Food-dependent disintegration of immediate release fosamprenavir tablets: In vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 77, Issue 2, 2011, Pages 313-319

  Brouwers, Joachim ^a   Anneveld, Bart ^b   Goudappel, Gert Jan ^c   Duchateau, Guus ^c   Annaert, Pieter ^a   Augustijns, Patrick ^a   Zeijdner, Evelijn ^b  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b TNO   (Netherlands)

^c UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

Author keywords

Fed state; Formulation development; Immediate release tablets; Magnetic resonance imaging; Tablet disintegration; TNO gastrointestinal model

Indexed keywords

FOSAMPRENAVIR;

ARTICLE; BIOAVAILABILITY; DRUG RELEASE; FOOD DRUG INTERACTION; GASTROINTESTINAL TRACT; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUTRITIONAL STATUS;

CARBAMATES; FASTING; FOOD-DRUG INTERACTIONS; GASTROINTESTINAL TRACT; HIV PROTEASE INHIBITORS; HUMANS; MAGNETIC RESONANCE IMAGING; PHOSPHORIC ACID ESTERS; POSTPRANDIAL PERIOD; SOLUBILITY; SULFONAMIDES; TABLETS;

EID: 79551535215     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.10.009     Document Type: Article

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