAG repeat instability in human cells
-
Lin Y, Wilson JH (2009) Diverse effects of individual mismatch repair components on transcription- induced CAG repeat instability in human cells. DNA Repair (Amst) 8(8):878-885
-
(2009)
DNA Repair (Amst)
, vol.8
, Issue.8
, pp. 878-885
-
-
Lin, Y.1
Wilson, J.H.2
-
115
-
-
32244438870
-
Transcription promotes contraction of CAG repeat tracts in human cells
-
DOI 10.1038/nsmb1042, PII NSMB1042
-
Lin Y, Dion V, Wilson JH (2006) Transcription promotes contraction of CAG repeat tracts in human cells. Nat Struct Mol Biol 13(2):179-180 (Pubitemid 43214723)
-
(2006)
Nature Structural and Molecular Biology
, vol.13
, Issue.2
, pp. 179-180
-
-
Lin, Y.1
Dion, V.2
Wilson, J.H.3
-
116
-
-
34547116188
-
Thiopurines, DNA damage, DNA repair and therapy-related cancer
-
153-170
-
Karran P (2006) Thiopurines, DNA damage, DNA repair and therapy-related cancer. Br Med Bull 79-80:153-170
-
(2006)
Br Med Bull
, pp. 79-80
-
-
Karran, P.1
-
117
-
-
0033616583
-
MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1
-
DOI 10.1073/pnas.96.7.3969
-
Bellacosa A, Cicchillitti L, Schepis F et al (1999) MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. Proc Natl Acad Sci USA 96(7):3969-3974 (Pubitemid 29169020)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.7
, pp. 3969-3974
-
-
Bellacosa, A.1
Cicchillitti, L.2
Schepis, F.3
Riccio, A.4
Yeung, A.T.5
Matsumoto, Y.6
Golemis, E.A.7
Genuardi, M.8
Neri, G.9
-
118
-
-
69549119023
-
MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos
-
Ruzov A, Shorning B, Mortusewicz O, Dunican DS, Leonhardt H, Meehan RR (2009) MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. Development 136(13):2277-2286
-
(2009)
Development
, vol.136
, Issue.13
, pp. 2277-2286
-
-
Ruzov, A.1
Shorning, B.2
Mortusewicz, O.3
Dunican, D.S.4
Leonhardt, H.5
Meehan, R.R.6
-
119
-
-
7044278257
-
The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity
-
DOI 10.1073/pnas.2334585100
-
Cortellino S, Turner D, Masciullo V et al (2003) The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc Natl Acad Sci USA 100(25):15071-15076 (Pubitemid 37518018)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.25
, pp. 15071-15076
-
-
Cortellino, S.1
Turner, D.2
Masciullo, V.3
Schepis, F.4
Albino, D.5
Daniel, R.6
Skalka, A.M.7
Meropol, N.J.8
Alberti, C.9
Larue, L.10
Bellacosa, A.11
-
120
-
-
43449097507
-
Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA
-
Boland MJ, Christman JK (2008) Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA. J Mol Biol 379(3):492-504
-
(2008)
J Mol Biol
, vol.379
, Issue.3
, pp. 492-504
-
-
Boland, M.J.1
Christman, J.K.2
-
121
-
-
33846909036
-
Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair
-
DOI 10.1093/nar/gkl1052
-
Li YQ, Zhou PZ, Zheng XD, Walsh CP, Xu GL (2007) Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. Nucleic Acids Res 35(2): 390-400 (Pubitemid 46237388)
-
(2007)
Nucleic Acids Research
, vol.35
, Issue.2
, pp. 390-400
-
-
Li, Y.-Q.1
Zhou, P.-Z.2
Zheng, X.-D.3
Walsh, C.P.4
Xu, G.-L.5
-
122
-
-
0038136913
-
Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1
-
DOI 10.1074/jbc.M209923200
-
Kimura H, Shiota K (2003) Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. J Biol Chem 278(7):4806-4812 (Pubitemid 36800984)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.7
, pp. 4806-4812
-
-
Kimura, H.1
Shiota, K.2
-
123
-
-
0035158704
-
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
-
DOI 10.1038/83730
-
Jackson-Grusby L, Beard C, Possemato R et al (2001) Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet 27(1):31-39 (Pubitemid 32044515)
-
(2001)
Nature Genetics
, vol.27
, Issue.1
, pp. 31-39
-
-
Jackson-Grusby, L.1
Beard, C.2
Possemato, R.3
Tudor, M.4
Fambrough, D.5
Csankovszki, G.6
Dausman, J.7
Lee, P.8
Wilson, C.9
Lander, E.10
Jaenisch, R.11
-
124
-
-
0033764146
-
Proliferating cell nuclear antigen and Msh2p- Msh6p interact to form an active mispair recognition complex
-
Flores-Rozas H, Clark D, Kolodner RD (2000) Proliferating cell nuclear antigen and Msh2p- Msh6p interact to form an active mispair recognition complex. Nat Genet 26(3):375-378
-
(2000)
Nat Genet
, vol.26
, Issue.3
, pp. 375-378
-
-
Flores-Rozas, H.1
Clark, D.2
Kolodner, R.D.3
-
125
-
-
45149112792
-
The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair
-
Iyer RR, Pohlhaus TJ, Chen S et al (2008) The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. J Biol Chem 283(19):13310-13319
-
(2008)
J Biol Chem
, vol.283
, Issue.19
, pp. 13310-13319
-
-
Iyer, R.R.1
Pohlhaus, T.J.2
Chen, S.3
-
126
-
-
33845895237
-
Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair
-
DOI 10.1093/nar/gkl944
-
Plotz G, Welsch C, Giron-Monzon L et al (2006) Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair. Nucleic Acids Res 34(22):6574-6586 (Pubitemid 46017952)
-
(2006)
Nucleic Acids Research
, vol.34
, Issue.22
, pp. 6574-6586
-
-
Plotz, G.1
Welsch, C.2
Giron-Monzon, L.3
Friedhoff, P.4
Albrecht, M.5
Piiper, A.6
Biondi, R.M.7
Lengauer, T.8
Zeuzem, S.9
Raedle, J.10
-
127
-
-
0035868951
-
HMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
-
DOI 10.1101/gad.191201
-
Kleczkowska HE, Marra G, Lettieri T, Jiricny J (2001) hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. Genes Dev 15(6):724-736 (Pubitemid 32244901)
-
(2001)
Genes and Development
, vol.15
, Issue.6
, pp. 724-736
-
-
Kleczkowska, H.E.1
Marra, G.2
Lettieri, T.3
Jiricny, J.4
-
128
-
-
0030271999
-
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
-
DOI 10.1016/S0092-8674(00)81323-9
-
Umar A, Buermeyer AB, Simon JA et al (1996) Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell 87(1):65-73 (Pubitemid 26337391)
-
(1996)
Cell
, vol.87
, Issue.1
, pp. 65-73
-
-
Umar, A.1
Buermeyer, A.B.2
Simon, J.A.3
Thomas, D.C.4
Clark, A.B.5
Liskay, R.M.6
Kunkel, T.A.7
-
129
-
-
3042544915
-
Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis
-
DOI 10.1074/jbc.M400971200
-
Chen F, Arseven OK, Cryns VL (2004) Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis. J Biol Chem 279(26):27542-27548 (Pubitemid 38812595)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.26
, pp. 27542-27548
-
-
Chen, F.1
Arseven, O.K.2
Cryns, V.L.3
-
130
-
-
24344454692
-
Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal
-
Kim MY, Zhang T, Kraus WL (2005) Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal. Genes Dev 19(17):1951-1967
-
(2005)
Genes Dev
, vol.19
, Issue.17
, pp. 1951-1967
-
-
Kim, M.Y.1
Zhang, T.2
Kraus, W.L.3
-
131
-
-
0035853763
-
Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death
-
Bischof O, Galande S, Farzaneh F, Kohwi-Shigematsu T, Campisi J (2001) Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death. J Biol Chem 276(15): 12068-12075
-
(2001)
J Biol Chem
, vol.276
, Issue.15
, pp. 12068-12075
-
-
Bischof, O.1
Galande, S.2
Farzaneh, F.3
Kohwi-Shigematsu, T.4
Campisi, J.5
-
132
-
-
33845359674
-
Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: Inactivation of its kinase activity toward p53
-
DOI 10.1152/ajprenal.00509.2005
-
Wang J, Pabla N, Wang CY, Wang W, Schoenlein PV, Dong Z (2006) Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53. Am J Physiol Renal Physiol 291(6):F1300-1307 (Pubitemid 44887243)
-
(2006)
American Journal of Physiology - Renal Physiology
, vol.291
, Issue.6
-
-
Wang, J.1
Pabla, N.2
Wang, C.-Y.3
Wang, W.4
Schoenlein, P.V.5
Dong, Z.6
-
133
-
-
0034674440
-
Inhibition of DNA methyltransferase inhibits DNA replication
-
DOI 10.1074/jbc.C900894199
-
Knox JD, Araujo FD, Bigey P et al (2000) Inhibition of DNA methyltransferase inhibits DNA replication. J Biol Chem 275(24):17986-17990 (Pubitemid 30414744)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.24
, pp. 17986-17990
-
-
Knox, J.D.1
Araujo, F.D.2
Bigey, P.3
Slack, A.D.4
Price, G.B.5
Zannis-Hadjopoulos, M.6
Szyf, M.7
-
134
-
-
0035545996
-
Mammalian G1- and S-phase checkpoints in response to DNA damage
-
DOI 10.1016/S0955-0674(00)00280-5
-
Bartek J, Lukas J (2001) Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol 13(6):738-747 (Pubitemid 33042735)
-
(2001)
Current Opinion in Cell Biology
, vol.13
, Issue.6
, pp. 738-747
-
-
Bartek, J.1
Lukas, J.2
-
135
-
-
0034576494
-
The many substrates and functions of ATM
-
Kastan MB, Lim DS (2000) The many substrates and functions of ATM. Nat Rev Mol Cell Biol 1(3):179-186
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, Issue.3
, pp. 179-186
-
-
Kastan, M.B.1
Lim, D.S.2
-
136
-
-
0035848819
-
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
-
DOI 10.1038/35071124
-
Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J (2001) The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410(6830):842-847 (Pubitemid 32303786)
-
(2001)
Nature
, vol.410
, Issue.6830
, pp. 842-847
-
-
Falck, J.1
Mailand, N.2
Syljuasen, R.G.3
Bartek, J.4
Lukas, J.5
-
137
-
-
0034903925
-
Mre11 complex and DNA replication: Linkage to E2F and sites of DNA synthesis
-
DOI 10.1128/MCB.21.17.6006-6016.2001
-
Maser RS, Mirzoeva OK, Wells J et al (2001) Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol 21(17):6006-6016 (Pubitemid 32743151)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.17
, pp. 6006-6016
-
-
Maser, R.S.1
Mirzoeva, O.K.2
Wells, J.3
Olivares, H.4
Williams, B.R.5
Zinkel, R.A.6
Farnham, P.J.7
Petrini, J.H.J.8
-
138
-
-
0030894095
-
Identification of Cdc45p, an essential factor required for DNA replication
-
DOI 10.1016/S0378-1119(96)00761-5, PII S0378111996007615
-
Hardy CF (1997) Identi fi cation of Cdc45p, an essential factor required for DNA replication. Gene 187(2):239-246 (Pubitemid 27140255)
-
(1997)
Gene
, vol.187
, Issue.2
, pp. 239-246
-
-
Hardy, C.F.J.1
-
139
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
DOI 10.1038/416552a
-
Rhee I, Bachman KE, Park BH et al (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416(6880):552-556 (Pubitemid 34288859)
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 552-556
-
-
Rhee, I.1
Bachman, K.E.2
Park, B.H.3
Jair, K.-W.4
Yen, R.-W.C.5
Schuebel, K.E.6
Cui, H.7
Feinberg, A.P.8
Lengauer, C.9
Kinzler, K.W.10
Baylin, S.B.11
Vogelstein, B.12
-
140
-
-
2642574054
-
CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1
-
DOI 10.1038/ng1365
-
Ting AH, Jair KW, Suzuki H, Yen RW, Baylin SB, Schuebel KE (2004) CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1. Nat Genet 36(6):582-584 (Pubitemid 38715984)
-
(2004)
Nature Genetics
, vol.36
, Issue.6
, pp. 582-584
-
-
Ting, A.H.1
Jair, K.-W.2
Suzuki, H.3
Yen, R.-W.C.4
Baylin, S.B.5
Schuebel, K.E.6
-
141
-
-
33847293264
-
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells
-
DOI 10.1038/ng1982, PII NG1982
-
Chen T, Hevi S, Gay F et al (2007) Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet 39(3):391-396 (Pubitemid 46328497)
-
(2007)
Nature Genetics
, vol.39
, Issue.3
, pp. 391-396
-
-
Chen, T.1
Hevi, S.2
Gay, F.3
Tsujimoto, N.4
He, T.5
Zhang, B.6
Ueda, Y.7
Li, E.8
-
142
-
-
33847250332
-
DNMT1 knockout delivers a strong blow to genome stability and cell viability
-
DOI 10.1038/ng0307-289, PII NG0307289
-
Brown KD, Robertson KD (2007) DNMT1 knockout delivers a strong blow to genome stability and cell viability. Nat Genet 39(3):289-290 (Pubitemid 46328481)
-
(2007)
Nature Genetics
, vol.39
, Issue.3
, pp. 289-290
-
-
Brown, K.D.1
Robertson, K.D.2
-
143
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
DOI 10.1126/science.281.5383.1677
-
Canman CE, Lim DS, Cimprich KA et al (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281(5383):1677-1679 (Pubitemid 28435584)
-
(1998)
Science
, vol.281
, Issue.5383
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.-S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
Sakaguchi, K.6
Appella, E.7
Kastan, M.B.8
Siliciano, J.D.9
-
144
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
DOI 10.1038/nature01368
-
Bakkenist CJ, Kastan MB (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421(6922):499-506 (Pubitemid 36168436)
-
(2003)
Nature
, vol.421
, Issue.6922
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
145
-
-
0032480226
-
DNA hypomethylation leads to elevated mutation rates
-
DOI 10.1038/25779
-
Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R (1998) DNA hypomethylation leads to elevated mutation rates. Nature 395(6697):89-93 (Pubitemid 28420236)
-
(1998)
Nature
, vol.395
, Issue.6697
, pp. 89-93
-
-
Chen, R.Z.1
Pettersson, U.2
Beard, C.3
Jackson-Grusby, L.4
Jaenisch, R.5
-
146
-
-
37849026412
-
DNA methylation inhibitor 5-Aza-2′ -deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B
-
Palii SS, Van Emburgh BO, Sankpal UT, Brown KD, Robertson KD (2008) DNA methylation inhibitor 5-Aza-2′ -deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol Cell Biol 28(2):752-771
-
(2008)
Mol Cell Biol
, vol.28
, Issue.2
, pp. 752-771
-
-
Palii, S.S.1
Van Emburgh, B.O.2
Sankpal, U.T.3
Brown, K.D.4
Robertson, K.D.5
-
147
-
-
33847348016
-
DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells
-
DOI 10.1083/jcb.200610062
-
Spada F, Haemmer A, Kuch D et al (2007) DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J Cell Biol 176(5):565-571 (Pubitemid 46333972)
-
(2007)
Journal of Cell Biology
, vol.176
, Issue.5
, pp. 565-571
-
-
Spada, F.1
Haemmer, A.2
Kuch, D.3
Rothbauer, U.4
Schermelleh, L.5
Kremmer, E.6
Carell, T.7
Langst, G.8
Leonhardt, H.9
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