Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase

Brain Research

Volumn 1451, Issue , 2012, Pages 110-116

  Chung, Eun Sook ^a   Bok, Eugene ^a,b   Chung, Young Cheul ^a,c   Baik, Hyung Hwan ^a   Jin, Byung Kwan ^a  

^a Kyung Hee University Hospital   (South Korea)

^b UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Cannabinoids; LPS; Microglial activation; NADPH oxidase; Oxidative stress; Proinflammatory cytokines

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID; CYTOKINE; DEXANABINOL; HYDROETHIDINE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PROTEIN P47; PROTEIN P67; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOPAMINERGIC NERVE CELL; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GROWTH INHIBITION; HISTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INJECTION; MICROGLIA; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NISSL STAINING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SUBSTANTIA NIGRA; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BENZOXAZINES; CANNABINOIDS; LIPOPOLYSACCHARIDES; MICROGLIA; MORPHOLINES; NADPH OXIDASE; NAPHTHALENES; NERVE DEGENERATION; NEURONS; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; SUBSTANTIA NIGRA; TETRAHYDROCANNABINOL;

RATTUS;

EID: 84859924311     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.02.058     Document Type: Article

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