Intensity-dependent constitutional MLH1 promoter methylation leads to early onset of colorectal cancer by affecting both alleles

Genes Chromosomes and Cancer

Volumn 50, Issue 3, 2011, Pages 178-185

  Auclair, Jessie ^a   Vaissière, Thomas ^b   Desseigne, Françoise ^a   Lasset, Christine ^a   Bonadona, Valérie ^a   Giraud, Sophie ^c   Saurin, Jean Christophe ^d   Joly, Marie Odile ^c   Leroux, Dominique ^e   Faivre, Laurence ^f,g   Audoynaud, Carole ^a   Montmain, Gilles ^a   Ruano, Eric ^a   Herceg, Zdenko ^b   Puisieux, Alain ^a,h,i,j   Wang, Qing ^a  

^a CENTRE LÉON BÉRARD   (France)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c EDOUARD HERRIOT HOSPITAL   (France)

^d CENTRE HOSPITALIER LYON SUD   (France)

^e GRENOBLE UNIVERSITY HOSPITAL   (France)

^f Medical University of Dijon   (France)

^g CENTRE GEORGES FRANÇOIS LECLERC   (France)

^h INSERM   (France)

ⁱ UNIVERSITÉ DE LYON   (France)

^j UNIVERSITÉ LYON 1   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1;

ALLELE; ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; TUMOR CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGE OF ONSET; ALLELES; BASE SEQUENCE; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICROSATELLITE INSTABILITY; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC;

EID: 78650947025     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20842     Document Type: Article

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