hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci

Genes and Development

Volumn 15, Issue 6, 2001, Pages 724-736

  Kleczkowska, Hanna E ^a,b   Marra, Giancarlo ^a   Lettieri, Teresa ^a,c   Jiricny, Josef ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY   (Poland)

^c ETH ZURICH   (Switzerland)

Author keywords

DNA repair; HMSH3; HMSH6; Mismatch repair; PCNA; Replication foci

Indexed keywords

BINDING PROTEIN; CYCLINE; PROTEIN MSH3; PROTEIN MSH6; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DNA STRAND; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BASE PAIR MISMATCH; BLOTTING, WESTERN; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENETIC COMPLEMENTATION TEST; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PEPTIDES; PRECIPITIN TESTS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TRANSFECTION;

EUKARYOTA;

EID: 0035868951     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.191201     Document Type: Article

References (65)

1. MutS mediates heteroduplex loop formation by a translocation mechanism
2. The great GATC: DNA methylation in E. coli
3. Nucleotide-promoted release of hMutSα from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism
4. p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex
5. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1
6. Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes
7. Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex
8. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
9. Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon
10. Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction
11. The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21
12. Isolation of MutSβ from human cells and comparison of the mismatch repair specificities of MutSβ and MutSα
13. Two modes of FEN1 binding to PCNA regulated by DNA
14. hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
15. ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
16. Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA
17. Sliding clamps: A tailored fit
18. Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines
19. Visualization of replication factories attached to nucleoskeleton
20. Replication factories and nuclear bodies: The ultrastructural characterization of replication sites during the cell cycle
21. hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha
22. Mutation of the magnesium binding site of hMSH6 disables the hMutS-α sliding clamp from translocating along DNA
23. Mediating mismatch repair
24. Mismatch repair defects in cancer
25. Mismatch-containing oligonucleotide duplexes bound by the E. coli mutS-encoded protein
26. Evidence for involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair
27. Proliferating cell nuclear antigen: More than a clamp for DNA polymerases
28. PCNA: Structure, functions and interactions
29. Mismatch repair: Mechanisms and relationship to cancer susceptibility
30. Eukaryotic DNA mismatch repair
31. Identification of base mismatches recognized by the heteroduplex-DNA-repair system of Streptococcus pneumoniae
32. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase
33. Dynamics of DNA replication factories in living cells
34. Effect of hMSH6 cDNA expression on the phenotype of mismatch repair deficient colon cancer cell line HCT15
35. An interaction between DNA ligase I and proliferating cell nuclear antigen: Implications for Okazaki fragment synthesis and joining
36. The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair
37. DNA polymerase delta is required for human mismatch repair in vitro
38. Mismatch repair deficiency associated with overexpression of the MSH3 gene
39. Methyl-directed DNA mismatch correction
40. Mechanisms and biological effects of mismatch repair
41. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
42. DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: Identification of a common targeting mechanism for the assembly of replication factories
43. The C-terminal region of p21SDI1/WAF1/ CIP 1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition
44. Molecular cloning of the N-terminus of GTBP
45. Post-replicative base excision repair in replication foci
46. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
47. hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
48. Mutations of GTBP in genetically unstable cells
49. Repair of DNA heteroduplexes containing small heterologous sequences in Escherichia coli
50. Identification of hMutLβ, a heterodimer of hMLH1 and hPMS1
51. Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21(Cip1)-like PCNA binding motif
52. Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding
53. Building a replisome from interacting pieces: Sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex
54. Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair
55. Mispair specificity of methyl-directed DNA mismatch correction in vitro
56. A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction
57. Heteroduplex repair in extracts of human HeLa cells
58. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2
59. Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1
60. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
61. PCNA binding through a conserved motif
62. A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
63. Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: A potential mechanism to coordinate DNA replication and repair
64. Dominant negative mutator mutations in the routs gene of Escherichia coli
65. Direct interaction of proliferating cell nuclear antigen with the p125 catalytic subunit of mammalian DNA polymerase delta