-
1
-
-
0029020134
-
Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer's disease
-
M. Bobinski, J. Wegiel, H.M. Wisniewski, M. Tarnawski, B. Reisberg, B. Mlodzik et al., Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer's disease, Dementia 6 (1995) 205-210.
-
(1995)
Dementia
, vol.6
, pp. 205-210
-
-
Bobinski, M.1
Wegiel, J.2
Wisniewski, H.M.3
Tarnawski, M.4
Reisberg, B.5
Mlodzik, B.6
-
2
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
D.R. Borchelt, G. Thinakaran, C.B. Eckman, M.K. Lee, F. Davenport, T. Ratovitsky et al., Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo, Neuron 17 (1996) 1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
-
3
-
-
0025863618
-
Neuropathological staging of Alzheimer-related changes
-
H. Braak, E. Braak, Neuropathological staging of Alzheimer-related changes, Acta Neuropathol. 82 (1991) 239-259.
-
(1991)
Acta Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
4
-
-
0026075602
-
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
-
M.C. Chartier-Harlin, F. Crawford, H. Houlden, A. Warren, D. Hughes, L. Fidani et al., Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene, Nature 353 (1991) 844-846.
-
(1991)
Nature
, vol.353
, pp. 844-846
-
-
Chartier-Harlin, M.C.1
Crawford, F.2
Houlden, H.3
Warren, A.4
Hughes, D.5
Fidani, L.6
-
5
-
-
0032895651
-
Transgenic mice with Alzheimer's presenilin mutations show accelerated neurodegeneration without amyloid plaque formation
-
D.H. Chui, H. Tanahashi, K. Ozawa, S. Ikeda, F. Checler, O. Ueda et al., Transgenic mice with Alzheimer's presenilin mutations show accelerated neurodegeneration without amyloid plaque formation, Nature Med. 5 (1999) 560-564.
-
(1999)
Nature Med.
, vol.5
, pp. 560-564
-
-
Chui, D.H.1
Tanahashi, H.2
Ozawa, K.3
Ikeda, S.4
Checler, F.5
Ueda, O.6
-
6
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
-
M. Citron, D. Westaway, W. Xia, G. Carlson, T. Diehl, G. Levesque et al., Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice, Nature Med. 3 (1997) 67-72.
-
(1997)
Nature Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
-
7
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
B. De Strooper, P. Saftig, K. Craessaerts, H. Vanderstichele, G. Guhde, W. Annaert et al., Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein, Nature 391 (1998) 387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
-
8
-
-
16044366039
-
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
-
K. Duff, C. Eckman, C. Zehr, X. Yu, C.M. Prada, J. Perez-Tur et al., Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1, Nature 383 (1996) 710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-Tur, J.6
-
9
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
see comments
-
A. Goate, M.C. Chartier-Harlin, M. Mullan, J. Brown, F. Crawford, L. Fidani et al., Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease, Nature 349 (1991) 704-706, (see comments).
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
-
10
-
-
13044278313
-
Preselenin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
-
A. Herreman, D. Hartmann, W. Annaert, P. Saftig, K. Craessaerts, L. Serneels et al., Preselenin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency, Proc. Natl. Acad. Sci. USA 96 (1999) 11872-11877.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11872-11877
-
-
Herreman, A.1
Hartmann, D.2
Annaert, W.3
Saftig, P.4
Craessaerts, K.5
Serneels, L.6
-
11
-
-
0031939135
-
The expression of preseniln-1 mRNA in skin fibroblasts from Alzheimer's disease
-
I. Ikeda, K. Urakami, K. Isoe, K. Ohno, K. Nakashima, The expression of preseniln-1 mRNA in skin fibroblasts from Alzheimer's disease, Dement. Geriatr. Cogn. Disord. 9 (1997) 145-148.
-
(1997)
Dement. Geriatr. Cogn. Disord.
, vol.9
, pp. 145-148
-
-
Ikeda, I.1
Urakami, K.2
Isoe, K.3
Ohno, K.4
Nakashima, K.5
-
12
-
-
0030574051
-
Quantification of presenilin-1 mRNA in Alzheimer's disease brains
-
J.A. Johnston, S. Froelich, L. Lannfelt, R.F. Cowburn, Quantification of presenilin-1 mRNA in Alzheimer's disease brains, FEBS Lett 394 (1996) 279-284.
-
(1996)
FEBS Lett
, vol.394
, pp. 279-284
-
-
Johnston, J.A.1
Froelich, S.2
Lannfelt, L.3
Cowburn, R.F.4
-
13
-
-
0028291383
-
Cytoskeletal neurofilament gene expression in brain tissue from Alzheimer's disease patients. I. Decrease in NF-L and NF-M message
-
S. Kittur, J. Hoh, H. Endo, W. Tourtellotte, B.S. Weeks, W. Markesbery et al., Cytoskeletal neurofilament gene expression in brain tissue from Alzheimer's disease patients. I. Decrease in NF-L and NF-M message, J. Genat. Psych. Neurol. 7 (1993) 153-158.
-
(1993)
J. Genat. Psych. Neurol.
, vol.7
, pp. 153-158
-
-
Kittur, S.1
Hoh, J.2
Endo, H.3
Tourtellotte, W.4
Weeks, B.S.5
Markesbery, W.6
-
14
-
-
13344282063
-
Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
-
D.M. Kovacs, H.J. Fausett, K.J. Page, T.W. Kim, R.D. Moir, D.E. Merriam et al., Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells, Nature Med. 2 (1996) 224-229.
-
(1996)
Nature Med.
, vol.2
, pp. 224-229
-
-
Kovacs, D.M.1
Fausett, H.J.2
Page, K.J.3
Kim, T.W.4
Moir, R.D.5
Merriam, D.E.6
-
15
-
-
0031725376
-
The stages of Alzheimer's disease: A reappraisal
-
H.C. Kraemer, J.L. Taylor, J.R. Tinklenberg, J.A. Yesavage, The stages of Alzheimer's disease: a reappraisal, Dement. Geriatr. Cogn. Disord. 9 (1998) 299-308.
-
(1998)
Dement. Geriatr. Cogn. Disord.
, vol.9
, pp. 299-308
-
-
Kraemer, H.C.1
Taylor, J.L.2
Tinklenberg, J.R.3
Yesavage, J.A.4
-
16
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
see comments
-
E. Levy-Lahad, W. Wasco, P. Poorkaj, D.M. Romano, J. Oshima, W.H. Pettingell et al., Candidate gene for the chromosome 1 familial Alzheimer's disease locus, Science 269 (1995) 973-977, see comments.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
-
17
-
-
9044239670
-
Familial and sporadic Alzheimer's disease: Neuropathology cannot exclude a common pathway
-
C.F. Lippa, A.M. Saunders, T.W. Smith, J.M. Swearer, D.A. Drachman, B. Ghetti et al., Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a common pathway, Neurology 46 (1996) 406-412.
-
(1996)
Neurology
, vol.46
, pp. 406-412
-
-
Lippa, C.F.1
Saunders, A.M.2
Smith, T.W.3
Swearer, J.M.4
Drachman, D.A.5
Ghetti, B.6
-
18
-
-
0029907245
-
Neuronal expression of STM2 mRNA in human brain is reduced in Alzheimer's disease
-
P.J. McMillan, J.B. Leverenz, P. Poorkaj, G.D. Schellenberg, D.M. Dorsa, Neuronal expression of STM2 mRNA in human brain is reduced in Alzheimer's disease, J. Histochem. Cytochem. 44 (1996) 1215-1222.
-
(1996)
J. Histochem. Cytochem.
, vol.44
, pp. 1215-1222
-
-
McMillan, P.J.1
Leverenz, J.B.2
Poorkaj, P.3
Schellenberg, G.D.4
Dorsa, D.M.5
-
19
-
-
0027024651
-
A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene
-
M. Mullan, H. Houlden, M. Windelspecht, L. Fidani, C. Lombardi, P. Diaz et al., A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene, Nat. Genet. 2 (1992) 340-342.
-
(1992)
Nat. Genet.
, vol.2
, pp. 340-342
-
-
Mullan, M.1
Houlden, H.2
Windelspecht, M.3
Fidani, L.4
Lombardi, C.5
Diaz, P.6
-
20
-
-
0025950987
-
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
-
J. Murrell, M. Farlow, B. Ghetti, M.D. Benson, A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease, Science 254 (1991) 97-99.
-
(1991)
Science
, vol.254
, pp. 97-99
-
-
Murrell, J.1
Farlow, M.2
Ghetti, B.3
Benson, M.D.4
-
21
-
-
0030681215
-
Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
-
National Institute on Aging and Reagan Institute Working Group, Consensus recommendations for the postmortem diagnosis of Alzheimer's disease, Neurobiol. Aging 18 (1997) S1-S2.
-
(1997)
Neurobiol. Aging
, vol.18
-
-
-
22
-
-
0030246887
-
Presenilin 1 mRNA expression in hippocampi of sporadic Alzheimer's disease patients
-
K. Nishiyama, S. Murayama, T. Suzuki, Y. Mitsui, Y. Sakaki, I. Kanazawa, Presenilin 1 mRNA expression in hippocampi of sporadic Alzheimer's disease patients, Neurosci. Res. 26 (1996) 75-78.
-
(1996)
Neurosci. Res.
, vol.26
, pp. 75-78
-
-
Nishiyama, K.1
Murayama, S.2
Suzuki, T.3
Mitsui, Y.4
Sakaki, Y.5
Kanazawa, I.6
-
23
-
-
0032708117
-
Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid β42 in transfected cells
-
L.M. Refolo, C. Eckman, C.M. Prada, D. Yager, K. Sambamurti, N. Mehta et al., Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid β42 in transfected cells, J. Neurochem. 73 (1999) 2383-2388.
-
(1999)
J. Neurochem.
, vol.73
, pp. 2383-2388
-
-
Refolo, L.M.1
Eckman, C.2
Prada, C.M.3
Yager, D.4
Sambamurti, K.5
Mehta, N.6
-
24
-
-
0029101491
-
Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type-3 gene
-
E.A. Rogaeva, R. Sherrington, E.A. Rogaeva, G. Levesque, M. Ikeda, Y. Liang et al., Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type-3 gene, Nature 376 (1995) 775-778.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaeva, E.A.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
-
25
-
-
0027337858
-
Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases
-
see comments
-
A.M. Saunders, K. Schmader, J.C. Breitner, M.D. Benson, W.T. Brown, L. Goldfarb et al., Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases, Lancet 342 (1993) 710-711, (see comments).
-
(1993)
Lancet
, vol.342
, pp. 710-711
-
-
Saunders, A.M.1
Schmader, K.2
Breitner, J.C.3
Benson, M.D.4
Brown, W.T.5
Goldfarb, L.6
-
26
-
-
0027327267
-
Association of apolipoprotein e allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
-
see comments
-
A.M. Saunders, W.J. Strittmatter, D. Schmechel, R.H. St. George-Hyslop, M.A. Periak-Vance, S.H. Joo, Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease, Neurology 43 (1993) 1467-1472, (see comments).
-
(1993)
Neurology
, vol.43
, pp. 1467-1472
-
-
Saunders, A.M.1
Strittmatter, W.J.2
Schmechel, D.3
St. George-Hyslop, R.H.4
Periak-Vance, M.A.5
Joo, S.H.6
-
27
-
-
16044373524
-
The amyloid β protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki et al., The amyloid β protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease, Nature Med. 2 (1996) 864-870.
-
(1996)
Nature Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
-
28
-
-
0030779784
-
Skeletal and CNS defects in presenilen-1-deficient mice
-
J. Shen, R.T. Bronson, D.F. Chen, W. Xia, D.J. Selkoe, S. Tonegawa, Skeletal and CNS defects in presenilen-1-deficient mice, Cell 89 (1997) 629-639.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
29
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
see comments
-
R. Sherrington, E.I. Rogaev, Y. Liang, E.A. Rogaeva, G. Levesque, M. Ikeda et al., Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease, Nature 375 (1995) 754-760, see comments.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
-
30
-
-
0033214070
-
A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and Notch signaling
-
H. Steiner, K. Duff, A. Capell, H. Romig, M.G. Grim, S. Lincoln et al., A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and Notch signaling, J. Biol. Chem. 274 (1999) 28669-28673.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 28669-28673
-
-
Steiner, H.1
Duff, K.2
Capell, A.3
Romig, H.4
Grim, M.G.5
Lincoln, S.6
-
31
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
W.J. Strittmatter, A.M. Saunders, D. Schmechel, M. Pericak-Vance, J. Enghild, G.S. Salvesen et al., Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proc. Natl. Acad. Sci. USA 90 (1993) 1977-1981.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
Salvesen, G.S.6
-
32
-
-
0031044834
-
Expression of presenilin-1 and -2 mRNA in rat and Alzheimer's disease brains
-
K. Takami, K. Terai, A. Matsuo, D.G. Walker, P.L. McGeer, Expression of presenilin-1 and -2 mRNA in rat and Alzheimer's disease brains, Brain Res. 748 (1997) 122-130.
-
(1997)
Brain Res.
, vol.748
, pp. 122-130
-
-
Takami, K.1
Terai, K.2
Matsuo, A.3
Walker, D.G.4
McGeer, P.L.5
-
33
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to familial Alzheimer's disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
-
T. Tomita, K. Maruyama, T.C. Saido, H. Kume, K. Shinozaki, S. Tokuhiro et al., The presenilin 2 mutation (N141I) linked to familial Alzheimer's disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue, Proc. Natl. Acad. Sci. USA 94 (1997) 2025-2030.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2025-2030
-
-
Tomita, T.1
Maruyama, K.2
Saido, T.C.3
Kume, H.4
Shinozaki, K.5
Tokuhiro, S.6
-
34
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
-
M.S. Wolfe, W. Xia, B.L. Ostaszewski, T.S. Diehl, W.T. Kimberly, D.J. Selkoe, Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity, Nature 398 (1999) 513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
35
-
-
17744401440
-
Presenilin 1 is required for Notch 1 and Dll 1 expression in the paraxial mesoderm
-
P.C. Wong, H. Zheng, H. Chen, M.W. Becher, D.J.S. Sirinathsinghji, M.E. Trumbauer et al., Presenilin 1 is required for Notch 1 and Dll 1 expression in the paraxial mesoderm, Nature 387 (1997) 288-292.
-
(1997)
Nature
, vol.387
, pp. 288-292
-
-
Wong, P.C.1
Zheng, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.S.5
Trumbauer, M.E.6
|