Disintegration of solid foods in human stomach

Journal of Food Science

Volumn 73, Issue 5, 2008, Pages

  Kong, F ^a,b   Singh, R P ^a,b  

^a University of California   (United States)

^b MASSEY UNIVERSITY   (New Zealand)

Author keywords

Controlled release; Digestion; Food disintegration; Gastric emptying; Stomach

Indexed keywords

BIOAVAILABILITY; DIGESTION; FLOW KINETICS; HUMAN; INTESTINE ABSORPTION; METABOLISM; PHYSIOLOGY; REVIEW; SOLUBILITY; STOMACH; STOMACH EMPTYING; TIME;

BIOLOGICAL AVAILABILITY; DIGESTION; GASTRIC EMPTYING; HUMANS; INTESTINAL ABSORPTION; RHEOLOGY; SOLUBILITY; STOMACH; TIME FACTORS;

EID: 44949255007     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2008.00766.x     Document Type: Review

References (135)

1. Abrahamsson B, Alpesten M, Bake B, Larsson A, Sjogren J. 1998. In vitro and in vivo erosion of two different hydrophilic gel matrix tablets. Eur J Pharm Biopharm 46 : 69 75.
2. Abrahamsson B, Albery T, Eriksson A, Gustafsson I, Sjoberg M. 2004. Food effects on tablet disintegration. Eur J Pharm Sci 22 : 165 72.
3. Abrahamsson B, Pal A, Sjoberg M, Carlsson M, Laurell E, Brasseur JG. 2005. A novel in vitro and numerical analysis of shear-induced drug release from extended-release tablets in the fed stomach. Pharm Res 22 (8 1215 26.
4. Agrawal KR, Lucas PW, Prinz JF, Bruce IC. 1997. Mechanical properties of foods responsible for resisting food breakdown in the human mouth. Arch Oral Biol 42 : 1 9.
5. Amidon GL, De Brincat GA, Najib N. 1991. Effects of gravity on gastric emptying, intestinal transit, and drug absorption. J Clin Pharmacol 31 : 968 73.
6. Aoki S, Ando H, Tatsuishi K, Uesugi K, Ozawa H. 1993. Determination of the mechanical impact force in the in vitro dissolution test and evaluation of the correlation between in vivo and in vitro release. Int J Pharm 95 (1-3 67 75.
7. Aoki S, Ando H, Ishii M, Ida K, Watanabe S, Ozawa H. 1994. Evaluation of the correlation between in vivo and in vitro release. Effect of the force of contraction and food on drug release. Biol Pharm Bull 17 (2 291 5.
8. Arnold JG, Dubois A. 1983. In vitro studies of intragastric digestion. Dig Dis Sci 28 (8 737 41.
9. Arora S, Ali J, Ahuja A, Khar RK, Baboota S. 2005. Floating drug delivery systems: a review. AAPS Pharm Sci Tech 6 (03 E372 90.
10. Benini L, Brighenti F, Castellani G, Brentegani MT, Casiraghi MC, Ruzzenente O, Sembenini C, Pellegrini N, Caliari S, Porrini M. 1994. Gastric emptying of solids is markedly delayed when meals are fried. Dig Dis Sci 39 (11 2288 94.
11. Benini L, Castellani G, Brighenti F, Heaton KW, Brentegani MT, Casiraghi MC, Sembenini C, Pellegrini N, Fioretta A, Minniti G. 1995. Gastric emptying of a solid meal is accelerated by the removal of dietary fibre naturally present in food. Gut 36 (6 825 30.
12. Bilecen D, Scheffler K, Seifritz E, Bongartz G, Steinbrich W. 2000. Hydro-MRI for the visualization of gastric wall motility using RARE magnetic resonance imaging sequences. Abdom Imaging 25 : 30 4.
13. Bjorck I, Granfeldt Y, Liljeberg H, Tovar J, Asp NG. 1994. Food properties affecting the digestion and absorption of carbohydrates. Am J Clin Nutr 59 (33 699 705.
14. Blackburn NA, Johnson IT. 1981. The effect of guar gum on the viscosity of the gastrointestinal contents and on glucose uptake from the perfused jejunum in the rat. Br J Nutr 46 : 239 46.
15. Blanquet S, Zeijdner E, Beyssac E, Meunier J, Denis S, Havenaar R, Alric M. 2004. A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions. Pharm Res 21 : 585 91.
16. Boulby P, Gowland P, Adams V, Spiller RC. 1997. Use of echo planar imaging to demonstrate the effect of posture on the intragastric distribution and emptying of an oil/water meal. Neurogastroenterol Motil 9 : 41 7.
17. Brand JC, Nicholson PL, Thorburn AW, Truswell AS. 1985. Food processing and the glycemic index. Am J Clin Nutr 42 : 1192 6.
18. Camillieri M, Prather CM. 1994. Axial forces during gastric emptying in health and models of disease. Dig Dis Sci 39 : 14S 17S.
19. Camilleri M, Malagelada JR, Brown ML, Becker G, Zinsmeister AR. 1985. Relation between antral motility and gastric emptying of solids and liquids in humans. Am J Physiol 249 (5 Pt 1 G580 5.
20. 13C-acetic acid breath tests. Obes Surg 17 (2 236 41.
21. Cardot JM, Beyssac E, Alric M. 2007. In vitro-in vivo correlation: importance of dissolution in IVIVC. Diss Tech (February) : 15 9.
22. Choe SY, Neudeck BL, Welage LS, Amidon GE, Barnett JL, Amidon GL. 2001. Novel method to assess gastric emptying in humans: the pellet gastric emptying test. Euro J Pharm Sci 14 (4 347 53.
23. Christian PE, Moore JG, Sorenson JA, Coleman RE, Weich DM. 1980. Effects of meal size and correction technique on gastric emptying time: studies with two tracers and opposed detectors. J Nucl Med 21 : 883 5.
24. Collins PJ, Horowitz M, Maddox A, Myers JC, Chatterton BE. 1996. Effects of increasing solid component size of a mixed solid/liquid meal on solid and liquid gastric emptying. Am J Physiol Gastrointest Liver Physiol 271 : G549 54.
25. Darwiche G, Bjorgell O, Almer LO. 2003. The addition of locust bean gum but not water delayed the gastric emptying rate of a nutrient semisolid meal in healthy subjects. BMC Gastroenterol 3 : 12.
26. Dean JR, Ma R. 2007. Approaches to assess the oral bioaccessibility of persistent organic pollutants: a critical review. Chemosphere 68 (8 1399 407.
27. De Boever P, Deplancke B, Verstraete W. 2000. Fermentation by gut microbiota cultured in a simulator of the human intestinal micorbial ecosystem is improved by supplementing a soygerm powder. J Nut 130 (10 2599 606.
28. De Schepper HU, Cremonini F, Chitkara D, Camilleri M. 2004. Assessment of gastric accommodation: overview and evaluation of current methods. Neurogastroenterol Mot 16 (3 275 85.
29. Dikeman CL, Fahey GC Jr. 2006. Viscosity as related to dietary fiber: a review. Crit Rev Food Sci Nutr 46 (8 649 63.
30. Di Lorenzo C, Williams CM, Hajnal F, Valenzuela JE. 1988. Pectin delays gastric emptying and increases satiety in obese subjects. Gastroenterol 95 (5 1211 5.
31. Dressman JB. 1986. Comparison of canine and human gastrointestinal physiology. Pharm Res 3 (3 123 31.
32. Dressman JB, Reppas C. 2000. In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs. Eur J Pharm Sci 11 (suppl. 2 73 80.
33. Dressman JB, Amidon GL, Reppas C, Shah VP. 1998. Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms. Pharml Res 15 : 11 22.
34. Ehrlein HJ, Pröve J. 1982. Effect of viscosity of test meals on gastric emptying in dogs. Q J Exp Physiol 67 : 419 25.
35. Elashoff JD, Reedy TJ, Meyer JH. 1982. Analysis of gastric emptying data. Gastroenterol 83 : 1306 12.
36. Emami J. 2006. In vitro-in vivo correlation: from theory to applications. J Pharm Pharmaceut Sci 9 (2 31 51.
37. Epstein S, Ragi S. 2004. Comment on disintegration/dissolution profiles of copies of Fosamax (alendronate) [letter]. Curr Med Res Opin 20 : 1035 7.
38. Faas H, Steingoetter A, Feinle C, Rades T, Lengsfeld H, Boesiger P, Fried M, Schwizer W. 2002. Effects of meal consistency and ingested fluid volume on the intragastric distribution of a drug model in humans - a magnetic resonance imaging study. Aliment Pharmacol Ther 16 (2 217 24.
39. Feinle C, Kunz P, Boesiger P, Fried M, Schwizer W. 1999. Scintigraphic validation of a magnetic resonance imaging method to study gastric emptying of a solid meal in humans. Gut 44 : 106 11.
40. FDA. 1997. Guidance for industry, extended release oral dosage forms: development, evaluation and application of an in vitro/in vivo correlation. CDER 1997.
41. FIP. 1996. FIP guidelines for dissolution testing of solid oral products (final draft, 1995). Drug Inf J 30 : 1071 84.
42. Fisher RS, Malmud LS, Bandini P, Rock E. 1982. Gastric emptying of a physiologic mixed solid-liquid meal. Clin Nucl Med 7 (5 215 21.
43. Foster KD, Woda A, Peyron MA. 2006. Effect of texture of plastic and elastic model foods on the parameters of mastication. J Neurophysiol 95 : 3469 79.
44. Garrett DA, Failla ML, Sarama RJ. 1999. Development of an in vitro digestion method to assess carotenoid bioavailability from meals. J Agric Food Chem 47 : 4301 9.
45. Gentilcore D, Chaikomin R, Jones KL, Russo A, Feinle-Bisset C, Wishart JM, Rayner CK, Horowitz M. 2006. Effects of fat on gastric emptying of and the glycemic, insulin, and incretin responses to a carbohydrate meal in type 2 diabetes. J Clin Endocrinol Metab 91 : 2062 7.
46. Gil-Izquierdo A, Zafrilla P, Tomás-Barberán FA. 2002. An in vitro method to simulate phenolic compound release from the food matrix in the gastrointestinal tract. Eur Food Res Technol 214 : 155 9.
47. Guerin S, Ramonet Y, LeCloarec J, Meunier-Salaün MC, Bourguet P, Malbert CH. 2001. Changes in intragastric meal distribution are better predictors of gastric emptying rate in conscious pigs than are meal viscosity or dietary fibre concentration. Br J Nutr 85 (3 343 50.
48. Hadi NA, Giouvanoudi A, Morton R, Horton P, Spyrou NM. 2002. Variations in gastric emptying times of three stomach regions for simple and complex meals using scintigraphy. IEEE Trans Nucl Sci 49 : 2328 31.
49. Hedrén E, Diaz V, Svanberg U. 2002. Estimation of carotenoid accessibility from carrots determined by an in vitro digestion method. Eur J Cli Nutr 56 : 425 30.
50. Hellström P, Grybäck P, Jacobsson H. 2006. The physiology of gastric emptying. Best Pract Res Clin Anaesthesiol 20 (3 397 407.
51. Hoebler C, Devaux MF, Karinthi A, Devaux MF, Guillon F, Gallant DJG, Bouchet B, Melegari C, Barry JL. 1998. Physical and chemical transformations of cereal food during oral digestion in human subjects. Br J Nutr 80 : 429 36.
52. Hoebler C, Devaux MF, Karinthi A, Belleville C, Barry JL. 2000. Particle size of solid food after human mastication and in vitro simulation of oral breakdown. Int J Food Sci Nutr 51 (5 353 66.
53. Hoebler C, Lecannu G, Belleville C, Devaux MF, Popineau Y, Barry JL. 2002. Development of an in vitro system simulating bucco-gastric digestion to assess the physical and chemical changes of food. Int J Food Sci Nut 53 (5 389 402.
54. Holm J, Hagander B, Bjorck I, Eliasson AC, Lundquist I. 1989. The effect of various thermal processes on the glycemic response to whole grain wheat products in humans and rats. J Nutr 119 : 1631 8.
55. Horowitz M, Collins PJ, Shearman DJ. 1986. Effect of increasing the caloric/osmotic content of the liquid component of a mixed solid and liquid meal on gastric emptying in obese subjects. Hum Nutr Clin Nutr 40 (1 51 6.
56. Houghton LA, Read NW, Heddle R, Horowitz M, Collins PJ, Chatterton B, Dent J. 1988. Relationship of the motor activity of the antrum, pylorus, and duodenum to gastric emptying of a solid-liquid mixed meal. Gastroenterol 94 (6 1285 91.
57. Indireshkumar K, Brasseur JG, Faas H, Hebbard GS, Kunz P, Feinle C, Li M, Boesiger P, Fried M, Schwizer W. 2000. Relative contributions of "pressure pump" and "peristaltic pump" to gastric emptying. Am J Physiol Gastrointest Liver Physiol 278 : G604 16.
58. Jalabert-Malbos ML, Mishellany-Dutour A, Woda A, Peyron MA. 2007. Particle size distribution in the food bolus after mastication of natural foods. Food Qual Pref 18 : 803 12.
59. Jones KL, O'Donovan DG, Hausken T, Russo A, Lei Y, Horowitz M. 2006. Effects of posture on gastric emptying, transpyloric flow and hunger after a glucose drink in healthy humans. Dig Dis Sci 51 : 1331 8.
60. Kalantzi L, Goumas K, Kalioras V, Abrahamsson B, Dressman JB, Reppas C. 2006. Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies. Pharm Res 23 : 165 76.
61. Kamba M, Seta Y, Kusai A, Ikeda M, Nishimura K. 2000. A unique dosage form to evaluate the mechanical destructive force in the gastrointestinal tract. Int J Pharm 208 : 61 70.
62. Kamba M, Seta Y, Kusai A, Nishimura K. 2001. Evaluation of the mechanical destructive force in the stomach of dog. Int J Pharm 228 : 209 17.
63. Kamba M, Seta Y, Kusai A, Nishimura K. 2002. Comparison of the mechanical destructive force in the small intestine of dog and human. Int J Pharm 237 : 139 49.
64. Kamba M, Seta Y, Takeda N, Hamaura T, Kusai A. Nakane H, Nishimura K. 2003. Measurement of agitation force in dissolution test and mechanical destructive force in disintegration test. Int J Pharm 250 : 99 109.
65. Kelly KA. 1980. Gastric emptying of liquids and solids: roles of proximal and distal stomach. Am J Physiol 239 (Gastrointest Liver Physiol 2 G71 6.
66. Kelly K, O'Mahony B, Lindsay B, Jones T, Grattan TJ, Rostami-Hodjegan A, Stevens HN, Wilson CG. 2004. Comparison of the rates of disintegration, gastric emptying, and drug absorption following administration of a new and a conventional paracetamol formulation, using γ scintigraphy. Pharm Res 20 (10 1668 73.
67. Kenyon CJ, Brown F, McClelland GR, Wilding IR. 1998. The use of pharmacoscintigraphy to elucidate food effects observed with a novel protease inhibitor (Saquinavir). Pharm Res 15 (3 417 22.
68. Kim DY, Myung SJ, Camilleri M. 2000. Novel testing of human gastric motor and sensory functions: rationale, methods and potential applications in clinical practice. Am J Gastroenterol 95 : 3365 73.
69. 13C breath tests: visions and realities. J Nutr 131 : 1637S 42S.
70. Krul CAM. 2003. Mutagenic and antimutagenic activity of food compounds, application of a dynamic in vitro gastrointestinal model. NCA (Netherlands Center Auternatives to Animal Use) Newsletter 14 : 2 4.
71. Krul C, Luiten-Schuite A, Baandagger R, Verhagen H, Mohn G, Feron V, Havenaar R. 2000. Application of a dynamic in vitro gastrointestinal tract model to study the availability of food mutagens, using heterocyclic aromatic amines as model compounds. Food Chem Toxicol 38 (9 783 92.
72. Krul C, Luiten-Schuite A, Tenfelde A, van Ommen B, Verhagen H, Havenaar R. 2001. Antimutagenic activity of green tea and black tea extracts studied in a dynamic in vitro gastrointestinal model. Mutat Res 474 (1 71 85.
73. Kwiatek MA, Steingoetter A, Pal A, Menne D, Brasseur JG, Hebbard G, Boesiger P, Thumshirn M, Fried M, Schwizer W. 2006. Quantification of distal antral contractile motility in healthy human stomach with magnetic resonance imaging. J Magn Reson Imaging 24 : 1101 9.
74. Lavin JH, French SJ, Read NW. 2002. Comparison of oral and gastric administration of sucrose and maltose on gastric emptying rate and appetite. Int J Obes 26 : 80 6.
75. Leclère CJ, Champ M, Boillot J, Guille G, Lecannu G, Molis C, Bornet F, Krempf M, Delort-Laval J, Galmiche JP. 1994. Role of viscous guar gums in lowering the glycemic response after a solid meal. Am J Clin Nutr 59 (4 914 21.
76. Lee SW, Lee JH, Han SH, Lee JW, Rhee C. 2005. Effect of various processing methods on the physical properties of cooked rice and on in vitro starch hydrolysis and blood glucose response in rats. Starch 57 (11 531 9.
77. Malagelada JR, Longstreth GF, Summerskill WHJ, Go VLW. 1976. Measurement of gastric functions during digestion of ordinary solid meals in man. Gastroenterol 70 : 203 10.
78. Marciani L, Gowland PA, Spiller RC, Manoj P, Moore RJ, Young P, Al-Sahab S, Bush D, Wright J, Fillery-Travis AJ. 2000. Gastric response to increased meal viscosity assessed by echo-planar magnetic resonance imaging in humans. J Nutr 130 : 122 7.
79. Marciani L, Gowland PA, Fillery-Travis A, Manoj P, Wright J, Smith A, Young P, Moore RJ, Spiller RC. 2001. Assessment of antral grinding of a model solid meal with echo-planar imaging. Am J Physiol 280 : G844 9.
80. Marciani L, Gowland PA, Spiller RC, Manoj P, Moore RJ, Young P, Fillery-Travis AJ. 2001. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. Am J Physiol Gastrointest Liver Physiol 280 : G1227 33.
81. Marciani L, Wickham MSJ, Singh G, Bush D, Pick D, Cox E, Fillery-Travis A, Faulks R, Marsden C, Gowland P, Spiller R. 2007. Enhancement of intragastric acid stability of a fat emulsion meal delays gastric emptying and increases cholecystokinin release and gall bladder contraction. Am J Physiol Gastrointest Liver Physiol 292 : G1607 13.
82. Marshall T, Constable P, Crochik S, Wittek T. 2005. Determination of abomasal emptying rate in suckling calves by use of nuclear scintigraphy and acetaminophen absorption. Am J Vet Res 66 : 364 74.
83. Mattila Sandholm T, Matto J, Saarela M. 1999. Lactic acid bacteria with health claims - interactions and interference with gastrointestinal flora. Int Dairy J 9 (1 25 35.
84. Meyer JH, Dressman J, Fink A, Amidon G. 1985. Effect of size and density on canine gastric emptying of nondigestible solids. Gastroenterol 89 (4 805 13.
85. Meyer JH, Doty JE. 1988. GI transit and absorption of solid food: multiple effects of guar. Am J Clin Nutr 48 : 267 73.
86. Meyer JH, Gu Y, Elashuff J, Reedy T, Dressman J, Amidon C. 1986. Effects of viscosity and fluid outflow on postcibal gastric emptying of solids. Am J Physiol 250 (Gastrointest Liver Physiol 13 G161 4.
87. Molly K, Vande Woestyne M, Verstraete W. 1993. Development of a S-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem. Appl Microbiol Biotechnol 39 : 254 8.
88. Moore JG, Christian PE, Coleman RE. 1981. Simultaneous gastric emptying of two solid foods. Gastroenterol 81 (2 257 66.
89. Moore JG, Christian PE, Brown JA, Brophy C, Datz FL, Taylor AT, Alazraki N. 1984. Influence of meal weight and caloric content on gastric emptying of meals in man. Dig Dis Sci 29 (6 513 9.
90. Moreno FJ. 2007. Gastrointestinal digestion of food allergens: effect on their allergenicity. Biom Pharm 61 : 50 60.
91. Nagah AM, Seal CJ. 2005. In vitro procedure to predict apparent antioxidant release from wholegrain foods measured using three different analytical methods. J Sci Food Agr 85 (7 1177 85.
92. Nollet L, Vande Velde I, Verstraete W. 1997. Effect of the addition of Peptostreptococcus productus ATCC35244 on the gastro-intestinal microbiota and its activity, as simulated in an in vitro simulator of the human gastro-intestinal tract. Appl Microbiol Biotechnol 48 : 99 104.
93. Norton I, Fryer P, Moore S. 2006. Product/process integration in food manufacture: engineering sustained health. AIChE J 52 : 1632 40.
94. Norton I, Moore S, Fryer P. 2007. Understanding food structuring and breakdown: engineering approaches to obesity. Obes Rev 8 : 83 8.
95. Omura AP, Steffe JF. 2003. Mixer viscometry to characterize fluid foods with large particulates. J Food Proc Eng 26 : 435 45.
96. Oomen AG, Rompelberg CJM, Bruil MA, Dobbe CJG, Pereboom DPKH, Sips AJAM. 2003. Development of an in vitro digestion model for estimating the bioaccessibility of soil contaminants. Arch Env Contam Toxicol 44 : 281 7.
97. Pal A, Abrahamsson B, Schwizer W, Hebbard GS, Brasseur JG. 2003. Application of a virtual stomach to evaluate gastric mixing and breakdown of solid food. Gastroenterol 124 : A673 4.
98. Pal A, Indireshkumar K, Schwizer W, Abrahamsson B, Fried M, Brasseur JG. 2004. Gastric flow and mixing studied using computer simulation. Proc Royal Soc London: Biol Sci 271 : 2587 94.
99. Pal A, Brasseur J, Abrahamsson B. 2007. A stomach road or "Magenstrasse" for gastric emptying. J Biomech 40 (6 1202 10.
100. Parada J, Aguilera JM. 2007. Food microstructure affects the bioavailability of several nutrients. J Food Sci 72 (2 R21 32.
101. Parkman HP, Hasler WL, Fisher RS. 2004. American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis. Gastroenterol 127 (5 1592 622.
102. Pera P, Bucca C, Borro P, Bernocco C, De Lillo A, Carossa S. 2002. Influence of mastication on gastric emptying. J Dent Res 81 : 179 81.
103. Peyron MA, Mishellany A, Woda A. 2004. Particle size distribution of food boluses after mastication of six natural foods. J Dent Res 83 (7 578 82.
104. Poitras P, Picard M, Dery R, Giguere A, Picard D, Maorais J, Plourde V, Boivin M. 1997. Evaluation of gastric emptying function in clinical practice. Dig Dis Sci 42 : 2183 9.
105. Rayner CK, Samsom M, Jones KL, Horowitz M. 2001. Relationships of upper gastrointestinal motor and sensory function with glycemic control. Diabetes Care 24 : 371 81.
106. Ruales J, Nair BM. 1994. Effect of processing on in vitro digestibility of protein and starch in quinoa seeds. Int J Food Sci Technol 29 (4 449 56 (1 p.1/4).
107. Sanz T, Luyten H. 2006. Effect of thickening agent in the in vitro mouth, stomach and intestine release of tyrosol from enriched custards. Food Hydroc 20 (5 703 11.
108. Scholz A, Abrahamsson B, Diebold SM, Kostewicz E, Polentarutti BI, Ungell A-L, Dressman JB. 2002. Influence of hydrodynamics and particle size on the absorption of felodipine in labradors. Pharm Res 19 : 42 6.
109. Scholz A, Kostewicz E, Abrahamsson B, Dressman JB. 2003. Can the USP paddle method be used to represent in-vivo hydrodynamics? J Pharm Pharmacol 55 : 443 51.
110. Schricker BR, Miller DD, Rasmussen RR, Van Campen D. 1981. A comparison of in vivo and in vitro methods for determining availability of iron from meals. Am J Clin Nutr 34 : 2257 63.
111. Schulze K. 2006. Imaging and modeling of digestion in the stomach and the duodenum. Neurogastroenterol Motil 18 : 172 83.
112. Schwizer W, Steingoetter A, Fox M. 2006. Magnetic resonance imaging for the assessment of gastrointestinal function. Scandinavian J Gastro 41 (11 1245 60.
113. Shameem M, Katori N, Aoyagi N, Kojima S. 1995. Oral solid controlled release dosage forms: role of GI-mechanical destructive forces and colonic release in drug absorption under fasted and fed conditions in humans. Pharm Res 12 (7 1049 54.
114. Siddiqui AM, Provost A, Schwarz WH. 1991. Peristaltic pumping of a second order fluid in a planar channel. Rheologica Acta 30 (3 249 62.
115. Siegel JA, Urbain JL, Adler LP, Charkes ND, Maurer AH, Krevsky B, Knight LC, Fisher RS, Malmud LS. 1988. Biphasic nature of gastric emptying. Gut 29 (1 85 9.
116. Simonian HP, Maurer AH, Knight LC, Kantor S, Kontos D, Megalooikonomou V, Fisher RS, Parkman HP. 2004. Simultaneous assessment of gastric accommodation and emptying: studies with liquid and solid meals. J Nucl Med 45 : 1155 60.
117. Souliman S, Blanquet S, Beyssac E, Cardot JMA. 2006. Level A in vitro/in vivo correlation in fasted and fed states using different methods: applied to solid immediate release oral dosage form. Eur J Pharm Sci 27 : 72 9.
118. Stotzer PO, Abrahamsson H. 2000. Human postprandial gastric emptying of indigestible solids can occur unrelated to antral phase III. Neurogastroenterol Mot 12 : 415 9.
119. Souliman S, Beyssac E, Cardot JM, Denis S, Alric M. 2007. Investigation of the biopharmaceutical behaviour of theophylline hydrophilic matrix tablets using USP methods and an artificial digestive system. Drug Dev Ind Pharm 33 (4 475 83.
120. Takahashi T, Sakata T. 2002. Large particles increase viscosity and yield stress of pig cecal contents without changing basic viscoelastic properties. J Nutr 132 : 1026 30.
121. Thomas A. 2006. Gut motility, sphincters and reflex control. Anaesthesia Intens Care Med 7 (2 57 8.
122. Urbain JC, Siegel JA, Charkes ND, Maurer AH, Malmud LS, Fisher RS. 1989. The two-component stomach: effects of meal particle size on fundal and antral emptying. Eur J Nucl Med 15 : 254 9.
123. Vaisman N, Reuven Y, Uzi M, Georgi G, Boehm G. 2006. Camel's milk and gastric emptying. Clin Nut 25 (4 622 5.
124. Vassallo MJ, Camilleri M, Prather CM, Hanson RB, Thomforde GM. 1992. Measurement of axial forces during emptying from the human stomach. Am J Physiol Gastrointest Liver Physiol 263 : G230 9.
125. Versantvoort CH, Van de Kamp E, Rompelberg CJM. 2004. RIVM report 320102002/2004. Development and applicability of an in vitro digestion model in assessing the bioaccessibility of contaminants from food. Available from : http:/www.rivm.nl/en/. Natl. Inst. for Public Health and the Environment, Bilthoven, The Netherlands. Accessed March 2008.
126. Versantvoort CH, Oomen AG, Van de Kamp E, Rompelberg CJ, Sips AJ. 2005. Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food. Food Chem Toxicol 43 (1 31 40.
127. Vertzoni M, Dressman J, Butler J, Hempenstall J, Reppas C. 2005. Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds. Eur J Pharm Biopharm 60 (3 413 7.
128. Verwei M, Arkbåge K, Havenaar R, van den Berg H, Witthöft C, Schaafsma G. 2003. Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model. J Nutr 133 : 2377 83.
129. Walsh KR, Zhang YC, Vodovotz Y, Schwartz SJ, Failla ML. 2003. Stability and bioaccessibility of isoflavones from soy bread during in vitro digestion. J Agric Food Chem 51 : 4603 9.
130. Weitschies W, Wedemeyer RS, Kosch O, Fach K, Nagel S, Soderlind E, Trahms L, Abrahamsson B, Monnikes H. 2005. Impact of the intragastric location of extended release tablets on food interactions. J Control Release 108 (2-3 375 85.
131. Williams S, Wright B, Truong V, Daubert CR, Vinyard CJ. 2005. Mechanical properties of foods used in experimental studies of primate masticatory function. Am J Primatol 67 : 329 46.
132. Yetley EA. 2007. Multivitamin and multimineral dietary supplements: definitions, characterization, bioavailability, and drug interactions. Am J Clin Nutr 85 (1 269S 76S.
133. Yeum KJ, Russell RM. 2002. Carotenoid bioavailability and bioconversion. Annu Rev Nutr 22 : 483 504.
134. Yoo JY, Chen XD. 2006. GIT physicochemical modeling - a critical review. Int J Food Eng 2 (4 4. http://www.bepress.com/ijfe/vol2/iss4/art4/.
135. Ziessman HA, Atkins FB, Vemulakonda US, Tall J, Harkness B, Fahey FH. 1996. Lag phase quantification for solid gastric emptying studies. J Nucl Med 37 : 1639 43.