Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer

Australian and New Zealand Journal of Obstetrics and Gynaecology

Volumn 48, Issue 5, 2008, Pages 505-509

  Zhang, Hui ^a   Zhang, Shiqian ^a   Cui, Jing ^b   Zhang, Aifeng ^a   Shen, Liang ^a   Yu, Hao ^a  

^a SHANDONG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

hMLH1; hMSH2; Methylation; Ovarian cancer

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MESSENGER RNA; PROTEIN MLH1; PROTEIN MSH2;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA ISOLATION; DNA METHYLATION; ENDOMETRIUM CARCINOMA; FEMALE; GENE EXPRESSION; GENE LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MISMATCH REPAIR; OVARY CANCER; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AZACITIDINE; BASE PAIR MISMATCH; CASE-CONTROL STUDIES; CELL LINE, TUMOR; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM STAGING; NUCLEAR PROTEINS; OVARIAN NEOPLASMS; PROGNOSIS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 54349126239     PISSN: 00048666     EISSN: 1479828X     Source Type: Journal    
DOI: 10.1111/j.1479-828X.2008.00892.x     Document Type: Article

References (24)

1. Moslehi R, Chu W, Karlan B et al. BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer. Am J Hum Genet 2000 66 : 1259 1272.
2. Jemal A, Murray T, Ward E et al. Cancer statistics, 2005. CA Cancer J Clin 2005 55 : 10 30.
3. Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer 2004 4 : 143 153.
4. Balch C, Huang TH, Brown R, Nephew KP. The epigenetics of ovarian cancer drug resistance and resensitization. Am J Obstet Gynecol 2004 191 : 1552 1572.
5. Sellar GC, Watt KP, Rabiasz GJ et al. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Nat Genet 2003 34 : 337 343.
6. Yu Y, Fujii S, Yuan J et al. Epigenetic regulation of ARHI in breast and ovarian cancer cells. Ann N Y Acad Sci 2003 983 : 268 277.
7. Momparler RL. Cancer epigenetics. Oncogene 2003 22 : 6479 6483.
8. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv Cancer Res 1998 72 : 141 196.
9. Tamura G. Alteration of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. World Gastroenterl 2006 12 : 192 198.
10. Demokan S, Suoglu Y, Demir D, Gozeler M, Dalay N. Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer. Ann Oncol 2006 17 : 995 999.
11. Murata H, Khattar NH, Gu L, Li GM. Roles of mismatch repair proteins hMSH2 and hMLH1 in the development of sporadic breast cancer. Cancer Lett 2005 223 : 143 150.
12. Ricciardiello L, Ceccarelli C, Angiolini G et al. High thymidylate synthase expression in colorectal cancer with microsatellite instability: Implications for chemotherapeutic strategies. Clin Cancer Res 2005 11 : 4234 4240.
13. Fang JY, Lu R, Mikovits JA, Cheng ZH, Zhu HY, Chen YX. Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1. Cancer Lett 2006 233 : 124 130.
14. Hsu HS, Wen CK, Tang YA et al. Promoter hypermethylation is the predominant mechanism in hMLH1 and hMSH2 deregulation and is a poor prognostic factor in nonsmoking lung cancer. Clin Cancer Res 2005 11 : 5410 5416.
15. Sengupta S, Chakrabarti S, Roy A, Panda CK, Roychoudhury S. Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype. Cancer 2007 109 : 703 712.
16. Tam KF, Liu VW, Liu SS et al. Methylation profile in benign, borderline and malignant ovarian tumors. J Cancer Res Clin Oncol 2007 133 : 331 341.
17. Hayashi M, Tamura G, Jin Z et al. Microsatellite instability in esophageal squamous cell carcinoma is not associated with hMLH1 promoter hypermethylation. Pathol Int 2003 53 : 270 276.
18. Helleman J, van Staveren IL, Dinjens WN et al. Mismatch repair and treatment resistance in ovarian cancer. BMC Cancer 2006 31 : 201.
19. Fujita M, Enomoto T, Yoshino K et al. Microsatellite instability and alterations in the hMSH2 gene in human ovarian cancer. Int J Cancer 1995 64 : 361 366.
20. Rathi A, Virmani AK, Schorge JO et al. Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women. Clin Cancer Res 2002 8 : 3324 3331.
21. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin 2000 50 : 7 33.
22. Rhyu MS. Molecular mechanisms underlying hereditary nonpolyposis colorectal carcinoma. J Natl Cancer Inst 1996 88 : 240 251.
23. Yan L, Yang X, Davidson NE. Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer. J Mammary Gland Biol Neoplasia 2001 6 : 183 192.
24. Li B, Goyal J, Dhar S et al. CpG methylation as a basis for breast tumor-specific loss of NES1/kallikreins 10 expression. Cancer Res 2001 61 : 8014 8021.