Achieving antral grinding forces in biorelevant In Vitro models: Comparing the USP dissolution apparatus II and the dynamic gastric model with human In Vivo data

AAPS PharmSciTech

Volumn 12, Issue 2, 2011, Pages 620-626

  Vardakou, Maria ^a   Mercuri, Annalisa ^a,b   Barker, Susan A ^b   Craig, Duncan Q M ^b   Faulks, Richard M ^a   Wickham, Martin S J ^a,c  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c LEATHERHEAD FOOD RESEARCH   (United Kingdom)

Author keywords

Biorelevant in vitro models; Dynamic gastric model; Gastric shear forces; In vitro in vivo correlations; Validation

Indexed keywords

ALGAROBA; AGAR; MICROSPHERE;

ARTICLE; DRUG SOLUBILITY; GRINDING; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; PRIORITY JOURNAL; STOMACH; STOMACH SECRETION; TEMPERATURE; TEST MEAL; VISCOSITY; BIOLOGICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; GASTROINTESTINAL MOTILITY; INSTRUMENTATION; METHODOLOGY; PHARMACEUTICS; PHYSIOLOGY; SOLUBILITY; STANDARD; STOMACH ANTRUM;

AGAR; CHEMISTRY, PHARMACEUTICAL; GASTROINTESTINAL MOTILITY; HUMANS; MICROSPHERES; MODELS, BIOLOGICAL; PYLORIC ANTRUM; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84861145662     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9616-z     Document Type: Article

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