Permeability assessment for solid oral drug formulations based on Caco-2 monolayer in combination with a flow through dissolution cell

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 66, Issue 2, 2007, Pages 286-295

  Motz, Stephan A ^a   Schaefer, Ulrich F ^a   Balbach, Stefan ^b   Eichinger, Thomas ^b   Lehr, Claus Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Biopharmaceutical classification system (BCS); Caco 2 cells; Dissolution; Oral absorption; Permeation; Propranolol HCl

Indexed keywords

PROPRANOLOL;

ACCURACY; ARTICLE; CELL CULTURE; CELL LINE; DISSOLUTION; DRUG FORMULATION; DRUG PENETRATION; HUMAN; HUMAN CELL; IN VITRO STUDY; KINETICS; REPRODUCIBILITY;

CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; EXCIPIENTS; HUMANS; INTESTINAL MUCOSA; KINETICS; METHACRYLATES; MODELS, BIOLOGICAL; POLYMERS; PROPRANOLOL; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 34247516835     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.10.015     Document Type: Article

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