메뉴 건너뛰기




Volumn 79-80, Issue 1, 2006, Pages 153-170

Thiopurines, DNA damage, DNA repair and therapy-related cancer

Author keywords

6 Mercaptopurine; 6 Thioguanine; Acute myeloid leukaemia; Azathioprine; DNA mismatch repair; Oxidative DNA damage; Skin cancer; Thiopurines

Indexed keywords

ANTINEOPLASTIC AGENT; PURINE DERIVATIVE;

EID: 34547116188     PISSN: 00071420     EISSN: 14718391     Source Type: Journal    
DOI: 10.1093/bmb/ldl020     Document Type: Review
Times cited : (167)

References (47)
  • 1
    • 0024554561 scopus 로고
    • The purine path to chemotherapy
    • Elion GB (1989) The purine path to chemotherapy. Science, 244, 41-47.
    • (1989) Science , vol.244 , pp. 41-47
    • Elion, G.B.1
  • 3
    • 0028963613 scopus 로고
    • Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurme-based maintenance therapy
    • Warren DJ, Andersen A, Slordal L (1995) Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurme-based maintenance therapy. Cancer Res, 55, 1670-1674.
    • (1995) Cancer Res , vol.55 , pp. 1670-1674
    • Warren, D.J.1    Andersen, A.2    Slordal, L.3
  • 4
    • 0842291670 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-g production in patients with Crohn's disease on AZA therapy
    • Cuffari C, Li DY, Mahoney J, Barnes JY, Bayless TM (2004) Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-g production in patients with Crohn's disease on AZA therapy. Dig Dis Sci, 49, 133-137.
    • (2004) Dig Dis Sci , vol.49 , pp. 133-137
    • Cuffari, C.1    Li, D.Y.2    Mahoney, J.3    Barnes, J.Y.4    Bayless, T.M.5
  • 5
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV (1999) Pharmacogenomics: translating functional genomics into rational therapeutics. Science, 286, 487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 6
    • 0242312707 scopus 로고    scopus 로고
    • Drug methylation in cancer therapy: Lessons from the TPMT polymorphism
    • Krynetski E, Evans WE (2003) Drug methylation in cancer therapy: lessons from the TPMT polymorphism. Oncogene, 22, 7403-7413.
    • (2003) Oncogene , vol.22 , pp. 7403-7413
    • Krynetski, E.1    Evans, W.E.2
  • 7
    • 0142240380 scopus 로고    scopus 로고
    • Preventing toxicity with a gene test
    • Marshall E (2003) Preventing toxicity with a gene test. Science 302, 588-590.
    • (2003) Science , vol.302 , pp. 588-590
    • Marshall, E.1
  • 8
    • 0016053706 scopus 로고
    • A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine
    • Tidd DM, Paterson AR (1974) A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res., 34, 738-746.
    • (1974) Cancer Res. , vol.34 , pp. 738-746
    • Tidd, D.M.1    Paterson, A.R.2
  • 9
    • 0027417198 scopus 로고
    • 6-mercaptopurine: Cytotoxicity and biochemical pharmacology in human malignant T-lymphoblasts
    • Bokkerink JPM, Stet EH, dAbreu RA et al. (1993) 6-mercaptopurine: cytotoxicity and biochemical pharmacology in human malignant T-lymphoblasts. Biochem Pharmacol, 45, 1455-1463.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1455-1463
    • Bokkerink, J.P.M.1    Stet, E.H.2    Dabreu, R.A.3
  • 10
    • 0027250367 scopus 로고
    • Reversal of 6-mercaptopurine and 6-mercaptopurine ribonucleoside cytotoxicity by amidoimidazole carboxamide ribonucleoside in Molt4 human malignant T-lymphoblasts
    • Stet EH, Abreu RAd, Bokkerink JPM et al. (1993) Reversal of 6-mercaptopurine and 6-mercaptopurine ribonucleoside cytotoxicity by amidoimidazole carboxamide ribonucleoside in Molt4 human malignant T-lymphoblasts. Biochem Pharmacol, 46, 547-550.
    • (1993) Biochem Pharmacol , vol.46 , pp. 547-550
    • Stet, E.H.1    Abreu, R.A.D.2    Bokkerink, J.P.M.3
  • 11
    • 0020512528 scopus 로고
    • Childhood leukemia: A relationship between intracellular 6-mercaptopurine metabolites and neutropenia
    • Lennard L, Rees CA, Lilleyman JS, Maddocks JL (1983) Childhood leukemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia. Br J Clin Pharmacol 16, 359-363.
    • (1983) Br J Clin Pharmacol , vol.16 , pp. 359-363
    • Lennard, L.1    Rees, C.A.2    Lilleyman, J.S.3    Maddocks, J.L.4
  • 12
    • 0029822592 scopus 로고    scopus 로고
    • Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine
    • Swann PF, Waters TR, Moulton DC, Xu Y-Z, Edwards M, Mace R (1996) Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Science, 273, 1109-1111.
    • (1996) Science , vol.273 , pp. 1109-1111
    • Swann, P.F.1    Waters, T.R.2    Moulton, D.C.3    Xu, Y.-Z.4    Edwards, M.5    Mace, R.6
  • 13
    • 0942289903 scopus 로고    scopus 로고
    • Human mismatch repair, drug-induced DNA damage, and secondary cancer
    • Karran P, Offman J, Bignami M (2003) Human mismatch repair, drug-induced DNA damage, and secondary cancer. Biochimie, 85, 1149-1160.
    • (2003) Biochimie , vol.85 , pp. 1149-1160
    • Karran, P.1    Offman, J.2    Bignami, M.3
  • 14
    • 0035423158 scopus 로고    scopus 로고
    • Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells
    • Dervieux T, Blanco JG, Krynetski EJ, Vanin EF, Roussel MF, Relling MV (2001) Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells. Cancer Res., 61, 5810-5816.
    • (2001) Cancer Res. , vol.61 , pp. 5810-5816
    • Dervieux, T.1    Blanco, J.G.2    Krynetski, E.J.3    Vanin, E.F.4    Roussel, M.F.5    Relling, M.V.6
  • 15
    • 0036082415 scopus 로고    scopus 로고
    • The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs
    • Coulthard SA, Hogarth LA, Little M et al. (2002) The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs. Mol Pharmacol, 62, 102-109.
    • (2002) Mol Pharmacol , vol.62 , pp. 102-109
    • Coulthard, S.A.1    Hogarth, L.A.2    Little, M.3
  • 16
    • 0037275722 scopus 로고    scopus 로고
    • Assessment of mismatch repair function in leukaemic cell lines and blasts from children with acute lymphoblastic leukaemia
    • Macheson EC, Hall AG (2003) Assessment of mismatch repair function in leukaemic cell lines and blasts from children with acute lymphoblastic leukaemia. Carcinogenesis, 24, 31-38.
    • (2003) Carcinogenesis , vol.24 , pp. 31-38
    • Macheson, E.C.1    Hall, A.G.2
  • 17
    • 0033647208 scopus 로고    scopus 로고
    • Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen
    • Taverna P, Liu L, Hanson AJ, Monks A, Gerson SL (2000) Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen. Cancer Chemother Pharmacol, 46, 507-516.
    • (2000) Cancer Chemother Pharmacol , vol.46 , pp. 507-516
    • Taverna, P.1    Liu, L.2    Hanson, A.J.3    Monks, A.4    Gerson, S.L.5
  • 18
    • 0041842544 scopus 로고    scopus 로고
    • Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- Mice
    • Krynetskaia NF, Brenner TL, Krynetski EY et al. (2003) Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice. Mol Pharmacol, 64, 456-465.
    • (2003) Mol Pharmacol , vol.64 , pp. 456-465
    • Krynetskaia, N.F.1    Brenner, T.L.2    Krynetski, E.Y.3
  • 19
    • 0037837443 scopus 로고    scopus 로고
    • DNA mismatch repair (MMR) mediates 6-thioguanine genocoxicity by introducing single-strand breaks to signal a G2-M arrest in mismatch repair-proficient RKO cells
    • Yan T, Berry SE, Desai AB, Kinsella TJ (2003) DNA mismatch repair (MMR) mediates 6-thioguanine genocoxicity by introducing single-strand breaks to signal a G2-M arrest in mismatch repair-proficient RKO cells. Clin Cancer Res, 9, 2327-2334.
    • (2003) Clin Cancer Res , vol.9 , pp. 2327-2334
    • Yan, T.1    Berry, S.E.2    Desai, A.B.3    Kinsella, T.J.4
  • 20
    • 1942521014 scopus 로고    scopus 로고
    • Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway
    • Yamane K, Taylor K, Kinsella TJ (2004) mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway. Biochem Biophys Res Commun, 318, 297-302.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 297-302
    • Yamane, K.1    Taylor, K.2    Kinsella, T.J.3
  • 22
    • 2442670292 scopus 로고    scopus 로고
    • 1 type methylating agents requires the ATR kinase
    • 1 type methylating agents requires the ATR kinase. Genes Dev, 18, 1331-1344.
    • (2004) Genes Dev , vol.18 , pp. 1331-1344
    • Stojic, L.1    Mojas, N.2    Cejka, P.3
  • 23
    • 3042650433 scopus 로고
    • Radiosensitization of E. coli by purine and pyrimidine analogues incorporated into deoxyribonucleic acid
    • Kaplan HS, Smith KC, Tomlin P (1961) Radiosensitization of E. coli by purine and pyrimidine analogues incorporated into deoxyribonucleic acid. Nature, 190, 794-796.
    • (1961) Nature , vol.190 , pp. 794-796
    • Kaplan, H.S.1    Smith, K.C.2    Tomlin, P.3
  • 24
    • 36949072476 scopus 로고
    • Interaction of the oxygen effect and radiosensitization produced by base analogues incorporated into deoxyribonucleic acid
    • Kaplan HS, Zavarine R, Earle J (1962) Interaction of the oxygen effect and radiosensitization produced by base analogues incorporated into deoxyribonucleic acid. Nature, 194, 662-664.
    • (1962) Nature , vol.194 , pp. 662-664
    • Kaplan, H.S.1    Zavarine, R.2    Earle, J.3
  • 25
    • 37049108224 scopus 로고
    • Photo-oxidation of 6-mercaptopurine in aqueous solution
    • Hemmens VJ, Moore DE (1984) Photo-oxidation of 6-mercaptopurine in aqueous solution. Chem Soc Perkin Trans, II, 209-211.
    • (1984) Chem Soc Perkin Trans , vol.2 , pp. 209-211
    • Hemmens, V.J.1    Moore, D.E.2
  • 26
    • 0022691484 scopus 로고
    • Photochemical sensitization by azathioprine and its metabolites-II. Azathioprine and nitroimidazole metabolites
    • Hemmens VJ, Moore DE (1986) Photochemical sensitization by azathioprine and its metabolites-II. Azathioprine and nitroimidazole metabolites. Photochem Photobiol, 43, 257-262.
    • (1986) Photochem Photobiol , vol.43 , pp. 257-262
    • Hemmens, V.J.1    Moore, D.E.2
  • 27
    • 24944519200 scopus 로고    scopus 로고
    • Azathioprine and UVA light generate mutagenic oxidative DNA damage
    • O'Donovan P, Perrett C, Zhang X et al. (2005) Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science, 309, 1871-1874.
    • (2005) Science , vol.309 , pp. 1871-1874
    • O'Donovan, P.1    Perrett, C.2    Zhang, X.3
  • 28
    • 77953838689 scopus 로고    scopus 로고
    • Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light
    • epublished ahead of print
    • Zhang X, Jeffs G, Ren X et al. (2006) Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light. DNA Repair, epublished ahead of print.
    • (2006) DNA Repair
    • Zhang, X.1    Jeffs, G.2    Ren, X.3
  • 29
    • 77953832082 scopus 로고
    • Azathioprine
    • Azathioprine. (1987) IARC Monographs, Supplement 7, 119.
    • (1987) IARC Monographs , Issue.SUPPL. 7 , pp. 119
  • 30
    • 0027731258 scopus 로고
    • Incidence and treatment of neoplasia after transplantation
    • Penn I (1993) Incidence and treatment of neoplasia after transplantation. J Heart Lung Transplant, 12, S328-S336.
    • (1993) J Heart Lung Transplant , vol.12
    • Penn, I.1
  • 31
    • 0033853911 scopus 로고    scopus 로고
    • Post-transplant malignancy: The role of immunosuppression
    • Penn I (2000) Post-transplant malignancy: the role of immunosuppression. Drug Safety, 23, 101-113.
    • (2000) Drug Safety , vol.23 , pp. 101-113
    • Penn, I.1
  • 32
    • 3242756741 scopus 로고    scopus 로고
    • Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation
    • Offman J, Opelz G, Doehler B et al. (2004) Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation. Blood, 104, 822-828.
    • (2004) Blood , vol.104 , pp. 822-828
    • Offman, J.1    Opelz, G.2    Doehler, B.3
  • 33
    • 0035912811 scopus 로고    scopus 로고
    • -/- lymphoblastoid cells to the methylating agent temozolomide
    • -/- lymphoblastoid cells to the methylating agent temozolomide. Proc Natl Acad Sci USA, 98, 7164-7169.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7164-7169
    • Marra, G.1    D'Atri, S.2    Corti, C.3
  • 34
    • 2642636861 scopus 로고    scopus 로고
    • Microsatellite instability and frameshift mutations in BAX and transforming growth factor b RII genes are very uncommon in acute lymphoblastic leukemia in vivo but not in cell lines
    • Molenaar JJ, Gerard B, Chambon-Pautas C et al. (1998) Microsatellite instability and frameshift mutations in BAX and transforming growth factor b RII genes are very uncommon in acute lymphoblastic leukemia in vivo but not in cell lines. Blood, 92, 230-233.
    • (1998) Blood , vol.92 , pp. 230-233
    • Molenaar, J.J.1    Gerard, B.2    Chambon-Pautas, C.3
  • 35
    • 17944364716 scopus 로고    scopus 로고
    • Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastoc leukemia
    • Blanco JG, Dervieux T, Edick MJ et al. (2001) Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastoc leukemia. Proc Natl Acad Sci USA, 98, 10338-10343.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10338-10343
    • Blanco, J.G.1    Dervieux, T.2    Edick, M.J.3
  • 36
    • 0033568538 scopus 로고    scopus 로고
    • Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells
    • Thomsen JB, Schroder H, Kristinsson J et al. (1999) Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells. Cancer, 86, 1080-1086.
    • (1999) Cancer , vol.86 , pp. 1080-1086
    • Thomsen, J.B.1    Schroder, H.2    Kristinsson, J.3
  • 37
    • 85088329939 scopus 로고    scopus 로고
    • Microsatellite instability in natural killer cell-like T cell lymphomas in immunocompromised and immunocompetent individuals
    • Larson RS (1997) Microsatellite instability in natural killer cell-like T cell lymphomas in immunocompromised and immunocompetent individuals. Blood, 89, 114-115.
    • (1997) Blood , vol.89 , pp. 114-115
    • Larson, R.S.1
  • 38
    • 0033519986 scopus 로고    scopus 로고
    • High incidence of secondary brain tumours after radiotherapy and antimetabolites
    • Relling MV, Rubnitz JE, Rivera GK et al. (1999) High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet, 354, 34-39.
    • (1999) Lancet , vol.354 , pp. 34-39
    • Relling, M.V.1    Rubnitz, J.E.2    Rivera, G.K.3
  • 39
    • 0031050526 scopus 로고    scopus 로고
    • Induction of cell killing, mutation and umu gene expression by 6-mercaptopurine or 2-thiouracil with UVA irradiation
    • Komeda K, Iwamoto S, Kominami S, Ohnishi T (1997) Induction of cell killing, mutation and umu gene expression by 6-mercaptopurine or 2-thiouracil with UVA irradiation. Photochem Photobiol, 65, 115-118.
    • (1997) Photochem Photobiol , vol.65 , pp. 115-118
    • Komeda, K.1    Iwamoto, S.2    Kominami, S.3    Ohnishi, T.4
  • 40
    • 22144457077 scopus 로고    scopus 로고
    • Human papillomavirus gene expression in cutaneous squamous cell carcinomas from immunosuppressed and immunocompetent individuals
    • Purdie KJ, Surentheran T, Sterling JC et al. (2005) Human papillomavirus gene expression in cutaneous squamous cell carcinomas from immunosuppressed and immunocompetent individuals. J Invest Dermatol, 125, 98-107.
    • (2005) J Invest Dermatol , vol.125 , pp. 98-107
    • Purdie, K.J.1    Surentheran, T.2    Sterling, J.C.3
  • 41
    • 0033939850 scopus 로고    scopus 로고
    • Protection by ultraviolet A and B sunscreens against in situ dipyrimidine photolesions in human epidermis is comparable to protection against sunburn
    • Young AR, Sheehan JM, Chadwick CA, Potten CS (2000) Protection by ultraviolet A and B sunscreens against in situ dipyrimidine photolesions in human epidermis is comparable to protection against sunburn. J Invest Dermatol, 115, 37-41.
    • (2000) J Invest Dermatol , vol.115 , pp. 37-41
    • Young, A.R.1    Sheehan, J.M.2    Chadwick, C.A.3    Potten, C.S.4
  • 42
    • 0035678944 scopus 로고    scopus 로고
    • Protection against pyrimidine dimers, p53, and 8-hydroxy-2′- deoxyguanosine expression in ultraviolet-irradiated human skin by sunscreens: Difference between UVB + UVA and UVB alone sunscreens
    • Liardet S, Scaletta C, Panizzon R, Hohlfeld P, Laurent-Applegate L (2001) Protection against pyrimidine dimers, p53, and 8-hydroxy-2′- deoxyguanosine expression in ultraviolet-irradiated human skin by sunscreens: difference between UVB + UVA and UVB alone sunscreens. J Invest Dermatol, 117, 1437-1441.
    • (2001) J Invest Dermatol , vol.117 , pp. 1437-1441
    • Liardet, S.1    Scaletta, C.2    Panizzon, R.3    Hohlfeld, P.4    Laurent-Applegate, L.5
  • 43
    • 0031920594 scopus 로고    scopus 로고
    • Defective global genomic repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema
    • Berg RJ, Ruven HJ, Sands AT, deGruijl FR, Mullenders LH (1998) Defective global genomic repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema. J Invest Dermatol, 110, 405-409.
    • (1998) J Invest Dermatol , vol.110 , pp. 405-409
    • Berg, R.J.1    Ruven, H.J.2    Sands, A.T.3    DeGruijl, F.R.4    Mullenders, L.H.5
  • 44
    • 0022354811 scopus 로고
    • Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells
    • Lennard L, Thomas S, Harrington CJ, Maddocks JL (1985) Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells. Br J Dermatol, 113, 723-729.
    • (1985) Br J Dermatol , vol.113 , pp. 723-729
    • Lennard, L.1    Thomas, S.2    Harrington, C.J.3    Maddocks, J.L.4
  • 45
    • 0344775175 scopus 로고    scopus 로고
    • The risk of skin cancer in renal transplant recipients in Queensland, Australia. A follow-up study
    • Bavinck JNB, Hardie DR, Green A et al. (1996) The risk of skin cancer in renal transplant recipients in Queensland, Australia. A follow-up study. Transplantation, 61, 715-721.
    • (1996) Transplantation , vol.61 , pp. 715-721
    • Bavinck, J.N.B.1    Hardie, D.R.2    Green, A.3
  • 46
    • 4043144895 scopus 로고    scopus 로고
    • Mycophenolate mofecil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): A randomised trial
    • Remuzzi G, Lesti M, Gotti E et al. (2004) Mycophenolate mofecil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial. Lancet, 364, 503-512.
    • (2004) Lancet , vol.364 , pp. 503-512
    • Remuzzi, G.1    Lesti, M.2    Gotti, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.