The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species

FASEB Journal

Volumn 21, Issue 11, 2007, Pages 2798-2806

  Siegmund, Sören V ^a,b   Qian, Ting ^c   De Minicis, Samuele ^a   Harvey White, Judith ^d   Kunos, George ^d   Vinod, K Y ^e   Hungund, Basalingappa ^a,e   Schwabe, Robert F ^a,f  

^a College of Physicians and Surgeons ^*  (United States)

^b MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^c University of Texas Medical Branch School of Medicine   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^e NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^f Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

2 AG; Fibrosis; Hepatocyte; HSC; ROS

Indexed keywords

2 ARACHIDONOYLGLYCEROL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CASPASE 3; CHOLESTEROL; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL DEATH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG CONCENTRATION; DRUG EFFECT; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER INJURY; MALE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT; STELLATE CELL;

ANIMALS; APOPTOSIS; ARACHIDONIC ACIDS; BLOTTING, WESTERN; CASPASES; CELLS, CULTURED; EMBRYO; ENDOCANNABINOIDS; FIBROBLASTS; FIBROSIS; GLYCERIDES; HEPATOCYTES; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34548499520     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7717com     Document Type: Article

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