Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 12, 1998, Pages 6870-6875

  Herman, James G ^a   Umar, Asad ^c   Polyak, Kornelia ^a,b   Graff, Jeremy R ^a   Ahuja, Nita ^a   Issa, Jean Pierre J ^a   Markowitz, Sanford ^b,d   Willson, James K V ^d   Hamilton, Stanley R ^a   Kinzler, Kenneth W ^a   Kane, Michael F ^e   Kolodner, Richard D ^e   Vogelstein, Bert ^a,b   Kunkel, Thomas A ^c   Baylin, Stephen B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE;

ARTICLE; COLORECTAL CARCINOMA; DNA METHYLATION; DNA REPAIR; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

CARCINOMA; CARRIER PROTEINS; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA REPAIR; DNA, SATELLITE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS);

EID: 13144266670     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.12.6870     Document Type: Article

References (31)

1. Thomas, D. C., Umar, A. & Kunkel, T. A. (1996) Mutat. Res. 350, 201-205.
2. Modrich, P. & Lahue, R. (1996) Annu. Rev. Biochem. 65, 101-33, 101-133.
3. Aaltonen, L. A., Peltomaki, P., Leach, F. S., Sistonen, P., Pylkkanen, L., Mecklin, J. P., Jarvinen, H., Powell, S. M., Jen, J., Hamilton, S. R., et al. (1993) Science 260, 812-816.
4. Thibodeau, S. N., Bren, G. & Schaid, D. (1993) Science 260, 816-819.
5. Peltomaki, P. & de la Chapelle, A. (1997) Adv. Cancer Res. 71, 93-119.
6. Papadopoulos, N. & Lindblom, A. (1997) Hum. Mutat. 10, 89-99.
7. Thibodeau, S. N., French, A. J., Roche, P. C., Cunningham, J. M., Tester, D. J., Lindor, N. M., Moslein, G., Baker, S. M., Liskay, R. M., Burgart, L. J., et al. (1996) Cancer Res. 56, 4836-4840.
8. Borresen, A. L., Lothe, R. A., Meling, G. I., Lystad, S., Morrison, P., Lipford, J., Kane, M. F., Rognum, T. O. & Kolodner, R. D. (1995) Hum. Mol. Genet. 4, 2065-2072.
9. Bubb, V. J., Curtis, L. J., Cunningham, C., Dunlop, M. G., Carothers, A. D., Morris, R. G., White, S., Bird, C. C. & Wyllie, A. H. (1996) Oncogene 12, 2641-2649.
10. Liu, B., Nicolaides, N. C., Markowitz, S., Willson, J. K., Parsons, R. E., Jen, J., Papadopoulos, N., Peltomaki, P., de la Chapelle, A., Hamilton, S. R., et al. (1995) Nat. Genet. 9, 48-55.
11. Wu, Y., Nystrom-Lahti, M., Osinga, J., Looman, M. W., Peltomaki, P., Aaltonen, L. A., de la Chapelle, A., Hofstra, R. M. & Buys, C. H. (1997) Genes Chromosomes Cancer 18, 269-278.
12. Herman, J. G., Merlo, A., Mao, L., Lapidus, R. G., Issa, J. P. J., Davidson, N. E., Sidransky, D. & Baylin, S. B. (1995) Cancer Res. 55, 4525-4530.
13. Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B. & Sidransky, D. (1995) Nat. Med. 1, 686-692.
14. Herman, J. G., Latif, F., Weng, Y., Lerman, M. I., Zbar, B., Liu, S., Samid, D., Duan, D. S., Gnarra, J. R., Linehan, W. M. & Baylin, S. B. (1994) Proc. Natl. Acad. Sci. USA 91, 9700-9704.
15. Lengauer, C., Kinzler, K. W. & Vogelstein, B. (1997) Proc. Natl. Acad. Sci. USA 94, 2545-2550.
16. Ahuja, N., Mohan, A. L., Li, Q., Stoiker, J. M., Herman, J. G., Hamilton, S. R., Baylin, S. B. & Issa, J. P. (1997) Cancer Res. 57, 3370-3374.
17. Boyer, J. C., Umar, A., Risinger, J. I., Lipford, J. R., Kane, M., Yin, S., Barrett, J. C., Kolodner, R. D. & Kunkel, T. A. (1995) Cancer Res. 55, 6063-6070.
18. Kane, M. F., Loda, M., Gaida, G. M., Lipman, J., Mishra, R., Goldman, H., Jessup, J. M. & Kolodner, R. (1997) Cancer Res. 57, 808-811.
19. Liu, B., Parsons, R., Papadopoulos, N., Nicolaides, N. C., Lynch, H. T., Watson, P., Jass, J. R., Dunlop, M., Wyllie, A., Peltomaki, P., et al. (1996) Nat. Med. 2, 169-174.
20. Hemminki, A., Peltomaki, P., Mecklin, J. P., Jarvinen, H., Salovaara, R., Nystrom-Lahti, M., de la Chapelle, A. & Aaltonen, L. A. (1994) Nat. Genet. 8, 405-410.
21. Willson, J. K., Bittner, G. N., Oberley, T. D., Meisner, L. F. & Weese, J. L. (1987) Cancer Res. 47, 2704-2713.
22. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W. & Vogelstein, B. (1995) Science 268, 1336-1338.
23. Umar, A., Boyer, J. C., Thomas, D. C., Nguyen, D. C., Risinger, J. I., Boyd, J., Ionov, Y., Perucho, M. & Kunkel, T. A. (1994) J. Biol. Chem. 269, 14367-14370.
24. Herman, J. G., Graff, J. R., Myohanen, S., Nelkin, B. D. & Baylin, S. B. (1996) Proc. Natl. Acad. Sci. USA 93, 9821-9826.
25. Bankfalvi, A., Navabi, H., Bier, B., Bocker, W., Jasani, B. & Schmid, K. W. (1994) J. Pathol. 174, 223-228.
26. Thomas, D. C., Umar, A. & Kunkel, T. A. (1995) Genomethods 7, 187-197.
27. Bird, A. (1992) Cell 70, 5-8.
28. Hampson, R., Humbert, O., Macpherson, P., Aquilina, G. & Karran, P. (1997) J. Biol. Chem. 272, 28596-28606.
29. Prowse, A. H., Webster, A. R., Richards, F. M., Richard, S., Olschwang, S., Resche, F., Affara, N. A. & Maher, E. R. (1997) Am. J. Hum. Genet. 60, 765-771.
30. Ohtani-Fujita, N., Dryja, T. P., Rapaport, J. M., Fujita, T., Matsumura, S., Ozasa, K., Watanabe, Y., Hayashi, K., Maeda, K., Kinoshita, S., et al. (1997) Cancer Genet. Cytogenet. 98, 43-49.
31. Rampino, N., Yamamoto, H., Ionov, Y., Li, Y., Sawai, H., Reed, J. C. & Perucho, M. (1997) Science 275, 967-969.