-
1
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate A À1-42/40 ratio in vitro and in vivo
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.-M.7
Kim, G.8
Eekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
2
-
-
0031006343
-
Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease
-
(1997)
J. Neurosci.
, vol.17
, Issue.13
, pp. 5101-5107
-
-
Busciglio, J.1
Hartmann, H.2
Lorenzo, A.3
Wong, C.4
Baumann, K.5
Sommer, B.6
Staufenbiel, M.7
Yankner, B.A.8
-
3
-
-
0030581697
-
Molecular cloning, sequencing, and brain expression of the presenilin 1 gene in Microcebes murians
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.228
, pp. 430-439
-
-
Calenda, A.1
Mestre-Frances, N.2
Czech, C.3
Pradier, L.4
Petter, A.5
Bons, N.6
Bellis, M.7
-
4
-
-
0030657665
-
Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation
-
(1997)
J. Neurochem.
, vol.69
, pp. 2432-2440
-
-
Capell, A.1
Saffrich, R.2
Olivo, J.-C.3
Meyn, L.4
Walter, J.5
Grunberg, J.6
Mathews, P.7
Nixon, R.8
Dotti, C.9
Haass, C.10
-
5
-
-
0026075602
-
Early-onset Alzheimer's disease caused by mutations at codon 717 of the -amyloid precursor protein gene
-
(1991)
Nature
, vol.353
, pp. 844-846
-
-
Chartier-Harlin, M.C.1
Crawford, F.2
Houlden, H.3
Warren, A.4
Hughes, D.5
Fidani, L.6
Goate, A.7
Rossor, M.8
Roques, P.9
Hardy, J.10
Mullan, M.11
-
6
-
-
0032127320
-
Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease
-
(1998)
J. Neurosci. Res.
, vol.53
, pp. 99-106
-
-
Chui, D.-H.1
Shirotani, K.2
Tanahashi, H.3
Akiyama, H.4
Ozawa, K.5
Kunishita, T.6
Takahashi, K.7
Makifuchi, T.8
Tabira, T.9
-
7
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid-protein in both transfected cells and transgenic mice
-
(1997)
Nat. Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodensko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St. George-Hyslop, P.22
Selkoe, D.J.23
more..
-
8
-
-
0029812077
-
Expression and analysis of presenilin 1 in a human neuronal system localization in cell bodies and dendrites
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9223-9228
-
-
Cook, D.G.1
Sung, J.C.2
Golde, T.E.3
Felsenstein, K.M.4
Wojczyk, B.S.5
Tanzi, R.E.6
Trojanowski, J.Q.7
Lee, V.M.-Y.8
Domes, R.W.9
-
9
-
-
15444341611
-
Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3590-3598
-
-
De Strooper, B.1
Beullens, M.2
Contreras, B.3
Levesque, L.4
Craessaerts, K.5
Cordell, B.6
Moechars, D.7
Bollen, M.8
Fraser, P.9
St. George-Hyslop, P.10
Van Leuven, F.11
-
10
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
11
-
-
0033535504
-
A presenilin-1-dependent Á-secretase mediates release of Notch intracellular domain
-
(1999)
Nature
, vol.398
, pp. 518-521
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Salfig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goate, A.11
Kopan, R.12
-
12
-
-
0030293854
-
Proteins topology of presenilin 1
-
(1996)
Neuron
, vol.17
, pp. 1023-1030
-
-
Doan, A.1
Thinakaran, G.2
Borchelt, D.R.3
Slunt, H.H.4
Ratovitsky, T.5
Podlisny, M.6
Selkoe, D.J.7
Seeger, M.8
Gandy, S.E.9
Price, D.L.10
Sisodia, S.S.11
-
13
-
-
16044366039
-
Increased amyloid-À42(43) in brains of mice expressing mutant presenilin 1
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.-M.5
Perez-Tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
14
-
-
10144234151
-
Identification and neuron specific expression of the S182/presenilin protein in human and rodent brains
-
(1996)
J. Neurosci. Res.
, vol.45
, pp. 308-320
-
-
Elder, G.A.1
Tezapsidis, N.2
Carter, J.3
Shioi, J.4
Bouras, C.5
Li, H.-C.6
Johnston, J.M.7
Efthimiopoulos, S.8
Friedrich V.L., Jr.9
Robakis, N.K.10
-
16
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Crawford, F.4
Fidani, L.5
Giuffra, L.6
Haynes, A.7
Irving, N.8
James, L.9
Mant, R.10
Newton, P.11
Rooke, K.12
Roques, P.13
Talbot, C.14
Pericak-Vance, M.15
Roses, A.16
Williamson, R.17
Rossor, M.18
Owen, M.19
Hardy, J.20
more..
-
17
-
-
0030891662
-
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide
-
(1996)
Neuroreport
, vol.8
, pp. 379-383
-
-
Guo, Q.1
Furukawa, K.2
Sopher, B.L.3
Pham, D.G.4
Xie, J.5
Robinson, N.6
Martin, G.M.7
Mattson, M.P.8
-
18
-
-
0030917601
-
Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid-peptide: Involvement of calcium and oxyradicals
-
(1997)
J. Neurosci.
, vol.17
, Issue.11
, pp. 4212-4222
-
-
Guo, Q.1
Sopher, B.L.2
Furukawa, K.3
Pham, D.G.4
Robinson, N.5
Martin, G.M.6
Mattson, M.P.7
-
20
-
-
0030922421
-
Presenilins: Genes for life and death
-
(1997)
Neuron
, vol.18
, pp. 687-690
-
-
Haass, C.1
-
21
-
-
0032925297
-
Dual roles of proteasome in the metabolism of presenilin 1
-
(1999)
J. Neurochem.
, vol.72
, pp. 255-261
-
-
Honda, T.1
Yasutake, K.2
Nihonmatsu, N.3
Mercken, M.4
Takahashi, H.5
Murayama, O.6
Murayama, M.7
Sato, K.8
Omori, A.9
Tsubuki, S.10
Saido, T.C.11
Takashima, A.12
-
22
-
-
0034212576
-
Familial Alzheimer's disease-associated mutations block translocation of full-length presenilin 1 to the nuclear envelope
-
(2000)
Neurosci. Res.
, vol.37
, pp. 101-111
-
-
Honda, T.1
Nihonmatsu, N.2
Yasutake, K.3
Ohtake, A.4
Sato, K.5
Tanaka, S.6
Murayama, O.7
Murayama, M.8
Takashima, A.9
-
24
-
-
13344282063
-
Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
-
(1996)
Nat. Med.
, vol.2
, pp. 224-229
-
-
Kovacs, D.M.1
Fausett, H.J.2
Page, K.J.3
Kim, T.W.4
Moir, R.D.5
Merriam, D.E.6
Hollister, R.D.7
Hallmark, O.G.8
Mancini, R.9
Felsenstein, K.M.10
Hyman, B.T.11
Tanzi, R.E.12
Wasco, W.13
-
25
-
-
0031017795
-
Light and electron microscopic localization of the presenilin-1 in primate brain
-
(1997)
J. Neurosci.
, vol.17
, Issue.6
, pp. 1971-1980
-
-
Lah, J.J.1
Heilman, C.J.2
Nash, N.R.3
Rees, H.D.4
Yi, H.5
Counts, S.E.6
Levey, A.I.7
-
26
-
-
0029150716
-
A familial Alzheimer's disease locus on chromosome 1
-
(1995)
Science
, vol.269
, pp. 970-973
-
-
Levy-Lahad, E.1
Wijsman, E.2
Nemens, E.3
Anderson, L.4
Goddard, K.5
Weber, J.6
Bird, T.7
Schellenberg, G.8
-
27
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
Yu, C.7
Jondro, P.D.8
Schmidt, S.D.9
Wang, K.10
Crowley, A.C.11
Fu, Y.-H.12
Guenette, S.Y.13
Galas, D.14
Nemens, E.15
Wijsman, E.M.16
Bird, T.D.17
Schellenberg, G.G.18
Tanzi, R.E.19
-
28
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12, a Caenohabditis elegans S182 Alzheimer's disease gene
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
32
-
-
0030575338
-
Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies
-
(1996)
FEBS Lett.
, vol.389
, pp. 297-303
-
-
Merken, M.1
Takahashi, H.2
Honda, T.3
Sato, K.4
Murayama, M.5
Nakazato, Y.6
Noguchi, K.7
Imahori, K.8
Takashima, A.9
-
33
-
-
0030832449
-
Different effects of Alzheimer-associated mutations of presenilin 1 on its processing
-
(1997)
Neurosci. Lett.
, vol.229
, pp. 61-64
-
-
Murayama, O.1
Honda, T.2
Mercken, M.3
Murayama, M.4
Yasutake, K.5
Nihonmatsu, N.6
Nakazato, Y.7
Michel, G.8
Song, S.9
Sato, K.10
Takahashi, H.11
Takashima, A.12
-
35
-
-
10544239098
-
Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease
-
(1996)
Am. J. Pathol.
, vol.149
, Issue.6
, pp. 1839-1846
-
-
Murphy G.M., Jr.1
Forno, L.S.2
Ellis, W.G.3
Nochlin, D.4
Levy-Lahad, E.5
Poorkaj, P.6
Bird, T.D.7
Jiang, Z.8
Cordell, B.9
-
36
-
-
0028818826
-
Carboxyl end-specific monoclonal antibodies to amyloid β protein (A β) subtypes (A β40 and A β42(43)) differentiate A β in senile plaques and amyloid angiopathy in brains of aged cynomolgus monkeys
-
(1995)
Neurosci. Lett.
, vol.201
, pp. 151-154
-
-
Nakamura, S.1
Tamaoka, A.2
Sawamura, N.3
Shoji, S.4
Nakayama, H.5
Ono, F.6
Sakakibara, I.7
Yoshikawa, Y.8
Mori, H.9
Goto, N.10
Doi, K.11
-
37
-
-
0030204135
-
Immunohistochemical characteristics of the constituents of senile plaques and amyloid angiopathy in aged cynomolgus monkeys
-
(1996)
J. Med. Primatol.
, vol.25
, pp. 294-300
-
-
Nakamura, S.1
Kiatipattanasakul, W.2
Nakayama, H.3
Ono, F.4
Sakakibara, I.5
Yoshikawa, Y.6
Goto, N.7
Doi, K.8
-
39
-
-
0030889220
-
Presenilin proteins undergo heterogenous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue
-
(1997)
Neurobiol. Dis.
, vol.3
, pp. 325-333
-
-
Podlisny, M.B.1
Citron, M.2
Amarante, P.3
Sherrinton, R.4
Xia, W.5
Zhang, J.6
Diehl, T.7
Levesque, G.8
Fraser, P.9
Haass, C.10
Koo, E.H.M.11
Seubert, P.12
St. George-Hyslop, P.13
Teplow, D.B.14
Selkoe, D.J.15
-
40
-
-
0033014046
-
Evidence for a physical interaction between presenilin and Notch
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3263-3268
-
-
Ray, W.J.1
Yao, M.2
Nowotny, P.3
Mumm, J.4
Zhang, W.5
Wu, J.Y.6
Kopan, R.7
Goate, A.M.8
-
41
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
Mar, L.11
Sorbi, S.12
Nacmias, B.13
Placentini, S.14
Amaducci, L.15
Chumakov, I.16
Cohen, D.17
Lannfelt, L.18
Fraser, P.E.19
Rommens, J.M.20
St. George-Hyslop, P.H.21
more..
-
42
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuer, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.J.20
Younkin, S.21
more..
-
43
-
-
0025753852
-
The molecular pathology of Alzheimer's disease
-
(1991)
Neuron
, vol.6
, pp. 487-498
-
-
Selkoe, D.J.1
-
44
-
-
0026471656
-
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
-
(1992)
Science
, vol.258
, pp. 668-671
-
-
Schellenberg, G.D.1
Bird, T.D.2
Wijsman, E.M.3
Orr, H.T.4
Anderson, L.5
Nemens, E.6
White, J.7
Bonnycastle, L.8
Weber, J.L.9
Alonso, E.10
Potter, H.11
Heston, L.L.12
Martin, G.M.13
-
46
-
-
0029004341
-
Cloning of gene bearing missense mutations in early-onset familial Alzheimer's disease
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
Tsuda, T.11
Mar, L.12
Foncin, J.-F.13
Bruni, A.C.14
Montesi, M.P.15
Sorbi, S.16
Rainero, I.17
Pinessi, L.18
Nee, L.19
Chumakov, I.20
Pollen, D.21
Brookes, A.22
Sanseau, P.23
Polinsky, R.J.24
Wasco, W.25
DaSilva, H.A.R.26
Hains, J.L.27
Pericak-Vance, M.A.28
Tanzi, R.E.29
Roses, A.D.30
Fraser, P.E.31
Rommens, J.M.32
St. George-Hyslop, P.H.33
more..
-
48
-
-
0024600679
-
Subcellular distribution of the transmissible agent in Creutzfeldt-Jakob disease mouse brain
-
(1989)
Microbiol. Immunol.
, vol.33
, Issue.1
, pp. 35-42
-
-
Tamai, Y.1
Kojima, H.2
Ohtani, Y.3
Uchida, K.4
Taguchi, F.5
Kawaguchi, T.6
Miura, S.7
Tateishi, J.8
-
49
-
-
15844425969
-
Endoproteolysis of presenilin 1 and regulated accumulation of processed derivatives in vivo
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovisky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.I.12
Gandy, S.E.13
Jenkins, N.A.14
Copeland, N.G.15
Price, D.L.16
-
50
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to Alzheimer's disease (Volga German Families) increase the secretion of amyloid protein ending at the 42nd (or 43rd) residue
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2025-2030
-
-
Tomita, T.1
Maruyama, K.2
Saito, T.3
Hideaki, K.4
Shinozaki, K.5
Tokuhiro, S.6
Capell, A.7
Walter, J.8
Grunberg, J.9
Haass, C.10
Iwatsubo, T.11
Obata, K.12
-
51
-
-
0029843172
-
Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: Double-labeling immunohistochemical study
-
(1996)
Acta Neuropathol.
, vol.92
, pp. 325-330
-
-
Uchihara, T.1
El Hachimi, H.K.2
Duyckaerts, C.3
Foncin, J.-F.4
Fraser, P.E.5
Levesque, L.6
St. George-Hyslop, P.H.7
Hauw, J.-J.8
-
52
-
-
8044231311
-
The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
-
(1996)
Mol. Med.
, vol.2
, pp. 673-691
-
-
Walter, J.1
Capell, A.2
Grunberg, J.3
Pesold, B.4
Schindzielorz, A.5
Prior, R.6
Podlisny, M.B.7
Fraser, P.8
St. George Hyslop, P.9
Selkoe, D.J.10
Haass, C.11
-
55
-
-
17744401440
-
Presenilin 1 is required for Notch1 and D 1 expression in the paraxial mesoderm
-
(1997)
Nature
, vol.387
, pp. 288-292
-
-
Wong, P.C.1
Zheng, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.S.5
Trumbauer, M.E.6
Chen, H.Y.7
Price, D.L.8
Van der Ploeg, L.H.T.9
Sisodia, S.S.10
-
56
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue amyloid-protein by Chinese hamster ovary cells stably expressing mutant presenilin
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7977-7982
-
-
Xia, W.1
Zhang, J.2
Kholodenko, D.3
Citron, M.4
Podlisky, M.B.5
Teplow, D.6
Haass, C.7
Seubert, P.8
Koo, E.9
Selroe, D.J.10
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