Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 335, Issue 2, 2010, Pages 294-301

  Moore, Nicole L T ^a   Greenleaf, Ashley L R ^a   Acheson, Shawn K ^b   Wilson, Wilkie A ^b   Swartzwelder, H Scott ^a,b   Kuhn, Cynthia M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID 1 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; TETRAHYDROCANNABINOL;

ADOLESCENCE; ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DRUG TOLERANCE; GROUPS BY AGE; HIPPOCAMPUS; LEARNING DISORDER; MAZE TEST; MEMORY DISORDER; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; DRUG TOLERANCE; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; SPATIAL BEHAVIOR; TETRAHYDROCANNABINOL;

EID: 78149245168     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.169359     Document Type: Article

References (37)

1. Abel EL (1971) Marihuana and memory: acquisition or retrieval? Science 173:1038-1040.
2. Breivogel CS, Sim LJ, and Childers SR (1997) Regional differences in cannabinoid receptor/G-protein coupling in rat brain. J Pharmacol Exp Ther 282:1632-1642.
3. Cha YM, Jones KH, Kuhn CM, Wilson WA, and Swartzwelder HS (2007) Sex differences in the effects of Δ9-tetrahydrocannabinol on spatial learning in adolescent and adult rats. Behav Pharmacol 18:563-569.
4. Cha YM, White AM, Kuhn CM, Wilson WA, and Swartzwelder HS (2006) Differential effects of Δ9-THC on learning in adolescent and adult rats. Pharmacol Biochem Behav 83:448-455.
5. Childers SR (2006) Activation of G-proteins in brain by endogenous and exogenous cannabinoids. AAPS J 8:E112-E117.
6. Defea K (2008) β-Arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction. Br J Pharmacol 153 (Suppl 1):S298-S309.
7. Delatte MS, Winsauer PJ, and Moerschbaecher JM (2002) Tolerance to the disruptive effects of Δ9-THC on learning in rats. Pharmacol Biochem Behav 74:129-140.
8. Egashira N, Mishima K, Iwasaki K, and Fujiwara M (2002) Intracerebral microinjections of Δ9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats. Brain Res 952:239-245.
9. Ellgren M, Spano SM, and Hurd YL (2007) Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats. Neuropsychopharmacology 32:607-615.
10. Hampson RE and Deadwyler SA (2000) Cannabinoids reveal the necessity of hippocampal neural encoding for short-term memory in rats. J Neurosci 20:8932-8942.
11. Hampson RE, Simeral JD, Kelly EJ, and Deadwyler SA (2003) Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons. Hippocampus 13:543-556.
12. Ihnatovych I, Novotny J, Haugvicova R, Bourova L, Mares P, and Svoboda P (2002) Opposing changes of trimeric G protein levels during ontogenetic development of rat brain. Brain Res Dev Brain Res 133:57-67.
13. Lichtman AH, Dimen KR, and Martin BR (1995) Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats. Psychopharmacology 119:282-290.
14. Mato S, Del Olmo E, and Pazos A (2003) Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain. Eur J Neurosci 17:1747-1754.
15. McKinney DL, Cassidy MP, Collier LM, Martin BR, Wiley JL, Selley DE, and Sim-Selley LJ (2008) Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to Δ9-tetrahydrocannabinol. J Pharmacol Exp Ther 324:664-673.
16. McLaughlin CR, Martin BR, Compton DR, and Abood ME (1994) Cannabinoid receptors in developing rats: detection of mRNA and receptor binding. Drug Alcohol Depend 36:27-31.
17. Moore TH, Zammit S, Lingford-Hughes A, Barnes TR, Jones PB, Burke M, and Lewis G (2007) Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 370:319-328.
18. Morozov YM and Freund TF (2003) Post-natal development of type 1 cannabinoid receptor immunoreactivity in the rat hippocampus. Eur J Neurosci 18:1213-1222.
19. Nava F, Carta G, Colombo G, and Gessa GL (2001) Effects of chronic Δ9-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze. Neuropharmacology 41:392-399.
20. Niyuhire F, Varvel SA, Martin BR, and Lichtman AH (2007) Exposure to marijuana smoke impairs memory retrieval in mice. J Pharmacol Exp Ther 322:1067-1075.
21. Onaivi ES, Green MR, and Martin BR (1990) Pharmacological characterization of cannabinoids in the elevated plus maze. J Pharmacol Exp Ther 253:1002-1009.
22. O'Shea M, McGregor IS, and Mallet PE (2006) Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar long-lasting deficits in object recognition and reduced social interaction in rats. J Psychopharmacol 20:611-621.
23. Pope HG Jr, Gruber AJ, Hudson JI, Cohane G, Huestis MA, and Yurgelun-Todd D (2003) Early-onset cannabis use and cognitive deficits: what is the nature of the association? Drug Alcohol Depend 69:303-310.
24. Pope HG Jr, Gruber AJ, and Yurgelun-Todd D (2001) Residual neuropsychologic effects of cannabis. Curr Psychiatry Rep 3:507-512.
25. Quinn HR, Matsumoto I, Callaghan PD, Long LE, Arnold JC, Gunasekaran N, Thompson MR, Dawson B, Mallet PE, Kashem MA, et al. (2008) Adolescent rats find repeated Δ9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology 33:1113-1126.
26. Rodríguez de Fonseca F, Ramos JA, Bonnin A, and Fernández-Ruiz JJ (1993) Presence of cannabinoid binding sites in the brain from early postnatal ages. Neuroreport 4:135-138.
27. Rubino T, Guidali C, Vigano D, Realini N, Valenti M, Massi P, and Parolaro D (2008a) CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour. Neuropharmacology 54:151-160.
28. Rubino T, Vigano' D, Realini N, Guidali C, Braida D, Capurro V, Castiglioni C, Cherubino F, Romualdi P, Candeletti S, et al. (2008b) Chronic Δ9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates. Neuropsychopharmacology 33:2760-2771.
29. Schneider M and Koch M (2003) Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats. Neuropsychopharmacology 28:1760-1769.
30. Schramm-Sapyta NL, Cha YM, Chaudhry S, Wilson WA, Swartzwelder HS, and Kuhn CM (2007) Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats. Psychopharmacology (Berl) 191:867-877.
31. Sim LJ, Selley DE, and Childers SR (1995) In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5′-[γ-[35S]thio]- triphosphate binding. Proc Natl Acad Sci USA 92:7242-7246.
32. Sim-Selley LJ (2003) Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids. Crit Rev Neurobiol 15:91-119.
33. Substance Abuse and Mental Health Services Administration (2007) National Survey on Drug Use and Health, Substance Abuse and Mental Health Services Administration, Rockville, MD.
34. Tsou K, Mackie K, Sañudo-Peña MC, and Walker JM (1999) Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing GABAergic interneurons in the rat hippocampal formation. Neuroscience 93:969-975.
35. Vorhees CV and Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848-858.
36. Wiley JL, O'Connell MM, Tokarz ME, and Wright MJ Jr (2007) Pharmacological effects of acute and repeated administration of Δ9-tetrahydrocannabinol in adolescent and adult rats. J Pharmacol Exp Ther 320:1097-1105.
37. Wise LE, Thorpe AJ, and Lichtman AH (2009) Hippocampal CB(1) receptors mediate the memory impairing effects of Δ9-tetrahydrocannabinol. Neuropsychopharmacology 34:2072-2080.