DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

Human Molecular Genetics

Volumn 10, Issue 26, 2001, Pages 3001-3007

  Esteller, Manel ^a,b   Fraga, Mario F ^b,j   Guo, Mingzhou ^a   Garcia Foncillas, Jesus ^c   Hedenfalk, Ingrid ^f,l   Godwin, Andrew K ^d   Trojan, Joerg ^e   Vaurs Barrière, Catherine ^g   Bignon, Yves Jean ⁿ   Ramus, Susan ^b   Benitez, Javier ^b   Caldes, Trinidad ⁱ   Akiyama, Yoshimitsu ^a,h   Yuasa, Yusuhito ^h   Launonen, Virpi ^m   Canal, Maria Jesus ^j   Rodriguez, Roberto ^j   Capella, Gabriel ^k   Peinado, Miguel Angel ^k   Borg, Ake ^l   Aaltonen, Lauri A ^m   Ponder, Bruce A ⁿ   Baylin, Stephen B ^a   Herman, James G ^a   more..

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Centro Nacional de Investigations Oncológicas   (Spain)

^c UNIVERSITY CLINIC OF NAVARRA   (Spain)

^d FOX CHASE CANCER CENTER   (United States)

^e GOETHE UNIVERSITY   (Germany)

^f NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^g CENTRE JEAN PERRIN   (France)

^h TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

ⁱ HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^j School of Biology   (Spain)

^k CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^l LUND UNIVERSITY   (Sweden)

^m UNIVERSITY OF HELSINKI   (Finland)

ⁿ ADDENBROOKE S HOSPITAL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BRCA1 PROTEIN; DNA; PROTEIN MLH1; PROTEIN P14; PROTEIN P16; PROTEIN SERINE THREONINE KINASE;

ALLELE; ARTICLE; BREAST CANCER; CANCER CELL; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA CONTENT; DNA METHYLATION; FAMILIAL CANCER; GENE MUTATION; GENE SILENCING; GENETICS; GENOME; GERM LINE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION;

EID: 18244388241     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.26.3001     Document Type: Article

References (41)

1. Deficient DNA mismatch repair: A common etiologic factor for colon cancer
2. The ABC of APC
3. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
4. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
5. A gene hypermethylation profile of human cancer
6. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
7. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
8. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
9. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
10. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
11. The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers
12. Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers
13. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
14. Methylation of the BRCA1 gene in sporadic breast cancer
15. Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers
16. Gene-expression profiles in hereditary breast cancer
17. 'Other' breast cancer susceptibility genes: Searching for more holy grail
18. Cancer epigenetics comes of age
19. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
20. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer
21. Loss of the wild-type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer
22. Molecular nature of colon tumors in hereditary non-polyposis colon cancer, familial polyposis, and sporadic colon cancer
23. Tumorigenesis in colorectal tumors from patients with hereditary non-polyposis colorectal cancer
24. Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
25. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer
26. Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents
27. Frameshift mutator mutations
28. De novo BRCA1 mutation in a patient with breast cancer and an inherited BRCA2 mutation
29. Hypomethylation distinguishes genes of some human cancers from their normal counterparts
30. Hypomethylation of DNA from benign and malignant human colon neoplasms
31. DNA methylation learns to fly
32. Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors
33. Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia
34. Incidence of hereditary non-polyposis colorectal cancer, and molecular screening for the disease
35. Peutz-Jeghers syndrome: Molecular analysis of a three-generation kindred with a novel defect in the serine threonine kinase gene STK11
36. Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds
37. Molecular analysis of the BRCA1 and BRCA2 genes in 32 breast and/or ovarian cancer Spanish families
38. High allele loss rates at 17q 12-q21 in breast and ovarian tumors from BRCA1-linked families. The Breast Cancer Linkage Consortium
39. Spanish family study on hereditary breast and/or ovarian cancer: Analysis of the BRCA1 gene
40. Low frequency of microsatellite instability in BRCA1 mutated breast tumours
41. Rapid quantification of DNA methylation by high performance capillary electrophoresis